UBA6-DT

Summary

UBA6-DT (UBA6 divergent transcript, HGNC:49083) is a long non-coding RNA gene on chromosome 4q13.2.

Predicted to be involved in RNA processing. Predicted to be located in nucleolus.

Source: NCBI Gene 550112 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49083
Approved symbol	UBA6-DT
Name	UBA6 divergent transcript
Location	4q13.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC550112
Ensembl gene	ENSG00000248049
Ensembl biotype	lncRNA
Entrez	550112
RNAcentral	URS000075CDB3 — lncRNA, 2301 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 30 — 30 lncRNA

ENST00000498917, ENST00000499180, ENST00000500538, ENST00000502758, ENST00000506606, ENST00000511571, ENST00000514109, ENST00000654961, ENST00000656992, ENST00000660649, ENST00000660972, ENST00000663060, ENST00000664183, ENST00000665294, ENST00000665498, ENST00000666396, ENST00000667140, ENST00000693410, ENST00000793751, ENST00000793752, ENST00000793753, ENST00000793754, ENST00000793755, ENST00000793756, ENST00000793757, ENST00000793758, ENST00000822403, ENST00000822404, ENST00000822405, ENST00000822408

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000498917 — 3 exons

Exon	Start	End
ENSE00001959712	67720422	67720632
ENSE00001972556	67701280	67701484
ENSE00001973334	67721477	67722505

Expression profiles

Bgee: expression breadth ubiquitous, 162 present calls, max score 85.93.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.6077 / max 129.1825, expressed in 1764 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47821	10.2059	1747
47820	1.4018	715

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.93	gold quality
cortical plate	UBERON:0005343	85.67	gold quality
adrenal tissue	UBERON:0018303	84.00	gold quality
ganglionic eminence	UBERON:0004023	82.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.31	gold quality
ventricular zone	UBERON:0003053	81.68	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	81.47	gold quality
granulocyte	CL:0000094	80.88	gold quality
right lobe of liver	UBERON:0001114	80.07	gold quality
islet of Langerhans	UBERON:0000006	79.45	gold quality
bone marrow cell	CL:0002092	79.36	gold quality
adenohypophysis	UBERON:0002196	78.86	gold quality
right coronary artery	UBERON:0001625	78.26	gold quality
body of pancreas	UBERON:0001150	78.08	gold quality
spinal cord	UBERON:0002240	77.79	gold quality
smooth muscle tissue	UBERON:0001135	77.67	gold quality
pancreas	UBERON:0001264	77.58	gold quality
popliteal artery	UBERON:0002250	77.22	gold quality
stromal cell of endometrium	CL:0002255	77.19	gold quality
tibial artery	UBERON:0007610	77.18	gold quality
hypothalamus	UBERON:0001898	77.11	gold quality
left adrenal gland	UBERON:0001234	77.02	gold quality
metanephros cortex	UBERON:0010533	76.92	gold quality
right adrenal gland	UBERON:0001233	76.80	gold quality
minor salivary gland	UBERON:0001830	76.75	gold quality
right adrenal gland cortex	UBERON:0035827	76.56	gold quality
aorta	UBERON:0000947	76.52	gold quality
left ovary	UBERON:0002119	76.52	gold quality
anterior cingulate cortex	UBERON:0009835	76.19	gold quality
left coronary artery	UBERON:0001626	76.12	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	10.29
E-ANND-3	no	3.98

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Amino acid restriction induces a long non-coding RNA UBA6-AS1 to regulate GCN2-mediated integrated stress response in breast cancer. (PMID:35137449)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.