UBE2R2-AS1

Summary

UBE2R2-AS1 (UBE2R2 antisense RNA 1, HGNC:49911) is a long non-coding RNA gene on chromosome 9p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49911
Approved symbol	UBE2R2-AS1
Name	UBE2R2 antisense RNA 1
Location	9p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000235481
Ensembl biotype	lncRNA
Entrez	101929688
RNAcentral	URS0002123160 — lncRNA, 858 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 lncRNA

ENST00000422764, ENST00000454429, ENST00000668091, ENST00000669609, ENST00000705030, ENST00000723661

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000422764 — 2 exons

Exon	Start	End
ENSE00001682705	33732975	33733244
ENSE00003992859	33738288	33738416

Expression profiles

Bgee: expression breadth ubiquitous, 130 present calls, max score 87.74.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0873 / max 15.3981, expressed in 31 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
100482	0.0873	31

Top tissues by expression

130 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.74	gold quality
body of pancreas	UBERON:0001150	78.06	gold quality
monocyte	CL:0000576	75.86	gold quality
bone marrow	UBERON:0002371	73.26	gold quality
pancreas	UBERON:0001264	72.00	gold quality
sural nerve	UBERON:0015488	71.41	gold quality
colonic epithelium	UBERON:0000397	70.52	gold quality
testis	UBERON:0000473	68.19	gold quality
left testis	UBERON:0004533	68.12	gold quality
blood	UBERON:0000178	68.00	gold quality
bone marrow cell	CL:0002092	67.33	silver quality
right testis	UBERON:0004534	67.15	gold quality
lower esophagus mucosa	UBERON:0035834	66.22	gold quality
stromal cell of endometrium	CL:0002255	65.17	gold quality
granulocyte	CL:0000094	64.77	gold quality
skeletal muscle tissue	UBERON:0001134	64.52	gold quality
ganglionic eminence	UBERON:0004023	63.63	gold quality
adrenal tissue	UBERON:0018303	62.13	gold quality
ventricular zone	UBERON:0003053	62.04	gold quality
mucosa of transverse colon	UBERON:0004991	61.11	gold quality
cortical plate	UBERON:0005343	60.92	gold quality
cerebellum	UBERON:0002037	57.94	gold quality
cerebellar cortex	UBERON:0002129	57.94	gold quality
cerebellar hemisphere	UBERON:0002245	57.90	gold quality
endometrium	UBERON:0001295	57.80	gold quality
right hemisphere of cerebellum	UBERON:0014890	57.77	gold quality
tonsil	UBERON:0002372	57.57	gold quality
skin of abdomen	UBERON:0001416	57.45	gold quality
esophagus mucosa	UBERON:0002469	57.20	gold quality
zone of skin	UBERON:0000014	57.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncUBE2R2-AS1 acts as a microRNA sponge of miR-302b to promote HCC progression via activation EGFR-PI3K-AKT signaling pathway. (PMID:32835579)
• UBE2R2-AS1 Inhibits Xenograft Growth in Nude Mice and Correlates with a Positive Prognosis in Glioma. (PMID:33528791)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.