UBN2

gene
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Also known as FLJ25778KIAA2030

Summary

UBN2 (ubinuclein 2, HGNC:21931) is a protein-coding gene on chromosome 7q34, encoding Ubinuclein-2 (Q6ZU65).

Predicted to be involved in chromatin organization. Located in nucleoplasm.

Source: NCBI Gene 254048 — RefSeq curated summary.

At a glance

  • Clinical variants (ClinVar): 214 total — 1 likely-pathogenic
  • Dosage sensitivity (ClinGen): haploinsufficiency little evidence, triplosensitivity no evidence
  • MANE Select transcript: NM_173569

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:21931
Approved symbolUBN2
Nameubinuclein 2
Location7q34
Locus typegene with protein product
StatusApproved
AliasesFLJ25778, KIAA2030
Ensembl geneENSG00000157741
Ensembl biotypeprotein_coding
OMIM613841
Entrez254048

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 5 protein_coding, 1 retained_intron

ENST00000473989, ENST00000483726, ENST00000486663, ENST00000609762, ENST00000896062, ENST00000896063

RefSeq mRNA: 1 — MANE Select: NM_173569 NM_173569

CCDS: CCDS43655

Canonical transcript exons

ENST00000473989 — 18 exons

ExonStartEnd
ENSE00001034663139273297139273410
ENSE00001034670139279318139279360
ENSE00001034672139272322139272440
ENSE00001034673139269394139269523
ENSE00001034675139273931139274074
ENSE00001209187139283024139284574
ENSE00001216442139282005139282055
ENSE00001216456139276097139276147
ENSE00001347624139266333139266403
ENSE00001369176139261252139261741
ENSE00001370910139293889139293981
ENSE00001391038139293232139293463
ENSE00001419086139258488139258625
ENSE00001419770139259267139259370
ENSE00001420725139251956139252057
ENSE00003596902139231237139231952
ENSE00003667858139237005139237097
ENSE00003705875139297787139308236

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 96.00.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1424 / max 114.2033, expressed in 1717 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter IDTPM avgSamples expressed
814337.14291661
814321.0346563
814340.6983318
814350.266693

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
upper arm skinUBERON:000426396.00gold quality
caput epididymisUBERON:000435895.97gold quality
corpus epididymisUBERON:000435995.75gold quality
cauda epididymisUBERON:000436094.12gold quality
spermCL:000001993.83gold quality
bronchial epithelial cellCL:000232893.70gold quality
bronchusUBERON:000218593.45gold quality
sural nerveUBERON:001548893.43gold quality
trabecular bone tissueUBERON:000248393.20gold quality
kidney epitheliumUBERON:000481993.00gold quality
upper leg skinUBERON:000426292.78gold quality
skin of hipUBERON:000155492.23gold quality
mucosa of paranasal sinusUBERON:000503091.98gold quality
cerebellar vermisUBERON:000472091.77gold quality
tibialis anteriorUBERON:000138591.38gold quality
ileal mucosaUBERON:000033191.32gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450291.21gold quality
deltoidUBERON:000147690.92gold quality
medial globus pallidusUBERON:000247790.69gold quality
tendon of biceps brachiiUBERON:000818890.64gold quality
globus pallidusUBERON:000187590.34gold quality
nippleUBERON:000203090.31gold quality
cardiac muscle of right atriumUBERON:000337990.06gold quality
lower lobe of lungUBERON:000894989.96gold quality
male germ line stem cell (sensu Vertebrata) in testisCL:0000089 ∩ UBERON:000047389.79gold quality
pancreatic ductal cellCL:000207989.73gold quality
corpus callosumUBERON:000233689.46gold quality
biceps brachiiUBERON:000150789.36gold quality
thymusUBERON:000237089.15gold quality
cardia of stomachUBERON:000116289.03gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3yes6.21

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

503 targeting UBN2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-3163100.0077.238605
HSA-MIR-8485100.0077.574731
HSA-MIR-6867-5P100.0082.213464
HSA-MIR-30A-5P100.0076.313233
HSA-MIR-30B-5P100.0076.293248
HSA-MIR-30C-5P100.0076.293248
HSA-MIR-30D-5P100.0076.323233
HSA-MIR-30E-5P100.0076.323242
HSA-MIR-5193100.0067.261744
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-190A-3P100.0080.355520
HSA-LET-7A-3P100.0074.033932
HSA-LET-7B-3P100.0074.083913
HSA-LET-7F-1-3P100.0074.023928
HSA-MIR-98-3P100.0074.083907
HSA-MIR-126-5P100.0072.713180
HSA-MIR-4668-3P100.0068.742635
HSA-MIR-4476100.0068.182030
HSA-MIR-6876-5P100.0067.682126
HSA-MIR-513A-5P100.0069.772465
HSA-MIR-5692A100.0074.406850
HSA-MIR-5011-5P100.0083.465820
HSA-MIR-656-3P100.0072.152788
HSA-MIR-200B-3P100.0073.312693
HSA-MIR-200C-3P100.0073.352685
HSA-MIR-429100.0073.442698
HSA-MIR-6798-5P100.0065.77699
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-6758-5P100.0066.211470
HSA-MIR-6856-5P100.0065.471298

Functional genomics

ClinGen dosage: haploinsufficiency 1 (little evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 1)

  • MiR-455-3p mediates PPARalpha through UBN2 to promote apoptosis and autophagy in acute myeloid leukemia cells. (PMID:37805161)

Cross-species orthologs

4 orthologs

OrganismSymbolGene ID
danio_rerioubn2aENSDARG00000063062
danio_rerioubn2bENSDARG00000100508
mus_musculusUbn2ENSMUSG00000038538
rattus_norvegicusUbn2ENSRNOG00000005564

Paralogs (1): UBN1 (ENSG00000118900)

Protein

Protein identifiers

Ubinuclein-2Q6ZU65 (reviewed: Q6ZU65)

All UniProt accessions (3): C9J6Y5, Q6ZU65, H7C4P8

UniProt curated annotations — full annotation on UniProt →

Tissue specificity. Expressed in several cell lines tested, including primary and transformed cell lines.

Similarity. Belongs to the ubinuclein family.

Isoforms (2)

UniProt IDNamesCanonical?
Q6ZU65-11yes
Q6ZU65-22

RefSeq proteins (1): NP_775840* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR014840HRDDomain
IPR026947UBN_middle_domDomain

Pfam: PF08729, PF14075

UniProt features (40 total): compositionally biased region 15, modified residue 12, region of interest 8, splice variant 2, chain 1, cross-link 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q6ZU65-F152.080.09

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (13): 13, 243, 250, 252, 311, 416, 419, 422, 584, 1068, 1123, 1148, 272

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 181 (showing top): PATIL_LIVER_CANCER, GOBP_REGULATION_OF_CHROMATIN_ORGANIZATION, GOBP_PROTEIN_DNA_COMPLEX_ORGANIZATION, GOBP_CHROMATIN_REMODELING, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, MARTENS_BOUND_BY_PML_RARA_FUSION, GOBP_NUCLEOSOME_ORGANIZATION, CSR_EARLY_UP.V1_DN, BARX1_TARGET_GENES, CIITA_TARGET_GENES, CREB3L4_TARGET_GENES, DLX4_TARGET_GENES, FEV_TARGET_GENES, FOXN3_TARGET_GENES, HOXC6_TARGET_GENES

GO Biological Process (1): chromatin organization (GO:0006325)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): obsolete extracellular space (GO:0005615), nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
cellular component organization1
binding1
intracellular membrane-bounded organelle1
nuclear lumen1
cellular anatomical structure1

Protein interactions and networks

STRING

1042 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
UBN2CABIN1Q9Y6J0838
UBN2KLRG2A4D1S0657
UBN2ZBTB2Q8N680566
UBN2HIRAP54198515
UBN2FAM47AQ5JRC9505
UBN2PHF3Q92576479
UBN2LMOD2Q6P5Q4435
UBN2DMRTC1Q5HYR2427
UBN2ASF1AQ9Y294422
UBN2MED13LQ71F56396
UBN2DIP2CQ9Y2E4393
UBN2C1orf74Q96LT6378
UBN2FMC1Q96HJ9377
UBN2PXT1Q8NFP0377
UBN2C7orf33Q8WU49374

IntAct

80 interactions, top by confidence:

ABTypeScore
ASF1AHAT1psi-mi:“MI:0914”(association)0.640
ASF1BHAT1psi-mi:“MI:0914”(association)0.640
TFAP4ANGPTL7psi-mi:“MI:0914”(association)0.640
HIRAUBN2psi-mi:“MI:0915”(physical association)0.560
BAG2HGSpsi-mi:“MI:0914”(association)0.530
RBBP4TNRC18psi-mi:“MI:0914”(association)0.530
HMGA1MACROH2A1psi-mi:“MI:0914”(association)0.530
ALX3CRTAPpsi-mi:“MI:0914”(association)0.530
HIRACSPG5psi-mi:“MI:0914”(association)0.530
TEAD2TEAD1psi-mi:“MI:0914”(association)0.530
ASF1AMCM4psi-mi:“MI:0914”(association)0.530
EN1NFIBpsi-mi:“MI:2364”(proximity)0.470
H3C1SMCHD1psi-mi:“MI:2364”(proximity)0.410
SetZKSCAN1psi-mi:“MI:0914”(association)0.350
ASF1ACDAN1psi-mi:“MI:0914”(association)0.350
ORF73ECI2psi-mi:“MI:0914”(association)0.350
TCF7L2LOC401309psi-mi:“MI:0914”(association)0.350
ESR1ESYT2psi-mi:“MI:0914”(association)0.350
Mpsi-mi:“MI:0914”(association)0.350
EN1RPA1psi-mi:“MI:0914”(association)0.350
KLF16psi-mi:“MI:0914”(association)0.350
TLX1IGF2BP3psi-mi:“MI:0914”(association)0.350
CALD1psi-mi:“MI:0914”(association)0.350
CALM3PLEKHG3psi-mi:“MI:0914”(association)0.350
CAPZBENAHpsi-mi:“MI:0914”(association)0.350
CTTNpsi-mi:“MI:0914”(association)0.350
DBNLZNF536psi-mi:“MI:0914”(association)0.350

BioGRID (127): UBN2 (Affinity Capture-MS), UBN2 (Proximity Label-MS), UBN2 (Proximity Label-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-MS), UBN2 (Affinity Capture-RNA), UBN2 (Affinity Capture-MS)

ESM2 similar proteins: A0A1B0GTU1, A2AUY4, B7ZS37, D3Z8Y2, D4A4L4, D4A666, E1B7L7, O46385, O60293, O75152, O95425, P0DQW0, Q08AZ1, Q3KQW7, Q3U1C4, Q3UH68, Q3ZC82, Q4G0F8, Q4V9H5, Q5F3Z9, Q5NBX1, Q5REG6, Q5ZJJ1, Q5ZM88, Q61464, Q62394, Q68FE9, Q6NZF1, Q6PJT7, Q6ZQ03, Q6ZU65, Q76L83, Q7TMD5, Q8BHZ4, Q8BJ05, Q8BLG0, Q8BZ32, Q8C9B9, Q8CCJ9, Q8K298

Diamond homologs: D4A666, E1B7L7, P25992, Q4G0F8, Q6ZU65, Q80WC1, Q9NPG3

SIGNOR signaling

1 interactions.

AEffectBMechanism
UBN2“form complex”“HIRA complex 2”binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 116 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Dengue Virus-Host Interactions105.5×7e-03

GO biological processes:

GO termPartnersFoldFDR
nucleosome assembly1012.9×4e-06
mRNA transport512.1×6e-03
chromatin remodeling96.0×3e-03
transcription by RNA polymerase II95.8×3e-03
mRNA processing85.8×7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

214 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic1
Uncertain significance167
Likely benign11
Benign11

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
689795NM_173569.4(UBN2):c.2024+1G>ALikely pathogenic

SpliceAI

2809 predictions. Top by Δscore:

VariantEffectΔscore
7:139236989:A:AGacceptor_gain1.0000
7:139236990:T:Gacceptor_gain1.0000
7:139236993:A:AGacceptor_gain1.0000
7:139236993:ACCTT:Aacceptor_gain1.0000
7:139236994:C:Gacceptor_gain1.0000
7:139236997:T:TAacceptor_gain1.0000
7:139237000:A:AGacceptor_gain1.0000
7:139237003:A:AGacceptor_gain1.0000
7:139237004:G:GGacceptor_gain1.0000
7:139237004:GAAGA:Gacceptor_gain1.0000
7:139237093:AATAT:Adonor_gain1.0000
7:139237094:ATAT:Adonor_gain1.0000
7:139237095:TAT:Tdonor_gain1.0000
7:139237096:AT:Adonor_gain1.0000
7:139237096:ATGTG:Adonor_loss1.0000
7:139237097:TGTG:Tdonor_loss1.0000
7:139237098:G:Adonor_loss1.0000
7:139237098:G:GGdonor_gain1.0000
7:139237099:TGAGT:Tdonor_loss1.0000
7:139237102:G:Cdonor_loss1.0000
7:139251950:TTGCA:Tacceptor_loss1.0000
7:139251951:TGCA:Tacceptor_loss1.0000
7:139251952:GCA:Gacceptor_loss1.0000
7:139251953:CA:Cacceptor_loss1.0000
7:139251954:A:ATacceptor_loss1.0000
7:139251954:AG:Aacceptor_gain1.0000
7:139251954:AGGGT:Aacceptor_gain1.0000
7:139251955:G:GTacceptor_loss1.0000
7:139251955:GG:Gacceptor_gain1.0000
7:139251955:GGGT:Gacceptor_gain1.0000

AlphaMissense

8700 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
7:139252016:G:CG208R1.000
7:139252019:T:CY209H1.000
7:139252032:A:GD213G1.000
7:139252037:T:CF215L1.000
7:139252038:T:CF215S1.000
7:139252038:T:GF215C1.000
7:139252039:T:AF215L1.000
7:139252039:T:GF215L1.000
7:139252041:T:AI216N1.000
7:139252043:G:CD217H1.000
7:139252044:A:CD217A1.000
7:139252044:A:GD217G1.000
7:139252044:A:TD217V1.000
7:139252048:C:AN218K1.000
7:139252048:C:GN218K1.000
7:139252049:T:CS219P1.000
7:139258488:T:CY222H1.000
7:139258491:G:CD223H1.000
7:139258492:A:CD223A1.000
7:139258492:A:TD223V1.000
7:139258498:T:CL225S1.000
7:139258501:T:AV226D1.000
7:139258503:C:AP227T1.000
7:139258504:C:AP227H1.000
7:139258504:C:GP227R1.000
7:139258513:T:CL230P1.000
7:139258528:G:AG235E1.000
7:139258528:G:TG235V1.000
7:139258530:G:CG236R1.000
7:139258531:G:AG236D1.000

dbSNP variants (sampled 300 via entrez): RS1000069066 (7:139246232 G>A), RS1000084221 (7:139326644 A>C,G), RS1000099104 (7:139298427 A>C), RS1000115882 (7:139315906 A>C,G), RS1000132512 (7:139281354 A>C,G), RS1000146610 (7:139246563 G>T), RS1000169416 (7:139320128 CAG>C), RS1000248070 (7:139275243 A>G), RS1000269890 (7:139314703 C>A,G,T), RS1000279474 (7:139240425 C>T), RS1000352385 (7:139306372 A>G,T), RS1000359399 (7:139265393 A>G), RS1000359434 (7:139287350 T>C,G), RS1000374871 (7:139281086 C>G,T), RS1000408570 (7:139298212 A>G)

Disease associations

OMIM: gene MIM:613841 | disease phenotypes:

GenCC curated gene-disease

Mondo (1): autism spectrum disorder (MONDO:0005258)

Orphanet (1): NON RARE IN EUROPE: Autism (Orphanet:106)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects cotreatment, decreases expression, affects expression, decreases methylation7
sodium arsenitedecreases expression, increases abundance, increases expression2
Phenylmercuric Acetateaffects cotreatment, decreases expression2
FR900359increases phosphorylation1
TAK-243increases sumoylation1
geldanamycinincreases expression1
triphenyl phosphateaffects expression1
pirinixic acidincreases expression, affects binding, increases activity1
arseniteaffects binding, decreases reaction1
butyraldehydedecreases expression1
di-n-butylphosphoric acidaffects expression1
perfluorooctane sulfonic acidincreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
dorsomorphinaffects cotreatment, decreases expression1
jinfukangdecreases expression1
NSC 689534affects binding, increases expression1
Sunitinibincreases expression1
Vorinostatdecreases expression1
Arsenicdecreases expression, increases abundance1
Copperaffects binding, increases expression1
Diethylstilbestrolincreases expression1
Methyl Methanesulfonateincreases expression1
Tetrachlorodibenzodioxinaffects expression1
Dronabinolincreases expression1
Thimerosaldecreases expression1
Tobacco Smoke Pollutiondecreases expression1
Urethaneincreases expression1
p-Chloromercuribenzoic Aciddecreases expression1
Magnetite Nanoparticlesincreases methylation1

Clinical trials (associated diseases)

300 trials via MONDO — disease-level, not drug-specific.

TrialPhaseStatusTitle
NCT00391261PHASE4COMPLETEDAn Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications.
NCT01028820PHASE4COMPLETEDFMRI Brain Activation of Aripiprazole Treatment in Autism Spectrum Disorders
NCT01333865PHASE4COMPLETEDA Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders
NCT01337700PHASE4COMPLETEDMilnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
NCT01695200PHASE4COMPLETEDOmega-3 Fatty Acids in Autism Spectrum Disorders
NCT02096952PHASE4COMPLETEDMethylphenidate ER Liquid Formulation in Adults With ASD and ADHD
NCT02235467PHASE4COMPLETEDMultisite Study: Parental Training Using Video Modelling to Develop Social Skills in Children With Autism
NCT02940574PHASE4COMPLETEDNeural and Behavioral Effects of Oxytocin in Autism Spectrum Disorders
NCT03333629PHASE4COMPLETEDPromoting Positive Outcomes for Individuals With ASD: Linking Early Detection, Treatment, and Long-term Outcomes
NCT03337646PHASE4COMPLETEDEvaluation of the Effect and Safety of Lisdexamfetamine in Children Aged 6-12 With ADHD and Autism
NCT03538431PHASE4COMPLETEDImproving Driving in Young People With Autism Spectrum Disorders
NCT03757585PHASE4COMPLETEDNatural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)
NCT04903353PHASE4COMPLETEDPragmatic Trial Comparing Weight Gain in Children With Autism Taking Risperidone Versus Aripiprazole
NCT05063656PHASE4COMPLETEDBiomarker-Driven Pharmacological Treatment of Adolescents With Autism Spectrum Disorder With Gabapentin
NCT05146245PHASE4UNKNOWNSafety and Pharmacokinetics of Antipsychotics in Children 2: Studying TDM in an RCT
NCT05916339PHASE4RECRUITINGAWARE: Management of ADHD in Autism Spectrum Disorder
NCT05954052PHASE4TERMINATEDA Study of Glutathione in Children With Autism Spectrum Disorder
NCT06853665PHASE4RECRUITINGThe TEAM Study - Treatment Efficacy for Autism/Attention Using Mixed Amphetamine
NCT07054697PHASE4COMPLETEDPilot-RCT With Individualized Homeopathic Treatment in the Children With Autism Spectrum Disorder
NCT07161804PHASE4COMPLETEDPilot RCT Using Homeopathic Medicines in ASD
NCT07439042PHASE4NOT_YET_RECRUITINGBuspirone for Anxiety in Autistic Youth
NCT01302964PHASE3COMPLETEDMirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders
NCT01706523PHASE3TERMINATEDOpen Label Extension Study of STX209 (Arbaclofen) in Autism Spectrum Disorders
NCT01825798PHASE3COMPLETEDTreatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD)
NCT01972074PHASE3COMPLETEDBehavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder
NCT02985749PHASE3COMPLETEDA Study of Oxytocin for the Treatment of Social Impairment in Individuals With High Functioning Autism Spectrum Disorder
NCT03197922PHASE3COMPLETEDTreatment of Encopresis in Children With Autism Spectrum Disorders
NCT03504917PHASE3TERMINATEDA Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension
NCT03553875PHASE3TERMINATEDMemantine for the Treatment of Social Deficits in Youth With Disorders of Impaired Social Interactions
NCT03640156PHASE3COMPLETEDModulating Socially Adaptive Mirror System Functioning in Autism by Oxytocin
NCT03715153PHASE3TERMINATEDEfficacy and Safety of Bumetanide Oral Liquid Formulation in Children Aged From 2 to Less Than 7 Years Old With Autism Spectrum Disorder.
NCT03715166PHASE3TERMINATEDEfficacy and Safety of Bumetanide Oral Liquid Formulation in Children and Adolescents Aged From 7 to Less Than 18 Years Old With Autism Spectrum Disorder
NCT04233502PHASE3WITHDRAWNEfficacy and Safety of Slenyto for Insomnia in Children With ASD
NCT04578756PHASE3COMPLETEDOpen-Label, Flexible-dose Study to Evaluate the Long-Term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Participants With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder
NCT04623398PHASE3COMPLETEDEffect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency)
NCT04725383PHASE3TERMINATEDAmitriptyline for Repetitive Behaviors in Autism Spectrum Disorders
NCT05212493PHASE3COMPLETEDThe Effects of Medical Cannabis in Children With Autistic Spectrum Disorder
NCT05361707PHASE3UNKNOWNEvaluating the Effects of Tasimelteon in Individuals With Autism Spectrum Disorder (ASD) and Sleep Disturbances
NCT05439616PHASE3COMPLETEDStudy of Cariprazine Oral Capsules or Solution to Assess Adverse Events and Change in Irritability Due to Autism Spectrum Disorder (ASD) in Participants Aged 5-17 Years With ASD
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