UBP1

Summary

UBP1 (upstream binding protein 1, HGNC:12507) is a protein-coding gene on chromosome 3p22.3, encoding Upstream-binding protein 1 (Q9NZI7). Functions as a transcriptional activator in a promoter context-dependent manner.

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of viral transcription and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm.

Source: NCBI Gene 7342 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 6 total
• MANE Select transcript: NM_014517

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12507
Approved symbol	UBP1
Name	upstream binding protein 1
Location	3p22.3
Locus type	gene with protein product
Status	Approved
Aliases	TFCP2L5, LBP-1a
Ensembl gene	ENSG00000153560
Ensembl biotype	protein_coding
OMIM	609784
Entrez	7342

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 7 protein_coding, 4 retained_intron, 4 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000283628, ENST00000283629, ENST00000411650, ENST00000447368, ENST00000456378, ENST00000464787, ENST00000466441, ENST00000467613, ENST00000481761, ENST00000486388, ENST00000490112, ENST00000492136, ENST00000496310, ENST00000908179, ENST00000964660, ENST00000964661

RefSeq mRNA: 3 — MANE Select: NM_014517 NM_001128160, NM_001128161, NM_014517

CCDS: CCDS2659, CCDS46788

Canonical transcript exons

ENST00000283629 — 16 exons

Exon	Start	End
ENSE00001011426	33416758	33416834
ENSE00001332218	33439736	33440405
ENSE00001823014	33388336	33390368
ENSE00003462192	33402801	33402904
ENSE00003462899	33392563	33392614
ENSE00003470154	33393312	33393454
ENSE00003480041	33425590	33425741
ENSE00003481829	33412722	33412827
ENSE00003486979	33396162	33396280
ENSE00003512521	33411581	33411687
ENSE00003532707	33400962	33401016
ENSE00003563942	33397045	33397135
ENSE00003619771	33408690	33408797
ENSE00003627335	33409236	33409346
ENSE00003627851	33409449	33409601
ENSE00003682346	33400189	33400282

Expression profiles

Bgee: expression breadth ubiquitous, 289 present calls, max score 96.22.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 16.4852 / max 155.1186, expressed in 1812 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
41626	14.0446	1811
41627	1.5671	515
41625	0.5668	349
41623	0.3067	133

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibia	UBERON:0000979	96.22	gold quality
cortical plate	UBERON:0005343	95.71	gold quality
blood vessel layer	UBERON:0004797	95.70	gold quality
rectum	UBERON:0001052	95.12	gold quality
sural nerve	UBERON:0015488	95.11	gold quality
visceral pleura	UBERON:0002401	94.79	gold quality
popliteal artery	UBERON:0002250	94.76	gold quality
tibial artery	UBERON:0007610	94.76	gold quality
vermiform appendix	UBERON:0001154	94.67	gold quality
right coronary artery	UBERON:0001625	94.64	gold quality
smooth muscle tissue	UBERON:0001135	94.62	gold quality
endothelial cell	CL:0000115	94.52	gold quality
descending thoracic aorta	UBERON:0002345	94.48	gold quality
lymph node	UBERON:0000029	94.43	gold quality
caecum	UBERON:0001153	94.43	gold quality
tonsil	UBERON:0002372	94.41	gold quality
aorta	UBERON:0000947	94.26	gold quality
calcaneal tendon	UBERON:0003701	94.17	gold quality
cerebellar vermis	UBERON:0004720	94.17	gold quality
parotid gland	UBERON:0001831	94.02	gold quality
palpebral conjunctiva	UBERON:0001812	93.95	gold quality
tendon	UBERON:0000043	93.88	gold quality
colonic epithelium	UBERON:0000397	93.88	gold quality
monocyte	CL:0000576	93.87	gold quality
mononuclear cell	CL:0000842	93.86	gold quality
leukocyte	CL:0000738	93.79	gold quality
cerebellar cortex	UBERON:0002129	93.78	gold quality
cerebellar hemisphere	UBERON:0002245	93.72	gold quality
saphenous vein	UBERON:0007318	93.72	gold quality
germinal epithelium of ovary	UBERON:0001304	93.61	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.28
E-MTAB-4850	no	290.56

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

3 targets.

Target	Regulation
CYP11A1	Unknown
CYP2A6	Activation
CYP2B6

Upstream regulators (CollecTRI, top): E2F1, FOS

miRNA regulators (miRDB)

117 targeting UBP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-3605-5P	99.96	67.12	932
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-1297	99.91	73.41	3162

Literature-anchored findings (GeneRIF, showing 5)

• LBP-1b is an important SF1-independent transcriptional activator stimulating P450scc expression in human placental JEG-3 cells, whereas LBP-9 modulates the action of LBP-1b, exerting both positive and negative effects (PMID:15471945)
• LBP-1b and LBP-9 both stimulate LBP-32/MGR promoter activity. (PMID:18004979)
• UBP1 is a critical blood pressure determinant using a combination of mouse and human genetics. (PMID:19662162)
• Data revealed that dimers composed of LBP-1a and LBP-1c were re-formed probably by a partner-exchange of LBP-1b-containing heterodimers. (PMID:19751393)
• Studies reveal that TFCP2, TFCP2L1, UBP1 belong to a transcription factors subfamily and involved in various aspects of cancer types and development as either proto-oncogenes or tumor suppressors. They can directly interact with each other; TFCP2, TFCP2L1 and UBP1 can form heteromeric DNA-binding complexes. In addition, TFCP2L1 can modulate the activity of TFCP2 and UBP1. [review] (PMID:29410248)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ubp1	ENSDARG00000018000
mus_musculus	Ubp1	ENSMUSG00000009741
rattus_norvegicus	Ubp1	ENSRNOG00000009729
drosophila_melanogaster	gem	FBGN0050011
caenorhabditis_elegans	grh-1	WBGENE00001707

Paralogs (5): GRHL2 (ENSG00000083307), TFCP2L1 (ENSG00000115112), GRHL1 (ENSG00000134317), TFCP2 (ENSG00000135457), GRHL3 (ENSG00000158055)

Protein

Protein identifiers

Upstream-binding protein 1 — Q9NZI7 (reviewed: Q9NZI7)

Alternative names: Transcription factor LBP-1

All UniProt accessions (3): Q9NZI7, C9JWL3, F8WEP8

UniProt curated annotations — full annotation on UniProt →

Function. Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.

Subunit / interactions. Interacts with TFCP2. Interacts with PIAS1, and is probably part of a complex containing TFCP2, UBP1 and PIAS1.

Subcellular location. Nucleus.

Tissue specificity. Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines.

Induction. By HIV-1 infection of lymphocytes.

Similarity. Belongs to the grh/CP2 family. CP2 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NZI7-1	1, LBP-1b	yes
Q9NZI7-4	2, LBP-1a

RefSeq proteins (3): NP_001121632, NP_001121633, NP_055332* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007604	CP2	Domain
IPR013761	SAM/pointed_sf	Homologous_superfamily
IPR037600	Ubp1_SAM	Domain
IPR040167	TF_CP2-like	Family
IPR041418	SAM_3	Domain
IPR057520	GRHL1/CP2_C	Domain

Pfam: PF04516, PF18016, PF25416

UniProt features (18 total): sequence conflict 6, modified residue 3, sequence variant 2, region of interest 2, compositionally biased region 2, chain 1, domain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NZI7-F1	76.04	0.56

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 22, 390, 393

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 172 (showing top): GOBP_NEGATIVE_REGULATION_OF_VIRAL_PROCESS, TACAATC_MIR508, CACCAGC_MIR138, GGGCATT_MIR365, TGTGTGA_MIR377, GOBP_BLOOD_VESSEL_MORPHOGENESIS, chr3p22, LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_DN, GOBP_REGULATION_OF_VIRAL_TRANSCRIPTION, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GNF2_DDX5, GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_VIRAL_TRANSCRIPTION, ATGTTTC_MIR494, BLALOCK_ALZHEIMERS_DISEASE_DN

GO Biological Process (4): angiogenesis (GO:0001525), regulation of transcription by RNA polymerase II (GO:0006357), negative regulation of viral transcription (GO:0032897), positive regulation of transcription by RNA polymerase II (GO:0045944)

GO Molecular Function (7): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), DNA-binding transcription factor activity (GO:0003700), protein binding (GO:0005515)

GO Cellular Component (4): chromatin (GO:0000785), nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
cellular anatomical structure	3
regulation of DNA-templated transcription	2
transcription by RNA polymerase II	2
regulation of transcription by RNA polymerase II	2
blood vessel morphogenesis	1
anatomical structure formation involved in morphogenesis	1
viral transcription	1
regulation of viral transcription	1
negative regulation of viral process	1
positive regulation of DNA-templated transcription	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
double-stranded DNA binding	1
sequence-specific DNA binding	1
nucleic acid binding	1
transcription cis-regulatory region binding	1
transcription regulator activity	1
binding	1
chromosome	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1

Protein interactions and networks

STRING

1538 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UBP1	TLCD3B	Q71RH2	763
UBP1	SGPP1	Q9BX95	760
UBP1	CYP11A1	P05108	613
UBP1	DPYD	Q12882	578
UBP1	FUBP1	Q96AE4	567
UBP1	PHC2	Q8IXK0	553
UBP1	APBB1	O00213	553
UBP1	PTBP1	P26599	537
UBP1	TYMS	P04818	534
UBP1	CBX2	Q14781	497
UBP1	PHC1	P78364	490
UBP1	USP7	Q93009	485
UBP1	MTDH	Q86UE4	482
UBP1	UCHL3	P15374	457
UBP1	EIF4E	P06730	452

IntAct

63 interactions, top by confidence:

A	B	Type	Score
LNX1	UBP1	psi-mi:“MI:0915”(physical association)	0.560
UBP1	MORF4L1	psi-mi:“MI:0915”(physical association)	0.560
TFCP2	UBP1	psi-mi:“MI:0915”(physical association)	0.550
FOXP3	FOXP2	psi-mi:“MI:0914”(association)	0.530
STK35	HSP90AA1	psi-mi:“MI:0914”(association)	0.530
DPYSL4	PLCG1	psi-mi:“MI:0914”(association)	0.530
MTHFD2	ACADL	psi-mi:“MI:0914”(association)	0.530
ANKRD29	ADD1	psi-mi:“MI:0914”(association)	0.530
UBP1	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
UBP1	FXR1	psi-mi:“MI:0915”(physical association)	0.370
ZNF184	UBP1	psi-mi:“MI:0915”(physical association)	0.370
UBP1	GLYCTK	psi-mi:“MI:0915”(physical association)	0.370
JAK2	SLC2A1	psi-mi:“MI:0914”(association)	0.350
Clasp2	IBTK	psi-mi:“MI:0914”(association)	0.350
FOXA1	NFIC	psi-mi:“MI:0914”(association)	0.350
FOXC1	NFIX	psi-mi:“MI:0914”(association)	0.350
FOXC2	ZNF536	psi-mi:“MI:0914”(association)	0.350
FOXE1	DDX39A	psi-mi:“MI:0914”(association)	0.350
FOXD3	MYL12B	psi-mi:“MI:0914”(association)	0.350
FOXN1	FOXN1	psi-mi:“MI:0914”(association)	0.350
FOXP1	MYL12B	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
vIRF	GPC4	psi-mi:“MI:0914”(association)	0.350
BCAR1	MYO1C	psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
BMI1	HMGB1P1	psi-mi:“MI:0914”(association)	0.350
	ARID1A	psi-mi:“MI:0914”(association)	0.350
SRF	GPC4	psi-mi:“MI:0914”(association)	0.350
	BANF1	psi-mi:“MI:0914”(association)	0.350

BioGRID (88): UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS), UBP1 (Affinity Capture-MS)

ESM2 similar proteins: A2A690, A2AWP8, A6QL63, F1LTE0, O08873, O14795, O43312, O70585, P0C7A6, P84060, Q08BT5, Q0VGY8, Q14161, Q15139, Q1LVW0, Q3KR37, Q5T6S3, Q62101, Q66H91, Q68FF6, Q6DFZ1, Q6GQW0, Q6IQ26, Q6P6Y1, Q6PAL8, Q6ZWH5, Q80TI0, Q80U28, Q80YA9, Q86UE8, Q8BG18, Q8BIE6, Q8R1S4, Q8WXG6, Q8WXI2, Q92538, Q9BZ71, Q9C0D5, Q9D2N4, Q9ESB5

Diamond homologs: G5EDF0, P13002, Q12800, Q3UNW5, Q4V860, Q5EY87, Q5FWH3, Q5M7R9, Q5PPL8, Q5RAR8, Q5RB16, Q6GL65, Q6ISB3, Q6NZH6, Q7T2U9, Q811S7, Q8K5C0, Q8TE85, Q921D9, Q9ERA0, Q9NZI5, Q9NZI6, Q9NZI7

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 91 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of cell differentiation	5	16.5×	3e-03
anatomical structure morphogenesis	6	10.3×	3e-03
chromatin remodeling	8	7.2×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

6 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	4
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2478 predictions. Top by Δscore:

Variant	Effect	Δscore
3:33393450:ATAAA:A	acceptor_gain	1.0000
3:33393451:TAAA:T	acceptor_gain	1.0000
3:33393452:AAA:A	acceptor_gain	1.0000
3:33393453:AA:A	acceptor_gain	1.0000
3:33393455:C:CC	acceptor_gain	1.0000
3:33393461:T:C	acceptor_gain	1.0000
3:33393461:T:TC	acceptor_gain	1.0000
3:33397039:TTTTA:T	donor_loss	1.0000
3:33397040:TTTA:T	donor_loss	1.0000
3:33397041:TTA:T	donor_loss	1.0000
3:33397042:TAC:T	donor_loss	1.0000
3:33397043:A:T	donor_loss	1.0000
3:33397044:C:CA	donor_loss	1.0000
3:33397133:CAC:C	acceptor_gain	1.0000
3:33397134:ACCTA:A	acceptor_loss	1.0000
3:33397136:C:CC	acceptor_gain	1.0000
3:33397137:T:A	acceptor_loss	1.0000
3:33400184:CATA:C	donor_loss	1.0000
3:33400185:ATAC:A	donor_loss	1.0000
3:33400186:TA:T	donor_loss	1.0000
3:33400187:A:AT	donor_loss	1.0000
3:33400279:TTTG:T	acceptor_gain	1.0000
3:33400280:TTG:T	acceptor_gain	1.0000
3:33400281:TG:T	acceptor_gain	1.0000
3:33400283:C:CC	acceptor_gain	1.0000
3:33400286:T:TC	acceptor_gain	1.0000
3:33400290:CAA:C	acceptor_gain	1.0000
3:33400292:A:AC	acceptor_gain	1.0000
3:33400292:A:C	acceptor_gain	1.0000
3:33400956:ACTT:A	donor_loss	1.0000

AlphaMissense

3574 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:33397066:A:G	L417P	1.000
3:33397075:C:T	G414E	1.000
3:33397076:C:G	G414R	1.000
3:33397076:C:T	G414R	1.000
3:33400239:A:G	L377P	1.000
3:33409312:C:G	R248P	1.000
3:33409326:T:A	K243N	1.000
3:33409326:T:G	K243N	1.000
3:33409327:T:A	K243I	1.000
3:33409328:T:C	K243E	1.000
3:33409329:C:A	R242S	1.000
3:33409329:C:G	R242S	1.000
3:33409330:C:A	R242M	1.000
3:33409330:C:G	R242T	1.000
3:33409331:T:A	R242W	1.000
3:33409331:T:C	R242G	1.000
3:33409339:C:A	G239V	1.000
3:33409339:C:T	G239D	1.000
3:33409340:C:A	G239C	1.000
3:33409340:C:G	G239R	1.000
3:33409340:C:T	G239S	1.000
3:33409341:T:A	K238N	1.000
3:33409341:T:G	K238N	1.000
3:33409342:T:A	K238I	1.000
3:33409343:T:C	K238E	1.000
3:33409449:C:A	K236N	1.000
3:33409449:C:G	K236N	1.000
3:33409451:T:C	K236E	1.000
3:33409452:A:C	F235L	1.000
3:33409452:A:T	F235L	1.000

dbSNP variants (sampled 300 via entrez): RS1000042094 (3:33404450 A>G), RS1000099112 (3:33431348 C>G,T), RS1000140679 (3:33413680 C>A), RS1000257366 (3:33413991 G>C), RS1000368040 (3:33393987 T>C), RS1000394126 (3:33443370 A>G), RS1000441976 (3:33394281 C>A,G,T), RS1000551629 (3:33432996 G>A), RS1000607681 (3:33426841 T>A,C), RS1000649827 (3:33403039 G>A,T), RS1000719105 (3:33401341 AAGTT>A), RS1000721624 (3:33427159 T>C), RS1000857769 (3:33433157 A>G), RS1000872636 (3:33401623 C>A,T), RS1000878536 (3:33438404 G>A,C)

Disease associations

OMIM: gene MIM:609784 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST90020029_1166	Waist circumference adjusted for body mass index	1.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, affects expression, decreases expression	3
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment	2
Valproic Acid	decreases expression, increases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	decreases expression	1
TAK-243	decreases sumoylation	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
bisphenol A	decreases expression	1
geraniol	decreases expression	1
sodium arsenite	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
ICG 001	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Arsenic Trioxide	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Caffeine	decreases phosphorylation	1
Hydrogen Peroxide	affects expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Asbestos, Serpentine	decreases methylation	1
Asbestos, Crocidolite	decreases methylation	1
Asbestos, Amosite	decreases methylation	1
Cadmium Chloride	decreases expression	1
Okadaic Acid	increases expression	1
Particulate Matter	decreases expression, increases abundance	1
Volatile Organic Compounds	increases oxidation, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.