UBR3

Summary

UBR3 (ubiquitin protein ligase E3 component n-recognin 3, HGNC:30467) is a protein-coding gene on chromosome 2q31.1, encoding E3 ubiquitin-protein ligase UBR3 (Q6ZT12). E3 ubiquitin-protein ligase which is a component of the N-end rule pathway.

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including sensory perception of smell; suckling behavior; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within in utero embryonic development and olfactory behavior. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm.

Source: NCBI Gene 130507 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 188 total
• MANE Select transcript: NM_172070

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30467
Approved symbol	UBR3
Name	ubiquitin protein ligase E3 component n-recognin 3
Location	2q31.1
Locus type	gene with protein product
Status	Approved
Aliases	KIAA2024, DKFZp434P117, FLJ37422
Ensembl gene	ENSG00000144357
Ensembl biotype	protein_coding
OMIM	613831
Entrez	130507

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 6 protein_coding, 4 retained_intron, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000272793, ENST00000392632, ENST00000430321, ENST00000439681, ENST00000444475, ENST00000465630, ENST00000474426, ENST00000477461, ENST00000484596, ENST00000487689, ENST00000949146, ENST00000949147, ENST00000949148

RefSeq mRNA: 1 — MANE Select: NM_172070 NM_172070

CCDS: CCDS2238

Canonical transcript exons

ENST00000272793 — 39 exons

Exon	Start	End
ENSE00001384213	170006990	170007190
ENSE00001384887	169958438	169958526
ENSE00001385568	169986645	169986794
ENSE00001561306	169827454	169828052
ENSE00001648398	169927320	169927405
ENSE00001670911	169928727	169928868
ENSE00002205246	169905114	169905293
ENSE00002205818	169906031	169906164
ENSE00002209953	169872236	169872375
ENSE00002219375	169875791	169875949
ENSE00002219551	169932912	169933008
ENSE00002237792	169946288	169946392
ENSE00002237844	169949605	169950065
ENSE00002245847	169896507	169896735
ENSE00002256494	169925619	169925747
ENSE00002256885	169895181	169895311
ENSE00002260450	169878525	169878574
ENSE00002266164	169947542	169947715
ENSE00002267144	169877494	169877637
ENSE00002271206	169923929	169923994
ENSE00002271358	169942493	169942634
ENSE00002273356	169914060	169914146
ENSE00002273745	169926838	169926971
ENSE00002280607	169926692	169926744
ENSE00002288213	169891165	169891231
ENSE00002308266	169924084	169924173
ENSE00003489673	170079814	170080023
ENSE00003495707	170061318	170061443
ENSE00003504146	170055460	170055584
ENSE00003522403	170015281	170015366
ENSE00003532333	170040882	170040985
ENSE00003561836	170080545	170080684
ENSE00003586034	170001304	170001414
ENSE00003613119	170029346	170029448
ENSE00003621646	170008804	170008940
ENSE00003636579	169994323	169994456
ENSE00003640473	170061079	170061186
ENSE00003646916	170081726	170084131
ENSE00003651264	170073428	170073607

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 99.49.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.3052 / max 308.8067, expressed in 1815 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
23583	23.9124	1814
23584	2.3969	1177
23582	0.9959	535

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vastus lateralis	UBERON:0001379	99.49	gold quality
biceps brachii	UBERON:0001507	99.48	gold quality
quadriceps femoris	UBERON:0001377	99.47	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.46	gold quality
deltoid	UBERON:0001476	99.43	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.40	gold quality
left ventricle myocardium	UBERON:0006566	99.33	gold quality
cardiac muscle of right atrium	UBERON:0003379	99.29	gold quality
tibialis anterior	UBERON:0001385	99.07	gold quality
skeletal muscle tissue	UBERON:0001134	98.86	gold quality
myocardium	UBERON:0002349	98.77	gold quality
heart right ventricle	UBERON:0002080	98.43	gold quality
Brodmann (1909) area 46	UBERON:0006483	98.25	gold quality
muscle tissue	UBERON:0002385	98.00	gold quality
skeletal muscle organ	UBERON:0014892	97.68	gold quality
endothelial cell	CL:0000115	97.65	gold quality
Brodmann (1909) area 23	UBERON:0013554	97.51	gold quality
gastrocnemius	UBERON:0001388	97.37	gold quality
body of tongue	UBERON:0011876	97.37	gold quality
muscle of leg	UBERON:0001383	97.27	gold quality
pigmented layer of retina	UBERON:0001782	97.10	gold quality
lateral nuclear group of thalamus	UBERON:0002736	96.98	gold quality
visceral pleura	UBERON:0002401	96.74	gold quality
parietal pleura	UBERON:0002400	96.69	gold quality
gingival epithelium	UBERON:0001949	96.66	gold quality
mucosa of paranasal sinus	UBERON:0005030	96.57	gold quality
epithelial cell of pancreas	CL:0000083	96.56	gold quality
corpus callosum	UBERON:0002336	96.56	gold quality
calcaneal tendon	UBERON:0003701	96.53	gold quality
tibia	UBERON:0000979	96.48	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.30

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

253 targeting UBR3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-485-3P	99.98	70.68	1585
HSA-MIR-539-3P	99.98	70.74	1616
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-6793-5P	99.97	65.95	758
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-2110	99.96	66.68	1930

Literature-anchored findings (GeneRIF, showing 4)

• The human E3 ubiquitin ligase UBR3 has a major activity that polyubiquitylates APE1 at multiple lysine residues clustered on the N-terminal tail. (PMID:21933813)
• UBR3/6 regulate cardiomyocyte Nav 1.5 channel protein levels via the ubiquitin-proteasome pathway. (PMID:26059563)
• UBR3 promotes inflammation and apoptosis via DUSP1/p38 pathway in the nucleus pulposus cells of patients with intervertebral disc degeneration. (PMID:35332432)
• Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study. (PMID:37958966)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ubr3	ENSDARG00000042508
mus_musculus	Ubr3	ENSMUSG00000044308
rattus_norvegicus	Ubr3	ENSRNOG00000008616
drosophila_melanogaster	Ubr3	FBGN0260970
caenorhabditis_elegans		WBGENE00017373

Paralogs (2): UBR2 (ENSG00000024048), UBR1 (ENSG00000159459)

Protein

Protein identifiers

E3 ubiquitin-protein ligase UBR3 — Q6ZT12 (reviewed: Q6ZT12)

Alternative names: N-recognin-3, RING-type E3 ubiquitin transferase UBR3, Ubiquitin-protein ligase E3-alpha-3, Ubiquitin-protein ligase E3-alpha-III, Zinc finger protein 650

All UniProt accessions (5): Q6ZT12, F8WEB7, H0Y3K2, H7BZD8, H7C481

UniProt curated annotations — full annotation on UniProt →

Function. E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A.

Subunit / interactions. Interacts with UBE2A and UBE2B.

Subcellular location. Membrane.

Pathway. Protein modification; protein ubiquitination.

Similarity. Belongs to the E3 ubiquitin-protein ligase UBR1-like family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q6ZT12-1	1	yes
Q6ZT12-2	2
Q6ZT12-3	3
Q6ZT12-4	4

RefSeq proteins (1): NP_742067* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003126	Znf_UBR	Domain
IPR039164	UBR1-like	Family
IPR044046	E3_ligase_UBR-like_C	Domain
IPR055194	UBR1-like_WH	Domain

Pfam: PF02207, PF18995, PF22960

UniProt features (21 total): splice variant 4, region of interest 4, transmembrane region 3, modified residue 3, compositionally biased region 2, zinc finger region 2, chain 1, coiled-coil region 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZT12-F1	78.17	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 343, 344, 1199

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (11): in utero embryonic development (GO:0001701), suckling behavior (GO:0001967), ubiquitin-dependent protein catabolic process (GO:0006511), sensory perception of smell (GO:0007608), embryo development ending in birth or egg hatching (GO:0009792), protein ubiquitination (GO:0016567), olfactory behavior (GO:0042048), positive regulation of protein catabolic process (GO:0045732), ubiquitin-dependent protein catabolic process via the N-end rule pathway (GO:0071596), negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel (GO:1904878), proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)

GO Molecular Function (6): ubiquitin-protein transferase activity (GO:0004842), zinc ion binding (GO:0008270), ubiquitin protein ligase activity (GO:0061630), protein binding (GO:0005515), transferase activity (GO:0016740), metal ion binding (GO:0046872)

GO Cellular Component (3): ubiquitin ligase complex (GO:0000151), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
chordate embryonic development	1
feeding behavior	1
protein ubiquitination	1
modification-dependent protein catabolic process	1
sensory perception of chemical stimulus	1
embryo development	1
protein modification by small protein conjugation	1
chemosensory behavior	1
positive regulation of catabolic process	1
protein catabolic process	1
regulation of protein catabolic process	1
positive regulation of protein metabolic process	1
proteasome-mediated ubiquitin-dependent protein catabolic process	1
calcium ion transmembrane transport via high voltage-gated calcium channel	1
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	1
negative regulation of calcium ion transmembrane transport	1
ubiquitin-dependent protein catabolic process	1
proteasomal protein catabolic process	1
ubiquitin-like protein transferase activity	1
transition metal ion binding	1
ubiquitin-protein transferase activity	1
ubiquitin-like protein ligase activity	1
binding	1
catalytic activity	1
cation binding	1
intracellular protein-containing complex	1
transferase complex	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1110 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UBR3	UBR7	Q8N806	709
UBR3	UBR5	O95071	622
UBR3	UBR4	Q5T4S7	567
UBR3	FBXO11	Q86XK2	554
UBR3	KBTBD12	Q3ZCT8	444
UBR3	DIAPH1	O60610	443
UBR3	ARHGAP4	P98171	423
UBR3	KLHL33	A6NCF5	419
UBR3	MAGEC2	Q9UBF1	416
UBR3	ATE1	O95260	414
UBR3	KLHL38	Q2WGJ6	414
UBR3	ATMIN	O43313	413
UBR3	BTRC	Q9Y297	409
UBR3	NINL	Q9Y2I6	399
UBR3	UBE2B	P23567	397

IntAct

121 interactions, top by confidence:

A	B	Type	Score
GPANK1	TTC19	psi-mi:“MI:0914”(association)	0.740
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
LDLRAD4	NEDD4	psi-mi:“MI:0914”(association)	0.690
KIRREL1	UBR3	psi-mi:“MI:0915”(physical association)	0.560
SPINT2	UPK3BL1	psi-mi:“MI:0914”(association)	0.530
LDLRAD4	WWP2	psi-mi:“MI:0914”(association)	0.530
CRP	QSOX1	psi-mi:“MI:0914”(association)	0.530
BMERB1	DCTN6	psi-mi:“MI:0914”(association)	0.530
ZSCAN32	ZNF197	psi-mi:“MI:0914”(association)	0.530
IFNA21	IFIT3	psi-mi:“MI:0914”(association)	0.530
IFNA8	IFIT3	psi-mi:“MI:0914”(association)	0.530
FAHD1	CLUH	psi-mi:“MI:0914”(association)	0.530
HSPB6	BAG3	psi-mi:“MI:0914”(association)	0.530
IFNA5	IFNA13	psi-mi:“MI:0914”(association)	0.530
IFNA10	ISG15	psi-mi:“MI:0914”(association)	0.530
EFCAB11	SFI1	psi-mi:“MI:0914”(association)	0.530
C1orf198	INPPL1	psi-mi:“MI:0914”(association)	0.530
IFNA8	UBR3	psi-mi:“MI:0914”(association)	0.530
FAM219A	OBSL1	psi-mi:“MI:0914”(association)	0.530
CYB5D2	ABLIM1	psi-mi:“MI:0914”(association)	0.530
ESR2	FBLL1	psi-mi:“MI:0914”(association)	0.460
DUSP28	UBR3	psi-mi:“MI:0915”(physical association)	0.400
TP53AIP1	UBR3	psi-mi:“MI:0915”(physical association)	0.400
WNT1	UBR3	psi-mi:“MI:0915”(physical association)	0.400
GTSF1	UBR3	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (144): UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS), UBR3 (Affinity Capture-MS)

ESM2 similar proteins: A0JMD0, A1A535, A1ZAB5, A2AIV2, A8E7C5, A8PJX4, A8XAA9, B0W2S0, B3MIW0, B3NPV8, B4GAM1, B4JW99, B4KT50, B4LQ23, B4MY63, B4P6P7, D3YVL2, E9PXF8, F4HS99, F4HZK4, F4J5S1, F4JKH6, O60502, O75153, O88379, P34466, P69735, Q0IHW8, Q0VA04, Q15042, Q17N71, Q291J5, Q5PQS3, Q5SW19, Q5TYW4, Q5U430, Q69YN4, Q6NTN5, Q6ZT12, Q7PZD5

Diamond homologs: F1QJX5, O60152, Q5U430, Q6ZT12, Q9W3M3, F4KCC2, O13731, Q07963

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 177 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Regulation of IFNA/IFNB signaling	7	25.0×	2e-06
TRAF6 mediated IRF7 activation	7	21.7×	4e-06
Evasion by RSV of host interferon responses	7	18.6×	1e-05
Interferon alpha/beta signaling	10	12.4×	2e-06
SARS-CoV-2 activates/modulates innate and adaptive immune responses	9	6.5×	1e-03
Factors involved in megakaryocyte development and platelet production	9	4.9×	9e-03

GO biological processes:

GO term	Partners	Fold	FDR
B cell activation involved in immune response	6	40.5×	4e-06
natural killer cell activation involved in immune response	6	38.1×	4e-06
T cell activation involved in immune response	6	27.0×	3e-05
response to exogenous dsRNA	6	20.2×	8e-05
type I interferon-mediated signaling pathway	7	15.4×	8e-05
humoral immune response	7	12.6×	2e-04
cellular response to virus	9	11.6×	3e-05
defense response to virus	13	5.8×	8e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

188 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	144
Likely benign	16
Benign	6

Top pathogenic / likely-pathogenic (0)

SpliceAI

6528 predictions. Top by Δscore:

Variant	Effect	Δscore
2:169828049:GCGG:G	donor_gain	1.0000
2:169862550:A:AG	donor_gain	1.0000
2:169872231:TACA:T	acceptor_loss	1.0000
2:169872233:CA:C	acceptor_loss	1.0000
2:169872234:A:AC	acceptor_loss	1.0000
2:169872234:A:AG	acceptor_gain	1.0000
2:169872234:AG:A	acceptor_gain	1.0000
2:169872235:G:A	acceptor_loss	1.0000
2:169872235:G:GA	acceptor_gain	1.0000
2:169872235:GG:G	acceptor_gain	1.0000
2:169872235:GGT:G	acceptor_gain	1.0000
2:169872376:G:GA	donor_loss	1.0000
2:169872377:T:A	donor_loss	1.0000
2:169875785:TTTTA:T	acceptor_loss	1.0000
2:169875786:TTTA:T	acceptor_loss	1.0000
2:169875787:TTAGC:T	acceptor_loss	1.0000
2:169875789:A:AG	acceptor_gain	1.0000
2:169875789:AGCA:A	acceptor_loss	1.0000
2:169875790:G:A	acceptor_loss	1.0000
2:169875790:G:GC	acceptor_gain	1.0000
2:169875790:GC:G	acceptor_gain	1.0000
2:169875790:GCA:G	acceptor_gain	1.0000
2:169875790:GCAGC:G	acceptor_gain	1.0000
2:169875791:CAGCT:C	acceptor_loss	1.0000
2:169875792:A:AG	acceptor_gain	1.0000
2:169875792:AG:A	acceptor_loss	1.0000
2:169875792:AGCT:A	acceptor_gain	1.0000
2:169875793:G:GG	acceptor_gain	1.0000
2:169875793:GC:G	acceptor_gain	1.0000
2:169875793:GCT:G	acceptor_gain	1.0000

AlphaMissense

12467 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:169827865:T:C	C120R	1.000
2:169827866:G:A	C120Y	1.000
2:169827867:C:G	C120W	1.000
2:169827872:T:C	L122P	1.000
2:169827875:T:A	V123D	1.000
2:169827877:T:A	W124R	1.000
2:169827877:T:C	W124R	1.000
2:169827878:G:C	W124S	1.000
2:169827879:G:C	W124C	1.000
2:169827879:G:T	W124C	1.000
2:169827889:T:C	F128L	1.000
2:169827890:T:C	F128S	1.000
2:169827890:T:G	F128C	1.000
2:169827891:C:A	F128L	1.000
2:169827891:C:G	F128L	1.000
2:169827896:C:A	A130D	1.000
2:169827902:G:C	R132P	1.000
2:169827904:T:A	C133S	1.000
2:169827904:T:C	C133R	1.000
2:169827905:G:A	C133Y	1.000
2:169827905:G:C	C133S	1.000
2:169827906:C:G	C133W	1.000
2:169827913:T:C	C136R	1.000
2:169827914:G:A	C136Y	1.000
2:169827914:G:T	C136F	1.000
2:169827915:C:G	C136W	1.000
2:169827938:T:C	L144P	1.000
2:169827940:T:A	C145S	1.000
2:169827940:T:C	C145R	1.000
2:169827941:G:A	C145Y	1.000

dbSNP variants (sampled 300 via entrez): RS1000008179 (2:169956388 G>A,T), RS1000009121 (2:170003172 A>G), RS1000012813 (2:169860784 A>G), RS1000036661 (2:170028214 CA>C), RS1000042077 (2:169973907 A>T), RS1000102163 (2:169874873 G>A,T), RS1000102498 (2:169946534 G>A,T), RS1000107313 (2:170009326 T>C), RS1000114448 (2:169906089 C>T), RS1000123283 (2:169988494 T>G), RS1000143006 (2:170055999 C>T), RS1000152274 (2:169857422 A>G), RS1000153996 (2:169902413 G>A), RS1000163916 (2:170017066 A>C), RS1000196949 (2:170016655 G>A)

Disease associations

OMIM: gene MIM:613831 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST002828_11	Urate levels in obese individuals	2.000000e-06
GCST003082_6	Longitudinal change in brain amyloid plaque burden	2.000000e-07
GCST003830_10	Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1)	6.000000e-07
GCST009391_942	Metabolite levels	6.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0007646	amyloid plaque accumulation rate
EFO:0005921	FEV change measurement
EFO:0010402	triacylglycerol 46:2 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
cobaltous chloride	increases expression	1
butyraldehyde	decreases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	decreases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
monomethylarsonous acid	decreases expression	1
ICG 001	decreases expression	1
bisphenol S	increases methylation, affects cotreatment	1
jinfukang	affects cotreatment, decreases expression	1
(+)-JQ1 compound	increases expression	1
Bortezomib	increases expression	1
Fulvestrant	increases methylation, affects cotreatment	1
Air Pollutants	increases abundance, affects expression	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Cisplatin	affects cotreatment, decreases expression	1
Doxorubicin	increases expression	1
Endosulfan	decreases expression	1
Hydrogen Peroxide	affects cotreatment, increases expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Phthalic Acids	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.