UBXN4

Summary

UBXN4 (UBX domain protein 4, HGNC:14860) is a protein-coding gene on chromosome 2q21.3, encoding UBX domain-containing protein 4 (Q92575). Involved in endoplasmic reticulum-associated protein degradation (ERAD).

UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).

Source: NCBI Gene 23190 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 87 total
• Druggable target: yes
• MANE Select transcript: NM_014607

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14860
Approved symbol	UBXN4
Name	UBX domain protein 4
Location	2q21.3
Locus type	gene with protein product
Status	Approved
Aliases	KIAA0242
Ensembl gene	ENSG00000144224
Ensembl biotype	protein_coding
OMIM	611216
Entrez	23190

Gene structure

Transcript identifiers

Ensembl transcripts: 21 — 15 protein_coding, 2 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000272638, ENST00000415164, ENST00000416538, ENST00000426921, ENST00000467065, ENST00000470687, ENST00000471246, ENST00000490163, ENST00000882676, ENST00000882677, ENST00000882678, ENST00000928823, ENST00000928824, ENST00000928825, ENST00000928826, ENST00000928827, ENST00000928828, ENST00000944515, ENST00000944516, ENST00000944517, ENST00000944518

RefSeq mRNA: 1 — MANE Select: NM_014607 NM_014607

CCDS: CCDS42761

Canonical transcript exons

ENST00000272638 — 13 exons

Exon	Start	End
ENSE00001269798	135741855	135742011
ENSE00003474674	135753539	135753567
ENSE00003521047	135748267	135748369
ENSE00003547148	135770571	135770735
ENSE00003550213	135776249	135776351
ENSE00003556279	135778948	135779079
ENSE00003583254	135755517	135755691
ENSE00003585360	135772420	135772547
ENSE00003588038	135780183	135780385
ENSE00003623067	135782749	135785056
ENSE00003670962	135761818	135761911
ENSE00003673641	135769769	135769823
ENSE00003683662	135754159	135754277

Expression profiles

Bgee: expression breadth ubiquitous, 303 present calls, max score 98.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 70.5819 / max 1385.2260, expressed in 1827 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
22659	36.1381	1820
22658	20.5495	1790
22655	9.3726	1712
22656	2.5775	1210
22657	1.2322	736
22660	0.7119	385

Top tissues by expression

303 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.89	gold quality
pylorus	UBERON:0001166	98.56	gold quality
cardia of stomach	UBERON:0001162	98.26	gold quality
secondary oocyte	CL:0000655	98.18	gold quality
cranial nerve II	UBERON:0000941	97.98	gold quality
seminal vesicle	UBERON:0000998	97.96	gold quality
adrenal tissue	UBERON:0018303	97.95	gold quality
body of pancreas	UBERON:0001150	97.78	gold quality
nipple	UBERON:0002030	97.58	gold quality
endometrium	UBERON:0001295	97.52	gold quality
pancreas	UBERON:0001264	97.48	gold quality
corpus epididymis	UBERON:0004359	97.47	gold quality
renal medulla	UBERON:0000362	97.39	gold quality
male germ cell	CL:0000015	97.38	gold quality
islet of Langerhans	UBERON:0000006	97.37	gold quality
ventricular zone	UBERON:0003053	97.35	gold quality
parietal pleura	UBERON:0002400	97.31	gold quality
tendon of biceps brachii	UBERON:0008188	97.29	gold quality
rectum	UBERON:0001052	97.27	gold quality
pancreatic ductal cell	CL:0002079	97.22	gold quality
oocyte	CL:0000023	97.20	gold quality
medial globus pallidus	UBERON:0002477	97.18	gold quality
caput epididymis	UBERON:0004358	97.16	gold quality
gall bladder	UBERON:0002110	97.14	gold quality
monocyte	CL:0000576	97.13	gold quality
cervix squamous epithelium	UBERON:0006922	97.04	gold quality
mononuclear cell	CL:0000842	97.02	gold quality
visceral pleura	UBERON:0002401	97.00	gold quality
pericardium	UBERON:0002407	96.94	gold quality
pleura	UBERON:0000977	96.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

113 targeting UBXN4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358

Literature-anchored findings (GeneRIF, showing 2)

• Erasin/UBXD2 may be involved in endoplasmic-reticulum-associated protein degradation and in Alzheimer’s disease. (PMID:16968747)
• Knockdown of erasin, a platform for p97/VCP and ubiquilin binding, or knockdown of ubiquilin in human cells slowed degradation of two classical endoplasmic reticulum-associated protein degradation substrates. (PMID:19822669)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ubxn4	ENSMUSG00000026353
rattus_norvegicus	Ubxn4	ENSRNOG00000003625
caenorhabditis_elegans		WBGENE00022703

Paralogs (5): TNRC6C (ENSG00000078687), TNRC6A (ENSG00000090905), TNRC6B (ENSG00000100354), UBAC1 (ENSG00000130560), UBXN1 (ENSG00000162191)

Protein

Protein identifiers

UBX domain-containing protein 4 — Q92575 (reviewed: Q92575)

Alternative names: Erasin, UBX domain-containing protein 2

All UniProt accessions (4): Q92575, C9JLR4, F8WB86, Q6PJ80

UniProt curated annotations — full annotation on UniProt →

Function. Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.

Subunit / interactions. Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.

Subcellular location. Endoplasmic reticulum membrane. Nucleus envelope.

Tissue specificity. Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).

Domain organisation. The UBX domain is required for interaction with VCP. The intramembrane domain also contains the signal for ER targeting.

Induction. By ER stress-inducing agents such as tunicamycin, thapsigargin, DTT and the calcium ionophore A23187 (at protein level).

RefSeq proteins (1): NP_055422* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001012	UBX_dom	Domain
IPR029071	Ubiquitin-like_domsf	Homologous_superfamily
IPR036249	Thioredoxin-like_sf	Homologous_superfamily

Pfam: PF00789, PF23187

UniProt features (24 total): strand 6, compositionally biased region 5, helix 3, region of interest 3, topological domain 2, chain 1, modified residue 1, sequence variant 1, intramembrane region 1, domain 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
2KXJ	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q92575-F1	76.04	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 489

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 189 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, MORF_RAB5A, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, MORF_PSMC2, OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP, ONKEN_UVEAL_MELANOMA_UP, MYOD_01, AMIT_EGF_RESPONSE_120_HELA, KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_DN, MORF_PPP6C, NRF2_Q4, STONER_ESOPHAGEAL_CARCINOGENESIS_UP, DODD_NASOPHARYNGEAL_CARCINOMA_UP

GO Biological Process (2): response to unfolded protein (GO:0006986), ERAD pathway (GO:0036503)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): nuclear envelope (GO:0005635), endoplasmic reticulum (GO:0005783), endoplasmic reticulum membrane (GO:0005789), cytosol (GO:0005829), nucleus (GO:0005634), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
endomembrane system	2
cytoplasm	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
response to topologically incorrect protein	1
proteasomal protein catabolic process	1
response to endoplasmic reticulum stress	1
response to chemical	1
binding	1
nucleus	1
organelle envelope	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1

Protein interactions and networks

STRING

1022 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UBXN4	VCP	P55072	961
UBXN4	FAF2	Q96CS3	825
UBXN4	UBXN6	Q9BZV1	690
UBXN4	UBQLN1	Q9UMX0	690
UBXN4	CD3D	P04234	685
UBXN4	UFD1	Q92890	657
UBXN4	UBXN7	O94888	620
UBXN4	UBE2G2	P56554	613
UBXN4	SEL1L	Q9UBV2	597
UBXN4	LRRC59	Q96AG4	579
UBXN4	UBXN10	Q96LJ8	578
UBXN4	FAF1	Q9UNN5	575
UBXN4	UBXN8	O00124	553
UBXN4	AMFR	P26442	553
UBXN4	UBXN1	Q04323	549

IntAct

91 interactions, top by confidence:

A	B	Type	Score
UBXN4	VCP	psi-mi:“MI:0915”(physical association)	0.740
VCP	UBXN4	psi-mi:“MI:0914”(association)	0.740
UBXN4	VCP	psi-mi:“MI:2364”(proximity)	0.740
VCP	UBXN4	psi-mi:“MI:2364”(proximity)	0.740
UBXN4	UBQLN1	psi-mi:“MI:0915”(physical association)	0.720
UBQLN1	UBXN4	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
VCP	UBXN8	psi-mi:“MI:0914”(association)	0.690
UBXN4	UBE4A	psi-mi:“MI:0914”(association)	0.620
UBXN4	UBE4A	psi-mi:“MI:0915”(physical association)	0.620
IGF1R	PIK3R2	psi-mi:“MI:2364”(proximity)	0.590
INSR	PIK3R2	psi-mi:“MI:2364”(proximity)	0.570
UBQLN1	UBXN4	psi-mi:“MI:0915”(physical association)	0.560
UBXN4	UBQLN1	psi-mi:“MI:0915”(physical association)	0.560
GNGT1	UBXN4	psi-mi:“MI:0915”(physical association)	0.560
NRAS	ESYT2	psi-mi:“MI:2364”(proximity)	0.480
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350

BioGRID (288): UBQLN1 (Two-hybrid), UBXN4 (Affinity Capture-MS), UBE4A (Affinity Capture-MS), UBXN4 (Affinity Capture-Western), UBXN4 (Affinity Capture-Western), PSMA6 (Affinity Capture-Western), ACTA2 (Affinity Capture-MS), VPS13A (Affinity Capture-MS), VPS13C (Affinity Capture-MS), IP6K1 (Affinity Capture-MS), FBXO11 (Affinity Capture-MS), UBE4A (Affinity Capture-MS), BCL11A (Affinity Capture-MS), DPP8 (Affinity Capture-MS), UBXN4 (Two-hybrid)

ESM2 similar proteins: E9PSK7, O12940, O35815, O43815, O48726, O55106, O60271, P04973, P09496, P35521, P54105, P54106, P54252, P54731, P70483, Q04753, Q05B58, Q15650, Q28678, Q3ZBU9, Q58A65, Q5EAE3, Q5R4I3, Q5R719, Q5RGJ6, Q5XIJ6, Q5ZKG8, Q61189, Q640W6, Q68FJ8, Q6DG43, Q6DKA1, Q6PGH0, Q8CFK2, Q8UVK2, Q924K2, Q92575, Q92994, Q96MW1, Q9CR27

Diamond homologs: E1BMF7, E1BY77, F1QFS9, P34631, P38237, P45974, P54201, P56399, P57075, Q04323, Q11119, Q28DG7, Q32KW2, Q3V3E1, Q3ZBU9, Q499N6, Q5BKP2, Q5HZY0, Q5R407, Q5R4I3, Q5XIR9, Q5ZJI9, Q6GL77, Q6GLV4, Q6IP50, Q6NXA9, Q7YTB0, Q8BGG7, Q8L6Y1, Q8TF42, Q8VCH8, Q8VDI7, Q922Y1, Q92575, Q92995, Q9BSL1, Q9BZV1, Q9TXH9, Q9VCE9, Q8H0T4

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 82 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by BRAF and RAF1 fusions	5	14.2×	6e-04
Autophagy	5	12.4×	9e-04
Macroautophagy	5	9.6×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
ERAD pathway	10	25.2×	4e-09
macroautophagy	5	16.7×	3e-03
insulin receptor signaling pathway	5	15.4×	3e-03
axonogenesis	5	11.2×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

87 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	64
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2627 predictions. Top by Δscore:

Variant	Effect	Δscore
2:135748261:TTACA:T	acceptor_loss	1.0000
2:135748262:TACA:T	acceptor_loss	1.0000
2:135748264:CA:C	acceptor_loss	1.0000
2:135748265:A:AG	acceptor_gain	1.0000
2:135748265:A:T	acceptor_loss	1.0000
2:135748266:G:GG	acceptor_gain	1.0000
2:135748365:AAAAG:A	donor_loss	1.0000
2:135748366:AAAG:A	donor_loss	1.0000
2:135748367:AAGG:A	donor_loss	1.0000
2:135748368:AG:A	donor_loss	1.0000
2:135748369:GGTT:G	donor_loss	1.0000
2:135748370:G:C	donor_loss	1.0000
2:135748371:T:A	donor_loss	1.0000
2:135754129:T:G	acceptor_gain	1.0000
2:135755511:GCCTA:G	acceptor_loss	1.0000
2:135755512:CCTA:C	acceptor_loss	1.0000
2:135755513:CTAG:C	acceptor_loss	1.0000
2:135755514:TA:T	acceptor_loss	1.0000
2:135755515:AGATG:A	acceptor_loss	1.0000
2:135755516:G:A	acceptor_loss	1.0000
2:135755687:AACAG:A	donor_loss	1.0000
2:135755688:ACAG:A	donor_loss	1.0000
2:135755689:CAG:C	donor_loss	1.0000
2:135755690:AG:A	donor_loss	1.0000
2:135755691:GG:G	donor_loss	1.0000
2:135755692:G:GC	donor_loss	1.0000
2:135755693:T:A	donor_loss	1.0000
2:135761804:A:AG	acceptor_gain	1.0000
2:135761805:T:G	acceptor_gain	1.0000
2:135761808:A:AG	acceptor_gain	1.0000

AlphaMissense

3326 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:135753556:T:C	F68S	1.000
2:135754182:A:C	S80R	1.000
2:135754184:T:A	S80R	1.000
2:135754184:T:G	S80R	1.000
2:135772424:G:C	R276P	1.000
2:135782858:T:A	W500R	1.000
2:135782858:T:C	W500R	1.000
2:135782860:G:C	W500C	1.000
2:135782860:G:T	W500C	1.000
2:135782863:T:A	N501K	1.000
2:135782863:T:G	N501K	1.000
2:135782864:G:A	G502R	1.000
2:135782864:G:C	G502R	1.000
2:135782865:G:A	G502E	1.000
2:135782865:G:T	G502V	1.000
2:135741936:T:A	W3R	0.999
2:135741936:T:C	W3R	0.999
2:135741961:C:A	A11D	0.999
2:135741964:T:A	I12N	0.999
2:135741973:C:A	A15D	0.999
2:135748302:T:A	W40R	0.999
2:135748302:T:C	W40R	0.999
2:135753555:T:C	F68L	0.999
2:135753556:T:G	F68C	0.999
2:135753557:T:A	F68L	0.999
2:135753557:T:G	F68L	0.999
2:135754177:C:A	P78Q	0.999
2:135754185:T:C	F81L	0.999
2:135754187:C:A	F81L	0.999
2:135754187:C:G	F81L	0.999

dbSNP variants (sampled 300 via entrez): RS1000004143 (2:135778746 C>T), RS1000059371 (2:135748734 A>T), RS1000096397 (2:135748019 G>A,T), RS1000213057 (2:135775116 T>A), RS1000262679 (2:135759281 T>A,G), RS1000267044 (2:135759592 C>A), RS1000392589 (2:135765904 G>C,T), RS1000464306 (2:135783933 G>A), RS1000464365 (2:135750453 C>G), RS1000495560 (2:135750146 A>T), RS1000516104 (2:135784283 A>G), RS1000569486 (2:135741062 A>G), RS1000620002 (2:135743297 T>C), RS1000695474 (2:135746679 G>A,C), RS1000793076 (2:135753815 A>C)

Disease associations

OMIM: gene MIM:611216 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001261_4	Corneal structure	1.000000e-06
GCST005951_44	Body mass index	1.000000e-09
GCST007576_42	Chronotype	5.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0008328	chronotype measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066308 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.28	Kd	5251	nM	CHEMBL5653589
5.28	ED50	5251	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149720: Binding affinity to human UBXN4 incubated for 45 mins by Kinobead based pull down assay	kd	5.2510	uM

CTD chemical–gene interactions

38 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol S	decreases methylation, increases expression	2
Valproic Acid	affects expression, decreases expression	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
dicrotophos	decreases expression	1
lasiocarpine	decreases expression	1
propionaldehyde	increases methylation	1
bisphenol A	increases expression	1
nonanal	increases methylation	1
n-hexanal	increases methylation	1
trichostatin A	affects expression	1
beta-lapachone	increases expression	1
sodium arsenite	increases expression	1
butyraldehyde	increases methylation	1
caprylic aldehyde	increases methylation	1
pentanal	increases methylation	1
heptanal	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
torcetrapib	increases expression	1
bisphenol B	increases expression	1
ON 01910	increases expression	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	increases expression	1
bisphenol AF	increases expression	1
Bortezomib	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Vorinostat	decreases expression	1
Acetaminophen	increases expression	1
Benzo(a)pyrene	increases methylation	1
Caffeine	increases phosphorylation	1
Endosulfan	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652762	Binding	Binding affinity to human UBXN4 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Cellosaurus cell lines

1 cell lines: 1 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2KC	Abcam HeLa UBXN4 KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.