UBXN6

Summary

UBXN6 (UBX domain protein 6, HGNC:14928) is a protein-coding gene on chromosome 19p13, encoding UBX domain-containing protein 6 (Q9BZV1). May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes.

Enables ATPase binding activity. Involved in ERAD pathway; endosome to lysosome transport via multivesicular body sorting pathway; and macroautophagy. Located in bounding membrane of organelle and cytosol. Part of endosome and protein-containing complex.

Source: NCBI Gene 80700 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 39 total
• MANE Select transcript: NM_025241

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14928
Approved symbol	UBXN6
Name	UBX domain protein 6
Location	19p13
Locus type	gene with protein product
Status	Approved
Aliases	UBXDC2
Ensembl gene	ENSG00000167671
Ensembl biotype	protein_coding
OMIM	611946
Entrez	80700

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 6 protein_coding, 5 retained_intron, 1 nonsense_mediated_decay

ENST00000301281, ENST00000394765, ENST00000587009, ENST00000587324, ENST00000588238, ENST00000590466, ENST00000591919, ENST00000592358, ENST00000592515, ENST00000593024, ENST00000882458, ENST00000950415

RefSeq mRNA: 2 — MANE Select: NM_025241 NM_001171091, NM_025241

CCDS: CCDS12129, CCDS54201

Canonical transcript exons

ENST00000301281 — 11 exons

Exon	Start	End
ENSE00001115472	4446500	4446719
ENSE00001115477	4446049	4446197
ENSE00001115478	4453458	4453522
ENSE00001115480	4446283	4446413
ENSE00001115484	4448318	4448415
ENSE00001115485	4446836	4446920
ENSE00001115486	4452364	4452492
ENSE00001207736	4457615	4457794
ENSE00002813499	4445006	4445623
ENSE00003477692	4453930	4454093
ENSE00003666356	4447550	4447625

Expression profiles

Bgee: expression breadth ubiquitous, 289 present calls, max score 98.86.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 38.2094 / max 2770.4521, expressed in 1817 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
178434	36.9863	1816
178433	0.7191	318
178432	0.3015	128
178431	0.1119	36
178435	0.0905	18

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	98.86	gold quality
left testis	UBERON:0004533	98.85	gold quality
left adrenal gland cortex	UBERON:0035825	98.65	gold quality
right adrenal gland	UBERON:0001233	98.62	gold quality
adrenal cortex	UBERON:0001235	98.61	gold quality
right adrenal gland cortex	UBERON:0035827	98.61	gold quality
left adrenal gland	UBERON:0001234	98.57	gold quality
adenohypophysis	UBERON:0002196	98.48	gold quality
pituitary gland	UBERON:0000007	98.34	gold quality
right frontal lobe	UBERON:0002810	98.15	gold quality
blood	UBERON:0000178	98.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	97.99	gold quality
right lobe of thyroid gland	UBERON:0001119	97.96	gold quality
cerebellar hemisphere	UBERON:0002245	97.89	gold quality
apex of heart	UBERON:0002098	97.88	gold quality
left lobe of thyroid gland	UBERON:0001120	97.87	gold quality
prefrontal cortex	UBERON:0000451	97.86	gold quality
anterior cingulate cortex	UBERON:0009835	97.86	gold quality
cerebellar cortex	UBERON:0002129	97.83	gold quality
adrenal gland	UBERON:0002369	97.77	gold quality
cingulate cortex	UBERON:0003027	97.77	gold quality
mucosa of stomach	UBERON:0001199	97.61	gold quality
left ovary	UBERON:0002119	97.60	gold quality
thyroid gland	UBERON:0002046	97.57	gold quality
skin of leg	UBERON:0001511	97.55	gold quality
right ovary	UBERON:0002118	97.53	gold quality
gastrocnemius	UBERON:0001388	97.51	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.45	gold quality
nucleus accumbens	UBERON:0001882	97.44	gold quality
adult organism	UBERON:0007023	97.36	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.78
E-MTAB-9221	yes	11.55
E-HCAD-10	no	1.91

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

19 targeting UBXN6, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6887-3P	99.66	67.83	1778
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-6760-5P	98.87	66.73	1515
HSA-MIR-3944-5P	98.50	67.55	997
HSA-MIR-5008-5P	98.42	65.87	1019
HSA-MIR-4637	97.69	68.14	632
HSA-MIR-6787-5P	97.54	63.85	457
HSA-MIR-509-3-5P	97.21	67.74	1517
HSA-MIR-509-5P	97.21	67.90	1512
HSA-MIR-4418	97.04	67.16	1372
HSA-MIR-27A-5P	97.01	65.63	528
HSA-MIR-6815-5P	96.05	65.55	662
HSA-MIR-6865-5P	96.05	65.58	675
HSA-MIR-10396B-5P	94.99	63.57	358
HSA-MIR-1908-5P	94.99	63.41	352
HSA-MIR-663A	94.99	63.54	378
HSA-MIR-6879-3P	93.93	64.00	759

Literature-anchored findings (GeneRIF, showing 13)

• UBXD1 is a novel co-factor of the human p97 ATPase. (PMID:18656546)
• An additional p97 binding site in UBXD1 that competed with the p47 cofactor for binding to the N domain of p97 was identified. (PMID:19174149)
• these findings suggest that UBXD1 is a regulatory component of endoplasmic reticulum-associated degradation that may modulate the adaptor binding to VCP. (PMID:19275885)
• Data show that expression of VCP mutant proteins, or siRNA-mediated depletion of UBXD1 leads to a block of CAV1 transport at the limiting membrane of enlarged endosomes in cultured cells. (PMID:21822278)
• UBXD1 modulates the trafficking of ERGIC-53-containing vesicles by controlling the interaction of transport factors with the cytoplasmic tail of ERGIC-53. (PMID:22337587)
• Data indicate that endosomal trafficking of CAV1 depends on ubiquitination of the N-terminal region and the subsequent recruitment of VCP-UBXD1. (PMID:23335559)
• UBXD1-N intercalates into the p97-ND1 interface, thereby modulating interdomain communication of p97 domains and its activity with relevance for disease pathogenesis (PMID:26475856)
• Upon damage, p97 translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1, PLAA, and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response. (PMID:27753622)
• These results indicate that the outer membrane protein MCL1 is degraded by the VCP-UBXD1 complex and that the process is promoted by the presence of mutant Huntingtin. (PMID:27913212)
• UBXD1 as mitochondrial recruitment factor for p97 further connects the ubiquitin-proteasome system to Parkin-dependent mitophagy and underlines the close cooperation between the different mechanisms involved in mitochondrial maintenance. (PMID:30120381)
• In HIV-positive long-term non-progressors, a higher prevalence of Ala31Thr in UBXN6 was found within its N-terminal region (PMID:31158522)
• Structure of the PUB Domain from Ubiquitin Regulatory X Domain Protein 1 (UBXD1) and Its Interaction with the p97 AAA+ ATPase. (PMID:31847414)
• UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. (PMID:34021047)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	ubxn6	ENSDARG00000003087
mus_musculus	Ubxn6	ENSMUSG00000019578
rattus_norvegicus	Ubxn6	ENSRNOG00000048509
drosophila_melanogaster	Gint3	FBGN0034372
caenorhabditis_elegans		WBGENE00019163

Paralogs (1): ASPSCR1 (ENSG00000169696)

Protein

Protein identifiers

UBX domain-containing protein 6 — Q9BZV1 (reviewed: Q9BZV1)

Alternative names: UBX domain-containing protein 1

All UniProt accessions (4): Q9BZV1, K7EJ02, K7ELN1, K7EP32

UniProt curated annotations — full annotation on UniProt →

Function. May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes.

Subunit / interactions. Interacts with VCP through the PUB domain (via C-terminus) and VIM motif (via N-terminus); the interaction is direct. Forms a ternary complex with CAV1 and VCP. Interacts with SYVN1. Interacts with HERPUD1. Interacts with VCPKMT. May interact with DERL1. Interacts with PLAA, VCP and YOD1; may form a complex involved in macroautophagy. Interacts with LMAN1.

Subcellular location. Cytoplasm. Cytosol. Membrane. Nucleus. Cytoskeleton. Microtubule organizing center. Centrosome. Early endosome membrane. Late endosome membrane. Lysosome membrane.

Tissue specificity. Enhanced expression in testis.

Domain organisation. The UBX domain lacks key residues critical for VCP binding.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BZV1-1	1	yes
Q9BZV1-2	2

RefSeq proteins (2): NP_001164562, NP_079517* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001012	UBX_dom	Domain
IPR018997	PUB_domain	Domain
IPR029071	Ubiquitin-like_domsf	Homologous_superfamily
IPR036339	PUB-like_dom_sf	Homologous_superfamily
IPR042774	UBXN6_PUB	Domain

Pfam: PF00789, PF09409

UniProt features (50 total): helix 18, strand 12, turn 5, region of interest 4, domain 2, sequence variant 2, modified residue 2, compositionally biased region 2, chain 1, splice variant 1, initiator methionine 1

Structure

Experimental structures (PDB)

9 structures.

PDB	Method	Resolution (Å)
8FCN	ELECTRON MICROSCOPY	2.95
8FCM	ELECTRON MICROSCOPY	3.27
8FCO	ELECTRON MICROSCOPY	3.31
8FCT	ELECTRON MICROSCOPY	3.42
8FCL	ELECTRON MICROSCOPY	3.51
8FCP	ELECTRON MICROSCOPY	3.52
8FCQ	ELECTRON MICROSCOPY	3.93
8FCR	ELECTRON MICROSCOPY	4.12
6SAP	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BZV1-F1	76.49	0.07

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 2, 96

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 129 (showing top): GOBP_RESPONSE_TO_NITROGEN_COMPOUND, GOBP_LYSOSOMAL_TRANSPORT, GOCC_VACUOLAR_MEMBRANE, GOBP_RESPONSE_TO_ENDOPLASMIC_RETICULUM_STRESS, GOBP_ENDOSOME_TO_LYSOSOME_TRANSPORT, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, GOBP_VACUOLAR_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, GOCC_MICROTUBULE_ORGANIZING_CENTER, GOBP_MACROAUTOPHAGY, GOCC_CENTROSOME, GOBP_MULTIVESICULAR_BODY_SORTING_PATHWAY, GOBP_PROTEASOMAL_PROTEIN_CATABOLIC_PROCESS, GOBP_ERAD_PATHWAY

GO Biological Process (4): macroautophagy (GO:0016236), endosome to lysosome transport via multivesicular body sorting pathway (GO:0032510), ERAD pathway (GO:0036503), response to stress (GO:0006950)

GO Molecular Function (2): ATPase binding (GO:0051117), protein binding (GO:0005515)

GO Cellular Component (13): nucleus (GO:0005634), cytoplasm (GO:0005737), lysosomal membrane (GO:0005765), endosome (GO:0005768), centrosome (GO:0005813), cytosol (GO:0005829), membrane (GO:0016020), early endosome membrane (GO:0031901), late endosome membrane (GO:0031902), protein-containing complex (GO:0032991), extracellular exosome (GO:0070062), lysosome (GO:0005764), cytoskeleton (GO:0005856)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
endosome membrane	2
autophagosome assembly	1
autophagy	1
endosome to lysosome transport	1
endosome transport via multivesicular body sorting pathway	1
proteasomal protein catabolic process	1
response to endoplasmic reticulum stress	1
response to chemical	1
response to stimulus	1
enzyme binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
lysosome	1
lytic vacuole membrane	1
endomembrane system	1
cytoplasmic vesicle	1
centriole	1
microtubule organizing center	1
cytoplasm	1
early endosome	1
late endosome	1
cellular_component	1
extracellular vesicle	1
lytic vacuole	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

978 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UBXN6	VCP	P55072	960
UBXN6	YOD1	Q5VVQ6	957
UBXN6	PLAA	Q9Y263	926
UBXN6	FAF2	Q96CS3	775
UBXN6	UFD1	Q92890	772
UBXN6	UBXN1	Q04323	744
UBXN6	UBXN7	O94888	744
UBXN6	UBXN2A	P68543	731
UBXN6	NPLOC4	Q8TAT6	703
UBXN6	NSFL1C	Q9UNZ2	702
UBXN6	UBXN4	Q92575	690
UBXN6	UBXN10	Q96LJ8	645
UBXN6	UBE4A	Q14139	639
UBXN6	UBE4B	O95155	626
UBXN6	ATXN3L	Q9H3M9	621

IntAct

103 interactions, top by confidence:

A	B	Type	Score
VCP	UBXN6	psi-mi:“MI:0915”(physical association)	0.960
UBXN6	VCP	psi-mi:“MI:0914”(association)	0.960
VCP	UBXN6	psi-mi:“MI:2364”(proximity)	0.960
UBXN6	VCP	psi-mi:“MI:2364”(proximity)	0.960
UBXN6	VCP	psi-mi:“MI:0915”(physical association)	0.960
UBXN6	VCP	psi-mi:“MI:0407”(direct interaction)	0.960
UBXN6	TRIM39	psi-mi:“MI:0915”(physical association)	0.740
TRIM39	UBXN6	psi-mi:“MI:0915”(physical association)	0.740
UBXN2A	UBXN6	psi-mi:“MI:0915”(physical association)	0.740
VCP	UBXN8	psi-mi:“MI:0914”(association)	0.690
UBXN6	MAGEA4	psi-mi:“MI:0915”(physical association)	0.670
MAGEA4	UBXN6	psi-mi:“MI:0915”(physical association)	0.670
UBXN6	MAGEA4	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (410): UBXN6 (Two-hybrid), UBXN6 (Two-hybrid), UBXN6 (Affinity Capture-RNA), UBXN6 (Affinity Capture-RNA), VCP (Affinity Capture-MS), POR (Affinity Capture-MS), VCPKMT (Affinity Capture-MS), UBXN2A (Affinity Capture-MS), ASPSCR1 (Affinity Capture-MS), FAM104A (Affinity Capture-MS), UBXN6 (Two-hybrid), VCP (Reconstituted Complex), VCP (Affinity Capture-MS), NSFL1C (Affinity Capture-MS), UBXN6 (Affinity Capture-MS)

ESM2 similar proteins: A1L131, A4IFK7, C5IJB0, D3ZND0, F1MX48, O60232, O95400, P35689, Q0VCT3, Q17QX2, Q2KIJ6, Q2YD98, Q3ZBK7, Q3ZBN4, Q4R4I0, Q53GS7, Q5EAN7, Q5FVK6, Q5PPF5, Q5RAS2, Q5T0F9, Q68F60, Q69ZT1, Q6AYI4, Q6NU18, Q6TLH3, Q7L4P6, Q7TMX5, Q8BL74, Q8BRN9, Q8BSI6, Q8C0R7, Q8C6D4, Q8N5A5, Q8R322, Q8VDM1, Q91VL8, Q91WA6, Q91WR3, Q969X0

Diamond homologs: E1BMF7, E1BY77, F1QFS9, P34631, P38237, P45974, P54201, P56399, P57075, Q04323, Q11119, Q28DG7, Q32KW2, Q3V3E1, Q3ZBU9, Q499N6, Q5BKP2, Q5HZY0, Q5R407, Q5R4I3, Q5XIR9, Q5ZJI9, Q6GL77, Q6GLV4, Q6IP50, Q6NXA9, Q7YTB0, Q8BGG7, Q8L6Y1, Q8TF42, Q8VCH8, Q8VDI7, Q922Y1, Q92575, Q92995, Q9BSL1, Q9BZV1, Q9TXH9, Q9VCE9, Q2KIJ6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
SMURF1	unknown	UBXN6	ubiquitination

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 63 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
ERAD pathway	5	15.6×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	28
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2128 predictions. Top by Δscore:

Variant	Effect	Δscore
19:4446041:ACACT:A	donor_loss	1.0000
19:4446042:CACTC:C	donor_loss	1.0000
19:4446043:ACTC:A	donor_loss	1.0000
19:4446044:CTCA:C	donor_loss	1.0000
19:4446045:TCACC:T	donor_loss	1.0000
19:4446046:CA:C	donor_loss	1.0000
19:4446047:A:AC	donor_gain	1.0000
19:4446047:ACCA:A	donor_loss	1.0000
19:4446047:ACCAG:A	donor_gain	1.0000
19:4446048:C:CA	donor_loss	1.0000
19:4446048:C:CC	donor_gain	1.0000
19:4446048:CCAG:C	donor_gain	1.0000
19:4446048:CCAGC:C	donor_gain	1.0000
19:4446193:AGTGC:A	acceptor_gain	1.0000
19:4446194:GTGC:G	acceptor_gain	1.0000
19:4446195:TGC:T	acceptor_gain	1.0000
19:4446196:GCCTG:G	acceptor_loss	1.0000
19:4446198:C:CC	acceptor_gain	1.0000
19:4446198:CTGGG:C	acceptor_loss	1.0000
19:4446199:T:A	acceptor_loss	1.0000
19:4446281:AC:A	donor_gain	1.0000
19:4446282:CC:C	donor_gain	1.0000
19:4446282:CCCTG:C	donor_gain	1.0000
19:4446334:A:AC	donor_gain	1.0000
19:4446335:C:CC	donor_gain	1.0000
19:4446409:CGGAC:C	acceptor_gain	1.0000
19:4446412:ACCTG:A	acceptor_loss	1.0000
19:4446414:C:CC	acceptor_gain	1.0000
19:4446414:CTGC:C	acceptor_loss	1.0000
19:4446495:CCCA:C	donor_loss	1.0000

AlphaMissense

2859 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:4446868:A:G	F223S	0.995
19:4447575:A:G	I197T	0.995
19:4446867:G:C	F223L	0.994
19:4446867:G:T	F223L	0.994
19:4446869:A:G	F223L	0.994
19:4446916:C:G	R207P	0.992
19:4447575:A:C	I197S	0.992
19:4447584:T:G	Y194S	0.992
19:4447585:A:C	Y194D	0.992
19:4447624:A:G	Y181H	0.992
19:4446190:G:C	F353L	0.991
19:4446190:G:T	F353L	0.991
19:4446192:A:G	F353L	0.991
19:4447624:A:C	Y181D	0.991
19:4446152:A:T	V366D	0.990
19:4446366:C:G	R323P	0.988
19:4447585:A:G	Y194H	0.988
19:4446899:C:G	G213R	0.987
19:4446899:C:T	G213R	0.987
19:4447554:A:G	F204S	0.987
19:4447571:C:A	K198N	0.986
19:4447571:C:G	K198N	0.986
19:4446191:A:G	F353S	0.985
19:4446878:C:G	A220P	0.985
19:4446886:A:G	F217S	0.985
19:4447553:A:C	F204L	0.985
19:4447553:A:T	F204L	0.985
19:4447555:A:G	F204L	0.985
19:4447573:T:C	K198E	0.985
19:4447620:A:G	L182P	0.985

dbSNP variants (sampled 300 via entrez): RS1000017959 (19:4448271 G>A), RS1000034734 (19:4444649 T>C), RS1000147570 (19:4444820 C>A), RS1000308323 (19:4454832 G>A,C), RS1000317189 (19:4448149 C>T), RS1000481626 (19:4459634 G>C), RS1000484037 (19:4445705 G>A,C), RS1000659050 (19:4454673 C>T), RS1001085082 (19:4451140 T>A), RS1001133208 (19:4458145 A>C), RS1001305564 (19:4447226 T>C), RS1001372856 (19:4452056 C>A,G,T), RS1001418988 (19:4457912 G>A,T), RS1001426596 (19:4452377 T>C,G), RS1001597251 (19:4447891 C>G,T)

Disease associations

OMIM: gene MIM:611946 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST005668_2	Delta-5 desaturase activity response to n3-polyunsaturated fat supplement	6.000000e-09
GCST009597_134	Multiple sclerosis	6.000000e-09
GCST90002403_273	Red blood cell count	1.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007764	delta-5 desaturase measurement
EFO:0009131	response to polyunsaturated fatty acid supplementation
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases expression	3
bisphenol S	decreases methylation, affects cotreatment, decreases expression	2
Smoke	increases abundance, increases expression, decreases expression	2
Tobacco Smoke Pollution	affects expression, decreases expression	2
triphenyl phosphate	affects expression	1
lead acetate	affects cotreatment, decreases expression	1
manganese chloride	decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
beta-methylcholine	affects expression	1
CGP 52608	affects binding, increases reaction	1
Temozolomide	decreases expression	1
Decitabine	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	affects reaction, increases degradation	1
Caffeine	increases phosphorylation	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	decreases expression	1
Gallic Acid	increases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Manganese	decreases expression, increases abundance	1
Methapyrilene	increases methylation	1
Rotenone	decreases expression	1
Selenium	increases expression	1
Tretinoin	increases expression	1
Valproic Acid	affects expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	increases expression	1
Aflatoxin B1	increases methylation	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3KP	Abcam HEK293T UBXN6 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.