UCA1

Summary

UCA1 (urothelial cancer associated 1, HGNC:37126) is a long non-coding RNA gene on chromosome 19p13.12.

This gene produces a long non-coding RNA that was found to be upregulated in bladder cancer and plays a regulatory role in cell proliferation. This transcript regulates several genes, including CREB (cAMP responsive element binding protein). Expression of this transcript is regulated by CCAAT/enhancer-binding protein-alpha.

Source: NCBI Gene 652995 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37126
Approved symbol	UCA1
Name	urothelial cancer associated 1
Location	19p13.12
Locus type	RNA, long non-coding
Status	Approved
Aliases	LINC00178, CUDR, UCAT1, onco-lncRNA-36
Ensembl gene	ENSG00000214049
Ensembl biotype	lncRNA
OMIM	617500
Entrez	652995
RNAcentral	URS000075D6E2 — lncRNA, 2314 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 51 lncRNA

ENST00000397381, ENST00000589333, ENST00000600160, ENST00000642256, ENST00000642269, ENST00000642440, ENST00000642894, ENST00000643552, ENST00000643567, ENST00000643818, ENST00000643846, ENST00000644103, ENST00000644174, ENST00000644400, ENST00000644502, ENST00000644567, ENST00000644590, ENST00000644730, ENST00000644796, ENST00000644845, ENST00000644962, ENST00000645156, ENST00000645177, ENST00000645221, ENST00000645251, ENST00000645389, ENST00000645708, ENST00000645764, ENST00000645805, ENST00000645821, ENST00000645877, ENST00000646128, ENST00000646397, ENST00000646494, ENST00000647185, ENST00000647292, ENST00000655191, ENST00000655708, ENST00000658824, ENST00000659568, ENST00000664784, ENST00000665604, ENST00000666830, ENST00000670862, ENST00000671188, ENST00000718453, ENST00000757091, ENST00000757092, ENST00000757093, ENST00000757094, ENST00000757095

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000397381 — 3 exons

Exon	Start	End
ENSE00002041068	15831255	15831356
ENSE00004107803	15834636	15836314
ENSE00004107809	15828936	15829338

Expression profiles

Bgee: expression breadth ubiquitous, 128 present calls, max score 96.28.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.6254 / max 75.8222, expressed in 116 samples.

FANTOM5 promoters (7 alternative TSS)

Promoter ID	TPM avg	Samples expressed
174348	0.2279	59
174350	0.1501	58
174351	0.0946	44
174349	0.0665	34
174352	0.0460	30
208716	0.0233	14
208715	0.0169	8

Top tissues by expression

128 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	96.28	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.51	gold quality
gall bladder	UBERON:0002110	85.62	gold quality
islet of Langerhans	UBERON:0000006	82.78	gold quality
placenta	UBERON:0001987	78.79	gold quality
urinary bladder	UBERON:0001255	77.67	gold quality
colonic epithelium	UBERON:0000397	75.39	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	73.81	gold quality
rectum	UBERON:0001052	72.62	gold quality
bone marrow	UBERON:0002371	70.59	gold quality
endocervix	UBERON:0000458	69.82	gold quality
lower esophagus mucosa	UBERON:0035834	69.40	gold quality
esophagus mucosa	UBERON:0002469	67.52	gold quality
bone marrow cell	CL:0002092	67.35	silver quality
pancreas	UBERON:0001264	66.48	gold quality
testis	UBERON:0000473	66.11	gold quality
right testis	UBERON:0004534	65.69	gold quality
left testis	UBERON:0004533	65.10	gold quality
sural nerve	UBERON:0015488	65.06	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	65.04	gold quality
liver	UBERON:0002107	64.63	gold quality
minor salivary gland	UBERON:0001830	63.28	gold quality
uterine cervix	UBERON:0000002	62.78	gold quality
saliva-secreting gland	UBERON:0001044	62.43	gold quality
ganglionic eminence	UBERON:0004023	61.98	gold quality
transverse colon	UBERON:0001157	61.20	gold quality
duodenum	UBERON:0002114	60.88	gold quality
mucosa of transverse colon	UBERON:0004991	60.60	gold quality
body of uterus	UBERON:0009853	60.57	gold quality
right lobe of liver	UBERON:0001114	60.56	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-10287	yes	552.04
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): ETS2, FOXC1, HIF1A, POU5F1

Literature-anchored findings (GeneRIF, showing 40)

• Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development. (PMID:18501714)
• UCA1 gene locates in the cytoplasm, and its mRNA expression level is closely correlated to the progression of bladder cancer. (PMID:20117985)
• UCA1 regulated cell cycle through CREB via PI3K-AKT dependent pathway in bladder cancer. (PMID:22285928)
• similar to the 1.4 kb transcript of UCA1, UCA1a(CUDR) may also play an important role in the growth and tumorigenesis of human bladder cancer (PMID:22576688)
• Expression of UCA1 lncRNA was enhanced in tongue squamous cell carcinoma and may play a role in lymph node metastasis. (PMID:24332332)
• UCA1 promotes breast tumor growth by suppression of Kip1. (PMID:24457952)
• C/EBPalpha siRNA treatment contributed to the downregulation of lncRNA-UCA1 expression, whereas overexpression of C/EBPalpha enhanced lncRNA-UCA1 expression. (PMID:24648007)
• These findings revealed the mechanism of lncRNA-UCA1 upregulation in hypoxic bladder cancer cells and suggested that effective blocking of lncRNA-UCA1 expression in the hypoxic microenvironment of bladder cancer could be a novel therapeutic strategy. (PMID:24737584)
• UCA1-induced hexokinase 2 (HK2) functions as an important mediator in promoting glycolysis in bladder cancer cells (PMID:24890811)
• Knockdown of UCA1 or Malat-1 lncRNA could attenuate the migrational ability of melanoma cells in in-vitro studies. Increased expression of UCA1 and Malat-1 lncRNAs might have a correlation with melanoma metastasis. (PMID:24892958)
• These data suggest an important role for UCA1 in the molecular aetiology of Colorectal cancer (PMID:24977734)
• Data showed that BRG1 as target protein of UCA1 with anti-oncogenic features in bladder cancer cells. UCA1 blocked recruitment of BRG1 to its target promoter, and thus led to reduced expression of p21 and accelerated cell growth. (PMID:24993775)
• This study provides evidence for hsa-miR-1 to play tumor suppressive roles via downregulating lncRNA UCA1 in bladder cancer (PMID:25015192)
• High expression of UCA1 was associated with carcinoma of the urinary bladder. (PMID:25123267)
• Circulating CUDR, LSINCT-5 and PTENP1 were identified as potential diagnostic markers for gastric cancer diagnosis. (PMID:25694351)
• Increased UCA1 expression is associated with gastric cancer. (PMID:25903045)
• Data indicate that an oncogenic long non-coding RNA UCA1 functioning in concert with the dominant negative isoform of 30-kDa dominant negative isoform CCAAT/enhancer-binding protein-alpha (C/EBPalpha-p30) in acute myeloid leukemia (AML). (PMID:26053097)
• The receiver-operating characteristic curve analyses demonstrated that each one had good sensitivity and specificity for distinguishing BC patients from non-BC ones (HYAL1, miR-210, miR-96, lncRNA-UCA1, 91.5 and ). (PMID:26138586)
• UCA1 may induce non-T790M acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors by activating the AKT/mTOR pathway and epithelial-mesenchymal transition in EGFR-mutant non-small cell lung cancer (PMID:26160838)
• UCA1 RNA is expressed and appeared in urine of urothelial carcinoma patients and is absent in urine of controls. (PMID:26161701)
• our findings suggested that UCA1 might be an important prognostic indicator in colorectal cancer (PMID:26238511)
• UCA1 functions as an oncogenic lncRNA in several malignancies, and it might become a potential biomarker or therapeutic target for human cancers (PMID:26341664)
• CUDR causes highly upregulated in liver cancer, HULC and beta-catenin abnormal expression by inhibiting HULC promoter methylation and promoting beta-catenin promoter-enhancer chromatin looping formation mediated by CUDR-ccctc-binding factor (CTCF) complex. (PMID:26347501)
• Urothelial carcinoma-associated 1 (UCA1)regulated the expression of GLS2 through interfering with miR-16, and repressed ROS formation in bladder cancer cells. (PMID:26373319)
• UCA1 can directly interact with miR-143, lower its expression and affect its downstream regulation. The UCA1-miR-143 axis constitutes a part of the oncogenic role of UCA1 in breast cancer. (PMID:26439035)
• High CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc. (PMID:26513297)
• our results identified that lncRNA-UCA1 enhances bladder cancer cell migration and invasion in part through the hsa-miR-145/ZEB1/2/FSCN1 pathway (PMID:26544536)
• This study showed that UCA1 and WRAP53 upregulation may serve as novel serum biomarkers for hepatocellular carcinoma diagnosis and prognosis. (PMID:26551349)
• Conclude that UCA1 functions as an oncogene in non-small cell lung carcinoma, acting mechanistically by upregulating ERBB4 in part through ‘spongeing’ miR-193a-3p. (PMID:26655272)
• conditional logistic regression analysis revealed the aberrant expression of CTD-2541M15, UCA1 and MEG3 closely linked with Gastric cancer (PMID:26718650)
• our study suggested that plasma UCA1 levels could be a promising candidate of noninvasive biomarker for gastric cancer early diagnosis. (PMID:26722487)
• our findings provided evidence that high UCA1 expression was closely associated with increased tumor aggressiveness, poor response to chemotherapy, and worse prognosis in patients with ovarian cancer (PMID:26851957)
• UCA1 was aberrantly upregulated in epithelial ovarian cancer tissues and cells. It correlated with lymph node metastasis, FIGO stage, and overall survival. In vitro, knockdown of UCA1 reduced the invasion and migration ability of EOC cells. It bound directly to mirR-485-5p and was involved in downregulation of its target MMP14. (PMID:26867765)
• Ectopic overexpression and gene silencing of UCA1 in renal cell carcinoma cell lines had opposite effects on cellular proliferation, migration and apoptosis, and the results suggested that UCA1 may function as an oncogene in renal cell carcinoma. (PMID:26935146)
• addition, we also test the level of miR-1 as it is reported to regulate the expression of UCA1. The results show that the level of plasma UCA1 is decreased at the early state of AMI patients and increased at day 3 after Acute myocardial infarction (PMID:26949706)
• UCA1 and miR-204-5p have roles in the CREB1/BCL2/RAB22A regulatory network in colorectal cancer (PMID:27046651)
• lncRNA UCA1 was an independent prognostic biomarker of disease-free survival in gastric cancer patients and acted as an oncogene to regulate the malignant proliferation and resistance to adriamycin in gastric cancer cells. (PMID:27056384)
• Suggest UCA1 and C-JUN mRNA as promising diagnostic and prognostic markers in hepatocellular carcinoma. (PMID:27215316)
• we discovered a novel mechanism through which UCA1 regulated miR-507 in melanoma (PMID:27389544)
• UCA1 may have a prognostic role in human solid tumors as it appears to be associated with poor clinical outcome [meta-analysis] (PMID:27517147)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.