UCK1

Summary

UCK1 (uridine-cytidine kinase 1, HGNC:14859) is a protein-coding gene on chromosome 9q34.13, encoding Uridine-cytidine kinase 1 (Q9HA47). Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate.

This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms.

Source: NCBI Gene 83549 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 31 total
• Druggable target: yes
• MANE Select transcript: NM_031432

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14859
Approved symbol	UCK1
Name	uridine-cytidine kinase 1
Location	9q34.13
Locus type	gene with protein product
Status	Approved
Aliases	URK1, FLJ12255
Ensembl gene	ENSG00000130717
Ensembl biotype	protein_coding
OMIM	609328
Entrez	83549

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 10 protein_coding, 4 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000372208, ENST00000372210, ENST00000372211, ENST00000372215, ENST00000459858, ENST00000482398, ENST00000484876, ENST00000491309, ENST00000494584, ENST00000851811, ENST00000851812, ENST00000851813, ENST00000851814, ENST00000851815, ENST00000936882

RefSeq mRNA: 5 — MANE Select: NM_031432 NM_001135954, NM_001261450, NM_001261451, NM_001318519, NM_031432

CCDS: CCDS48046, CCDS59151, CCDS59152, CCDS6944

Canonical transcript exons

ENST00000372215 — 7 exons

Exon	Start	End
ENSE00001945595	131531067	131531263
ENSE00003461588	131525929	131525977
ENSE00003527707	131529128	131529270
ENSE00003550425	131530486	131530645
ENSE00003590939	131528944	131529038
ENSE00003614725	131529488	131529584
ENSE00003634270	131523801	131525221

Expression profiles

Bgee: expression breadth ubiquitous, 234 present calls, max score 95.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 8.6509 / max 169.7466, expressed in 1783 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
102836	6.6344	1761
102835	2.0165	1041

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
pancreatic ductal cell	CL:0002079	95.08	silver quality
cerebellar hemisphere	UBERON:0002245	94.93	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.90	gold quality
cerebellar cortex	UBERON:0002129	94.87	gold quality
cerebellum	UBERON:0002037	94.26	gold quality
tibialis anterior	UBERON:0001385	94.14	gold quality
mucosa of stomach	UBERON:0001199	93.17	gold quality
right lobe of liver	UBERON:0001114	93.08	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.65	gold quality
apex of heart	UBERON:0002098	92.61	gold quality
amygdala	UBERON:0001876	92.55	gold quality
gastrocnemius	UBERON:0001388	92.40	gold quality
anterior cingulate cortex	UBERON:0009835	92.35	gold quality
ileal mucosa	UBERON:0000331	92.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.27	gold quality
lower esophagus	UBERON:0013473	92.26	gold quality
right frontal lobe	UBERON:0002810	92.23	gold quality
putamen	UBERON:0001874	92.20	gold quality
lower esophagus mucosa	UBERON:0035834	92.03	gold quality
muscle of leg	UBERON:0001383	92.00	gold quality
spinal cord	UBERON:0002240	92.00	gold quality
hypothalamus	UBERON:0001898	91.95	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	91.69	gold quality
nucleus accumbens	UBERON:0001882	91.58	gold quality
caudate nucleus	UBERON:0001873	91.40	gold quality
muscle layer of sigmoid colon	UBERON:0035805	91.31	gold quality
cerebellar vermis	UBERON:0004720	91.28	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.06	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.06	gold quality
body of pancreas	UBERON:0001150	90.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

41 targeting UCK1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-574-5P	100.00	66.01	989
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-9718	99.94	68.91	918
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4319	99.76	69.83	2586
HSA-MIR-1208	99.70	68.28	1533
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-18A-3P	99.56	65.68	1092
HSA-MIR-6733-3P	99.54	67.80	1281
HSA-MIR-1224-5P	99.48	65.59	803
HSA-MIR-548B-3P	99.38	67.26	1000
HSA-MIR-4318	99.38	66.94	1505
HSA-MIR-5190	99.15	67.76	1234
HSA-MIR-7977	98.65	66.18	2590
HSA-MIR-6887-5P	98.56	68.49	1295
HSA-MIR-6795-5P	98.52	68.51	1277
HSA-MIR-7114-5P	98.51	67.87	1349
HSA-MIR-628-5P	98.36	67.74	844
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-4691-3P	98.11	66.83	1204
HSA-MIR-4469	97.93	65.81	1319
HSA-MIR-4494	97.86	64.93	850
HSA-MIR-194-3P	97.36	65.96	1027

Literature-anchored findings (GeneRIF, showing 4)

• ribavirin is a potential substrate of UCK-1, and RMP formed could be chemically coupled to AsOR to form a conjugate for liver specific targeting. (PMID:18080217)
• Results from a study on gene expression variability markers in early-stage human embryos shows that UCK1 is a putative expression variability marker for the 3-day, 8-cell embryo stage. (PMID:26288249)
• Knockdown of endogenous UCK2 as well as overexpression of UCK1 resulted in decreased metabolism of uridine and cytidine and protected neuroblastoma cells from 3-deazauridine-induced toxicity. Subcellular localization studies showed that UCK1-GFP and UCK2-GFP were localized in the cell nucleus and cytosol, respectively. (PMID:27239701)
• UCK1 and 2 are both expressed in several neuroblastoma cell lines, including four MYCN single copy cell lines and five MYCN amplified cell lines (PMID:27906629)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	uck1	ENSDARG00000022218
mus_musculus	Uck1	ENSMUSG00000002550
rattus_norvegicus	Uck1	ENSRNOG00000011467
drosophila_melanogaster	Uck	FBGN0263398
caenorhabditis_elegans		WBGENE00007089

Paralogs (3): UPRT (ENSG00000094841), UCK2 (ENSG00000143179), UCKL1 (ENSG00000198276)

Protein

Protein identifiers

Uridine-cytidine kinase 1 — Q9HA47 (reviewed: Q9HA47)

Alternative names: Cytidine monophosphokinase 1, Uridine monophosphokinase 1

All UniProt accessions (3): Q9HA47, A0A024R8E7, G3V170

UniProt curated annotations — full annotation on UniProt →

Function. Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.

Tissue specificity. Ubiquitous.

Pathway. Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.

Similarity. Belongs to the uridine kinase family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q9HA47-1	1	yes
Q9HA47-2	2
Q9HA47-3	3
Q9HA47-4	4

RefSeq proteins (5): NP_001129426, NP_001248379, NP_001248380, NP_001305448, NP_113620* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000764	Uridine_kinase-like	Family
IPR006083	PRK/URK	Domain
IPR027417	P-loop_NTPase	Homologous_superfamily

Pfam: PF00485

Enzyme classification (BRENDA):

• EC 2.7.1.48 — uridine/cytidine kinase (BRENDA: 11 organisms, 140 substrates, 53 inhibitors, 88 Km, 32 kcat entries)

Substrate kinetics (BRENDA)

7 substrates with measured Km, best-characterized 7. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
CYTIDINE	0.023–4	38
URIDINE	0.04–11.5	31
ATP	0.062–5	10
5-FLUOROURIDINE	0.03–0.069	2
3-DEAZAURIDINE	0.2	1
5-AZACYTIDINE	11	1
6-AZAURIDINE	0.34	1

Catalyzed reactions (Rhea), 2 shown:

• uridine + ATP = UMP + ADP + H(+) (RHEA:16825)
• cytidine + ATP = CMP + ADP + H(+) (RHEA:24674)

UniProt features (45 total): helix 13, binding site 8, strand 7, sequence conflict 5, splice variant 3, region of interest 2, modified residue 2, turn 2, chain 1, compositionally biased region 1, active site 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
9SGF	X-RAY DIFFRACTION	2.18
9SGG	X-RAY DIFFRACTION	2.4
2JEO	X-RAY DIFFRACTION	2.5
2UVQ	X-RAY DIFFRACTION	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HA47-F1	84.13	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 65

Ligand- & substrate-binding residues (8): 178; 186; 215; 30–38; 87; 115; 120; 169

Post-translational modifications (2): 251, 253

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-73614	Pyrimidine salvage

MSigDB gene sets: 135 (showing top): SHEPARD_BMYB_MORPHOLINO_UP, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_PYRIMIDINE_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, GOBP_NUCLEOSIDE_PHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_ORGANOPHOSPHATE_BIOSYNTHETIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GOBP_NUCLEOBASE_CONTAINING_SMALL_MOLECULE_METABOLIC_PROCESS, MARTINEZ_RB1_TARGETS_UP, GOBP_PYRIMIDINE_NUCLEOTIDE_METABOLIC_PROCESS, GOBP_CARBOHYDRATE_DERIVATIVE_BIOSYNTHETIC_PROCESS, GOBP_NUCLEOSIDE_TRIPHOSPHATE_METABOLIC_PROCESS, GOBP_NUCLEOSIDE_TRIPHOSPHATE_BIOSYNTHETIC_PROCESS, LANDIS_ERBB2_BREAST_PRENEOPLASTIC_DN, GOBP_PYRIMIDINE_CONTAINING_COMPOUND_SALVAGE

GO Biological Process (4): UMP salvage (GO:0044206), CTP salvage (GO:0044211), CMP biosynthetic process (GO:0009224), nucleobase-containing small molecule metabolic process (GO:0055086)

GO Molecular Function (7): uridine kinase activity (GO:0004849), ATP binding (GO:0005524), cytidine kinase activity (GO:0043771), nucleotide binding (GO:0000166), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (2): cytoplasm (GO:0005737), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Nucleotide salvage	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
UMP biosynthetic process	2
pyrimidine ribonucleotide salvage	2
nucleoside kinase activity	2
cellular anatomical structure	2
CTP biosynthetic process	1
pyrimidine ribonucleoside monophosphate biosynthetic process	1
pyrimidine ribonucleotide biosynthetic process	1
CMP metabolic process	1
nucleobase-containing compound metabolic process	1
small molecule metabolic process	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
CMP biosynthetic process	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
binding	1
transferase activity, transferring phosphorus-containing groups	1
catalytic activity	1
intracellular anatomical structure	1
cytoplasm	1

Protein interactions and networks

STRING

1834 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UCK1	UPP2	O95045	834
UCK1	UMPS	P11172	811
UCK1	UPP1	Q16831	808
UCK1	UPRT	Q96BW1	714
UCK1	TYMP	P19971	644
UCK1	TK2	O00142	629
UCK1	CMPK1	P30085	611
UCK1	DCK	P27707	610
UCK1	DPYD	Q12882	590
UCK1	CDA	P32320	579
UCK1	TYMS	P04818	565
UCK1	UPB1	Q9UBR1	562
UCK1	DTYMK	P23919	504
UCK1	CTPS2	Q9NRF8	500
UCK1	DCTD	P32321	497

IntAct

17 interactions, top by confidence:

A	B	Type	Score
MPPED1	TXNDC9	psi-mi:“MI:0914”(association)	0.640
UCK1	UCK1	psi-mi:“MI:0915”(physical association)	0.550
UPRT	SERPINB4	psi-mi:“MI:0914”(association)	0.530
UCK2	IAH1	psi-mi:“MI:0914”(association)	0.530
UPRT	UCK2	psi-mi:“MI:0914”(association)	0.530
PLA2G12A	UCK1	psi-mi:“MI:0915”(physical association)	0.370
KLHL2	DCTN6	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350
UCK2	DCAF6	psi-mi:“MI:0914”(association)	0.350
UCK1	ezrA	psi-mi:“MI:0915”(physical association)	0.000
UCK1	UCK1	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (40): UCK1 (Affinity Capture-MS), UCK1 (Affinity Capture-MS), UCK1 (Co-fractionation), UCK1 (Affinity Capture-MS), UCK1 (Affinity Capture-MS), UCK1 (Affinity Capture-MS), UCK1 (Affinity Capture-MS), UCK1 (Two-hybrid), UCK1 (Two-hybrid), UCK1 (Proximity Label-MS), PGK1 (Affinity Capture-MS), UCK1 (Affinity Capture-MS), KLHL2 (Affinity Capture-MS), UCK2 (Affinity Capture-MS), PLA2G12A (Affinity Capture-MS)

ESM2 similar proteins: A4IFD0, A4IG62, A7GT59, B1H116, B5FG51, C0ZAS6, O00763, O23617, P16118, P32232, P49872, P52623, P70266, Q0P5A4, Q13057, Q4R4K2, Q5E3Z9, Q5EBA1, Q5R9C1, Q5T6J7, Q5VV42, Q66I71, Q6AY55, Q6GPD9, Q6P4Y0, Q6PA79, Q7L5N7, Q7SYM0, Q7ZV79, Q80YD1, Q8IYB8, Q8MIR4, Q8T154, Q8WV93, Q91309, Q91348, Q91WE6, Q91YL3, Q920P5, Q99PM9

Diamond homologs: A0Q140, A2RDZ9, A2RJB4, A4IR72, A5ITD6, A5VKU8, A6QHF2, A6TR08, A6U280, A7GGE1, A7GT59, A7X320, A7Z727, A8AWT2, A8FFL8, A8YU29, A8Z4E9, A9WCC8, B1H116, B1IJ68, B1KXA7, B1MXP1, B2G882, B4U220, B5XM21, B7GIU0, B8G8N0, B9DNJ4, B9DSN2, B9E6Y9, B9LED5, C0M9M0, C0MCM8, C0ZAS6, C1FSX6, C3L140, C5D4Y5, O32033, O65583, O74427

SIGNOR signaling

11 interactions.

A	Effect	B	Mechanism
UCK1	“down-regulates quantity”	ATP(4-)	“chemical modification”
UCK1	“up-regulates quantity”	ADP(3-)	“chemical modification”
UCK1	“down-regulates quantity”	cytidine	“chemical modification”
UCK1	“up-regulates quantity”	“cytidine 5’-monophosphate(2-)”	“chemical modification”
UCK1	“down-regulates quantity”	uridine	“chemical modification”
UCK1	“up-regulates quantity”	“uridine 5’-monophosphate(2-)”	“chemical modification”
USP28	“up-regulates quantity by stabilization”	UCK1	deubiquitination
KLHL2	“down-regulates quantity by destabilization”	UCK1	ubiquitination
ATM	“down-regulates quantity by destabilization”	UCK1	phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

31 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	27
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1218 predictions. Top by Δscore:

Variant	Effect	Δscore
9:131525218:GCAA:G	acceptor_gain	1.0000
9:131525219:CAA:C	acceptor_gain	1.0000
9:131525219:CAAC:C	acceptor_gain	1.0000
9:131525221:AC:A	acceptor_loss	1.0000
9:131525222:C:CC	acceptor_gain	1.0000
9:131525222:CTG:C	acceptor_loss	1.0000
9:131525228:C:CT	acceptor_gain	1.0000
9:131525229:A:T	acceptor_gain	1.0000
9:131525923:TCTTA:T	donor_loss	1.0000
9:131525924:CTTA:C	donor_loss	1.0000
9:131525925:TTACC:T	donor_loss	1.0000
9:131525926:TACCC:T	donor_loss	1.0000
9:131525927:A:AC	donor_gain	1.0000
9:131525927:AC:A	donor_gain	1.0000
9:131525928:C:CC	donor_gain	1.0000
9:131525928:CC:C	donor_gain	1.0000
9:131525978:C:CC	acceptor_gain	1.0000
9:131529039:C:CC	acceptor_gain	1.0000
9:131529122:CCTTA:C	donor_loss	1.0000
9:131529123:CTTA:C	donor_loss	1.0000
9:131529124:TTAC:T	donor_loss	1.0000
9:131529125:TA:T	donor_loss	1.0000
9:131529126:A:T	donor_loss	1.0000
9:131529127:C:CG	donor_loss	1.0000
9:131529127:CCT:C	donor_gain	1.0000
9:131529271:C:CC	acceptor_gain	1.0000
9:131529271:CTGAG:C	acceptor_loss	1.0000
9:131529272:T:G	acceptor_loss	1.0000
9:131529279:C:CT	acceptor_gain	1.0000
9:131529485:TA:T	donor_loss	1.0000

AlphaMissense

1816 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:131525209:A:G	L222P	1.000
9:131525218:G:T	A219D	1.000
9:131525933:A:C	N216K	1.000
9:131525933:A:T	N216K	1.000
9:131525949:G:T	P211Q	1.000
9:131525952:A:G	I210T	1.000
9:131525952:A:T	I210N	1.000
9:131525964:G:T	A206D	1.000
9:131525972:C:A	K203N	1.000
9:131525972:C:G	K203N	1.000
9:131528953:G:C	F198L	1.000
9:131528953:G:T	F198L	1.000
9:131528955:A:G	F198L	1.000
9:131528962:G:C	F195L	1.000
9:131528962:G:T	F195L	1.000
9:131528964:A:G	F195L	1.000
9:131528971:C:A	K192N	1.000
9:131528971:C:G	K192N	1.000
9:131528996:A:G	L184P	1.000
9:131529133:C:G	R168P	1.000
9:131529139:A:G	L166P	1.000
9:131529149:C:A	D163Y	1.000
9:131529149:C:G	D163H	1.000
9:131529165:G:C	F157L	1.000
9:131529165:G:T	F157L	1.000
9:131529167:A:G	F157L	1.000
9:131529220:C:A	G139V	1.000
9:131529221:C:A	G139C	1.000
9:131529221:C:G	G139R	1.000
9:131530494:T:A	D87V	1.000

dbSNP variants (sampled 300 via entrez): RS1000387978 (9:131528852 C>T), RS1000602001 (9:131525571 C>G), RS1000716511 (9:131530697 G>A), RS1000911274 (9:131525829 C>G,T), RS1000918219 (9:131532442 T>G), RS1001118132 (9:131529994 G>A), RS1001481120 (9:131532203 G>A), RS1001861921 (9:131528707 C>T), RS1002175780 (9:131530976 G>A,C,T), RS1003019925 (9:131527451 G>A), RS1003114842 (9:131527187 C>T), RS1003166623 (9:131532023 G>C,T), RS1003587558 (9:131531779 C>A,G,T), RS1003818865 (9:131525807 G>A), RS1004468909 (9:131528274 C>A)

Disease associations

OMIM: gene MIM:609328 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (2): CHEMBL3542438 (PROTEIN FAMILY), CHEMBL5682 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance	2
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	increases methylation, affects cotreatment	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
celastrol	increases expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	increases expression	1
Fulvestrant	affects cotreatment, increases methylation, decreases methylation	1
Leflunomide	decreases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Cadmium	decreases expression	1
Caffeine	increases phosphorylation	1
Choline	affects expression	1
Doxorubicin	decreases expression	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Methyl Methanesulfonate	increases expression	1
Phthalic Acids	increases methylation	1
Smoke	decreases expression	1
Valproic Acid	increases methylation	1
Antirheumatic Agents	increases expression	1
Copper Sulfate	decreases expression	1

ChEMBL screening assays

7 unique, capped per target: 7 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL1064154	Binding	Activity of cloned uridine-cytidine kinase 1 in human HuH7 cells up to 1 mM	The mechanism of action of beta-D-2’-deoxy-2’-fluoro-2’-C-methylcytidine involves a second metabolic pathway leading to beta-D-2’-deoxy-2’-fluoro-2’-C-methyluridine 5’-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. — Antimicrob Agents Chemother

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3KR	Abcam HEK293T UCK1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.