UEVLD

Summary

UEVLD (UEV and lactate/malate dehyrogenase domains, HGNC:30866) is a protein-coding gene on chromosome 11p15.1, encoding Ubiquitin-conjugating enzyme E2 variant 3 (Q8IX04). Possible negative regulator of polyubiquitination.

Predicted to enable ubiquitin binding activity. Predicted to be involved in endosome to lysosome transport. Located in extracellular exosome.

Source: NCBI Gene 55293 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 77 total
• MANE Select transcript: NM_001040697

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30866
Approved symbol	UEVLD
Name	UEV and lactate/malate dehyrogenase domains
Location	11p15.1
Locus type	gene with protein product
Status	Approved
Aliases	Attp, UEV3
Ensembl gene	ENSG00000151116
Ensembl biotype	protein_coding
OMIM	610985
Entrez	55293

Gene structure

Transcript identifiers

Ensembl transcripts: 25 — 19 protein_coding, 3 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000300038, ENST00000320750, ENST00000379387, ENST00000396196, ENST00000396197, ENST00000490736, ENST00000535340, ENST00000535484, ENST00000539569, ENST00000540666, ENST00000540917, ENST00000541984, ENST00000543987, ENST00000854034, ENST00000854035, ENST00000854036, ENST00000854037, ENST00000854038, ENST00000854039, ENST00000938975, ENST00000966332, ENST00000966333, ENST00000966334, ENST00000966335, ENST00000966336

RefSeq mRNA: 8 — MANE Select: NM_001040697 NM_001040697, NM_001261382, NM_001261383, NM_001261384, NM_001261385, NM_001261386, NM_001297771, NM_018314

CCDS: CCDS41624, CCDS58122, CCDS58123, CCDS58124, CCDS58125, CCDS73266, CCDS7843

Canonical transcript exons

ENST00000396197 — 12 exons

Exon	Start	End
ENSE00002235260	18529609	18532487
ENSE00002247674	18588613	18588734
ENSE00003484029	18536406	18536469
ENSE00003485804	18544623	18544796
ENSE00003539257	18558228	18558330
ENSE00003551051	18575347	18575412
ENSE00003582285	18566347	18566482
ENSE00003631421	18546880	18547050
ENSE00003643377	18564892	18565010
ENSE00003654351	18570214	18570377
ENSE00003668451	18534330	18534453
ENSE00003675138	18578724	18578808

Expression profiles

Bgee: expression breadth ubiquitous, 275 present calls, max score 91.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.9408 / max 66.4794, expressed in 1792 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118946	6.0738	1731
118947	3.7996	1634
118948	1.0674	754

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of sigmoid colon	UBERON:0004993	91.79	gold quality
colonic mucosa	UBERON:0000317	91.78	gold quality
bronchial epithelial cell	CL:0002328	91.63	gold quality
mucosa of paranasal sinus	UBERON:0005030	91.08	gold quality
seminal vesicle	UBERON:0000998	90.75	gold quality
heart right ventricle	UBERON:0002080	90.00	gold quality
oral cavity	UBERON:0000167	89.27	gold quality
calcaneal tendon	UBERON:0003701	88.85	gold quality
penis	UBERON:0000989	88.21	gold quality
biceps brachii	UBERON:0001507	87.96	gold quality
buccal mucosa cell	CL:0002336	87.77	gold quality
mammalian vulva	UBERON:0000997	87.70	gold quality
cauda epididymis	UBERON:0004360	87.70	gold quality
adrenal tissue	UBERON:0018303	87.58	gold quality
rectum	UBERON:0001052	87.27	gold quality
caput epididymis	UBERON:0004358	87.21	gold quality
superficial temporal artery	UBERON:0001614	87.19	gold quality
corpus epididymis	UBERON:0004359	87.12	gold quality
germinal epithelium of ovary	UBERON:0001304	86.90	gold quality
endometrium	UBERON:0001295	86.68	gold quality
skin of hip	UBERON:0001554	86.58	gold quality
jejunal mucosa	UBERON:0000399	86.45	gold quality
jejunum	UBERON:0002115	86.20	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	85.95	gold quality
stromal cell of endometrium	CL:0002255	85.76	gold quality
islet of Langerhans	UBERON:0000006	85.67	gold quality
palpebral conjunctiva	UBERON:0001812	85.63	gold quality
corpus callosum	UBERON:0002336	85.19	gold quality
monocyte	CL:0000576	85.14	gold quality
endothelial cell	CL:0000115	84.98	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.18
E-MTAB-6379	no	1305.39
E-GEOD-36552	no	35.57

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

94 targeting UEVLD, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-559	99.95	72.28	3609
HSA-MIR-548AB	99.95	71.31	3488
HSA-MIR-548A-5P	99.94	71.27	3482
HSA-MIR-548AD-5P	99.94	71.23	3502
HSA-MIR-548AE-5P	99.94	71.23	3502
HSA-MIR-548AK	99.94	71.24	3488
HSA-MIR-548AM-5P	99.94	71.24	3488
HSA-MIR-548AP-5P	99.94	71.14	3489
HSA-MIR-548AQ-5P	99.94	71.34	3426
HSA-MIR-548AR-5P	99.94	71.28	3515
HSA-MIR-548AS-5P	99.94	71.22	3482
HSA-MIR-548AU-5P	99.94	71.24	3488
HSA-MIR-548AY-5P	99.94	71.23	3502
HSA-MIR-548B-5P	99.94	71.23	3502
HSA-MIR-548BB-5P	99.94	71.27	3509
HSA-MIR-548C-5P	99.94	71.24	3488
HSA-MIR-548D-5P	99.94	71.23	3502
HSA-MIR-548H-5P	99.94	71.24	3488
HSA-MIR-548I	99.94	71.25	3481
HSA-MIR-548J-5P	99.94	71.14	3489

Literature-anchored findings (GeneRIF, showing 1)

• identification, sequencing and analysis of cDNA in various colon carcinoma cell lines as well as normal and tumor samples from colon (PMID:12427560)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	uevld	ENSDARG00000009266
mus_musculus	Uevld	ENSMUSG00000043262
rattus_norvegicus	Uevld	ENSRNOG00000013624
drosophila_melanogaster	TSG101	FBGN0036666
caenorhabditis_elegans		WBGENE00015658

Paralogs (1): TSG101 (ENSG00000074319)

Protein

Protein identifiers

Ubiquitin-conjugating enzyme E2 variant 3 — Q8IX04 (reviewed: Q8IX04)

Alternative names: EV and lactate/malate dehydrogenase domain-containing protein

All UniProt accessions (2): Q8IX04, A8MYV4

UniProt curated annotations — full annotation on UniProt →

Function. Possible negative regulator of polyubiquitination.

Subunit / interactions. Homodimer.

Tissue specificity. Colon, colon carcinoma cell lines, normal cervical epithelium, carcinomas of the uterine cervix and peripheral blood leukocytes.

Similarity. In the N-terminal section; belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. In the C-terminal section; belongs to the LDH/MDH superfamily.

Isoforms (7)

UniProt ID	Names	Canonical?
Q8IX04-1	1	yes
Q8IX04-2	2
Q8IX04-3	3
Q8IX04-4	4
Q8IX04-5	5
Q8IX04-6	6
Q8IX04-7	7

RefSeq proteins (8): NP_001035787, NP_001248311, NP_001248312, NP_001248313, NP_001248314, NP_001248315, NP_001284700, NP_060784 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001236	Lactate/malate_DH_N	Domain
IPR001557	L-lactate/malate_DH	Family
IPR008883	UEV_N	Domain
IPR015955	Lactate_DH/Glyco_Ohase_4_C	Homologous_superfamily
IPR016135	UBQ-conjugating_enzyme/RWD	Homologous_superfamily
IPR022383	Lactate/malate_DH_C	Domain
IPR036291	NAD(P)-bd_dom_sf	Homologous_superfamily

Pfam: PF00056, PF02866, PF05743

UniProt features (42 total): strand 14, helix 12, splice variant 9, sequence conflict 3, chain 1, domain 1, binding site 1, turn 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
2I6T	X-RAY DIFFRACTION	2.1
3DL2	X-RAY DIFFRACTION	2.1

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8IX04-F1	87.34	0.65

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 191–219

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 137 (showing top): GOBP_LYSOSOMAL_TRANSPORT, GOBP_ENDOSOME_TO_LYSOSOME_TRANSPORT, GOBP_VACUOLAR_TRANSPORT, GOBP_VESICLE_MEDIATED_TRANSPORT, GOBP_ORGANIC_ACID_METABOLIC_PROCESS, SENESE_HDAC1_TARGETS_UP, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_CH_OH_GROUP_OF_DONORS, GOCC_ESCRT_COMPLEX, GOCC_MEMBRANE_PROTEIN_COMPLEX, GOMF_UBIQUITIN_LIKE_PROTEIN_BINDING, SENESE_HDAC1_AND_HDAC2_TARGETS_UP, GOBP_INTRACELLULAR_TRANSPORT, GOCC_ESCRT_I_COMPLEX, ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY, GOMF_UBIQUITIN_BINDING

GO Biological Process (5): regulation of DNA-templated transcription (GO:0006355), endosome to lysosome transport (GO:0008333), protein transport (GO:0015031), carboxylic acid metabolic process (GO:0019752), protein modification process (GO:0036211)

GO Molecular Function (5): oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616), ubiquitin binding (GO:0043130), catalytic activity (GO:0003824), protein binding (GO:0005515), oxidoreductase activity (GO:0016491)

GO Cellular Component (5): ESCRT I complex (GO:0000813), nucleus (GO:0005634), extracellular exosome (GO:0070062), cytoplasm (GO:0005737), vesicle (GO:0031982)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
lysosomal transport	1
intercellular transport	1
vesicle-mediated transport	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
oxoacid metabolic process	1
protein metabolic process	1
macromolecule modification	1
oxidoreductase activity, acting on CH-OH group of donors	1
ubiquitin-like protein binding	1
molecular_function	1
binding	1
catalytic activity	1
endosome membrane	1
ESCRT complex	1
membrane protein complex	1
intracellular membrane-bounded organelle	1
extracellular vesicle	1
intracellular anatomical structure	1
cellular anatomical structure	1
membrane-bounded organelle	1

Protein interactions and networks

STRING

4485 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UEVLD	GGH	Q92820	898
UEVLD	SPTY2D1	Q68D10	574
UEVLD	TBC1D32	Q96NH3	528
UEVLD	UFL1	O94874	460
UEVLD	I3L0A0	I3L0A0	437
UEVLD	TRIP4	Q15650	429
UEVLD	CGAS	Q8N884	421
UEVLD	ERICH1	Q86X53	416
UEVLD	CDC16	Q13042	415
UEVLD	CHCT1	Q86WR6	410
UEVLD	UBE2V2	Q15819	405
UEVLD	ELOB	Q15370	403
UEVLD	TOM1	O60784	397
UEVLD	MAPKAP1	Q9BPZ7	394
UEVLD	CSNK1A1	P48729	387

IntAct

28 interactions, top by confidence:

A	B	Type	Score
WDR59	EPB41L2	psi-mi:“MI:0914”(association)	0.530
MORN4	UEVLD	psi-mi:“MI:0914”(association)	0.500
MORN4	UEVLD	psi-mi:“MI:0915”(physical association)	0.500
UEVLD	SDF2L1	psi-mi:“MI:0915”(physical association)	0.370
UEVLD	GALM	psi-mi:“MI:0915”(physical association)	0.370
UEVLD	RNF4	psi-mi:“MI:0915”(physical association)	0.370
RNF114	UEVLD	psi-mi:“MI:0915”(physical association)	0.370
TRAF6	UEVLD	psi-mi:“MI:0915”(physical association)	0.370
UEVLD	LRSAM1	psi-mi:“MI:0915”(physical association)	0.370
DTX3	UEVLD	psi-mi:“MI:0915”(physical association)	0.370
ECE1	UEVLD	psi-mi:“MI:0915”(physical association)	0.370
NEK4	E2F8	psi-mi:“MI:0914”(association)	0.350
BIRC2	UMAD1	psi-mi:“MI:0914”(association)	0.350
RBCK1	UMAD1	psi-mi:“MI:0914”(association)	0.350
TANK	CNOT1	psi-mi:“MI:0914”(association)	0.350
TNIP1	UMAD1	psi-mi:“MI:0914”(association)	0.350
TNIP2	CHUK	psi-mi:“MI:0914”(association)	0.350
TRADD	HNRNPCL2	psi-mi:“MI:0914”(association)	0.350
TRAF2	TMEM178B	psi-mi:“MI:0914”(association)	0.350
RBCK1	KHNYN	psi-mi:“MI:0914”(association)	0.350
SHARPIN	UMAD1	psi-mi:“MI:0914”(association)	0.350
TNIP2	TMEM178B	psi-mi:“MI:0914”(association)	0.350
WDR59	HDAC3	psi-mi:“MI:0914”(association)	0.350
CAPRIN1	VPS37C	psi-mi:“MI:0914”(association)	0.350
PRPSAP1	TRAFD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (31): UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Affinity Capture-MS), UEVLD (Co-fractionation)

ESM2 similar proteins: A0A3L7I2I8, A0A8J1LLF7, A0A974H8H3, A4II46, A6JFQ6, A6JUQ6, B3DLA6, O60733, O70291, P32298, P41034, P42694, P49638, P97570, P97819, Q02384, Q07889, Q07890, Q2KIX2, Q32PW3, Q4R678, Q59H18, Q5F361, Q5FVD6, Q5GIG6, Q5M7E1, Q5RCA6, Q5SPP0, Q5SYC1, Q66H63, Q6DFV5, Q6NRC7, Q6PC62, Q7SXV1, Q7TQP6, Q8AVG0, Q8BG92, Q8BM85, Q8BWP5, Q8BWW9

Diamond homologs: A0A1F3, A5A6N7, O13276, O13277, O13278, O93401, O93537, O93538, O93539, O93540, O93541, O93542, O93543, O93544, O93545, O93546, P00336, P00337, P00338, P00339, P00340, P00341, P00342, P04642, P06151, P07195, P07864, P13490, P13491, P13743, P16125, P19629, P19858, P20373, P22988, P22989, P29038, P33571, P42119, P42120

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 32 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
TNFR1-induced proapoptotic signaling	5	104.6×	4e-08
TNFR1-induced NF-kappa-B signaling pathway	6	96.0×	3e-09
Regulation of TNFR1 signaling	6	64.0×	2e-08

GO biological processes:

GO term	Partners	Fold	FDR
canonical NF-kappaB signal transduction	8	104.7×	1e-12
tumor necrosis factor-mediated signaling pathway	5	59.0×	1e-06
negative regulation of canonical NF-kappaB signal transduction	8	49.1×	4e-10
protein polyubiquitination	6	24.7×	5e-06
positive regulation of canonical NF-kappaB signal transduction	9	23.4×	8e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

77 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2502 predictions. Top by Δscore:

Variant	Effect	Δscore
11:18534454:C:CC	acceptor_gain	1.0000
11:18544797:C:CC	acceptor_gain	1.0000
11:18544804:T:TC	acceptor_gain	1.0000
11:18544808:A:C	acceptor_gain	1.0000
11:18547046:CAAAT:C	acceptor_gain	1.0000
11:18558225:GA:G	donor_loss	1.0000
11:18558327:TACC:T	acceptor_gain	1.0000
11:18558329:CC:C	acceptor_gain	1.0000
11:18558330:CC:C	acceptor_gain	1.0000
11:18564887:CATA:C	donor_loss	1.0000
11:18564888:ATAC:A	donor_loss	1.0000
11:18564889:TACC:T	donor_loss	1.0000
11:18564890:ACCTT:A	donor_loss	1.0000
11:18564891:C:T	donor_loss	1.0000
11:18566479:TAGG:T	acceptor_gain	1.0000
11:18566483:C:CC	acceptor_gain	1.0000
11:18568656:C:CT	donor_gain	1.0000
11:18568656:CTA:C	donor_gain	1.0000
11:18568657:T:TT	donor_gain	1.0000
11:18575345:AC:A	donor_gain	1.0000
11:18575346:CC:C	donor_gain	1.0000
11:18575413:C:CC	acceptor_gain	1.0000
11:18578763:CAT:C	donor_gain	1.0000
11:18578772:T:A	donor_gain	1.0000
11:18578807:TA:T	acceptor_gain	1.0000
11:18578809:C:CC	acceptor_gain	1.0000
11:18587205:A:C	donor_gain	1.0000
11:18532485:TCC:T	acceptor_gain	0.9900
11:18532486:CCC:C	acceptor_gain	0.9900
11:18534325:ATTAC:A	donor_loss	0.9900

AlphaMissense

3085 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:18532452:A:C	S428R	0.997
11:18532452:A:T	S428R	0.997
11:18532454:T:G	S428R	0.997
11:18570222:A:G	W117R	0.996
11:18570222:A:T	W117R	0.996
11:18575385:A:G	L52P	0.994
11:18570312:A:G	C87R	0.993
11:18578800:G:C	F17L	0.992
11:18578800:G:T	F17L	0.992
11:18578802:A:G	F17L	0.992
11:18544736:C:T	G316E	0.991
11:18570220:C:A	W117C	0.991
11:18570220:C:G	W117C	0.991
11:18532458:A:C	F426L	0.990
11:18532458:A:T	F426L	0.990
11:18532460:A:G	F426L	0.990
11:18534395:C:G	A395P	0.990
11:18544762:A:C	S307R	0.990
11:18544762:A:T	S307R	0.990
11:18544764:T:G	S307R	0.990
11:18544730:C:T	G318E	0.989
11:18564915:A:G	C197R	0.989
11:18570245:A:T	I109K	0.988
11:18570317:G:T	P85H	0.988
11:18570348:A:G	W75R	0.988
11:18570348:A:T	W75R	0.988
11:18547029:G:A	S246F	0.987
11:18570310:G:C	C87W	0.987
11:18570317:G:C	P85R	0.986
11:18575382:A:G	L53P	0.986

dbSNP variants (sampled 300 via entrez): RS1000053602 (11:18555093 C>T), RS1000063755 (11:18556736 C>A,T), RS1000077530 (11:18536083 G>A), RS1000109228 (11:18584373 G>T), RS1000117978 (11:18549784 G>A,T), RS1000167740 (11:18542699 A>G,T), RS1000191815 (11:18550141 A>G), RS1000252344 (11:18587229 C>T), RS1000324186 (11:18543552 C>A), RS1000342571 (11:18586554 T>C), RS1000342935 (11:18543286 AT>A), RS1000412626 (11:18535519 G>T), RS1000440613 (11:18550482 T>C), RS1000466685 (11:18535821 T>G), RS1000498602 (11:18562749 T>C)

Disease associations

OMIM: gene MIM:610985 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
aristolochic acid I	increases expression	1
GSK-J4	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
beta-lapachone	increases expression	1
sodium arsenite	decreases expression, increases abundance	1
aflatoxin B2	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
pyrimidifen	decreases expression	1
torcetrapib	increases expression	1
Acetaminophen	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Arsenic	decreases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Ivermectin	decreases expression	1
Nickel	decreases expression	1
Smoke	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Aflatoxin B1	decreases methylation	1
Lactic Acid	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_TW18	HAP1 UEVLD (-) 1	Cancer cell line	Male
CVCL_TW19	HAP1 UEVLD (-) 2	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.