UGT2B11

Summary

UGT2B11 (UDP glucuronosyltransferase family 2 member B11, HGNC:12545) is a protein-coding gene on chromosome 4q13.2, encoding UDP-glucuronosyltransferase 2B11 (O75310). UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Enables glucuronosyltransferase activity. Involved in estrogen metabolic process. Predicted to be located in endoplasmic reticulum membrane.

Source: NCBI Gene 10720 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 26 total
• Druggable target: yes
• MANE Select transcript: NM_001073

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12545
Approved symbol	UGT2B11
Name	UDP glucuronosyltransferase family 2 member B11
Location	4q13.2
Locus type	gene with protein product
Status	Approved
Ensembl gene	ENSG00000213759
Ensembl biotype	protein_coding
OMIM	603064
Entrez	10720

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 1 protein_coding, 1 retained_intron

ENST00000446444, ENST00000513315

RefSeq mRNA: 1 — MANE Select: NM_001073 NM_001073

CCDS: CCDS3527

Canonical transcript exons

ENST00000446444 — 6 exons

Exon	Start	End
ENSE00001487511	69199951	69200719
ENSE00001641198	69214002	69214748
ENSE00002448993	69212573	69212721
ENSE00002467428	69204430	69204649
ENSE00002516239	69208351	69208482
ENSE00002534262	69205480	69205567

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 81.85.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0982 / max 13.9594, expressed in 30 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
52353	0.0982	30

Top tissues by expression

117 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.85	gold quality
liver	UBERON:0002107	78.98	gold quality
gall bladder	UBERON:0002110	78.83	gold quality
right lobe of liver	UBERON:0001114	78.65	gold quality
metanephros cortex	UBERON:0010533	64.13	gold quality
cortex of kidney	UBERON:0001225	63.45	gold quality
adult mammalian kidney	UBERON:0000082	63.40	gold quality
kidney	UBERON:0002113	62.51	gold quality
monocyte	CL:0000576	58.09	gold quality
islet of Langerhans	UBERON:0000006	57.57	gold quality
duodenum	UBERON:0002114	56.68	gold quality
leukocyte	CL:0000738	55.92	gold quality
body of pancreas	UBERON:0001150	54.72	gold quality
pancreas	UBERON:0001264	54.56	gold quality
endometrium	UBERON:0001295	51.05	gold quality
left lobe of thyroid gland	UBERON:0001120	48.31	gold quality
thyroid gland	UBERON:0002046	48.28	gold quality
bone marrow	UBERON:0002371	46.78	gold quality
adrenal tissue	UBERON:0018303	46.53	gold quality
bone marrow cell	CL:0002092	46.09	silver quality
blood	UBERON:0000178	45.97	gold quality
tonsil	UBERON:0002372	45.81	gold quality
right lobe of thyroid gland	UBERON:0001119	45.00	gold quality
vermiform appendix	UBERON:0001154	44.24	gold quality
urinary bladder	UBERON:0001255	44.22	gold quality
cortical plate	UBERON:0005343	43.73	gold quality
smooth muscle tissue	UBERON:0001135	43.71	gold quality
transverse colon	UBERON:0001157	43.43	gold quality
thoracic mammary gland	UBERON:0005200	43.20	gold quality
fallopian tube	UBERON:0003889	40.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.24

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

6 targeting UGT2B11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-12122	99.56	69.33	1672
HSA-MIR-548G-3P	99.48	68.67	2159
HSA-MIR-548AV-3P	99.43	68.50	1721
HSA-MIR-2355-3P	96.84	68.54	909

Literature-anchored findings (GeneRIF, showing 2)

• significant expression of UGT2B11 was detected in the liver, breast and kidney, and was clearly different from the distribution of UGT2B28 (PMID:21679149)
• CYP3A4, CYP3A7, UGT2B11 and UGT2B15 genes are significantly downregulated in melanosis coli. (PMID:26238215)

Cross-species orthologs

107 orthologs

Organism	Symbol	Gene ID
danio_rerio	ugt5d1	ENSDARG00000002394
danio_rerio	ugt5c2	ENSDARG00000006372
danio_rerio	ugt5a1	ENSDARG00000016479
danio_rerio	ugt5g1	ENSDARG00000032862
danio_rerio	ugt5g2	ENSDARG00000043901
danio_rerio	ugt5f1	ENSDARG00000054835
danio_rerio	ugt5e1	ENSDARG00000058048
danio_rerio	ugt5c3	ENSDARG00000061439
danio_rerio	ugt5c1	ENSDARG00000061444
danio_rerio	si:ch73-334d15.1	ENSDARG00000061672
danio_rerio	ugt2a7	ENSDARG00000091624
danio_rerio	ugt5b4	ENSDARG00000091916
danio_rerio	ugt2b1	ENSDARG00000093043
danio_rerio	ugt5a2	ENSDARG00000093640
danio_rerio	ugt5b3	ENSDARG00000099276
danio_rerio	ugt5b2	ENSDARG00000101495
danio_rerio	ugt5b5	ENSDARG00000104203
danio_rerio	ugt5b1	ENSDARG00000104995
danio_rerio	ugt2b3	ENSDARG00000109611
danio_rerio		ENSDARG00000110614
danio_rerio		ENSDARG00000113218
danio_rerio	ugt2b5	ENSDARG00000116986
drosophila_melanogaster	Ugt36A1	FBGN0015663
drosophila_melanogaster	Ugt35B1	FBGN0026314
drosophila_melanogaster	Ugt35A1	FBGN0026315
drosophila_melanogaster	Ugt37C1	FBGN0026754
drosophila_melanogaster	Ugt37B1	FBGN0026755
drosophila_melanogaster	Ugt37A1	FBGN0026756
drosophila_melanogaster	Ugt36E1	FBGN0027070
drosophila_melanogaster	Ugt49B1	FBGN0027073
drosophila_melanogaster	Ugt36F1	FBGN0027074
drosophila_melanogaster	Ugt307A1	FBGN0031887
drosophila_melanogaster	Ugt36D1	FBGN0032713
drosophila_melanogaster	Ugt49C1	FBGN0034605
drosophila_melanogaster	Ugt316A1	FBGN0036842
drosophila_melanogaster	Ugt37A2	FBGN0038082
drosophila_melanogaster	Ugt37A3	FBGN0038083
drosophila_melanogaster	Ugt49B2	FBGN0038886
drosophila_melanogaster	Ugt303B3	FBGN0039085
drosophila_melanogaster	Ugt303B1	FBGN0039086
drosophila_melanogaster	Ugt303B2	FBGN0039087
drosophila_melanogaster	Ugt304A1	FBGN0040250
drosophila_melanogaster	Ugt302K1	FBGN0040251
drosophila_melanogaster	Ugt303A1	FBGN0040252
drosophila_melanogaster	Ugt35E1	FBGN0040253
drosophila_melanogaster	Ugt35E2	FBGN0040255
drosophila_melanogaster	Ugt302E1	FBGN0040257
drosophila_melanogaster	Ugt302C1	FBGN0040259
drosophila_melanogaster	Ugt37D1	FBGN0040260
drosophila_melanogaster	Ugt37E1	FBGN0040261
drosophila_melanogaster	Ugt37C2	FBGN0040262
drosophila_melanogaster	Ugt305A1	FBGN0042179
drosophila_melanogaster	Ugt35D1	FBGN0051002
caenorhabditis_elegans		WBGENE00007072
caenorhabditis_elegans		WBGENE00007073
caenorhabditis_elegans		WBGENE00007402
caenorhabditis_elegans		WBGENE00007422
caenorhabditis_elegans		WBGENE00007455
caenorhabditis_elegans		WBGENE00007885
caenorhabditis_elegans		WBGENE00007946
caenorhabditis_elegans		WBGENE00008097
caenorhabditis_elegans		WBGENE00008486
caenorhabditis_elegans		WBGENE00009255
caenorhabditis_elegans		WBGENE00010904
caenorhabditis_elegans		WBGENE00011006
caenorhabditis_elegans		WBGENE00011340
caenorhabditis_elegans		WBGENE00011452
caenorhabditis_elegans		WBGENE00011453
caenorhabditis_elegans		WBGENE00012788
caenorhabditis_elegans		WBGENE00013900
caenorhabditis_elegans		WBGENE00013905
caenorhabditis_elegans		WBGENE00013906
caenorhabditis_elegans		WBGENE00015141
caenorhabditis_elegans		WBGENE00015369
caenorhabditis_elegans		WBGENE00015371
caenorhabditis_elegans		WBGENE00015449
caenorhabditis_elegans		WBGENE00015577
caenorhabditis_elegans	ugt-28	WBGENE00015693
caenorhabditis_elegans	ugt-27	WBGENE00015694
caenorhabditis_elegans	ugt-26	WBGENE00015695
caenorhabditis_elegans		WBGENE00015739
caenorhabditis_elegans		WBGENE00015965
caenorhabditis_elegans		WBGENE00016013
caenorhabditis_elegans		WBGENE00017315
caenorhabditis_elegans		WBGENE00017329
caenorhabditis_elegans		WBGENE00017331
caenorhabditis_elegans		WBGENE00017332
caenorhabditis_elegans		WBGENE00017333
caenorhabditis_elegans		WBGENE00017334
caenorhabditis_elegans		WBGENE00017336
caenorhabditis_elegans		WBGENE00017959
caenorhabditis_elegans		WBGENE00018206
caenorhabditis_elegans		WBGENE00018543
caenorhabditis_elegans		WBGENE00018931
caenorhabditis_elegans		WBGENE00019232
caenorhabditis_elegans		WBGENE00019233
caenorhabditis_elegans		WBGENE00019234
caenorhabditis_elegans		WBGENE00019235
caenorhabditis_elegans		WBGENE00019515
caenorhabditis_elegans		WBGENE00019516
caenorhabditis_elegans		WBGENE00020587
caenorhabditis_elegans		WBGENE00020592
caenorhabditis_elegans		WBGENE00020593
caenorhabditis_elegans		WBGENE00020594
caenorhabditis_elegans		WBGENE00021709
caenorhabditis_elegans		WBGENE00044282
caenorhabditis_elegans		WBGENE00044286

Paralogs (21): UGT2B10 (ENSG00000109181), UGT2A3 (ENSG00000135220), UGT2B28 (ENSG00000135226), UGT3A1 (ENSG00000145626), UGT2B4 (ENSG00000156096), UGT1A6 (ENSG00000167165), UGT3A2 (ENSG00000168671), UGT2B7 (ENSG00000171234), UGT2A1 (ENSG00000173610), UGT8 (ENSG00000174607), UGT2B15 (ENSG00000196620), UGT2B17 (ENSG00000197888), UGT1A9 (ENSG00000241119), UGT1A1 (ENSG00000241635), UGT1A8 (ENSG00000242366), UGT1A10 (ENSG00000242515), UGT1A7 (ENSG00000244122), UGT1A4 (ENSG00000244474), UGT2A2 (ENSG00000271271), UGT1A3 (ENSG00000288702), UGT1A5 (ENSG00000288705)

Protein

Protein identifiers

UDP-glucuronosyltransferase 2B11 — O75310 (reviewed: O75310)

All UniProt accessions (1): O75310

UniProt curated annotations — full annotation on UniProt →

Function. UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Subcellular location. Microsome membrane. Endoplasmic reticulum membrane.

Tissue specificity. Widely expressed.

Similarity. Belongs to the UDP-glycosyltransferase family.

RefSeq proteins (1): NP_001064* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002213	UDP_glucos_trans	Family
IPR035595	UDP_glycos_trans_CS	Conserved_site
IPR050271	UDP-glycosyltransferase	Family

Pfam: PF00201

Enzyme classification (BRENDA):

• EC 2.4.1.17 — glucuronosyltransferase (BRENDA: 32 organisms, 1285 substrates, 660 inhibitors, 855 Km, 6 kcat entries)

Substrate kinetics (BRENDA)

189 substrates with measured Km, best-characterized 15. Km ranges are aggregated across organisms/conditions.

Substrate	Km (mM)	Measurements
4-METHYLUMBELLIFERONE	0.0001–4.204	44
MORPHINE	0.0355–37.4	31
4-NITROPHENOL	0.0102–2	24
PROPOFOL	0.0072–0.9	19
ZIDOVUDINE	0.508–1.54	19
1-NAPHTHOL	0.0025–27	18
IMIPRAMINE	0.0072–1.442	13
TRANS-4-HYDROXYTAMOXIFEN	0.0037–0.319	13
SCOPOLETIN	0.061–7.64	11
SEROTONIN	3.7–55.9	11
2-HYDROXYESTRONE	0.0102–6	10
CIS-4-HYDROXYTAMOXIFEN	0.0074–0.193	10
DOPAMINE	1.89–3.11	10
1-HYDROXYBENZO(A)PYRENE	0.0113–2.869	9
1-HYDROXYPYRENE	0.0032–2.326	9

Catalyzed reactions (Rhea), 1 shown:

• glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+) (RHEA:21032)

UniProt features (5 total): signal peptide 1, chain 1, transmembrane region 1, modified residue 1, glycosylation site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O75310-F1	93.28	0.86

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 135

Glycosylation sites (1): 315

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-156588	Glucuronidation
R-HSA-9749641	Aspirin ADME

MSigDB gene sets: 48 (showing top): REACTOME_BIOLOGICAL_OXIDATIONS, GOBP_REGULATION_OF_HORMONE_LEVELS, chr4q13, GOBP_LIPID_METABOLIC_PROCESS, KEGG_STARCH_AND_SUCROSE_METABOLISM, KEGG_STEROID_HORMONE_BIOSYNTHESIS, VECCHI_GASTRIC_CANCER_EARLY_DN, GOBP_ESTROGEN_METABOLIC_PROCESS, GOBP_STEROID_METABOLIC_PROCESS, KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450, GOCC_NUCLEAR_OUTER_MEMBRANE_ENDOPLASMIC_RETICULUM_MEMBRANE_NETWORK, KEGG_DRUG_METABOLISM_OTHER_ENZYMES, REACTOME_GLUCURONIDATION, GOCC_ORGANELLE_SUBCOMPARTMENT, GOMF_HEXOSYLTRANSFERASE_ACTIVITY

GO Biological Process (2): xenobiotic metabolic process (GO:0006805), estrogen metabolic process (GO:0008210)

GO Molecular Function (5): glucuronosyltransferase activity (GO:0015020), protein binding (GO:0005515), UDP-glycosyltransferase activity (GO:0008194), transferase activity (GO:0016740), glycosyltransferase activity (GO:0016757)

GO Cellular Component (3): endoplasmic reticulum membrane (GO:0005789), endoplasmic reticulum (GO:0005783), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Phase II - Conjugation of compounds	1
Drug ADME	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
metabolic process	1
cellular response to xenobiotic stimulus	1
steroid metabolic process	1
hormone metabolic process	1
UDP-glycosyltransferase activity	1
hexosyltransferase activity	1
binding	1
glycosyltransferase activity	1
catalytic activity	1
transferase activity	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
cytoplasm	1
endomembrane system	1
intracellular membrane-bounded organelle	1
cellular anatomical structure	1

Protein interactions and networks

STRING

778 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UGT2B11	SLC35A2	P78381	883
UGT2B11	PPIG	Q13427	761
UGT2B11	CYP3A4	P05184	726
UGT2B11	SLCO1B1	Q9Y6L6	722
UGT2B11	SULT1C3	Q6IMI6	632
UGT2B11	SULT1B1	O43704	631
UGT2B11	CYP2C9	P11712	629
UGT2B11	CYP1A2	P05177	629
UGT2B11	SULT1C4	O75897	621
UGT2B11	CYP2C19	P33259	616
UGT2B11	CYP2D6	P10635	591
UGT2B11	SULT2A1	Q06520	589
UGT2B11	CYP2B6	P20813	589
UGT2B11	GSTA1	P08263	551
UGT2B11	CYP2C8	P10632	535

IntAct

8 interactions, top by confidence:

A	B	Type	Score
UGT2B11	ASPH	psi-mi:“MI:0915”(physical association)	0.560
UGT2B11	TMBIM6	psi-mi:“MI:0915”(physical association)	0.560
UGT2B28	POTEF	psi-mi:“MI:0914”(association)	0.350
ASPH	UGT2B11	psi-mi:“MI:0915”(physical association)	0.000
TMBIM6	UGT2B11	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (6): UGT2B11 (Affinity Capture-MS), UGT2B11 (Two-hybrid), UGT2B11 (Two-hybrid), UGT2B11 (Affinity Capture-MS), UGT2B11 (Affinity Capture-MS), UGT2B11 (Affinity Capture-MS)

ESM2 similar proteins: A0A291PQF1, A0A291PQG3, A0A291PQH4, A8WLF6, O16881, O19103, O75310, P08541, P08542, P09875, P16662, P17717, P18569, P19488, P34317, P36511, P36513, P36537, Q09426, Q10941, Q10944, Q16880, Q18081, Q1LZI1, Q20086, Q21706, Q22180, Q22181, Q22295, Q25489, Q27757, Q3SY77, Q3UP75, Q5RFJ3, Q62789, Q63ZR6, Q64676, Q6K1J1, Q6NUS8, Q6PDD0

Diamond homologs: A0A0A1H7N4, A0A0A1HA03, A0A0C1EH92, A0A0D5ZDC8, A0A0G2EAR7, A0A193AU77, A0A193AUF6, A0A1L7U2E9, A0A224AKZ9, A0A224AM54, A0A291PQF1, A0A2Z5CV93, A0A364KRL8, A0A478EC03, B3VI56, F8WKW0, G2WW48, K4GHR9, K4GHS2, K4GKX2, K7NBW3, O02663, O23401, O60656, O75310, O81498, O97951, P06133, P08430, P08542, P09875, P0DTE4, P0DTE5, P17717, P19224, P20720, P22309, P36510, P36513, P36537

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

26 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	20
Likely benign	5
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

862 predictions. Top by Δscore:

Variant	Effect	Δscore
4:69200499:A:C	donor_gain	1.0000
4:69200516:A:AC	donor_gain	1.0000
4:69200555:T:TA	donor_gain	1.0000
4:69200568:A:AC	donor_gain	1.0000
4:69200569:C:CC	donor_gain	1.0000
4:69200570:TGG:T	donor_gain	1.0000
4:69208345:TCTTA:T	donor_loss	1.0000
4:69208346:CTTA:C	donor_loss	1.0000
4:69208347:TTA:T	donor_loss	1.0000
4:69208348:TACCT:T	donor_loss	1.0000
4:69208349:A:T	donor_loss	1.0000
4:69212731:A:AC	acceptor_gain	1.0000
4:69200495:CAAAA:C	donor_gain	0.9900
4:69200545:CCCAA:C	donor_gain	0.9900
4:69200549:A:AC	donor_gain	0.9900
4:69200569:CTG:C	donor_gain	0.9900
4:69200571:GGA:G	donor_gain	0.9900
4:69204446:CTGT:C	donor_gain	0.9900
4:69208479:TTTC:T	acceptor_gain	0.9900
4:69208479:TTTCC:T	acceptor_loss	0.9900
4:69208480:TTCCT:T	acceptor_loss	0.9900
4:69208481:TCC:T	acceptor_loss	0.9900
4:69208482:CCT:C	acceptor_loss	0.9900
4:69208483:C:CA	acceptor_loss	0.9900
4:69208483:C:CC	acceptor_gain	0.9900
4:69208484:T:A	acceptor_loss	0.9900
4:69212568:TTTAC:T	donor_loss	0.9900
4:69212569:TTAC:T	donor_loss	0.9900
4:69212570:TA:T	donor_loss	0.9900
4:69212572:C:CT	donor_loss	0.9900

AlphaMissense

3524 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:69205561:A:G	W337R	0.985
4:69205561:A:T	W337R	0.985
4:69204466:A:G	L425P	0.975
4:69204593:C:G	A383P	0.973
4:69214288:A:C	F145L	0.971
4:69214288:A:T	F145L	0.971
4:69214290:A:G	F145L	0.971
4:69205485:A:G	L362P	0.968
4:69208468:A:C	F295L	0.967
4:69208468:A:T	F295L	0.967
4:69208470:A:G	F295L	0.967
4:69214093:C:A	R210S	0.967
4:69214093:C:G	R210S	0.967
4:69204625:A:T	I372K	0.965
4:69205502:C:A	W356C	0.965
4:69205502:C:G	W356C	0.965
4:69205504:A:G	W356R	0.964
4:69205504:A:T	W356R	0.964
4:69214210:A:C	S171R	0.964
4:69214210:A:T	S171R	0.964
4:69214212:T:G	S171R	0.964
4:69200632:A:C	F466L	0.962
4:69200632:A:T	F466L	0.962
4:69200634:A:G	F466L	0.962
4:69214621:G:C	S34R	0.961
4:69214621:G:T	S34R	0.961
4:69214623:T:G	S34R	0.961
4:69205553:A:C	F339L	0.960
4:69205553:A:T	F339L	0.960
4:69205555:A:G	F339L	0.960

dbSNP variants (sampled 300 via entrez): RS1000261670 (4:69224381 A>G), RS1000294357 (4:69219919 G>A,T), RS10007579 (4:69214990 C>A,G,T), RS10007587 (4:69215010 C>G,T), RS1000891814 (4:69205820 A>T), RS1000900923 (4:69212925 G>A), RS1001057716 (4:69200747 A>G), RS1001127443 (4:69208957 A>G), RS10012181 (4:69215036 A>G), RS1001382133 (4:69210716 C>G,T), RS1001494842 (4:69206598 A>G,T), RS1001510690 (4:69216881 A>G), RS1001643371 (4:69210474 A>G), RS1001721056 (4:69218373 T>C), RS1001981997 (4:69209712 G>A,C)

Disease associations

OMIM: gene MIM:603064 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523985 (PROTEIN FAMILY)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Phenobarbital	affects expression, decreases expression, increases expression	3
Aflatoxin B1	decreases methylation, increases expression	2
methyleugenol	increases expression	1
2-hydroxyestriol	increases glucuronidation	1
sodium arsenite	decreases expression	1
4-phenylphenol	increases glucuronidation	1
4-nitrophenol	increases glucuronidation	1
4-hydroxyestrone	increases glucuronidation	1
2-aminophenol	increases glucuronidation	1
1-naphthol	increases glucuronidation	1
obeticholic acid	increases expression	1
abrine	decreases expression	1
Acetaminophen	decreases expression	1
Beclomethasone	increases expression	1
Benzo(a)pyrene	decreases expression	1
Biological Factors	decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Estradiol	increases expression	1
Estriol	increases glucuronidation	1
Hymecromone	increases glucuronidation	1
Menthol	increases glucuronidation	1
N-Nitrosopyrrolidine	increases expression	1
Silicon Dioxide	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	decreases methylation	1
8-Bromo Cyclic Adenosine Monophosphate	decreases expression	1
Okadaic Acid	affects expression	1
Copper Sulfate	decreases expression	1

ChEMBL screening assays

35 unique, capped per target: 35 admet

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4339708	ADMET	Drug metabolism in human hepatocytes assessed as UGT-mediated glucuronidation by measuring O-glucuronide formation at 10 uM measured after 4 hrs by LC-MS analysis	Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators. — ACS Med Chem Lett

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.