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UHMK1

gene
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Also known as KISKist

Summary

UHMK1 (U2AF homology motif kinase 1, HGNC:19683) is a protein-coding gene on chromosome 1q23.3, encoding Serine/threonine-protein kinase Kist (Q8TAS1). Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase.

The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.

Source: NCBI Gene 127933 — RefSeq curated summary.

At a glance

  • GWAS associations: 4
  • Clinical variants (ClinVar): 66 total — 1 likely-pathogenic
  • MANE Select transcript: NM_175866

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:19683
Approved symbolUHMK1
NameU2AF homology motif kinase 1
Location1q23.3
Locus typegene with protein product
StatusApproved
AliasesKIS, Kist
Ensembl geneENSG00000152332
Ensembl biotypeprotein_coding
OMIM608849
Entrez127933

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 7 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000282169, ENST00000489294, ENST00000538489, ENST00000545294, ENST00000874788, ENST00000874789, ENST00000874790, ENST00000949405

RefSeq mRNA: 3 — MANE Select: NM_175866 NM_001184763, NM_144624, NM_175866

CCDS: CCDS1239, CCDS53423, CCDS53424

Canonical transcript exons

ENST00000489294 — 8 exons

ExonStartEnd
ENSE00001004723162500913162501104
ENSE00001225664162499955162500247
ENSE00001838796162522404162529631
ENSE00001888659162497818162498268
ENSE00003523851162518102162518190
ENSE00003537713162512725162512823
ENSE00003610580162512500162512576
ENSE00003652154162503754162503848

Expression profiles

Bgee: expression breadth ubiquitous, 259 present calls, max score 99.03.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 50.3923 / max 377.7889, expressed in 1824 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
629849.84371824
63000.3855154
62990.163144

Top tissues by expression

259 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
kidney epitheliumUBERON:000481999.03gold quality
ileal mucosaUBERON:000033199.02gold quality
substantia nigra pars compactaUBERON:000196598.92gold quality
dorsal root ganglionUBERON:000004498.89gold quality
epithelium of nasopharynxUBERON:000195198.75gold quality
substantia nigra pars reticulataUBERON:000196698.67gold quality
superior vestibular nucleusUBERON:000722798.60gold quality
trigeminal ganglionUBERON:000167598.52gold quality
nasal cavity epitheliumUBERON:000538498.38gold quality
endothelial cellCL:000011598.27gold quality
epithelial cell of pancreasCL:000008398.16gold quality
medulla oblongataUBERON:000189698.08gold quality
lateral nuclear group of thalamusUBERON:000273698.03gold quality
germinal epithelium of ovaryUBERON:000130497.90gold quality
Brodmann (1909) area 23UBERON:001355497.89gold quality
cardiac muscle of right atriumUBERON:000337997.82gold quality
ponsUBERON:000098897.70gold quality
tibialis anteriorUBERON:000138597.68gold quality
palpebral conjunctivaUBERON:000181297.68gold quality
seminal vesicleUBERON:000099897.35gold quality
amniotic fluidUBERON:000017397.26gold quality
corpus epididymisUBERON:000435997.24gold quality
renal medullaUBERON:000036297.23gold quality
deltoidUBERON:000147697.21gold quality
caput epididymisUBERON:000435897.20gold quality
deciduaUBERON:000245097.17gold quality
epithelium of mammary glandUBERON:000324497.11gold quality
mammary ductUBERON:000176597.10gold quality
superior surface of tongueUBERON:000737197.08gold quality
eyeUBERON:000097097.00gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

ExperimentMarker?Max mean expression
E-ANND-3no0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CDK8, CDK9, FOXM1, GABPA, PAX5, POLR2A

miRNA regulators (miRDB)

288 targeting UHMK1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-6833-3P100.0070.633197
HSA-MIR-4768-5P100.0069.492861
HSA-MIR-3163100.0077.238605
HSA-MIR-3613-3P100.0076.367965
HSA-MIR-5692A100.0074.406850
HSA-MIR-450A-1-3P100.0069.331837
HSA-MIR-5011-5P100.0083.465820
HSA-MIR-1277-5P100.0073.955056
HSA-MIR-340-5P100.0072.504437
HSA-MIR-9-5P100.0072.282361
HSA-LET-7A-3P100.0074.033932
HSA-LET-7B-3P100.0074.083913
HSA-LET-7F-1-3P100.0074.023928
HSA-MIR-98-3P100.0074.083907
HSA-MIR-190A-3P100.0080.355520
HSA-MIR-188-3P100.0068.761240
HSA-MIR-5692B100.0071.322622
HSA-MIR-5692C100.0071.322622
HSA-MIR-4510100.0066.602050
HSA-MIR-6127100.0066.762188
HSA-MIR-6129100.0066.462080
HSA-MIR-6130100.0066.692012
HSA-MIR-6133100.0066.482064
HSA-MIR-371B-5P99.9975.344759
HSA-MIR-428299.9975.366408
HSA-MIR-186-5P99.9970.833707
HSA-MIR-511-3P99.9968.851467
HSA-MIR-196A-1-3P99.9972.152772
HSA-MIR-607799.9968.042299
HSA-MIR-366299.9973.825684

Literature-anchored findings (GeneRIF, showing 20)

  • We identify the kinase responsible for S10 phosphorylation as human kinase interacting stathmin (hKIS) and show that it regulates cell cycle progression in response to mitogens. (PMID:12093740)
  • KIS gene was overexpressed in NF1-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNSTs) as compared to dermal neurofibroma which suggests a possible implication of KIS in the genesis of NF1-associated tumors. (PMID:12782393)
  • Evidence indicating that UHMK1 may be a candidate susceptibility gene for Schizophrenia in the British population. UHMK1 is situated between previously implicated genes RGS4 and NOS1AP. (PMID:16978587)
  • These results provide preliminary evidence that the UHMK1 gene increases susceptibility to schizophrenia. Further confirmation in adequately powered samples is needed. (PMID:16978587)
  • KIS promoter is activated by serum-responsive GABP binding to Ets-binding sites which leads to KIS gene expression, cell migration, and cell cycle progression (PMID:17726090)
  • Results show that KIS is a direct transcriptional target of FoxM1. (PMID:17984092)
  • Overexpression of KIS protein kinase is associated with acute myelogenous leukemia, myelodysplastic syndrome and acute lymphoblastic leukemia (PMID:18384876)
  • A follow up article showing further association between markers in UHMK1 and schizophrenia in a London based sample. Association replicated in an independent Scottish sample. (PMID:18414510)
  • The association between UHMK1 and schizophrenia is confirmed. (PMID:18414510)
  • KIS is expressed in neurons, and its encoded protein is localised to the nucleus and cytoplasm. No difference in KIS expression was found between schizophrenics and controls or in the lymphoblast cell lines. (PMID:19747464)
  • The contribution of UHMK1 gene in schizophrenia susceptibility, was explored. (PMID:21399567)
  • Moreover, we showed that CATS and KIS antagonize the transactivation capacity of CALM/AF10.In summary, our results show that CATS interacts with and is a substrate for KIS, suggesting that KIS regulates CATS function (PMID:23419774)
  • genome-wide association study identified the UHMK1 gene as a novel bone mineral density locus specific to East Asians. (PMID:27424934)
  • UHMK1 plays a role in hematopoietic cell differentiation and suppression of autonomous clonal growth of leukemia cells. (PMID:29307747)
  • provide a model by which YAP supports cell proliferation through the induction of important cell cycle regulators in a UHMK1- and MYBL2-dependent manner (PMID:30936457)
  • UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. (PMID:31975428)
  • UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells. (PMID:35151311)
  • UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling. (PMID:35501324)
  • UHMK1 promotes lung adenocarcinoma oncogenesis by regulating the PI3K/AKT/mTOR signaling pathway. (PMID:36919755)
  • KIS counteracts PTBP2 and regulates alternative exon usage in neurons. (PMID:38597390)

Cross-species orthologs

7 orthologs

OrganismSymbolGene ID
danio_reriouhmk1ENSDARG00000059575
mus_musculusUhmk1ENSMUSG00000026667
rattus_norvegicusUhmk1l1ENSRNOG00000002941
rattus_norvegicusENSRNOG00000069116
drosophila_melanogasterCstF64FBGN0027841
caenorhabditis_elegansWBGENE00000774
caenorhabditis_elegansR06C1.4WBGENE00011059

Paralogs (5): U2AF2 (ENSG00000063244), CSTF2 (ENSG00000101811), RBMX2 (ENSG00000134597), ZCRB1 (ENSG00000139168), CSTF2T (ENSG00000177613)

Protein

Protein identifiers

Serine/threonine-protein kinase Kist — Q8TAS1 (reviewed: Q8TAS1)

Alternative names: Kinase interacting with stathmin, PAM COOH-terminal interactor protein 2, U2AF homology motif kinase 1

All UniProt accessions (1): Q8TAS1

UniProt curated annotations — full annotation on UniProt →

Function. Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA.

Subunit / interactions. Interacts with stathmin and CDKN1B/p27Kip1. Interacts with PAM.

Subcellular location. Nucleus.

Tissue specificity. Widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes.

Similarity. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Isoforms (3)

UniProt IDNamesCanonical?
Q8TAS1-11yes
Q8TAS1-22
Q8TAS1-33

RefSeq proteins (3): NP_001171692, NP_653225, NP_787062* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR000504RRM_domDomain
IPR000719Prot_kinase_domDomain
IPR011009Kinase-like_dom_sfHomologous_superfamily
IPR012677Nucleotide-bd_a/b_plait_sfHomologous_superfamily
IPR034372UHMK1Family
IPR035979RBD_domain_sfHomologous_superfamily

Pfam: PF00069, PF00076

Catalyzed reactions (Rhea), 2 shown:

  • L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+) (RHEA:17989)
  • L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+) (RHEA:46608)

UniProt features (12 total): splice variant 3, domain 2, sequence variant 2, binding site 2, chain 1, mutagenesis site 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q8TAS1-F190.310.71

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 158 (proton acceptor)

Ligand- & substrate-binding residues (2): 29–37; 54

Mutagenesis-validated functional residues (1):

PositionPhenotype
54loss of kinase activity.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

IDPathway
R-HSA-9634638Estrogen-dependent nuclear events downstream of ESR-membrane signaling

MSigDB gene sets: 216 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, HORIUCHI_WTAP_TARGETS_DN, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_PEPTIDYL_SERINE_MODIFICATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_REGULATION_OF_PROTEIN_EXPORT_FROM_NUCLEUS, GOBP_TRANSLATIONAL_INITIATION, GOBP_NEUROGENESIS, ACTGCAG_MIR173P, GOBP_TRANSLATION, GOBP_POSITIVE_REGULATION_OF_TRANSLATIONAL_INITIATION, GOBP_NUCLEAR_TRANSPORT, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_REGULATION_OF_NUCLEOCYTOPLASMIC_TRANSPORT, GOBP_REGULATION_OF_CELLULAR_LOCALIZATION

GO Biological Process (6): peptidyl-serine phosphorylation (GO:0018105), neuron projection development (GO:0031175), positive regulation of translational initiation (GO:0045948), regulation of protein export from nucleus (GO:0046825), regulation of cell cycle (GO:0051726), protein phosphorylation (GO:0006468)

GO Molecular Function (11): RNA binding (GO:0003723), protein serine/threonine kinase activity (GO:0004674), ATP binding (GO:0005524), ribonucleoprotein complex binding (GO:0043021), protein serine kinase activity (GO:0106310), nucleotide binding (GO:0000166), nucleic acid binding (GO:0003676), protein kinase activity (GO:0004672), protein binding (GO:0005515), kinase activity (GO:0016301), transferase activity (GO:0016740)

GO Cellular Component (5): nucleus (GO:0005634), nucleoplasm (GO:0005654), axon (GO:0030424), dendrite cytoplasm (GO:0032839), neuronal ribonucleoprotein granule (GO:0071598)

Reactome top-level categories

Rollup of top-1 pathways:

CategoryPathways
Extra-nuclear estrogen signaling1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
protein kinase activity2
binding2
neuron projection cytoplasm2
protein phosphorylation1
peptidyl-serine modification1
neuron development1
plasma membrane bounded cell projection organization1
translational initiation1
regulation of translational initiation1
positive regulation of translation1
protein export from nucleus1
regulation of intracellular protein transport1
regulation of nucleocytoplasmic transport1
cell cycle1
regulation of cellular process1
phosphorylation1
protein modification process1
nucleic acid binding1
adenyl ribonucleotide binding1
purine ribonucleoside triphosphate binding1
protein-containing complex binding1
nucleoside phosphate binding1
heterocyclic compound binding1
kinase activity1
phosphotransferase activity, alcohol group as acceptor1
catalytic activity, acting on a protein1
transferase activity, transferring phosphorus-containing groups1
catalytic activity1
intracellular membrane-bounded organelle1
nuclear lumen1
cellular anatomical structure1
neuron projection1
dendrite1
cytoplasmic ribonucleoprotein granule1

Protein interactions and networks

STRING

1904 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
UHMK1STMN1P16949910
UHMK1KCNIP4Q6PIL6777
UHMK1KCNIP2Q9NS61737
UHMK1KCNIP1Q9NZI2730
UHMK1KCND3Q9UK17698
UHMK1KCNC1P48547659
UHMK1KCNIP3Q9Y2W7655
UHMK1PRPF40AO75400562
UHMK1KCND2Q9NZV8559
UHMK1STYXL1Q9Y6J8553
UHMK1SF3B1O75533550
UHMK1AKIRIN1Q9H9L7537
UHMK1PAX5Q02548522
UHMK1METTL25Q8N6Q8507
UHMK1NUDT11Q96G61489

IntAct

15 interactions, top by confidence:

ABTypeScore
UHMK1ABL1psi-mi:“MI:0915”(physical association)0.400
EDEM2HACD1psi-mi:“MI:0914”(association)0.350
PDK4CNOT1psi-mi:“MI:0914”(association)0.350
UHMK1CNOT1psi-mi:“MI:0914”(association)0.350
BEX1H2AXpsi-mi:“MI:0914”(association)0.350
EEF1DAHCYL1psi-mi:“MI:0914”(association)0.350
L3HYPDHHELZpsi-mi:“MI:0914”(association)0.350
EDEM2HIGD1Cpsi-mi:“MI:0914”(association)0.350
SF1UHMK1psi-mi:“MI:0915”(physical association)0.000
UHMK1SF1psi-mi:“MI:0915”(physical association)0.000
FYNUHMK1psi-mi:“MI:0915”(physical association)0.000

BioGRID (50): UHMK1 (Affinity Capture-MS), UHMK1 (Two-hybrid), UHMK1 (Proximity Label-MS), UHMK1 (Affinity Capture-Western), UHMK1 (Two-hybrid), UHMK1 (Two-hybrid), LMO1 (Two-hybrid), TSGA10IP (Two-hybrid), NDUFAF3 (Two-hybrid), TMSB4X (Two-hybrid), UHMK1 (Affinity Capture-RNA), UHMK1 (Affinity Capture-MS), UHMK1 (Affinity Capture-MS), UHMK1 (Affinity Capture-MS), UHMK1 (Affinity Capture-MS)

ESM2 similar proteins: A0A0U1RPR8, A0A7N9VSG0, D3ZGQ5, D3ZHP7, O08644, O09127, O15197, O43542, O73875, O73878, O75676, P0C0K6, P0C0K7, P21709, P23800, P29317, P29322, P41243, P51839, P51840, P52785, P54753, P54754, P54760, P54761, P55203, P57078, P97343, Q1KL86, Q3U3Q1, Q4V7Q6, Q5RCY1, Q5ZJH6, Q60750, Q62270, Q63285, Q6PHR2, Q7ZZC8, Q80YD6, Q86SG6

Diamond homologs: A0A0A0LLY1, A0A0D1C8Z4, A0A0R4IEW8, A7EWN6, B0BN49, B5DF91, C0HFE5, D3Z4I3, M0R7T6, O09032, O22703, O23212, O35698, O43040, O74978, O94290, P19684, P25299, P26368, P26369, P26378, P33240, P48810, P49311, P70372, P90727, P90978, P97343, P98179, Q00916, Q03250, Q03878, Q05966, Q08473, Q08935, Q08E07, Q10B98, Q12926, Q13595, Q14576

SIGNOR signaling

12 interactions.

AEffectBMechanism
UHMK1down-regulatesMBPphosphorylation
UHMK1up-regulatesSF1phosphorylation
UHMK1down-regulatesSTMN1phosphorylation
UHMK1up-regulatesPIMREGphosphorylation
UHMK1unknownPAMphosphorylation
UHMK1up-regulatesCDKN1Bphosphorylation
UHMK1unknownSYN1phosphorylation

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic1
Uncertain significance47
Likely benign1
Benign0

Top pathogenic / likely-pathogenic (1)

Variant IDHGVSClassification
224812NM_175866.5(UHMK1):c.1214C>T (p.Pro405Leu)Likely pathogenic

SpliceAI

1455 predictions. Top by Δscore:

VariantEffectΔscore
1:162499953:A:AGacceptor_gain1.0000
1:162499954:G:GAacceptor_gain1.0000
1:162499954:GT:Gacceptor_gain1.0000
1:162500245:CAGGT:Cdonor_loss1.0000
1:162500246:AGG:Adonor_loss1.0000
1:162500247:GGTA:Gdonor_loss1.0000
1:162500248:G:GGdonor_gain1.0000
1:162500248:GTA:Gdonor_loss1.0000
1:162500249:T:Adonor_loss1.0000
1:162500912:GGAT:Gacceptor_gain1.0000
1:162503751:A:AGacceptor_gain1.0000
1:162503751:AAG:Aacceptor_gain1.0000
1:162503752:A:Gacceptor_gain1.0000
1:162512497:TA:Tacceptor_loss1.0000
1:162512498:A:AGacceptor_gain1.0000
1:162512498:AG:Aacceptor_loss1.0000
1:162512498:AGCAT:Aacceptor_gain1.0000
1:162512499:G:Aacceptor_loss1.0000
1:162512499:G:GTacceptor_gain1.0000
1:162512499:GC:Gacceptor_gain1.0000
1:162512499:GCA:Gacceptor_gain1.0000
1:162512499:GCAT:Gacceptor_gain1.0000
1:162512499:GCATG:Gacceptor_gain1.0000
1:162512574:TTGGT:Tdonor_loss1.0000
1:162512575:TGGT:Tdonor_loss1.0000
1:162512577:G:Adonor_loss1.0000
1:162512577:G:GGdonor_gain1.0000
1:162512578:TAA:Tdonor_loss1.0000
1:162512723:A:AGacceptor_gain1.0000
1:162512724:G:GGacceptor_gain1.0000

AlphaMissense

2742 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
1:162498162:G:CK54N1.000
1:162498162:G:TK54N1.000
1:162500159:A:GD158G1.000
1:162500159:A:TD158V1.000
1:162500182:T:AW166R1.000
1:162500182:T:CW166R1.000
1:162500216:A:CD177A1.000
1:162500216:A:TD177V1.000
1:162500217:C:AD177E1.000
1:162500217:C:GD177E1.000
1:162512767:T:CL323P1.000
1:162522411:T:AV374D1.000
1:162500021:A:TE112V0.999
1:162500150:T:AV155D0.999
1:162500152:C:GH156D0.999
1:162500155:G:CA157P0.999
1:162500159:A:CD158A0.999
1:162500160:C:AD158E0.999
1:162500160:C:GD158E0.999
1:162500162:T:AL159H0.999
1:162500164:A:GK160E0.999
1:162500166:A:CK160N0.999
1:162500166:A:TK160N0.999
1:162500173:A:GN163D0.999
1:162500175:C:AN163K0.999
1:162500175:C:GN163K0.999
1:162500177:T:AI164K0.999
1:162500210:T:AL175H0.999
1:162500215:G:CD177H0.999
1:162500216:A:GD177G0.999

dbSNP variants (sampled 300 via entrez): RS1000016631 (1:162513544 A>G), RS1000075882 (1:162507354 G>A), RS1000325456 (1:162513261 T>A,C), RS1000371584 (1:162528400 A>C,G), RS1000446593 (1:162528694 GTAGAT>G), RS1000487701 (1:162497849 A>C,G,T), RS1000558355 (1:162515535 C>T), RS1000598810 (1:162521602 C>G), RS1000807438 (1:162502994 A>G), RS1000859978 (1:162503199 A>G), RS1001024955 (1:162521909 G>A), RS1001127232 (1:162526241 A>G,T), RS1001143728 (1:162509206 T>G), RS1001225283 (1:162518450 C>G), RS1001306355 (1:162499989 T>C)

Disease associations

OMIM: gene MIM:608849 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

StudyTraitp-value
GCST003437_1Discordance in emotional problems in monozygotic twins2.000000e-07
GCST003611_1Bone mineral density (total hip)3.000000e-06
GCST003612_1Bone mineral density (femoral neck)4.000000e-07
GCST006575_29Takayasu arteritis2.000000e-07

EFO canonical traits (3, from GWAS)

EFO IDTrait name
EFO:0007803emotional symptom measurement
EFO:0007702hip bone mineral density
EFO:0007785femoral neck bone mineral density

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — Other-unique family

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

ChemicalActions (top 5)PubMed papers
Estradiolaffects cotreatment, decreases expression, increases expression3
trichostatin Aaffects cotreatment, decreases expression2
geldanamycinincreases expression1
methylmercuric chloridedecreases expression1
triphenyl phosphateaffects expression1
alpha-pineneaffects cotreatment, decreases expression, increases oxidation, increases abundance1
pirinixic acidaffects binding, increases activity, increases expression1
arsenitedecreases reaction, affects binding1
sodium arseniteincreases expression1
ferrous chlorideincreases expression1
cupric oxideincreases expression1
methacrylaldehydeaffects cotreatment, decreases expression, increases oxidation, increases abundance1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
ICG 001increases expression1
abrinedecreases expression1
dorsomorphinaffects cotreatment, decreases expression1
jinfukangdecreases expression1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acidincreases expression1
Resveratrolincreases expression, affects cotreatment1
Vorinostatdecreases expression1
Leflunomidedecreases expression1
Norethindrone Acetateaffects cotreatment, decreases expression1
Acetaminophenincreases expression1
Acroleinaffects cotreatment, decreases expression, increases oxidation, increases abundance1
Air Pollutantsaffects cotreatment, decreases expression, increases abundance, increases oxidation1
Azacitidineincreases expression1
Benzo(a)pyreneaffects methylation1
Cadmiumincreases abundance, increases expression1
Coumestroldecreases expression1
Mercuric Chloridedecreases expression1

Cellosaurus cell lines

4 cell lines: 4 cancer cell line

First 10 cell lines (id-ordered, not curated):

CellosaurusNameCategorySex
CVCL_B2KEAbcam HeLa UHMK1 KOCancer cell lineFemale
CVCL_TW26HAP1 UHMK1 (-) 1Cancer cell lineMale
CVCL_TW27HAP1 UHMK1 (-) 2Cancer cell lineMale
CVCL_TW28HAP1 UHMK1 (-) 3Cancer cell lineMale

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

  • Disease cohort memberships (association, not causation — diseases whose associated-gene cohort lists this gene; a subset are also under Associated diseases): Takayasu arteritis

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
v1.1.2
BioBTree
v2.0.2

Sources 76

This page pulls from 76 datasets indexed by BioBTree:

alphafoldalphamissenseantibodybgeebgee_evidencebindingdbbiogrid_interactionbrendabrenda_kineticsccdscellosauruschembl_activitychembl_targetciviccivic_evidenceclingen_dosageclingen_gene_validityclinical_trialsclinvarcollectrictd_gene_interactiondbsnpdepmapdiamond_similarityefoensemblentrezesm2_similarityexonfantom5_genefantom5_promotergenccgenerifgogoparentgtopdbgtopdb_interactiongwasgwas_studyhgnchpointactinterprointogenjasparmeshmimmirdbmondomsigdborphanetorthologparalogpdbpfampharmgkb_clinicalpharmgkb_genepharmgkb_guidelinepharmgkb_variantpubchempubchem_activitypubchem_assaypubmedreactomereactomeparentrefseqrhearnacentralscxa_expressionscxa_gene_experimentsignorspliceaistring_interactiontranscriptufeatureuniprot