UICLM

Summary

UICLM (up-regulated in colorectal cancer liver metastasis, HGNC:54869) is a long non-coding RNA gene on chromosome 2q37.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54869
Approved symbol	UICLM
Name	up-regulated in colorectal cancer liver metastasis
Location	2q37.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	CROCC2-AS1
Ensembl gene	ENSG00000233392
Ensembl biotype	lncRNA
Entrez	200772
RNAcentral	URS000075EAD4 — lncRNA, 2274 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 3 lncRNA, 1 retained_intron

ENST00000418218, ENST00000438506, ENST00000457369, ENST00000835917

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418218 — 9 exons

Exon	Start	End
ENSE00001605466	240955845	240955867
ENSE00001611143	240957362	240957617
ENSE00001617198	240967327	240967451
ENSE00001645664	240963264	240963746
ENSE00001685470	240963989	240964176
ENSE00001721209	240959077	240959122
ENSE00001772116	240959240	240959418
ENSE00001795998	240956370	240956460
ENSE00001800768	240954617	240955499

Expression profiles

Bgee: expression breadth ubiquitous, 141 present calls, max score 90.01.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4681 / max 167.5280, expressed in 91 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
34873	0.2960	74
34872	0.1442	38
34874	0.0279	10

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
granulocyte	CL:0000094	90.01	gold quality
spleen	UBERON:0002106	88.00	gold quality
monocyte	CL:0000576	82.40	gold quality
leukocyte	CL:0000738	81.78	gold quality
metanephros cortex	UBERON:0010533	77.25	gold quality
epithelial cell of pancreas	CL:0000083	76.55	gold quality
right lobe of liver	UBERON:0001114	74.25	gold quality
lymph node	UBERON:0000029	73.11	gold quality
tendon of biceps brachii	UBERON:0008188	71.82	gold quality
tendon	UBERON:0000043	71.65	silver quality
blood	UBERON:0000178	69.50	gold quality
liver	UBERON:0002107	68.00	gold quality
bone marrow cell	CL:0002092	65.87	silver quality
metanephros	UBERON:0000081	65.44	gold quality
adrenal tissue	UBERON:0018303	64.58	gold quality
oviduct epithelium	UBERON:0004804	63.40	silver quality
apex of heart	UBERON:0002098	61.90	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	61.70	gold quality
vermiform appendix	UBERON:0001154	61.17	gold quality
upper lobe of left lung	UBERON:0008952	60.53	gold quality
adult mammalian kidney	UBERON:0000082	60.27	gold quality
pancreatic ductal cell	CL:0002079	60.17	silver quality
islet of Langerhans	UBERON:0000006	59.70	silver quality
cortex of kidney	UBERON:0001225	58.97	gold quality
upper lobe of lung	UBERON:0008948	58.59	gold quality
buccal mucosa cell	CL:0002336	58.54	gold quality
body of stomach	UBERON:0001161	58.54	gold quality
pigmented layer of retina	UBERON:0001782	58.51	silver quality
hindlimb stylopod muscle	UBERON:0004252	58.16	gold quality
parotid gland	UBERON:0001831	58.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.14

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.