UNC5A

Summary

UNC5A (unc-5 netrin receptor A, HGNC:12567) is a protein-coding gene on chromosome 5q35.2, encoding Netrin receptor UNC5A (Q6ZN44). Receptor for netrin required for axon guidance.

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).

Source: NCBI Gene 90249 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 100 total
• MANE Select transcript: NM_133369

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12567
Approved symbol	UNC5A
Name	unc-5 netrin receptor A
Location	5q35.2
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1976, UNC5H1
Ensembl gene	ENSG00000113763
Ensembl biotype	protein_coding
OMIM	607869
Entrez	90249

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 nonsense_mediated_decay

ENST00000329542, ENST00000509580, ENST00000513890, ENST00000927830, ENST00000970734

RefSeq mRNA: 1 — MANE Select: NM_133369 NM_133369

CCDS: CCDS34299

Canonical transcript exons

ENST00000329542 — 15 exons

Exon	Start	End
ENSE00001158964	176879310	176879488
ENSE00001158973	176878475	176878639
ENSE00001158980	176878244	176878393
ENSE00001158987	176877894	176878127
ENSE00001158992	176877535	176877703
ENSE00001159001	176877192	176877279
ENSE00001159009	176874264	176874566
ENSE00001400922	176810559	176810820
ENSE00001430991	176862624	176862845
ENSE00003545204	176868561	176868664
ENSE00003601466	176870370	176870534
ENSE00003617779	176868784	176868964
ENSE00003636035	176873968	176874156
ENSE00003666765	176868130	176868273
ENSE00003827647	176879721	176880898

Expression profiles

Bgee: expression breadth ubiquitous, 145 present calls, max score 97.69.

FANTOM5 (CAGE): breadth broad, TPM avg 2.4667 / max 228.6698, expressed in 395 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
60437	1.0737	276
60438	0.8284	205
60436	0.2255	107
60435	0.2000	94
60434	0.1064	47
60439	0.0327	23

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	97.69	gold quality
middle temporal gyrus	UBERON:0002771	95.99	gold quality
Brodmann (1909) area 23	UBERON:0013554	95.35	gold quality
primary visual cortex	UBERON:0002436	95.07	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.15	gold quality
right frontal lobe	UBERON:0002810	93.99	gold quality
cerebellar hemisphere	UBERON:0002245	93.28	gold quality
cerebellar cortex	UBERON:0002129	93.15	gold quality
occipital lobe	UBERON:0002021	92.80	gold quality
cerebellum	UBERON:0002037	92.36	gold quality
frontal cortex	UBERON:0001870	92.30	gold quality
prefrontal cortex	UBERON:0000451	92.27	gold quality
superior frontal gyrus	UBERON:0002661	91.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.56	gold quality
neocortex	UBERON:0001950	91.31	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	91.29	gold quality
cerebral cortex	UBERON:0000956	90.11	gold quality
postcentral gyrus	UBERON:0002581	90.01	gold quality
parietal lobe	UBERON:0001872	89.90	gold quality
anterior cingulate cortex	UBERON:0009835	89.55	gold quality
ganglionic eminence	UBERON:0004023	89.33	gold quality
entorhinal cortex	UBERON:0002728	88.61	gold quality
Ammon’s horn	UBERON:0001954	86.90	gold quality
temporal lobe	UBERON:0001871	86.23	gold quality
cortical plate	UBERON:0005343	85.76	gold quality
forebrain	UBERON:0001890	84.61	gold quality
amygdala	UBERON:0001876	84.45	gold quality
brain	UBERON:0000955	84.40	gold quality
cerebellar vermis	UBERON:0004720	83.38	gold quality
Brodmann (1909) area 46	UBERON:0006483	82.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.62

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): FOXC1, TP53

miRNA regulators (miRDB)

123 targeting UNC5A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4692	100.00	67.32	2066
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-4514	99.99	67.10	1870
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-4492	99.87	68.25	3611
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6756-5P	99.82	67.97	2466
HSA-MIR-448	99.79	72.37	2103
HSA-MIR-320A-3P	99.77	69.73	2107
HSA-MIR-320B	99.77	69.73	2107
HSA-MIR-320C	99.77	69.73	2107
HSA-MIR-320D	99.77	69.73	2107

Literature-anchored findings (GeneRIF, showing 9)

• may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis (PMID:12655055)
• UNC5 orthologues define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis in cancer cells (review) (PMID:15573119)
• UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis (PMID:20372800)
• FANCC interferes with UNC5A’s functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A. (PMID:24676280)
• these data suggest an important role for UNC5A, a candidate tumor suppressor, in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer (PMID:24737586)
• The results suggest that netrin-1 promotes glioma cell proliferation by activating NF-kappaB signaling via UNC5A. (PMID:28710382)
• UNC5A is capable of impeding autophagy and promoting HCV restriction through specific impact on virion infectivity, in a cell death-independent and DAPK-related manner. (PMID:28783179)
• Such data indicate that cooperation between the UPR and UNC5A depletion as previously observed by ourselves in HCC patients samples may foster liver cancer development and growth. (PMID:29277614)
• These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERalpha and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERalpha(+) breast cancers (PMID:29720215)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	unc5a	ENSDARG00000099034
mus_musculus	Unc5a	ENSMUSG00000025876
rattus_norvegicus	Unc5a	ENSRNOG00000059840
drosophila_melanogaster	unc-5	FBGN0034013
caenorhabditis_elegans		WBGENE00006745

Paralogs (4): UNC5B (ENSG00000107731), UNC5CL (ENSG00000124602), UNC5D (ENSG00000156687), UNC5C (ENSG00000182168)

Protein

Protein identifiers

Netrin receptor UNC5A — Q6ZN44 (reviewed: Q6ZN44)

Alternative names: Protein unc-5 homolog 1, Protein unc-5 homolog A

All UniProt accessions (3): Q6ZN44, H0Y8R2, H0Y9G2

UniProt curated annotations — full annotation on UniProt →

Function. Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Subunit / interactions. Homodimer and homooligomer. Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediating some interaction with PKC. Interacts (via extracellular domain) with FLRT2 (via extracellular domain). Interacts (via extracellular domain) with FLRT3 (via extracellular domain).

Subcellular location. Cell membrane. Membrane raft. Cell projection. Neuron projection.

Post-translational modifications. Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. The two extracellular TSRs of UNC5A contain WxxWxxWxxC motifs that can be C-mannosylated on all tryptophans. DPY19L1 preferentially mannosylates the first two tryptophans and DPY19L3 prefers the third. C-mannosylation by DPY19L1 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface.

Domain organisation. The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis.

Induction. By p53/TP53.

Miscellaneous. Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.

Similarity. Belongs to the unc-5 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6ZN44-1	1	yes
Q6ZN44-2	2
Q6ZN44-3	3

RefSeq proteins (1): NP_588610* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000488	Death_dom	Domain
IPR000884	TSP1_rpt	Repeat
IPR000906	ZU5_dom	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR011029	DEATH-like_dom_sf	Homologous_superfamily
IPR013098	Ig_I-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR033772	UPA	Domain
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR036383	TSP1_rpt_sf	Homologous_superfamily
IPR037936	UNC5A-D	Family
IPR042155	Death_UNC5A	Domain
IPR057755	UNC5A-D-like_N	Domain

Pfam: PF00531, PF00791, PF07679, PF17217, PF25609

UniProt features (52 total): strand 20, glycosylation site 6, disulfide bond 6, domain 5, splice variant 3, topological domain 2, turn 2, helix 2, signal peptide 1, chain 1, region of interest 1, site 1, sequence conflict 1, transmembrane region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
4V2A	X-RAY DIFFRACTION	2.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6ZN44-F1	78.19	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 340–341 (cleavage; by caspase-3)

Disulfide bonds (6): 65–126, 77–124, 170–221, 254–288, 258–293, 266–278

Glycosylation sites (6): 107, 218, 245, 248, 251, 287

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-373752	Netrin-1 signaling
R-HSA-418886	Netrin mediated repulsion signals
R-HSA-418889	Caspase activation via Dependence Receptors in the absence of ligand

MSigDB gene sets: 104 (showing top): GSE37336_LY6C_POS_VS_NEG_NAIVE_CD4_TCELL_DN, PID_NETRIN_PATHWAY, GOBP_NEUROGENESIS, CACCAGC_MIR138, SUH_COEXPRESSED_WITH_ID1_AND_ID2_UP, GOCC_NEURON_PROJECTION, GOBP_CELL_PROJECTION_ORGANIZATION, REACTOME_APOPTOSIS, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, AGCTCCT_MIR28, HILLION_HMGA1B_TARGETS, GOCC_CELL_PROJECTION_MEMBRANE, ATGTACA_MIR493, GOCC_LEADING_EDGE_MEMBRANE, MARSON_BOUND_BY_FOXP3_UNSTIMULATED

GO Biological Process (5): apoptotic process (GO:0006915), neuron projection development (GO:0031175), anterior/posterior axon guidance (GO:0033564), netrin-activated signaling pathway (GO:0038007), signal transduction (GO:0007165)

GO Molecular Function (2): netrin receptor activity (GO:0005042), protein binding (GO:0005515)

GO Cellular Component (7): plasma membrane (GO:0005886), neuron projection membrane (GO:0032589), neuronal cell body membrane (GO:0032809), membrane raft (GO:0045121), membrane (GO:0016020), cell projection (GO:0042995), neuron projection (GO:0043005)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Axon guidance	1
Netrin-1 signaling	1
Caspase activation via extrinsic apoptotic signalling pathway	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
neuron development	1
plasma membrane bounded cell projection organization	1
axon guidance	1
cell surface receptor signaling pathway	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
netrin-activated signaling pathway	1
binding	1
membrane	1
cell periphery	1
cell projection membrane	1
leading edge membrane	1
neuron projection	1
neuronal cell body	1
cell body membrane	1
membrane microdomain	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

1488 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UNC5A	NTN1	O95631	998
UNC5A	FLRT1	Q9NZU1	854
UNC5A	NEO1	Q92859	808
UNC5A	NTN4	Q9HB63	702
UNC5A	FLRT3	Q9NZU0	643
UNC5A	ALOX12	P18054	639
UNC5A	SEMA3A	Q14563	638
UNC5A	DSCAM	O60469	635
UNC5A	DCC	P43146	620
UNC5A	NTN3	O00634	619
UNC5A	MAGED1	Q9Y5V3	602
UNC5A	SEMA3F	Q13275	596
UNC5A	UIMC1	Q96RL1	596
UNC5A	NTN5	Q8WTR8	561
UNC5A	EFNB2	P52799	560

IntAct

6 interactions, top by confidence:

A	B	Type	Score
FGFR4	UNC5A	psi-mi:“MI:0915”(physical association)	0.400
UNC5A	MPIG6B	psi-mi:“MI:0915”(physical association)	0.400
LRRN1	UNC5A	psi-mi:“MI:0915”(physical association)	0.400
LRRTM2	UNC5A	psi-mi:“MI:0915”(physical association)	0.400
M		psi-mi:“MI:0914”(association)	0.350

BioGRID (9): UNC5A (Affinity Capture-Western), MAGED1 (Two-hybrid), UNC5A (Two-hybrid), FANCC (Affinity Capture-Western), UNC5A (Affinity Capture-Western), NTN1 (Reconstituted Complex), MAGED1 (Reconstituted Complex), MAGED1 (Affinity Capture-Western), UNC5A (Affinity Capture-RNA)

ESM2 similar proteins: A0A8M9PFP2, A1X150, A2A863, A4IH88, B0S5G3, B2RXS4, F1LW30, F1R520, G5ED46, L7VG99, O08721, O08722, O08747, O60486, O73878, O94985, O95185, P10493, P14543, P16144, P35590, P54761, P55292, Q06806, Q0VCN6, Q14393, Q5FWR8, Q5R9Q9, Q61592, Q63772, Q64632, Q6DDG2, Q6Q0N0, Q6UXZ4, Q6ZN44, Q761X5, Q7T2Z5, Q8IZJ1, Q8K1S2, Q8K1S3

Diamond homologs: A0A0G2K2P5, A0A8P0N4K0, C5IAW9, F1LW30, O08721, O08722, O08747, O62683, O95049, O95185, O97758, P39447, P57105, Q07157, Q0P5E6, Q13424, Q28626, Q32LE7, Q3T0C9, Q5EBL8, Q5ZIK2, Q61234, Q6NXB2, Q6QA76, Q6R653, Q6UXZ4, Q6ZN44, Q761X5, Q7KRY7, Q7T2Z5, Q80VW5, Q86UL8, Q8IV45, Q8IZJ1, Q8JGT4, Q8K1S2, Q8K1S3, Q8K1S4, Q95168, Q9CZG9

SIGNOR signaling

6 interactions.

A	Effect	B	Mechanism
UNC5A	“down-regulates activity”	DCC	binding
UNC5A	up-regulates	Chemorepulsion_of_axon
NTN4	up-regulates	UNC5A	binding
PRKCA	“down-regulates quantity”	UNC5A	phosphorylation
UNC5A	“up-regulates activity”	PICK1	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

100 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	88
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

3279 predictions. Top by Δscore:

Variant	Effect	Δscore
5:176862843:GTG:G	donor_gain	1.0000
5:176868270:GCCT:G	donor_gain	1.0000
5:176868272:CT:C	donor_gain	1.0000
5:176868274:G:GG	donor_gain	1.0000
5:176868556:TCTA:T	acceptor_loss	1.0000
5:176868558:TAGAT:T	acceptor_loss	1.0000
5:176868559:A:AG	acceptor_gain	1.0000
5:176868559:A:AT	acceptor_loss	1.0000
5:176868560:G:GA	acceptor_gain	1.0000
5:176868560:G:GT	acceptor_loss	1.0000
5:176868560:GATTT:G	acceptor_gain	1.0000
5:176868665:GT:G	donor_loss	1.0000
5:176868666:T:A	donor_loss	1.0000
5:176868782:AGGT:A	acceptor_gain	1.0000
5:176868783:GGTG:G	acceptor_gain	1.0000
5:176868960:CTACG:C	donor_loss	1.0000
5:176868962:ACGG:A	donor_loss	1.0000
5:176868966:T:A	donor_loss	1.0000
5:176868992:G:GT	donor_gain	1.0000
5:176868993:G:T	donor_gain	1.0000
5:176869607:C:A	acceptor_gain	1.0000
5:176869608:G:A	acceptor_gain	1.0000
5:176869612:A:AG	acceptor_gain	1.0000
5:176869612:AGT:A	acceptor_gain	1.0000
5:176869613:G:GA	acceptor_gain	1.0000
5:176869613:GTG:G	acceptor_gain	1.0000
5:176870356:T:TA	acceptor_gain	1.0000
5:176870364:A:AG	acceptor_gain	1.0000
5:176870365:T:G	acceptor_gain	1.0000
5:176870368:A:AG	acceptor_gain	1.0000

AlphaMissense

5480 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:176862746:T:A	C65S	1.000
5:176862746:T:C	C65R	1.000
5:176862747:G:A	C65Y	1.000
5:176862747:G:C	C65S	1.000
5:176862748:C:G	C65W	1.000
5:176862777:T:C	F75S	1.000
5:176862782:T:A	C77S	1.000
5:176862782:T:C	C77R	1.000
5:176862783:G:C	C77S	1.000
5:176862796:G:C	W81C	1.000
5:176862796:G:T	W81C	1.000
5:176868207:T:A	C124S	1.000
5:176868207:T:C	C124R	1.000
5:176868208:G:C	C124S	1.000
5:176868209:C:G	C124W	1.000
5:176868213:T:A	C126S	1.000
5:176868213:T:C	C126R	1.000
5:176868214:G:A	C126Y	1.000
5:176868214:G:C	C126S	1.000
5:176868215:C:G	C126W	1.000
5:176868564:T:C	L147S	1.000
5:176868576:T:C	F151S	1.000
5:176868576:T:G	F151C	1.000
5:176868627:T:C	L168P	1.000
5:176868632:T:A	C170S	1.000
5:176868632:T:C	C170R	1.000
5:176868633:G:A	C170Y	1.000
5:176868633:G:C	C170S	1.000
5:176868634:C:G	C170W	1.000
5:176868647:G:C	G175R	1.000

dbSNP variants (sampled 300 via entrez): RS1000028597 (5:176852878 G>A), RS1000043108 (5:176822338 T>C), RS1000122169 (5:176816024 C>T), RS1000143 (5:176857900 A>C,G,T), RS1000144 (5:176857712 C>G,T), RS1000145 (5:176857314 T>G), RS1000184745 (5:176875273 C>A,T), RS1000225156 (5:176809882 G>A,C,T), RS1000239024 (5:176846819 G>A), RS1000273992 (5:176839187 A>G,T), RS1000286426 (5:176877031 G>A,C,T), RS1000289483 (5:176820655 G>A,C), RS1000332211 (5:176864188 C>G), RS1000365929 (5:176851801 G>C), RS1000385332 (5:176827142 G>A)

Disease associations

OMIM: gene MIM:607869 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST005956_15	Waist-to-hip ratio adjusted for BMI	1.000000e-07
GCST005957_13	Waist-to-hip ratio adjusted for BMI (age <50)	3.000000e-07
GCST005962_42	Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test)	1.000000e-08
GCST012317_10	Triglyceride levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder	5.000000e-06

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008007	age at assessment
EFO:0008343	sex interaction measurement
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases methylation	3
Valproic Acid	affects expression, increases expression	3
bisphenol A	increases methylation, increases expression	2
Panobinostat	affects cotreatment, decreases expression	2
Phenylmercuric Acetate	affects cotreatment, decreases expression	2
methylmercuric chloride	increases expression	1
propionaldehyde	decreases expression	1
trichostatin A	decreases expression, increases expression	1
sodium arsenite	decreases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
Grape Seed Proanthocyanidins	increases expression, affects cotreatment	1
dorsomorphin	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Zoledronic Acid	increases expression	1
Acetaminophen	decreases expression	1
Atrazine	increases expression	1
Catechin	increases expression, affects cotreatment	1
Estradiol	increases expression	1
Lead	affects expression	1
Methapyrilene	increases methylation	1
Phthalic Acids	decreases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Smoke	decreases expression	1
Tretinoin	decreases expression	1
Aflatoxin B1	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.