UNC5B-AS1

Summary

UNC5B-AS1 (UNC5B antisense RNA 1, HGNC:45096) is a long non-coding RNA gene on chromosome 10q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:45096
Approved symbol	UNC5B-AS1
Name	UNC5B antisense RNA 1
Location	10q22.1
Locus type	RNA, long non-coding
Status	Approved
Aliases	UASR1, TP53LC05
Ensembl gene	ENSG00000237512
Ensembl biotype	lncRNA
Entrez	728978
RNAcentral	URS000075EE9C — lncRNA, 652 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000447119, ENST00000449737, ENST00000846834

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000447119 — 2 exons

Exon	Start	End
ENSE00004275028	71217219	71217635
ENSE00004275030	71217994	71218308

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 91.93.

FANTOM5 (CAGE): breadth broad, TPM avg 2.3890 / max 348.6675, expressed in 667 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
109871	0.6928	204
109870	0.6755	245
109873	0.6742	275
109872	0.2653	113
109874	0.0812	27

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	91.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.93	gold quality
right atrium auricular region	UBERON:0006631	82.55	gold quality
cardiac atrium	UBERON:0002081	82.28	gold quality
bone marrow cell	CL:0002092	79.76	gold quality
heart left ventricle	UBERON:0002084	79.13	gold quality
cardiac ventricle	UBERON:0002082	78.95	gold quality
left ventricle myocardium	UBERON:0006566	78.47	gold quality
heart	UBERON:0000948	77.63	gold quality
heart right ventricle	UBERON:0002080	77.36	silver quality
pancreatic ductal cell	CL:0002079	76.62	silver quality
right uterine tube	UBERON:0001302	76.02	gold quality
nasal cavity mucosa	UBERON:0001826	74.65	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	73.48	gold quality
sural nerve	UBERON:0015488	71.64	silver quality
hindlimb stylopod muscle	UBERON:0004252	71.27	gold quality
lower esophagus mucosa	UBERON:0035834	71.21	gold quality
vena cava	UBERON:0004087	70.60	gold quality
palpebral conjunctiva	UBERON:0001812	69.87	gold quality
germinal epithelium of ovary	UBERON:0001304	69.75	gold quality
amygdala	UBERON:0001876	69.11	gold quality
calcaneal tendon	UBERON:0003701	69.08	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	68.90	gold quality
upper arm skin	UBERON:0004263	67.18	gold quality
muscle tissue	UBERON:0002385	67.16	gold quality
ganglionic eminence	UBERON:0004023	66.66	gold quality
esophagus mucosa	UBERON:0002469	66.44	gold quality
bronchial epithelial cell	CL:0002328	65.57	gold quality
kidney epithelium	UBERON:0004819	65.56	gold quality
vagina	UBERON:0000996	65.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• UNC5B-AS1 promoted ovarian cancer progression by regulating the H3K27me on NDRG2 via EZH2. (PMID:31903696)
• Promoting effect of PAX5-activated lncRNA UASR1 on growth of colorectal cancer by regulating the mTOR pathway. (PMID:32271416)
• [Effects of LncRNA UNC5B-AS1 on adhesion, invasion and migration of lung cancer cells and its mechanism]. (PMID:33719270)
• UNC5B-AS1 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells via regulating miR-4306/KDM2A axis. (PMID:34612138)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.