UNC5D

Summary

UNC5D (unc-5 netrin receptor D, HGNC:18634) is a protein-coding gene on chromosome 8p12, encoding Netrin receptor UNC5D (Q6UXZ4). Receptor for the netrin NTN4 that promotes neuronal cell survival.

Predicted to enable netrin receptor activity. Involved in cell-cell adhesion via plasma-membrane adhesion molecules. Predicted to be located in cell surface and plasma membrane.

Source: NCBI Gene 137970 — RefSeq curated summary.

At a glance

• GWAS associations: 14
• Clinical variants (ClinVar): 92 total
• MANE Select transcript: NM_080872

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18634
Approved symbol	UNC5D
Name	unc-5 netrin receptor D
Location	8p12
Locus type	gene with protein product
Status	Approved
Aliases	KIAA1777, Unc5h4
Ensembl gene	ENSG00000156687
Ensembl biotype	protein_coding
OMIM	616466
Entrez	137970

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000287272, ENST00000404895, ENST00000416672, ENST00000420357, ENST00000449677, ENST00000453357, ENST00000474634

RefSeq mRNA: 3 — MANE Select: NM_080872 NM_001322818, NM_001410918, NM_080872

CCDS: CCDS6093, CCDS83279, CCDS94280

Canonical transcript exons

ENST00000404895 — 17 exons

Exon	Start	End
ENSE00000890769	35595554	35595657
ENSE00001027806	35568098	35568241
ENSE00001027816	35683547	35683727
ENSE00001027820	35766902	35767066
ENSE00001027821	35750582	35750809
ENSE00001027824	35731012	35731096
ENSE00001027827	35774299	35774477
ENSE00001027829	35748527	35748695
ENSE00001027830	35759320	35759469
ENSE00001089445	35726152	35726529
ENSE00001156706	35705929	35705961
ENSE00001156724	35549292	35549510
ENSE00001551072	35790359	35796540
ENSE00001732550	35235475	35235887
ENSE00003530178	35722210	35722395
ENSE00003582659	35686545	35686709
ENSE00003627915	35684582	35684749

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 95.25.

FANTOM5 (CAGE): breadth broad, TPM avg 3.7820 / max 175.5400, expressed in 373 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
88401	3.2037	353
88400	0.4375	189
88402	0.1408	82

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
embryo	UBERON:0000922	95.25	gold quality
ganglionic eminence	UBERON:0004023	95.25	gold quality
endothelial cell	CL:0000115	92.95	gold quality
Brodmann (1909) area 23	UBERON:0013554	90.19	gold quality
middle temporal gyrus	UBERON:0002771	88.18	gold quality
cortical plate	UBERON:0005343	84.92	gold quality
primary visual cortex	UBERON:0002436	81.70	gold quality
Brodmann (1909) area 46	UBERON:0006483	81.14	gold quality
entorhinal cortex	UBERON:0002728	80.92	gold quality
buccal mucosa cell	CL:0002336	80.81	silver quality
occipital lobe	UBERON:0002021	80.80	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	80.36	gold quality
superior frontal gyrus	UBERON:0002661	80.32	gold quality
parietal lobe	UBERON:0001872	77.81	gold quality
duodenum	UBERON:0002114	77.56	gold quality
postcentral gyrus	UBERON:0002581	77.46	gold quality
prefrontal cortex	UBERON:0000451	75.74	gold quality
jejunal mucosa	UBERON:0000399	75.20	gold quality
frontal cortex	UBERON:0001870	74.71	gold quality
ventricular zone	UBERON:0003053	74.62	gold quality
neocortex	UBERON:0001950	73.72	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	73.66	gold quality
islet of Langerhans	UBERON:0000006	73.28	gold quality
cerebral cortex	UBERON:0000956	72.52	gold quality
Brodmann (1909) area 9	UBERON:0013540	72.09	gold quality
temporal lobe	UBERON:0001871	71.02	gold quality
superior vestibular nucleus	UBERON:0007227	70.40	gold quality
ileal mucosa	UBERON:0000331	69.59	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	69.40	gold quality
jejunum	UBERON:0002115	69.03	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-HCAD-25	yes	1393.46
E-GEOD-75140	yes	594.41
E-HCAD-35	yes	71.45
E-ANND-3	yes	7.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): TP53

miRNA regulators (miRDB)

350 targeting UNC5D, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-6740-5P	100.00	65.64	932
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-3662	99.99	73.82	5684

Literature-anchored findings (GeneRIF, showing 9)

• UNC5H4 amplifies p53-dependent apoptotic response. (PMID:18402767)
• UNC5D is a functional tumor suppressor that is frequently downregulated in RCCs due to promoter hypermethylation and LOH. (PMID:23589179)
• UNC5D forms a positive feedback loop with p53 and E2F1 to promote NGF dependence-mediated programmed cell death during neuroblastoma regression. (PMID:23778138)
• the dependence receptor UNC5H4 may act as a putative tumor suppressor in neuroblastoma. (PMID:24519068)
• Unc5D is thus a newly identified transcriptional target of proapoptotic p53 and may also act upstream of p53 to induce p53dependent apoptosis by phosphorylation at ser15. (PMID:24691657)
• The authors identified a locus on chromosome 8, containing UNC5D, and demonstrated evidence of its genome-wide significance with mental composite scores. Within this locus, the joint effects of two independent single nucleotide polymorphisms had a p-value of 4.38 x 10(-9) for mental composite scores. (PMID:28754176)
• these results suggested that UNC5D as a novel putative metastatic suppressor gene that is commonly down-regulated by hypermethylation in PCa. (PMID:30632669)
• Hypermethylated promoters of genes UNC5D and KCNA1 as potential novel diagnostic biomarkers in colorectal cancer. (PMID:33078631)
• The expression of UNC5D is abnormal in the early stage of colorectal tumors associated with its proliferation and migration. (PMID:38235871)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	unc5db	ENSDARG00000061541
danio_rerio	unc5da	ENSDARG00000092722
mus_musculus	Unc5d	ENSMUSG00000063626
rattus_norvegicus	Unc5d	ENSRNOG00000011858
drosophila_melanogaster	unc-5	FBGN0034013
caenorhabditis_elegans		WBGENE00006745

Paralogs (4): UNC5B (ENSG00000107731), UNC5A (ENSG00000113763), UNC5CL (ENSG00000124602), UNC5C (ENSG00000182168)

Protein

Protein identifiers

Netrin receptor UNC5D — Q6UXZ4 (reviewed: Q6UXZ4)

Alternative names: Protein unc-5 homolog 4, Protein unc-5 homolog D

All UniProt accessions (5): Q6UXZ4, C9J1I0, C9J2B6, E9PDS8, H7BXJ2

UniProt curated annotations — full annotation on UniProt →

Function. Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell.

Subunit / interactions. Interacts (via extracellular domain) with FLRT2 (via extracellular domain); the interaction is direct. Interacts (via extracellular domain) with FLRT3 (via extracellular domain); the interaction is direct. Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself.

Subcellular location. Cell membrane.

Post-translational modifications. Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.

Induction. Up-regulated by p53/TP53 in response to DNA damage.

Similarity. Belongs to the unc-5 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q6UXZ4-1	1	yes
Q6UXZ4-2	2

RefSeq proteins (3): NP_001309747, NP_001397847, NP_543148* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000488	Death_dom	Domain
IPR000884	TSP1_rpt	Repeat
IPR000906	ZU5_dom	Domain
IPR003598	Ig_sub2	Domain
IPR003599	Ig_sub	Domain
IPR007110	Ig-like_dom	Domain
IPR011029	DEATH-like_dom_sf	Homologous_superfamily
IPR013098	Ig_I-set	Domain
IPR013783	Ig-like_fold	Homologous_superfamily
IPR033772	UPA	Domain
IPR036179	Ig-like_dom_sf	Homologous_superfamily
IPR036383	TSP1_rpt_sf	Homologous_superfamily
IPR037936	UNC5A-D	Family
IPR042058	UNC5D_Death	Domain
IPR057755	UNC5A-D-like_N	Domain

Pfam: PF00090, PF00531, PF00791, PF07679, PF17217, PF25609

UniProt features (28 total): disulfide bond 9, domain 6, glycosylation site 4, topological domain 2, signal peptide 1, chain 1, region of interest 1, site 1, splice variant 1, sequence variant 1, transmembrane region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6UXZ4-F1	75.01	0.46

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 416–417 (cleavage; by caspase-3)

Disulfide bonds (9): 75–136, 87–134, 180–231, 264–301, 268–305, 279–291, 320–354, 324–359, 332–344

Glycosylation sites (4): 117, 228, 353, 376

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-418886	Netrin mediated repulsion signals

MSigDB gene sets: 148 (showing top): GOCC_CELL_SURFACE, GOBP_NEUROGENESIS, CACCAGC_MIR138, ATGTTAA_MIR302C, GOBP_CELL_CELL_ADHESION, MODULE_171, MODULE_301, GOBP_CENTRAL_NERVOUS_SYSTEM_NEURON_DIFFERENTIATION, GOBP_REGULATION_OF_NEURON_MIGRATION, GOBP_NEURON_MIGRATION, chr8p12, GOBP_CELL_PROJECTION_ORGANIZATION, VECCHI_GASTRIC_CANCER_EARLY_DN, ATGTCAC_MIR489, MODULE_188

GO Biological Process (7): apoptotic process (GO:0006915), axon guidance (GO:0007411), pyramidal neuron differentiation (GO:0021859), obsolete cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742), regulation of neuron migration (GO:2001222), signal transduction (GO:0007165), netrin-activated signaling pathway (GO:0038007)

GO Molecular Function (2): netrin receptor activity (GO:0005042), protein binding (GO:0005515)

GO Cellular Component (3): plasma membrane (GO:0005886), cell surface (GO:0009986), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Netrin-1 signaling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
programmed cell death	1
apoptotic signaling pathway	1
execution phase of apoptosis	1
axonogenesis	1
neuron projection guidance	1
central nervous system neuron differentiation	1
neuron migration	1
regulation of cell migration	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
cell surface receptor signaling pathway	1
transmembrane signaling receptor activity	1
netrin-activated signaling pathway	1
binding	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

1300 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UNC5D	NTN1	O95631	860
UNC5D	FLRT2	O43155	827
UNC5D	FLRT3	Q9NZU0	781
UNC5D	DCC	P43146	675
UNC5D	NEO1	Q92859	673
UNC5D	ADGRL3	Q9HAR2	597
UNC5D	NTN4	Q9HB63	545
UNC5D	NTN3	O00634	540
UNC5D	NTNG2	Q96CW9	513
UNC5D	NTNG1	Q9Y2I2	504
UNC5D	SEMA3A	Q14563	499
UNC5D	DSCAM	O60469	498
UNC5D	BCL11B	Q9C0K0	489
UNC5D	FLRT1	Q9NZU1	471
UNC5D	CUX2	O14529	471

IntAct

5 interactions, top by confidence:

A	B	Type	Score
MPIG6B	UNC5D	psi-mi:“MI:0915”(physical association)	0.400
SIGLEC15	UNC5D	psi-mi:“MI:0915”(physical association)	0.400
TYRO3	UNC5D	psi-mi:“MI:0915”(physical association)	0.400
M		psi-mi:“MI:0914”(association)	0.350

BioGRID (7): UNC5D (Affinity Capture-MS), UNC5D (Affinity Capture-MS), FLRT2 (Reconstituted Complex), UNC5D (Reconstituted Complex), UNC5D (Affinity Capture-MS), UNC5D (Protein-peptide), UNC5D (Affinity Capture-RNA)

ESM2 similar proteins: A0A0G2JEB6, A0JM56, B0DOB4, B0FXQ5, B1ANS9, B4F7L9, B4GQJ7, B5DHW4, B7FF06, B7FF07, B7FF08, B7FF09, B7FF12, C5IAW9, F1LW30, F1P4W9, O08747, O95185, P0DM40, Q008S8, Q18264, Q32NR9, Q3V0B4, Q402B2, Q4G0P3, Q5R4M2, Q5T0N1, Q5XI14, Q6AXU1, Q6DCF6, Q6NRS1, Q6P2C0, Q6P5D8, Q6UXZ4, Q6ZTR5, Q6ZU64, Q761X5, Q7T2Z5, Q80W93, Q86YR7

Diamond homologs: A0A0G2K2P5, A0A8P0N4K0, C5IAW9, F1LW30, O08721, O08722, O08747, O62683, O95049, O95185, O97758, P39447, P57105, Q07157, Q0P5E6, Q13424, Q28626, Q32LE7, Q3T0C9, Q5EBL8, Q5ZIK2, Q61234, Q6NXB2, Q6QA76, Q6R653, Q6UXZ4, Q6ZN44, Q761X5, Q7KRY7, Q7T2Z5, Q80VW5, Q86UL8, Q8IV45, Q8IZJ1, Q8JGT4, Q8K1S2, Q8K1S3, Q8K1S4, Q95168, Q9CZG9

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
UNC5D	“down-regulates activity”	DCC	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

92 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	84
Likely benign	2
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

6278 predictions. Top by Δscore:

Variant	Effect	Δscore
8:35294717:A:AG	acceptor_gain	1.0000
8:35549286:TCACA:T	acceptor_loss	1.0000
8:35549287:CACAG:C	acceptor_loss	1.0000
8:35549289:CAGG:C	acceptor_loss	1.0000
8:35549290:A:AT	acceptor_loss	1.0000
8:35549291:G:T	acceptor_loss	1.0000
8:35549506:CTCAG:C	donor_loss	1.0000
8:35549507:TCAGG:T	donor_loss	1.0000
8:35549508:CAG:C	donor_loss	1.0000
8:35549509:AG:A	donor_loss	1.0000
8:35549510:GGTAG:G	donor_loss	1.0000
8:35549511:GT:G	donor_loss	1.0000
8:35549512:T:A	donor_loss	1.0000
8:35568093:A:AG	acceptor_gain	1.0000
8:35568093:ATCAG:A	acceptor_gain	1.0000
8:35568094:TCA:T	acceptor_loss	1.0000
8:35568095:CA:C	acceptor_loss	1.0000
8:35568096:A:AG	acceptor_gain	1.0000
8:35568096:AGGTT:A	acceptor_loss	1.0000
8:35568097:G:GT	acceptor_gain	1.0000
8:35568097:GGT:G	acceptor_gain	1.0000
8:35568097:GGTTT:G	acceptor_gain	1.0000
8:35568219:G:GT	donor_gain	1.0000
8:35568237:AGCCT:A	donor_gain	1.0000
8:35568238:GCCT:G	donor_gain	1.0000
8:35568238:GCCTG:G	donor_gain	1.0000
8:35568239:CCT:C	donor_gain	1.0000
8:35568240:CT:C	donor_gain	1.0000
8:35568240:CTGTA:C	donor_loss	1.0000
8:35568241:TGT:T	donor_loss	1.0000

AlphaMissense

6287 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:35549348:C:T	P54S	1.000
8:35549349:C:A	P54H	1.000
8:35549354:T:C	F56L	1.000
8:35549355:T:C	F56S	1.000
8:35549355:T:G	F56C	1.000
8:35549356:C:A	F56L	1.000
8:35549356:C:G	F56L	1.000
8:35549366:C:T	P60S	1.000
8:35549367:C:A	P60Q	1.000
8:35549367:C:G	P60R	1.000
8:35549382:T:A	I65N	1.000
8:35549387:A:G	K67E	1.000
8:35549389:G:C	K67N	1.000
8:35549389:G:T	K67N	1.000
8:35549406:T:C	L73P	1.000
8:35549411:T:A	C75S	1.000
8:35549411:T:C	C75R	1.000
8:35549412:G:A	C75Y	1.000
8:35549412:G:C	C75S	1.000
8:35549412:G:T	C75F	1.000
8:35549413:C:G	C75W	1.000
8:35549436:T:A	I83K	1.000
8:35549436:T:C	I83T	1.000
8:35549436:T:G	I83R	1.000
8:35549441:T:C	F85L	1.000
8:35549442:T:C	F85S	1.000
8:35549442:T:G	F85C	1.000
8:35549443:C:A	F85L	1.000
8:35549443:C:G	F85L	1.000
8:35549444:A:G	K86E	1.000

dbSNP variants (sampled 300 via entrez): RS1000000845 (8:35581718 C>T), RS1000001133 (8:35278024 A>T), RS1000012738 (8:35599478 T>C,G), RS1000020013 (8:35764622 C>T), RS1000023547 (8:35404300 G>A), RS1000026505 (8:35623807 G>A), RS1000036294 (8:35760666 G>A), RS1000048191 (8:35242278 G>A), RS1000059999 (8:35325586 G>T), RS1000062933 (8:35484687 T>C), RS1000067329 (8:35634784 G>C,T), RS1000069024 (8:35365664 G>A,T), RS1000075821 (8:35666666 G>A), RS1000081440 (8:35538632 A>G), RS1000083598 (8:35641439 G>A)

Disease associations

OMIM: gene MIM:616466 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

14 associations (top):

Study	Trait	p-value
GCST002783_231	Body mass index	3.000000e-07
GCST002783_411	Body mass index	5.000000e-06
GCST002932_3	Manganese levels	5.000000e-06
GCST003838_15	Morning vs. evening chronotype	2.000000e-08
GCST004769_1	Mental development (prenatal lead exposure interaction)	4.000000e-06
GCST006168_5	Pulse pressure x alcohol consumption interaction (2df test)	3.000000e-09
GCST006585_2577	Blood protein levels	1.000000e-08
GCST006585_2682	Blood protein levels	2.000000e-06
GCST007576_216	Chronotype	3.000000e-08
GCST008163_431	Height	3.000000e-06
GCST008398_11	Glycated hemoglobin levels	1.000000e-06
GCST009897_5	Reading disability	2.000000e-06
GCST010242_244	HDL cholesterol levels	1.000000e-08
GCST012216_6	Vegetable consumption	3.000000e-08

EFO canonical traits (8, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0008230	mental development measurement
EFO:0004329	alcohol drinking
EFO:0005763	pulse pressure measurement
EFO:0008328	chronotype measurement
EFO:0004541	HbA1c measurement
EFO:0004612	high density lipoprotein cholesterol measurement
EFO:0008111	diet measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, increases expression	5
trichostatin A	affects cotreatment, decreases expression	3
Resveratrol	affects cotreatment, decreases expression	2
methylmercuric chloride	decreases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
propionaldehyde	increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	increases methylation	1
Sunitinib	increases expression	1
Arsenic Trioxide	decreases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, increases abundance, increases oxidation	1
Vehicle Emissions	increases abundance, increases expression	1
Benzo(a)pyrene	increases methylation	1
Copper	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	decreases expression	1
Doxorubicin	decreases expression	1
Estradiol	affects cotreatment, decreases expression	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment	1
Ozone	increases oxidation, increases abundance, affects cotreatment	1
Plant Extracts	decreases expression, affects cotreatment	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Tretinoin	decreases expression	1
Triclosan	increases expression	1
1-Methyl-4-phenylpyridinium	decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.