UPK1A-AS1

Summary

UPK1A-AS1 (UPK1A antisense RNA 1, HGNC:40603) is a long non-coding RNA gene on chromosome 19q13.12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40603
Approved symbol	UPK1A-AS1
Name	UPK1A antisense RNA 1
Location	19q13.12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000226510
Ensembl biotype	lncRNA
Entrez	100862728
RNAcentral	URS000075A473 — lncRNA, 813 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000443196, ENST00000727123

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000443196 — 2 exons

Exon	Start	End
ENSE00004052337	35667943	35668685
ENSE00004052338	35673235	35673501

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 65.79.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0361 / max 7.3670, expressed in 15 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
180541	0.0361	15

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	65.79	gold quality
ganglionic eminence	UBERON:0004023	60.71	gold quality
urinary bladder	UBERON:0001255	58.92	gold quality
monocyte	CL:0000576	56.63	gold quality
leukocyte	CL:0000738	56.54	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	56.31	silver quality
lower esophagus mucosa	UBERON:0035834	56.22	gold quality
ectocervix	UBERON:0012249	54.03	gold quality
blood	UBERON:0000178	54.01	gold quality
liver	UBERON:0002107	52.92	gold quality
skin of leg	UBERON:0001511	52.62	gold quality
placenta	UBERON:0001987	52.51	gold quality
prefrontal cortex	UBERON:0000451	52.41	gold quality
hindlimb stylopod muscle	UBERON:0004252	52.03	gold quality
zone of skin	UBERON:0000014	51.80	gold quality
uterine cervix	UBERON:0000002	51.78	gold quality
esophagus mucosa	UBERON:0002469	51.27	gold quality
lymph node	UBERON:0000029	51.19	gold quality
vagina	UBERON:0000996	50.99	gold quality
skin of abdomen	UBERON:0001416	50.56	gold quality
right lobe of liver	UBERON:0001114	50.55	silver quality
endometrium	UBERON:0001295	50.46	gold quality
myometrium	UBERON:0001296	49.53	gold quality
adult mammalian kidney	UBERON:0000082	49.15	gold quality
islet of Langerhans	UBERON:0000006	48.95	gold quality
esophagus	UBERON:0001043	48.63	gold quality
bone marrow	UBERON:0002371	48.60	silver quality
kidney	UBERON:0002113	48.08	gold quality
vermiform appendix	UBERON:0001154	48.05	gold quality
gall bladder	UBERON:0002110	48.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.60

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA UPK1A-AS1 indicates poor prognosis of hepatocellular carcinoma and promotes cell proliferation through interaction with EZH2. (PMID:33121524)
• Cancer-associated fibroblast-induced lncRNA UPK1A-AS1 confers platinum resistance in pancreatic cancer via efficient double-strand break repair. (PMID:35264742)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.