UQCR10

Summary

UQCR10 (ubiquinol-cytochrome c reductase, complex III subunit X, HGNC:30863) is a protein-coding gene on chromosome 22q12.2, encoding Cytochrome b-c1 complex subunit 9 (Q9UDW1). Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. It is a selective cancer dependency (DepMap: 20.1% of cell lines).

UCRC is a subunit of mitochondrial complex III (ubiquinol-cytochrome c reductase; EC 1.10.2.2), which forms the middle segment of the respiratory chain of the inner mitochondrial membrane (Schagger et al., 1995 [PubMed 8592474]).

Source: NCBI Gene 29796 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 9 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 20.1% of screened cell lines
• MANE Select transcript: NM_013387

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30863
Approved symbol	UQCR10
Name	ubiquinol-cytochrome c reductase, complex III subunit X
Location	22q12.2
Locus type	gene with protein product
Status	Approved
Aliases	HSPC051, UCRC, QCR9, UCCR7.2
Ensembl gene	ENSG00000184076
Ensembl biotype	protein_coding
OMIM	610843
Entrez	29796

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000330029, ENST00000401406, ENST00000894362, ENST00000894363

RefSeq mRNA: 2 — MANE Select: NM_013387 NM_001003684, NM_013387

CCDS: CCDS46680, CCDS46681

Canonical transcript exons

ENST00000330029 — 2 exons

Exon	Start	End
ENSE00001554436	29767369	29767548
ENSE00001802165	29769678	29770413

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 99.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 135.9688 / max 1314.3100, expressed in 1825 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
191631	135.9688	1825

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of tongue	UBERON:0011876	99.61	gold quality
lateral nuclear group of thalamus	UBERON:0002736	99.56	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	99.48	gold quality
lateral globus pallidus	UBERON:0002476	99.39	gold quality
diaphragm	UBERON:0001103	99.38	gold quality
heart right ventricle	UBERON:0002080	99.38	gold quality
substantia nigra pars reticulata	UBERON:0001966	99.37	gold quality
substantia nigra pars compacta	UBERON:0001965	99.34	gold quality
pons	UBERON:0000988	99.33	gold quality
biceps brachii	UBERON:0001507	99.33	gold quality
adult organism	UBERON:0007023	99.25	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.22	gold quality
mucosa of sigmoid colon	UBERON:0004993	99.22	gold quality
hindlimb stylopod muscle	UBERON:0004252	99.21	gold quality
renal medulla	UBERON:0000362	99.17	gold quality
colonic mucosa	UBERON:0000317	99.16	gold quality
tongue	UBERON:0001723	99.16	gold quality
triceps brachii	UBERON:0001509	99.10	gold quality
cardiac ventricle	UBERON:0002082	99.09	gold quality
jejunum	UBERON:0002115	99.08	gold quality
mucosa of transverse colon	UBERON:0004991	99.08	gold quality
heart left ventricle	UBERON:0002084	99.07	gold quality
apex of heart	UBERON:0002098	99.07	gold quality
oral cavity	UBERON:0000167	99.03	gold quality
pharyngeal mucosa	UBERON:0000355	98.99	gold quality
superior surface of tongue	UBERON:0007371	98.95	gold quality
jejunal mucosa	UBERON:0000399	98.94	gold quality
pigmented layer of retina	UBERON:0001782	98.89	gold quality
right atrium auricular region	UBERON:0006631	98.89	gold quality
corpus epididymis	UBERON:0004359	98.87	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-HCAD-1	yes	75.57
E-MTAB-8410	yes	47.50
E-HCAD-10	yes	30.75
E-MTAB-7316	yes	21.91
E-GEOD-135922	yes	10.33
E-GEOD-106540	no	708.18
E-MTAB-7606	no	539.91
E-MTAB-6379	no	466.13
E-MTAB-7037	no	332.36
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

41 targeting UQCR10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-23A-3P	99.95	74.24	3163
HSA-MIR-23B-3P	99.95	74.24	3163
HSA-MIR-23C	99.95	73.92	3192
HSA-MIR-202-3P	99.84	71.41	1290
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-3136-3P	99.57	66.59	781
HSA-MIR-7155-3P	99.57	66.48	794
HSA-MIR-4649-3P	99.56	66.90	1783
HSA-MIR-888-3P	99.53	69.77	1057
HSA-MIR-671-5P	99.52	67.11	1277
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-4786-3P	99.36	68.35	1390
HSA-MIR-888-5P	99.30	70.15	1855
HSA-MIR-3922-3P	99.25	64.96	1136
HSA-MIR-7160-5P	99.11	67.17	2207
HSA-MIR-922	99.02	67.23	1838
HSA-MIR-1911-5P	98.92	67.53	325
HSA-MIR-5001-3P	98.91	67.28	1394
HSA-MIR-1294	98.91	69.26	1030
HSA-MIR-9986	98.91	69.28	1024
HSA-MIR-4742-3P	98.73	69.82	1803
HSA-MIR-323A-5P	98.59	65.13	651
HSA-MIR-676-5P	98.49	68.87	1492
HSA-MIR-892B	98.00	67.11	821
HSA-MIR-6819-5P	97.96	66.59	1071
HSA-MIR-943	97.81	64.42	694

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 20.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• Functionality of complex III of the mitochondrial electron transport chain is required for the hypoxic stabilization of HIF-1 alpha and HIF-2 alpha (PMID:16054089)
• Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients (PMID:22277967)
• Reciprocal fusion gene involving UQCR10 and C1orf194 is associated with spinal ependymoma. (PMID:27401149)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	uqcr10	ENSDARG00000104517
mus_musculus	Uqcr10	ENSMUSG00000059534
rattus_norvegicus	Uqcr10-ps1	ENSRNOG00000009521
rattus_norvegicus	Uqcr10	ENSRNOG00000059061

Protein

Protein identifiers

Cytochrome b-c1 complex subunit 9 — Q9UDW1 (reviewed: Q9UDW1)

Alternative names: Complex III subunit 9, Complex III subunit X, Cytochrome c1 non-heme 7 kDa protein, Ubiquinol-cytochrome c reductase complex 7.2 kDa protein

All UniProt accessions (1): Q9UDW1

UniProt curated annotations — full annotation on UniProt →

Function. Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.

Subunit / interactions. Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with STMP1.

Subcellular location. Mitochondrion inner membrane.

Similarity. Belongs to the UQCR10/QCR9 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9UDW1-1	1	yes
Q9UDW1-2	2

RefSeq proteins (2): NP_001003684, NP_037519* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008027	QCR9	Family
IPR036656	QCR9_sf	Homologous_superfamily

Pfam: PF05365

UniProt features (13 total): turn 3, helix 3, topological domain 2, initiator methionine 1, chain 1, transmembrane region 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

5 structures.

PDB	Method	Resolution (Å)
9HZL	ELECTRON MICROSCOPY	2.52
9CG3	ELECTRON MICROSCOPY	2.96
5XTE	ELECTRON MICROSCOPY	3.4
5XTH	ELECTRON MICROSCOPY	3.9
5XTI	ELECTRON MICROSCOPY	17.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9UDW1-F1	95.04	0.92

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-611105	Respiratory electron transport
R-HSA-9865881	Complex III assembly

MSigDB gene sets: 188 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, SASAI_TARGETS_OF_CXCR6_AND_PTCH1_UP, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, TGACCTY_ERR1_Q2, GOBP_MONOATOMIC_CATION_TRANSPORT, AACWWCAANK_UNKNOWN, GOBP_GENERATION_OF_PRECURSOR_METABOLITES_AND_ENERGY, GOBP_MITOCHONDRIAL_ELECTRON_TRANSPORT_UBIQUINOL_TO_CYTOCHROME_C, GOBP_OXIDATIVE_PHOSPHORYLATION, GOBP_ELECTRON_TRANSPORT_CHAIN, LANDIS_ERBB2_BREAST_PRENEOPLASTIC_DN, KEGG_HUNTINGTONS_DISEASE, GOCC_MITOCHONDRIAL_ENVELOPE, HNF4_01, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13

GO Biological Process (3): mitochondrial electron transport, ubiquinol to cytochrome c (GO:0006122), cellular respiration (GO:0045333), proton transmembrane transport (GO:1902600)

GO Molecular Function (2): quinol-cytochrome-c reductase activity (GO:0008121), protein binding (GO:0005515)

GO Cellular Component (4): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), respiratory chain complex III (GO:0045275), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Aerobic respiration and respiratory electron transport	1
Respiratory electron transport	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
aerobic electron transport chain	1
mitochondrial ATP synthesis coupled electron transport	1
energy derivation by oxidation of organic compounds	1
monoatomic cation transmembrane transport	1
electron transfer activity	1
proton transmembrane transporter activity	1
oxidoreduction-driven active transmembrane transporter activity	1
oxidoreductase activity, acting on diphenols and related substances as donors	1
active monoatomic ion transmembrane transporter activity	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
cytochrome complex	1
respiratory chain complex	1
transmembrane transporter complex	1
oxidoreductase complex	1
cellular anatomical structure	1

Protein interactions and networks

STRING

1791 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UQCR10	HSCB	Q8IWL3	957
UQCR10	UQCRH	P07919	947
UQCR10	UQCRB	P14927	945
UQCR10	UQCRQ	O14949	933
UQCR10	MT-CYB	P00156	854
UQCR10	CYC1	P08574	840
UQCR10	UQCRC2	P22695	839
UQCR10	UQCR11	O14957	833
UQCR10	UQCRC1	P31930	830
UQCR10	UQCRFS1	P47985	827
UQCR10	OSBP2	Q969R2	810
UQCR10	COX6B1	P14854	769
UQCR10	COX5B	P10606	732
UQCR10	COX7B	P24311	669
UQCR10	CYCS	P00001	667

IntAct

47 interactions, top by confidence:

A	B	Type	Score
UQCRC1	UQCRQ	psi-mi:“MI:0915”(physical association)	0.740
NDUFS3	NDUFS8	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
UQCRH	COX7A2L	psi-mi:“MI:0914”(association)	0.640
UQCRQ	COX7A2L	psi-mi:“MI:0914”(association)	0.640
NDUFA9	NDUFS8	psi-mi:“MI:0914”(association)	0.530
TIMMDC1	NDUFS8	psi-mi:“MI:0914”(association)	0.530
KPNB1	POM121C	psi-mi:“MI:0914”(association)	0.530
OLFML3	UQCR10	psi-mi:“MI:0915”(physical association)	0.400
	DENR	psi-mi:“MI:0915”(physical association)	0.400
	TK2	psi-mi:“MI:0915”(physical association)	0.400
NDUFA11	NDUFS8	psi-mi:“MI:0914”(association)	0.350
S100A4	BBX	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
NMES1	NDUFS8	psi-mi:“MI:0914”(association)	0.350
NMES1	COX7A2L	psi-mi:“MI:0914”(association)	0.350
RALB	XPO1	psi-mi:“MI:0914”(association)	0.350
RALB	IPO8	psi-mi:“MI:0914”(association)	0.350
MYLK2	PSMD3	psi-mi:“MI:0914”(association)	0.350
RYBP	PIPSL	psi-mi:“MI:0914”(association)	0.350
MAPT	SHTN1	psi-mi:“MI:0914”(association)	0.350
UQCR10	COX7A2L	psi-mi:“MI:0914”(association)	0.350
TMED10	CYC1	psi-mi:“MI:0914”(association)	0.350
SLC39A4	ESYT2	psi-mi:“MI:0914”(association)	0.350
SLC52A3	TMEM120B	psi-mi:“MI:0914”(association)	0.350

BioGRID (68): UQCR10 (Affinity Capture-RNA), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Synthetic Lethality), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS), UQCR10 (Affinity Capture-MS)

ESM2 similar proteins: A2VDV9, A5PJ82, C0HLM6, D2H617, D3Z7Q2, D3Z9R8, D4ACP2, E2R5I0, E7EXZ6, F1MDB2, F6USH3, G1QDE8, G1S9B8, O00483, P00130, P10818, P11951, P13182, P43024, P56378, P56379, Q01321, Q0MQ97, Q0MQ98, Q0MQ99, Q0Q4Z0, Q28851, Q2NKS2, Q3SZ44, Q3YAJ5, Q4FZG9, Q4R542, Q5RCY6, Q5RDZ8, Q5REX0, Q62425, Q69YU5, Q6PBH5, Q78RX3, Q7YRK7

Diamond homologs: A0A1D8PLP3, O74433, P00130, Q6CJX2, Q8R1I1, Q9UDW1, P22289, Q7SGT7, Q9XY35, Q54QR8, Q9LXJ2, P46270

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
UQCR10	“form complex”	“CoQ-cytochrome c reductase-Mitochondrial respiratory chain complex III”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 52 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Respiratory electron transport	10	25.0×	1e-09
Complex I biogenesis	5	21.8×	4e-04
Aerobic respiration and respiratory electron transport	5	11.7×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
aerobic respiration	6	32.3×	9e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

9 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	7
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

314 predictions. Top by Δscore:

Variant	Effect	Δscore
22:29767545:GGGG:G	donor_gain	1.0000
22:29767546:G:GT	donor_gain	1.0000
22:29767546:GGG:G	donor_gain	1.0000
22:29767546:GGGGT:G	donor_loss	1.0000
22:29767547:GG:G	donor_gain	1.0000
22:29767547:GGG:G	donor_gain	1.0000
22:29767547:GGGTG:G	donor_loss	1.0000
22:29767548:GG:G	donor_gain	1.0000
22:29767548:GGTGA:G	donor_loss	1.0000
22:29767550:T:A	donor_loss	1.0000
22:29769676:A:AG	acceptor_gain	1.0000
22:29769677:G:GG	acceptor_gain	1.0000
22:29767549:G:GG	donor_gain	0.9900
22:29767593:GAC:G	donor_gain	0.9900
22:29767594:ACA:A	donor_gain	0.9900
22:29769671:A:AG	acceptor_gain	0.9900
22:29769673:T:G	acceptor_gain	0.9900
22:29769677:GAA:G	acceptor_gain	0.9900
22:29769670:A:G	acceptor_gain	0.9800
22:29769673:TGCAG:T	acceptor_loss	0.9800
22:29769674:GCAG:G	acceptor_loss	0.9800
22:29769675:CAGAA:C	acceptor_loss	0.9800
22:29769676:A:C	acceptor_loss	0.9800
22:29769677:G:GC	acceptor_loss	0.9800
22:29769677:GA:G	acceptor_gain	0.9800
22:29767519:G:GT	donor_gain	0.9700
22:29769662:T:A	acceptor_loss	0.9700
22:29769669:A:AG	acceptor_gain	0.9700
22:29769672:A:G	acceptor_gain	0.9700
22:29769677:GAAGC:G	acceptor_gain	0.9700

AlphaMissense

414 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:29767480:G:C	G28R	0.973
22:29769686:G:C	W53C	0.971
22:29769686:G:T	W53C	0.971
22:29769684:T:A	W53R	0.956
22:29769684:T:C	W53R	0.956
22:29767478:T:A	V27E	0.948
22:29767463:C:A	A22D	0.947
22:29767496:A:T	E33V	0.938
22:29767546:G:T	G50W	0.936
22:29767522:G:C	A42P	0.935
22:29767526:T:A	I43N	0.935
22:29769682:T:C	L52P	0.934
22:29767481:G:A	G28D	0.929
22:29767466:T:A	L23H	0.926
22:29767516:G:C	A40P	0.920
22:29769680:G:C	K51N	0.920
22:29769680:G:T	K51N	0.920
22:29767448:G:T	R17M	0.919
22:29767547:G:T	G50V	0.918
22:29769685:G:C	W53S	0.918
22:29769698:G:C	K57N	0.918
22:29769698:G:T	K57N	0.918
22:29767466:T:G	L23R	0.917
22:29767546:G:A	G50R	0.915
22:29767546:G:C	G50R	0.915
22:29767502:C:A	A35D	0.913
22:29767499:G:C	R34P	0.910
22:29767513:G:C	G39R	0.898
22:29767517:C:A	A40E	0.895
22:29767504:T:C	F36L	0.894

dbSNP variants (sampled 300 via entrez): RS1000215510 (22:29770712 T>C), RS1001496647 (22:29769359 G>A), RS1001821344 (22:29768967 C>G), RS1002449165 (22:29767529 A>G,T), RS1002884328 (22:29767127 G>GGGA), RS1003576055 (22:29770746 G>T), RS1004565234 (22:29768920 C>T), RS1004724399 (22:29766852 C>A,T), RS1005000154 (22:29769341 A>C), RS1005701117 (22:29765475 C>T), RS1006501189 (22:29770238 A>C), RS1006646477 (22:29770491 G>C), RS1006742916 (22:29770365 A>G), RS1007608945 (22:29769061 A>G), RS1007791336 (22:29767061 G>A)

Disease associations

OMIM: gene MIM:610843 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST003974_1	Tonsillectomy	1.000000e-09
GCST004131_67	Inflammatory bowel disease	4.000000e-08
GCST004132_86	Crohn’s disease	8.000000e-07
GCST005537_65	Chronic inflammatory diseases (ankylosing spondylitis, Crohn’s disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy)	6.000000e-09
GCST006629_42	Pulse pressure	2.000000e-11
GCST90002387_177	Immature fraction of reticulocytes	4.000000e-28
GCST90020026_214	Hip index	2.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007924	tonsillectomy risk measurement
EFO:0005763	pulse pressure measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL2388 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	4
bisphenol A	affects expression, decreases expression	3
sodium arsenite	increases expression, decreases expression, increases abundance	3
Acetaminophen	affects cotreatment, decreases expression	2
Air Pollutants	decreases expression, increases abundance	2
Arsenic	decreases expression, increases abundance, increases expression	2
Doxorubicin	increases expression, affects expression	2
Lipopolysaccharides	affects cotreatment, decreases expression, increases expression	2
Particulate Matter	decreases expression, increases abundance	2
bisphenol F	affects cotreatment, increases expression	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
methylparaben	decreases expression	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	increases expression, affects cotreatment	1
bisphenol B	increases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Vorinostat	increases expression	1
Cadmium	increases expression, increases abundance	1
Carbamazepine	affects expression	1
Dexamethasone	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Fluorouracil	affects expression	1
Indomethacin	increases expression, affects cotreatment	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL663989	Binding	Compound was tested for inhibition of Cytochrome bc1 complex in controling fungal diseases in crop plants; Active	Synthesis and structural analysis of the active enantiomer of famoxadone, a potent inhibitor of cytochrome bc1. — Bioorg Med Chem Lett

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.