USP2-AS1

Summary

USP2-AS1 (USP2 antisense RNA 1, HGNC:48673) is a long non-coding RNA gene on chromosome 11q23.3.

Predicted to enable U4 snRNA binding activity. Predicted to be involved in formation of quadruple SL/U4/U5/U6 snRNP and spliceosomal tri-snRNP complex assembly. Predicted to be part of U4/U6 x U5 tri-snRNP complex and U6 snRNP.

Source: NCBI Gene 100499227 — RefSeq curated summary.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48673
Approved symbol	USP2-AS1
Name	USP2 antisense RNA 1
Location	11q23.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	THY1-AS1, gLINC
Ensembl gene	ENSG00000245248
Ensembl biotype	lncRNA
Entrez	100499227
RNAcentral	URS0000759D26 — lncRNA, 1156 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 97 — 97 lncRNA

ENST00000498979, ENST00000500970, ENST00000528510, ENST00000530002, ENST00000530918, ENST00000577297, ENST00000578923, ENST00000656105, ENST00000656292, ENST00000658767, ENST00000659432, ENST00000660630, ENST00000664208, ENST00000668377, ENST00000668500, ENST00000669703, ENST00000670603, ENST00000706362, ENST00000706364, ENST00000706371, ENST00000706372, ENST00000706409, ENST00000706410, ENST00000706411, ENST00000706412, ENST00000706413, ENST00000706414, ENST00000706415, ENST00000706416, ENST00000706417, ENST00000706418, ENST00000706419, ENST00000706420, ENST00000706421, ENST00000706422, ENST00000706423, ENST00000706424, ENST00000706425, ENST00000706426, ENST00000706427, ENST00000706428, ENST00000706429, ENST00000706430, ENST00000706432, ENST00000706433, ENST00000706434, ENST00000706435, ENST00000706444, ENST00000706445, ENST00000706446, ENST00000706473, ENST00000706474, ENST00000706475, ENST00000706476, ENST00000706477, ENST00000706478, ENST00000706479, ENST00000706480, ENST00000706481, ENST00000783129, ENST00000783130, ENST00000783131, ENST00000783132, ENST00000783133, ENST00000783134, ENST00000783135, ENST00000783136, ENST00000783137, ENST00000783138, ENST00000783139, ENST00000783140, ENST00000783141, ENST00000783142, ENST00000783143, ENST00000783144, ENST00000783145, ENST00000783146, ENST00000783147, ENST00000783148, ENST00000783149, ENST00000783150, ENST00000783151, ENST00000783152, ENST00000783153, ENST00000783154, ENST00000783155, ENST00000783156, ENST00000783157, ENST00000783158, ENST00000783159, ENST00000783160, ENST00000783161, ENST00000783162, ENST00000783163, ENST00000783164, ENST00000783165, ENST00000844114

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000498979 — 4 exons

Exon	Start	End
ENSE00001990197	119394981	119395154
ENSE00002725892	119469809	119469975
ENSE00004156922	119381757	119381908
ENSE00004156926	119498550	119500626

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 90.01.

FANTOM5 (CAGE): breadth broad, TPM avg 2.2520 / max 52.3259, expressed in 798 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117113	1.1558	433
117116	0.9871	443
117114	0.1091	60

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	90.01	gold quality
right testis	UBERON:0004534	89.62	gold quality
testis	UBERON:0000473	85.62	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.40	gold quality
right uterine tube	UBERON:0001302	79.56	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.80	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	76.21	gold quality
mucosa of stomach	UBERON:0001199	73.22	gold quality
bone marrow cell	CL:0002092	71.81	silver quality
right atrium auricular region	UBERON:0006631	70.11	gold quality
prefrontal cortex	UBERON:0000451	69.78	gold quality
nucleus accumbens	UBERON:0001882	69.68	gold quality
smooth muscle tissue	UBERON:0001135	69.52	gold quality
cardiac atrium	UBERON:0002081	69.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	69.19	gold quality
apex of heart	UBERON:0002098	68.62	gold quality
right frontal lobe	UBERON:0002810	68.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.40	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.18	gold quality
anterior cingulate cortex	UBERON:0009835	68.17	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.17	gold quality
lower esophagus	UBERON:0013473	68.14	gold quality
sural nerve	UBERON:0015488	67.84	gold quality
caudate nucleus	UBERON:0001873	67.76	gold quality
heart left ventricle	UBERON:0002084	67.59	gold quality
ventricular zone	UBERON:0003053	67.46	gold quality
putamen	UBERON:0001874	67.20	gold quality
tibial artery	UBERON:0007610	67.14	gold quality
popliteal artery	UBERON:0002250	67.08	gold quality
cardiac ventricle	UBERON:0002082	66.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.51

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis. (PMID:35081364)
• Downregulation of lncRNA USP2AS1 in the placentas of pregnant women with nondiabetic fetal macrosomia promotes trophoblast cell proliferation. (PMID:35674181)
• Hypoxia-Regulated lncRNA USP2-AS1 Drives Head and Neck Squamous Cell Carcinoma Progression. (PMID:36359803)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.