USP27X-DT

Summary

USP27X-DT (USP27X divergent transcript, HGNC:27249) is a long non-coding RNA gene on chromosome Xp11.23.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27249
Approved symbol	USP27X-DT
Name	USP27X divergent transcript
Location	Xp11.23
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000234390
Ensembl biotype	lncRNA
Entrez	158572
RNAcentral	URS000075C662 — lncRNA, 2304 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000437322

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437322 — 2 exons

Exon	Start	End
ENSE00004173984	49876242	49878747
ENSE00004173986	49879091	49879440

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 88.73.

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	88.73	gold quality
pancreatic ductal cell	CL:0002079	78.91	silver quality
epithelial cell of pancreas	CL:0000083	73.28	gold quality
left ventricle myocardium	UBERON:0006566	69.43	gold quality
cardiac muscle of right atrium	UBERON:0003379	69.36	gold quality
upper arm skin	UBERON:0004263	69.31	gold quality
placenta	UBERON:0001987	67.30	gold quality
ventricular zone	UBERON:0003053	66.86	gold quality
right adrenal gland	UBERON:0001233	66.63	gold quality
adrenal tissue	UBERON:0018303	66.63	gold quality
right adrenal gland cortex	UBERON:0035827	66.59	gold quality
left adrenal gland	UBERON:0001234	66.33	gold quality
islet of Langerhans	UBERON:0000006	66.25	gold quality
left adrenal gland cortex	UBERON:0035825	65.49	gold quality
descending thoracic aorta	UBERON:0002345	65.37	gold quality
adrenal gland	UBERON:0002369	65.37	gold quality
adrenal cortex	UBERON:0001235	65.24	gold quality
popliteal artery	UBERON:0002250	65.04	gold quality
tibial artery	UBERON:0007610	65.02	gold quality
aorta	UBERON:0000947	64.89	gold quality
thoracic aorta	UBERON:0001515	64.78	gold quality
ascending aorta	UBERON:0001496	64.55	gold quality
pituitary gland	UBERON:0000007	64.48	gold quality
right coronary artery	UBERON:0001625	63.51	gold quality
adenohypophysis	UBERON:0002196	63.15	gold quality
left coronary artery	UBERON:0001626	62.92	gold quality
cerebellar cortex	UBERON:0002129	62.90	gold quality
cerebellar hemisphere	UBERON:0002245	62.87	gold quality
coronary artery	UBERON:0001621	62.72	gold quality
cerebellum	UBERON:0002037	62.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation. (PMID:38279869)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.