USP3-AS1

Summary

USP3-AS1 (USP3 antisense RNA 1, HGNC:44140) is a long non-coding RNA gene on chromosome 15q22.31.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44140
Approved symbol	USP3-AS1
Name	USP3 antisense RNA 1
Location	15q22.31
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000259248
Ensembl biotype	lncRNA
Entrez	100130855
RNAcentral	URS000075C5F6 — lncRNA, 1788 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 22 — 22 lncRNA

ENST00000558831, ENST00000559357, ENST00000559737, ENST00000559861, ENST00000560067, ENST00000560350, ENST00000560622, ENST00000560962, ENST00000561191, ENST00000561256, ENST00000649220, ENST00000656865, ENST00000657335, ENST00000665700, ENST00000668026, ENST00000726078, ENST00000726079, ENST00000726080, ENST00000726081, ENST00000726082, ENST00000726083, ENST00000726084

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000558831 — 4 exons

Exon	Start	End
ENSE00002547011	63593749	63593877
ENSE00002554394	63587710	63589100
ENSE00002568215	63594695	63594786
ENSE00002570344	63600589	63600760

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 86.60.

FANTOM5 (CAGE): breadth broad, TPM avg 1.8470 / max 54.5813, expressed in 768 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
150426	1.8470	768

Top tissues by expression

244 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.60	gold quality
left testis	UBERON:0004533	86.36	gold quality
right testis	UBERON:0004534	85.68	gold quality
testis	UBERON:0000473	84.65	gold quality
monocyte	CL:0000576	84.26	gold quality
bone marrow cell	CL:0002092	83.99	gold quality
leukocyte	CL:0000738	83.15	gold quality
buccal mucosa cell	CL:0002336	82.91	silver quality
colonic epithelium	UBERON:0000397	81.84	gold quality
calcaneal tendon	UBERON:0003701	78.92	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.86	gold quality
secondary oocyte	CL:0000655	77.57	gold quality
body of pancreas	UBERON:0001150	76.84	gold quality
skin of abdomen	UBERON:0001416	76.46	gold quality
body of uterus	UBERON:0009853	76.29	gold quality
oocyte	CL:0000023	76.23	gold quality
granulocyte	CL:0000094	75.94	gold quality
tibial artery	UBERON:0007610	75.52	gold quality
popliteal artery	UBERON:0002250	75.49	gold quality
skin of leg	UBERON:0001511	75.36	gold quality
hindlimb stylopod muscle	UBERON:0004252	75.18	gold quality
ectocervix	UBERON:0012249	75.13	gold quality
right uterine tube	UBERON:0001302	74.55	gold quality
aorta	UBERON:0000947	74.50	gold quality
muscle layer of sigmoid colon	UBERON:0035805	74.25	gold quality
adrenal tissue	UBERON:0018303	74.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.02	gold quality
left uterine tube	UBERON:0001303	73.87	gold quality
ascending aorta	UBERON:0001496	73.87	gold quality
cerebellar hemisphere	UBERON:0002245	73.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	3.65

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.