USP30-AS1

Summary

USP30-AS1 (USP30 antisense RNA 1, HGNC:40909) is a long non-coding RNA gene on chromosome 12q24.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40909
Approved symbol	USP30-AS1
Name	USP30 antisense RNA 1
Location	12q24.11
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000256262
Ensembl biotype	lncRNA
Entrez	100131733
RNAcentral	URS000075A227 — lncRNA, 978 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000478808, ENST00000832754

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000478808 — 2 exons

Exon	Start	End
ENSE00004248544	109051572	109052738
ENSE00004248545	109053686	109054008

Expression profiles

Bgee: expression breadth ubiquitous, 155 present calls, max score 86.24.

FANTOM5 (CAGE): breadth broad, TPM avg 1.6380 / max 53.8943, expressed in 410 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133182	1.6380	410

Top tissues by expression

232 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.24	gold quality
granulocyte	CL:0000094	80.59	gold quality
monocyte	CL:0000576	80.45	gold quality
leukocyte	CL:0000738	80.36	gold quality
upper arm skin	UBERON:0004263	79.90	gold quality
right lobe of liver	UBERON:0001114	79.34	gold quality
kidney epithelium	UBERON:0004819	79.27	gold quality
mucosa of transverse colon	UBERON:0004991	78.32	gold quality
colonic epithelium	UBERON:0000397	78.18	gold quality
sperm	CL:0000019	78.00	silver quality
cardiac muscle of right atrium	UBERON:0003379	77.34	gold quality
left ventricle myocardium	UBERON:0006566	77.26	gold quality
bone marrow cell	CL:0002092	76.00	gold quality
spleen	UBERON:0002106	74.47	gold quality
liver	UBERON:0002107	74.33	gold quality
vermiform appendix	UBERON:0001154	73.61	gold quality
oocyte	CL:0000023	72.69	gold quality
nasal cavity epithelium	UBERON:0005384	72.65	gold quality
lymph node	UBERON:0000029	72.59	gold quality
caecum	UBERON:0001153	71.25	gold quality
right lung	UBERON:0002167	70.32	gold quality
superficial temporal artery	UBERON:0001614	69.84	gold quality
blood	UBERON:0000178	69.78	gold quality
small intestine Peyer’s patch	UBERON:0003454	69.40	gold quality
epithelial cell of pancreas	CL:0000083	69.34	gold quality
rectum	UBERON:0001052	69.19	gold quality
small intestine	UBERON:0002108	69.19	gold quality
duodenum	UBERON:0002114	69.03	gold quality
gingival epithelium	UBERON:0001949	68.36	gold quality
right adrenal gland cortex	UBERON:0035827	68.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• USP30-AS1 contributes to mitochondrial quality control in glioblastoma cells. (PMID:34653676)
• lncRNA USP30-AS1 sponges miR-765 and modulates the progression of colon cancer. (PMID:35260141)
• [Bioinformatics analysis of the association between long non-coding RNA ubiquitin-specific peptidase 30 antisense RNA 1 (lncRNA USP30-AS1) and immune cell infiltration in ovarian serous cystadenocarcinoma]. (PMID:37732580)
• Prognostic role of long non-coding RNA USP30-AS1 in ovarian cancer: insights into immune cell infiltration in the tumor microenvironment. (PMID:38054797)
• Exosomal lncRNA USP30-AS1 activates the Wnt/beta-catenin signaling pathway to promote cervical cancer progression via stabilization of beta-catenin by USP30. (PMID:39014929)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.