USP42

Summary

USP42 (ubiquitin specific peptidase 42, HGNC:20068) is a protein-coding gene on chromosome 7p22.1, encoding Ubiquitin carboxyl-terminal hydrolase 42 (Q9H9J4). Deubiquitinating enzyme which may play an important role during spermatogenesis.

Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination; regulation of apoptotic process; and regulation of protein stability. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus.

Source: NCBI Gene 84132 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 296 total
• MANE Select transcript: NM_032172

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:20068
Approved symbol	USP42
Name	ubiquitin specific peptidase 42
Location	7p22.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12697
Ensembl gene	ENSG00000106346
Ensembl biotype	protein_coding
OMIM	620946
Entrez	84132

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 6 protein_coding, 3 nonsense_mediated_decay, 1 retained_intron

ENST00000306177, ENST00000404008, ENST00000426246, ENST00000451154, ENST00000465073, ENST00000479544, ENST00000521713, ENST00000921020, ENST00000921021, ENST00000921022

RefSeq mRNA: 3 — MANE Select: NM_032172 NM_001365764, NM_001389650, NM_032172

CCDS: CCDS47535

Canonical transcript exons

ENST00000306177 — 18 exons

Exon	Start	End
ENSE00001877189	6160555	6161564
ENSE00001904122	6104949	6105032
ENSE00003467463	6156754	6157055
ENSE00003472088	6146148	6146248
ENSE00003472509	6111125	6111374
ENSE00003506149	6140914	6140984
ENSE00003561438	6135841	6135951
ENSE00003568793	6150412	6150506
ENSE00003572993	6145516	6145656
ENSE00003622785	6115323	6115523
ENSE00003625428	6149583	6150302
ENSE00003631344	6153756	6155195
ENSE00003646779	6147739	6147892
ENSE00003649708	6139092	6139194
ENSE00003651159	6140128	6140195
ENSE00003656294	6142932	6143014
ENSE00003670767	6144085	6144196
ENSE00003681521	6159450	6159493

Expression profiles

Bgee: expression breadth ubiquitous, 256 present calls, max score 98.52.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 7.3093 / max 74.3740, expressed in 1737 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
77137	7.3093	1737

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	98.52	gold quality
epithelial cell of pancreas	CL:0000083	92.96	gold quality
ileal mucosa	UBERON:0000331	91.34	gold quality
pancreatic ductal cell	CL:0002079	87.85	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.24	gold quality
oviduct epithelium	UBERON:0004804	86.01	gold quality
Brodmann (1909) area 23	UBERON:0013554	84.94	gold quality
tibialis anterior	UBERON:0001385	84.81	silver quality
adult organism	UBERON:0007023	84.78	gold quality
nipple	UBERON:0002030	84.62	gold quality
cartilage tissue	UBERON:0002418	84.18	gold quality
postcentral gyrus	UBERON:0002581	83.93	gold quality
entorhinal cortex	UBERON:0002728	83.75	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.61	gold quality
testis	UBERON:0000473	83.55	gold quality
visceral pleura	UBERON:0002401	83.31	gold quality
nasal cavity epithelium	UBERON:0005384	83.29	gold quality
parietal lobe	UBERON:0001872	83.10	gold quality
pylorus	UBERON:0001166	82.98	gold quality
right testis	UBERON:0004534	82.89	gold quality
thymus	UBERON:0002370	82.78	gold quality
left testis	UBERON:0004533	82.69	gold quality
cortical plate	UBERON:0005343	82.35	gold quality
tibia	UBERON:0000979	82.31	gold quality
cerebellar vermis	UBERON:0004720	82.25	gold quality
pigmented layer of retina	UBERON:0001782	82.11	gold quality
retina	UBERON:0000966	82.10	gold quality
bronchial epithelial cell	CL:0002328	82.05	gold quality
germinal epithelium of ovary	UBERON:0001304	82.03	gold quality
epithelium of nasopharynx	UBERON:0001951	81.94	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	4.46

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

145 targeting USP42, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3925-3P	100.00	69.95	1237
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-181A-5P	99.99	72.96	2995
HSA-MIR-181B-5P	99.99	72.97	2996
HSA-MIR-181C-5P	99.99	72.95	2996
HSA-MIR-181D-5P	99.99	73.04	2997
HSA-MIR-223-3P	99.99	70.14	1140
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595
HSA-MIR-3692-3P	99.98	70.27	2139
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-520D-5P	99.98	73.34	4883

Literature-anchored findings (GeneRIF, showing 8)

• the function of USP42 is required to allow the rapid activation of p53-dependent transcription and a p53-dependent cell-cycle arrest in response to stress. (PMID:22085928)
• we report, for the first time, the identification of a RUNX1-USP42 fusion transcript detected at diagnosis in a child with AML and del(5). (PMID:24673627)
• a role for USP42 in regulating transcription by deubiquitylating histones (PMID:25336640)
• USP42 overexpression could be a potential prognostic marker for GC, regulate the survival and invasive properties of GC, and may represent a novel therapeutic molecular target for this tumor. (PMID:27030989)
• circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis. (PMID:32938310)
• Japanese Encephalitis Virus infection increases USP42 to stabilize TRIM21 and OAS1 for neuroinflammatory and anti-viral response in human microglia. (PMID:35779335)
• [Ubiquitin-specific protease 42 regulates osteogenic differentiation of human adipose-derived stem cells]. (PMID:38318890)
• Investigating USP42 Mutation as Underlying Cause of Familial Non-Medullary Thyroid Carcinoma. (PMID:38338801)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	usp42	ENSDARG00000077300
mus_musculus	Usp42	ENSMUSG00000051306
rattus_norvegicus	Usp42	ENSRNOG00000001059

Paralogs (71): USP2 (ENSG00000036672), USP28 (ENSG00000048028), USP36 (ENSG00000055483), USP13 (ENSG00000058056), USP33 (ENSG00000077254), USP40 (ENSG00000085982), USP48 (ENSG00000090686), USP14 (ENSG00000101557), USP11 (ENSG00000102226), USP10 (ENSG00000103194), USP31 (ENSG00000103404), USP5 (ENSG00000111667), USP4 (ENSG00000114316), USP9Y (ENSG00000114374), USP34 (ENSG00000115464), USP35 (ENSG00000118369), USP45 (ENSG00000123552), USP22 (ENSG00000124422), USP9X (ENSG00000124486), USP6 (ENSG00000129204), USP29 (ENSG00000131864), USP26 (ENSG00000134588), USP30 (ENSG00000135093), USP15 (ENSG00000135655), USP37 (ENSG00000135913), USP44 (ENSG00000136014), USP20 (ENSG00000136878), USP8 (ENSG00000138592), USP3 (ENSG00000140455), USP21 (ENSG00000143258), USP43 (ENSG00000154914), USP25 (ENSG00000155313), USP16 (ENSG00000156256), USP24 (ENSG00000162402), USP1 (ENSG00000162607), USP49 (ENSG00000164663), USP38 (ENSG00000170185), USP50 (ENSG00000170236), USP47 (ENSG00000170242), USP32 (ENSG00000170832)

Protein

Protein identifiers

Ubiquitin carboxyl-terminal hydrolase 42 — Q9H9J4 (reviewed: Q9H9J4)

Alternative names: Deubiquitinating enzyme 42, Ubiquitin thioesterase 42, Ubiquitin-specific-processing protease 42

All UniProt accessions (6): Q9H9J4, B4DP25, C9JPC9, E5RJP3, E7EWZ4, F8WD92

UniProt curated annotations — full annotation on UniProt →

Function. Deubiquitinating enzyme which may play an important role during spermatogenesis.

Tissue specificity. Broadly expressed.

Similarity. Belongs to the peptidase C19 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H9J4-1	1	yes
Q9H9J4-2	2

RefSeq proteins (3): NP_001352693, NP_001376579, NP_115548* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001394	Peptidase_C19_UCH	Domain
IPR018200	USP_CS	Conserved_site
IPR028889	USP	Domain
IPR038765	Papain-like_cys_pep_sf	Homologous_superfamily
IPR050164	Peptidase_C19	Family

Pfam: PF00443

UniProt features (41 total): compositionally biased region 14, modified residue 9, region of interest 8, sequence conflict 4, active site 2, chain 1, domain 1, splice variant 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H9J4-F1	49.27	0.22

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 120 (nucleophile); 371 (proton acceptor)

Post-translational modifications (9): 75, 483, 754, 856, 1181, 1219, 1222, 1226, 1247

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5689880	Ub-specific processing proteases

MSigDB gene sets: 195 (showing top): GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_UP, TGGTGCT_MIR29A_MIR29B_MIR29C, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, AAGCCAT_MIR135A_MIR135B, GOBP_MALE_GAMETE_GENERATION, GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL, chr7p22, FOSTER_TOLERANT_MACROPHAGE_UP, GOMF_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY, GROSS_HYPOXIA_VIA_HIF1A_UP, LIAO_METASTASIS, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, GOBP_REGULATION_OF_PROTEIN_STABILITY, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, CUI_TCF21_TARGETS_2_DN

GO Biological Process (6): proteolysis (GO:0006508), spermatogenesis (GO:0007283), protein deubiquitination (GO:0016579), cell differentiation (GO:0030154), regulation of protein stability (GO:0031647), regulation of apoptotic process (GO:0042981)

GO Molecular Function (5): cysteine-type deubiquitinase activity (GO:0004843), protein binding (GO:0005515), peptidase activity (GO:0008233), cysteine-type peptidase activity (GO:0008234), hydrolase activity (GO:0016787)

GO Cellular Component (3): nucleus (GO:0005634), nucleoplasm (GO:0005654), cytosol (GO:0005829)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Deubiquitination	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein metabolic process	1
developmental process involved in reproduction	1
male gamete generation	1
cysteine-type deubiquitinase activity	1
protein modification by small protein removal	1
cellular developmental process	1
regulation of biological quality	1
apoptotic process	1
regulation of programmed cell death	1
cysteine-type peptidase activity	1
deubiquitinase activity	1
binding	1
hydrolase activity	1
catalytic activity, acting on a protein	1
peptidase activity	1
catalytic activity	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cytoplasm	1

Protein interactions and networks

STRING

656 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
USP42	TP53	P04637	572
USP42	ZUP1	Q96AP4	566
USP42	USP28	Q96RU2	510
USP42	USP13	Q92995	490
USP42	DHX9	Q08211	481
USP42	USP5	P45974	479
USP42	OTUD5	Q96G74	447
USP42	OTUB1	Q96FW1	439
USP42	RSPO1	Q2MKA7	431
USP42	TMTC2	Q8N394	419
USP42	UCHL3	P15374	409
USP42	PAN2	Q504Q3	406
USP42	H2BC21	Q16778	404
USP42	USP25	Q9UHP3	399
USP42	USP54	Q70EL1	398

IntAct

44 interactions, top by confidence:

A	B	Type	Score
YWHAZ	LMNA	psi-mi:“MI:0914”(association)	0.560
N	RBM47	psi-mi:“MI:0914”(association)	0.530
RPS3	ZNF316	psi-mi:“MI:0914”(association)	0.530
MAGEB2	POLRMT	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL13	RRP8	psi-mi:“MI:0914”(association)	0.530
SRSF3	CASC3	psi-mi:“MI:0914”(association)	0.530
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480
Dlg4	USP42	psi-mi:“MI:0407”(direct interaction)	0.440
USP42	TP53	psi-mi:“MI:0915”(physical association)	0.400
TP53	USP42	psi-mi:“MI:0915”(physical association)	0.400
USP42	KPNA3	psi-mi:“MI:0914”(association)	0.350
N	RBM47	psi-mi:“MI:0914”(association)	0.350
ANK2	IGKV2-40	psi-mi:“MI:0914”(association)	0.350
ZCCHC10	C1orf226	psi-mi:“MI:0914”(association)	0.350
RPL11	ZNF724	psi-mi:“MI:0914”(association)	0.350
SRSF4		psi-mi:“MI:0914”(association)	0.350
AHCYL1	TRAF5	psi-mi:“MI:0914”(association)	0.350
PRKRA	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
JMJD6	U2SURP	psi-mi:“MI:0914”(association)	0.350
NFKBIL1	TNRC18	psi-mi:“MI:0914”(association)	0.350
RNPS1	TAF4	psi-mi:“MI:0914”(association)	0.350
DHX8	ISY1-RAB43	psi-mi:“MI:0914”(association)	0.350
H1-1	POLRMT	psi-mi:“MI:0914”(association)	0.350
H1-6	RIOK3	psi-mi:“MI:0914”(association)	0.350
HMGA1	GTPBP10	psi-mi:“MI:0914”(association)	0.350
LIN28A	GTPBP10	psi-mi:“MI:0914”(association)	0.350

BioGRID (83): HIST2H2BE (Affinity Capture-Western), USP42 (Proximity Label-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), ZEB1 (Affinity Capture-Western), USP42 (Reconstituted Complex), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS), USP42 (Affinity Capture-MS)

ESM2 similar proteins: A5PK23, A7MB40, B1AQJ2, B2RQC2, B5DEH0, D3ZEN0, D3ZQL6, D3ZU96, E1B9W9, E1BE02, F6NSX9, G5E5X0, O00257, O55187, O94966, O95402, P00519, P0C2N5, P30658, P42335, P48382, P59598, Q14781, Q3TN34, Q3U108, Q3U8K7, Q3UJD6, Q3ULZ2, Q4G0F8, Q5DTT2, Q68CZ2, Q6J1Y9, Q6ZPY7, Q76I79, Q7LBC6, Q7TN02, Q7TT28, Q86V15, Q8BLG0, Q8IY33

Diamond homologs: A4FUN7, A5PMR2, A5PN09, A6H8I0, A6NNY8, A6QNM7, A6QR55, A7Z056, A8MUK1, B1AY15, B1WBD7, B2GUZ1, B2RQC2, C9JJH3, C9JLJ4, C9JPN9, C9JVI0, D3ZU96, D6R901, D6R9N7, D6RA61, D6RBM5, D6RBQ6, D6RCP7, D6RJB6, E1B9W9, F6Z5C0, M9PD06, O22207, O60079, O75604, O94966, P0C8Z3, P35123, P39538, P40818, P50102, P51784, Q09738, Q0WX57

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 59 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	8	20.0×	4e-07
mRNA Splicing	7	19.7×	2e-06
Peptide chain elongation	6	19.5×	2e-05
Viral mRNA Translation	6	19.5×	2e-05
PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA	6	19.3×	2e-05
Selenocysteine synthesis	6	18.5×	2e-05
Eukaryotic Translation Termination	6	18.5×	2e-05
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	6	18.1×	2e-05

GO biological processes:

GO term	Partners	Fold	FDR
cytoplasmic translation	7	24.9×	2e-06
regulation of alternative mRNA splicing, via spliceosome	5	23.5×	2e-04
RNA splicing	10	17.0×	1e-07
mRNA processing	6	9.1×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

296 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	250
Likely benign	23
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2975 predictions. Top by Δscore:

Variant	Effect	Δscore
7:6105028:GTCAG:G	donor_gain	1.0000
7:6105033:G:GG	donor_gain	1.0000
7:6105033:GTA:G	donor_loss	1.0000
7:6105034:T:A	donor_loss	1.0000
7:6115321:A:AG	acceptor_gain	1.0000
7:6115322:G:GG	acceptor_gain	1.0000
7:6115524:G:GG	donor_gain	1.0000
7:6135947:GCGGC:G	donor_gain	1.0000
7:6135948:CGGC:C	donor_gain	1.0000
7:6135949:GGC:G	donor_gain	1.0000
7:6135949:GGCG:G	donor_gain	1.0000
7:6135950:GC:G	donor_gain	1.0000
7:6135950:GCG:G	donor_gain	1.0000
7:6135951:CG:C	donor_loss	1.0000
7:6135952:G:GC	donor_loss	1.0000
7:6135952:G:GG	donor_gain	1.0000
7:6135953:TA:T	donor_loss	1.0000
7:6135954:A:AC	donor_loss	1.0000
7:6135955:AGTA:A	donor_loss	1.0000
7:6139090:A:AT	acceptor_loss	1.0000
7:6139091:GGT:G	acceptor_gain	1.0000
7:6139091:GGTAT:G	acceptor_gain	1.0000
7:6139191:A:AG	donor_gain	1.0000
7:6139192:TAA:T	donor_gain	1.0000
7:6139193:AA:A	donor_gain	1.0000
7:6139193:AAG:A	donor_loss	1.0000
7:6139194:AGT:A	donor_loss	1.0000
7:6139195:G:GG	donor_gain	1.0000
7:6139196:TAAG:T	donor_loss	1.0000
7:6140912:A:AG	acceptor_gain	1.0000

AlphaMissense

8682 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000050211 (7:6105024 C>G,T), RS1000050769 (7:6134194 A>G), RS1000054556 (7:6129350 G>A,C,T), RS1000066276 (7:6147797 T>C), RS1000076411 (7:6147543 C>T), RS1000076434 (7:6157994 G>A), RS1000131064 (7:6159900 G>A), RS1000150357 (7:6093453 C>G,T), RS1000195226 (7:6148104 G>A,C), RS1000198019 (7:6080370 C>A,T), RS1000209564 (7:6096658 G>A), RS1000236423 (7:6117135 A>G), RS1000240513 (7:6096441 T>C), RS1000246919 (7:6080413 T>G), RS1000248429 (7:6125020 A>G)

Disease associations

OMIM: gene MIM:620946 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST006998_2	Cerebrospinal fluid p-tau levels in mild cognitive impairment	9.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004760	t-tau measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, decreases expression, affects expression, increases methylation	6
trichostatin A	decreases expression, affects cotreatment	2
Tobacco Smoke Pollution	increases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	decreases expression	1
3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide	decreases expression	1
FR900359	affects phosphorylation	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, decreases reaction	1
coumarin	decreases phosphorylation	1
beta-methylcholine	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	decreases expression, affects cotreatment	1
torcetrapib	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases expression	1
Temozolomide	increases expression	1
Acetaminophen	decreases expression	1
Benzo(a)pyrene	increases methylation, affects methylation	1
Caffeine	decreases phosphorylation	1
Cisplatin	decreases expression	1
Dexamethasone	affects cotreatment, decreases expression	1
Doxorubicin	decreases expression	1
Formaldehyde	decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Thiram	increases expression	1
Urethane	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Copper Sulfate	increases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2KP	Abcam HeLa USP42 KO	Cancer cell line	Female
CVCL_XU96	HAP1 USP42 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.