USP46-DT

Summary

USP46-DT (USP46 divergent transcript, HGNC:43991) is a long non-coding RNA gene on chromosome 4q12.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:43991
Approved symbol	USP46-DT
Name	USP46 divergent transcript
Location	4q12
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000248866
Ensembl biotype	lncRNA
Entrez	643783
RNAcentral	URS000075BD2C — lncRNA, 890 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000503051, ENST00000783207

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000503051 — 2 exons

Exon	Start	End
ENSE00002053080	52660892	52661668
ENSE00002057043	52659406	52659676

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 94.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.2667 / max 31.5899, expressed in 1233 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
47609	1.3859	787
47608	0.8808	607

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	94.10	gold quality
calcaneal tendon	UBERON:0003701	82.27	gold quality
apex of heart	UBERON:0002098	78.67	gold quality
right atrium auricular region	UBERON:0006631	77.64	gold quality
tibial nerve	UBERON:0001323	76.18	gold quality
cardiac atrium	UBERON:0002081	75.75	gold quality
smooth muscle tissue	UBERON:0001135	75.12	gold quality
metanephros cortex	UBERON:0010533	75.09	gold quality
left coronary artery	UBERON:0001626	74.88	gold quality
heart left ventricle	UBERON:0002084	74.82	gold quality
rectum	UBERON:0001052	74.37	gold quality
heart	UBERON:0000948	74.05	gold quality
cardiac ventricle	UBERON:0002082	73.96	gold quality
right adrenal gland cortex	UBERON:0035827	73.84	gold quality
right adrenal gland	UBERON:0001233	73.57	gold quality
body of uterus	UBERON:0009853	73.50	gold quality
descending thoracic aorta	UBERON:0002345	73.08	gold quality
left adrenal gland	UBERON:0001234	73.04	gold quality
coronary artery	UBERON:0001621	72.81	gold quality
tendon	UBERON:0000043	72.77	gold quality
ganglionic eminence	UBERON:0004023	72.72	gold quality
tibial artery	UBERON:0007610	72.62	gold quality
left ovary	UBERON:0002119	72.61	gold quality
popliteal artery	UBERON:0002250	72.61	gold quality
right ovary	UBERON:0002118	72.60	gold quality
gall bladder	UBERON:0002110	72.52	gold quality
right coronary artery	UBERON:0001625	72.39	gold quality
left adrenal gland cortex	UBERON:0035825	72.34	gold quality
aorta	UBERON:0000947	72.12	gold quality
mucosa of stomach	UBERON:0001199	72.05	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.72

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.