USP54

Summary

USP54 (ubiquitin specific peptidase 54, HGNC:23513) is a protein-coding gene on chromosome 10q22.2, encoding Ubiquitin carboxyl-terminal hydrolase 54 (Q70EL1). Deubiquitinase that specifically mediates ‘Lys-63’-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins.

Enables K63-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination and proteolysis.

Source: NCBI Gene 159195 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 177 total
• MANE Select transcript: NM_001391956

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23513
Approved symbol	USP54
Name	ubiquitin specific peptidase 54
Location	10q22.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ37318, bA137L10.3, bA137L10.4
Ensembl gene	ENSG00000166348
Ensembl biotype	protein_coding
Entrez	159195

Gene structure

Transcript identifiers

Ensembl transcripts: 54 — 44 protein_coding, 7 protein_coding_CDS_not_defined, 2 retained_intron, 1 nonsense_mediated_decay

ENST00000339859, ENST00000413442, ENST00000418501, ENST00000422491, ENST00000424265, ENST00000433394, ENST00000451492, ENST00000461520, ENST00000464635, ENST00000466048, ENST00000474929, ENST00000480210, ENST00000481991, ENST00000492357, ENST00000497106, ENST00000498143, ENST00000498213, ENST00000680396, ENST00000681793, ENST00000685297, ENST00000687418, ENST00000687698, ENST00000689425, ENST00000691043, ENST00000693251, ENST00000874399, ENST00000874400, ENST00000874401, ENST00000874402, ENST00000874403, ENST00000874404, ENST00000928932, ENST00000928933, ENST00000928934, ENST00000928935, ENST00000928936, ENST00000928937, ENST00000928938, ENST00000928939, ENST00000928940, ENST00000928941, ENST00000928942, ENST00000928943, ENST00000928944, ENST00000928945, ENST00000928946, ENST00000928947, ENST00000928948, ENST00000928949, ENST00000928950, ENST00000928951, ENST00000928952, ENST00000946544, ENST00000946545

RefSeq mRNA: 21 — MANE Select: NM_001391956 NM_001320437, NM_001320441, NM_001350995, NM_001378208, NM_001378209, NM_001378210, NM_001391941, NM_001391942, NM_001391945, NM_001391946, NM_001391947, NM_001391948, NM_001391949, NM_001391950, NM_001391951, NM_001391952, NM_001391953, NM_001391954, NM_001391955, NM_001391956, NM_152586

CCDS: CCDS7329, CCDS91265

Canonical transcript exons

ENST00000687698 — 24 exons

Exon	Start	End
ENSE00001648278	73591278	73591342
ENSE00003463359	73534600	73534770
ENSE00003473950	73504850	73504990
ENSE00003483170	73526647	73526780
ENSE00003493062	73542803	73542885
ENSE00003511017	73530143	73530523
ENSE00003514774	73541633	73541738
ENSE00003537903	73519797	73519992
ENSE00003541807	73500655	73500838
ENSE00003578204	73529680	73529911
ENSE00003584911	73516375	73517747
ENSE00003595135	73530704	73530835
ENSE00003602320	73497538	73499188
ENSE00003609408	73541375	73541521
ENSE00003619326	73505308	73505426
ENSE00003623772	73520908	73521027
ENSE00003649552	73543018	73543131
ENSE00003652075	73575512	73575675
ENSE00003656844	73523583	73523750
ENSE00003659549	73539444	73539593
ENSE00003663908	73536269	73536437
ENSE00003667326	73545538	73545672
ENSE00003790062	73571421	73571513
ENSE00003931546	73575798	73576361

Expression profiles

Bgee: expression breadth ubiquitous, 249 present calls, max score 99.05.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.6949 / max 597.0157, expressed in 1590 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110079	5.3394	608
110083	4.4863	1401
110075	0.8640	270
110077	0.5584	254
110078	0.2554	132
110081	0.1093	55
110080	0.0596	27
110076	0.0224	8

Top tissues by expression

253 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	99.05	gold quality
corpus callosum	UBERON:0002336	98.88	gold quality
inferior vagus X ganglion	UBERON:0005363	98.39	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.68	gold quality
gastrocnemius	UBERON:0001388	97.63	gold quality
spinal cord	UBERON:0002240	97.63	gold quality
subthalamic nucleus	UBERON:0001906	97.26	gold quality
muscle of leg	UBERON:0001383	96.93	gold quality
deltoid	UBERON:0001476	96.85	gold quality
medulla oblongata	UBERON:0001896	96.82	gold quality
right lobe of thyroid gland	UBERON:0001119	96.81	gold quality
left lobe of thyroid gland	UBERON:0001120	96.59	gold quality
lateral globus pallidus	UBERON:0002476	96.54	gold quality
ventral tegmental area	UBERON:0002691	96.54	gold quality
thyroid gland	UBERON:0002046	96.51	gold quality
dorsal plus ventral thalamus	UBERON:0001897	96.34	gold quality
globus pallidus	UBERON:0001875	96.29	gold quality
superior vestibular nucleus	UBERON:0007227	96.19	gold quality
midbrain	UBERON:0001891	96.15	gold quality
substantia nigra	UBERON:0002038	96.09	gold quality
pancreatic ductal cell	CL:0002079	96.05	silver quality
medial globus pallidus	UBERON:0002477	96.04	gold quality
substantia nigra pars reticulata	UBERON:0001966	95.62	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.22	gold quality
skeletal muscle tissue	UBERON:0001134	95.20	gold quality
sural nerve	UBERON:0015488	94.98	gold quality
putamen	UBERON:0001874	94.55	gold quality
upper arm skin	UBERON:0004263	94.53	gold quality
amygdala	UBERON:0001876	94.35	gold quality
pons	UBERON:0000988	94.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	17.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

59 targeting USP54, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-6794-5P	99.76	66.38	1048
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-30B-3P	99.70	65.76	2325
HSA-MIR-3689A-3P	99.70	65.73	2306
HSA-MIR-3689B-3P	99.70	65.71	2311
HSA-MIR-3689C	99.70	65.71	2311
HSA-MIR-6779-5P	99.70	65.76	2363
HSA-MIR-4716-3P	99.69	66.73	1022
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-7-5P	99.67	70.53	1809
HSA-MIR-5197-5P	99.64	69.08	1494
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-6716-5P	99.56	68.62	1244
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451

Literature-anchored findings (GeneRIF, showing 3)

• we have demonstrated that USP54 is overexpressed in colon CSCs and promotes both colon carcinoma and melanoma progression. (PMID:27769071)
• USP54 is a potential therapeutic target in castration-resistant prostate cancer. (PMID:38321455)
• Ubiquitin-specific protease 54 regulates GLUT1-mediated aerobic glycolysis to inhibit lung adenocarcinoma progression by modifying p53 degradation. (PMID:38744954)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	usp54a	ENSDARG00000077948
mus_musculus	Usp54	ENSMUSG00000034235
rattus_norvegicus	Usp54	ENSRNOG00000027012

Paralogs (1): USP53 (ENSG00000145390)

Protein

Protein identifiers

Ubiquitin carboxyl-terminal hydrolase 54 — Q70EL1 (reviewed: Q70EL1)

Alternative names: Ubiquitin-specific peptidase 54

All UniProt accessions (15): A0A7P0T9K1, A0A7P0T9N2, A0A804D9U3, A0A8I5KNN9, A0A8I5KRV2, A0A8I5KTP4, Q70EL1, A0A8I5KYV7, A0A8I5KYW2, H7C1E9, H7C296, R4GN32, X6RGF2, X6RH50, X6RHN7

UniProt curated annotations — full annotation on UniProt →

Function. Deubiquitinase that specifically mediates ‘Lys-63’-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins. Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within ‘Lys-63’-linked chains. Not able to deubiquitinate substrates with shorter ubiquitin chains. Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation.

Tissue specificity. Weakly expressed in a few tissues.

Similarity. Belongs to the peptidase C19 family.

Isoforms (7)

UniProt ID	Names	Canonical?
Q70EL1-1	1	yes
Q70EL1-4	2
Q70EL1-6	3
Q70EL1-7	4
Q70EL1-8	5
Q70EL1-9	6
Q70EL1-10	7

RefSeq proteins (21): NP_001307366, NP_001307370, NP_001337924, NP_001365137, NP_001365138, NP_001365139, NP_001378870, NP_001378871, NP_001378874, NP_001378875, NP_001378876, NP_001378877, NP_001378878, NP_001378879, NP_001378880, NP_001378881, NP_001378882, NP_001378883, NP_001378884, NP_001378885, NP_689799 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001394	Peptidase_C19_UCH	Domain
IPR028889	USP	Domain
IPR038765	Papain-like_cys_pep_sf	Homologous_superfamily
IPR052398	Ubiquitin_hydrolase_53/54	Family

Pfam: PF00443

UniProt features (107 total): compositionally biased region 18, strand 16, helix 12, binding site 12, region of interest 11, splice variant 8, modified residue 7, sequence conflict 7, turn 5, sequence variant 4, active site 2, mutagenesis site 2, chain 1, domain 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
8C61	X-RAY DIFFRACTION	2.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q70EL1-F1	48.67	0.18

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (2): 42 (nucleophile); 302 (proton acceptor)

Ligand- & substrate-binding residues (12): 67; 69; 74; 77; 133; 145; 150; 153; 166; 169; 225; 229

Post-translational modifications (7): 12, 481, 603, 632, 671, 674, 1189

Mutagenesis-validated functional residues (2):

Position	Phenotype
100	strongly decreased ability to catalyze deubiquitination.
161	reduced ability to mediate cleavage of tri- and tetra-ubiquitin chains.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 136 (showing top): GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_UP, GCANCTGNY_MYOD_Q6, GOBP_PROTEIN_MODIFICATION_BY_SMALL_PROTEIN_REMOVAL, CAGCTG_AP4_Q5, MYOD_01, GOMF_CYSTEINE_TYPE_PEPTIDASE_ACTIVITY, GOBP_POST_TRANSLATIONAL_PROTEIN_MODIFICATION, CHIANG_LIVER_CANCER_SUBCLASS_INTERFERON_DN, TGGNNNNNNKCCAR_UNKNOWN, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN, AR_01, AR_Q2, MASSARWEH_TAMOXIFEN_RESISTANCE_UP, GOBP_PROTEOLYSIS, GEORGES_TARGETS_OF_MIR192_AND_MIR215

GO Biological Process (2): proteolysis (GO:0006508), protein deubiquitination (GO:0016579)

GO Molecular Function (6): cysteine-type deubiquitinase activity (GO:0004843), K63-linked deubiquitinase activity (GO:0061578), protein binding (GO:0005515), peptidase activity (GO:0008233), cysteine-type peptidase activity (GO:0008234), hydrolase activity (GO:0016787)

GO Cellular Component (0):

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
deubiquitinase activity	2
protein metabolic process	1
cysteine-type deubiquitinase activity	1
protein modification by small protein removal	1
cysteine-type peptidase activity	1
binding	1
hydrolase activity	1
catalytic activity, acting on a protein	1
peptidase activity	1
catalytic activity	1

Protein interactions and networks

STRING

894 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
USP54	PAN2	Q504Q3	660
USP54	USP50	Q70EL3	633
USP54	USP39	Q53GS9	578
USP54	USP43	Q70EL4	575
USP54	C1orf74	Q96LT6	517
USP54	USP33	Q8TEY7	503
USP54	USP38	Q8NB14	486
USP54	USP8	P40818	478
USP54	USPL1	Q5W0Q7	468
USP54	USP35	Q9P2H5	454
USP54	USP49	Q70CQ1	453
USP54	USP45	Q70EL2	450
USP54	USP11	P51784	445
USP54	USP13	Q92995	439
USP54	USP48	Q86UV5	433

IntAct

114 interactions, top by confidence:

A	B	Type	Score
IKBKG	IKBKB	psi-mi:“MI:0914”(association)	0.980
CCT2	TXNDC9	psi-mi:“MI:0914”(association)	0.730
USP54	rep	psi-mi:“MI:0915”(physical association)	0.660
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
PDCL3	PEX7	psi-mi:“MI:0914”(association)	0.640
CCT3	TXNDC9	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
YWHAB	BLTP3B	psi-mi:“MI:0914”(association)	0.610
EIF4E2	USP54	psi-mi:“MI:0915”(physical association)	0.560
NXT2	USP54	psi-mi:“MI:0915”(physical association)	0.560
VRK3	USP54	psi-mi:“MI:0915”(physical association)	0.560
USP54	DYRK1A	psi-mi:“MI:0914”(association)	0.550
rep	SBNO1	psi-mi:“MI:0914”(association)	0.530
YWHAZ	BLTP3B	psi-mi:“MI:0914”(association)	0.530
CLEC11A	VWA8	psi-mi:“MI:0914”(association)	0.530
CAPN2	MYO9A	psi-mi:“MI:0914”(association)	0.530
DISC1	AP4M1	psi-mi:“MI:0914”(association)	0.530
PIGT	ZNF609	psi-mi:“MI:0914”(association)	0.530
PNMA2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
ATXN1	USP54	psi-mi:“MI:0915”(physical association)	0.510
USP54	CHMP1A	psi-mi:“MI:0407”(direct interaction)	0.440
CHMP1B	USP54	psi-mi:“MI:0407”(direct interaction)	0.440
USP54	CHMP2A	psi-mi:“MI:0407”(direct interaction)	0.440

BioGRID (266): USP54 (Affinity Capture-MS), USP54 (Two-hybrid), USP54 (Two-hybrid), USP54 (Affinity Capture-MS), USP54 (Affinity Capture-MS), USP54 (Affinity Capture-MS), USP54 (Affinity Capture-MS), USP54 (Affinity Capture-MS), USP54 (Affinity Capture-MS), USP54 (Affinity Capture-MS), USP54 (Proximity Label-MS), USP54 (Proximity Label-MS), USP54 (Proximity Label-MS), USP54 (Proximity Label-MS), USP54 (Proximity Label-MS)

ESM2 similar proteins: A0A2R6W1B1, A0FKI7, A2XC52, A2XTW9, A2Y0Q2, B8AMA8, B8B8I3, F4I9G2, O94972, P07106, P20067, P41135, P85828, Q5EAE9, Q5EAH9, Q5R7V3, Q5T8D3, Q5XEM9, Q5XG73, Q5XI67, Q6EPZ2, Q6GPE9, Q6IE24, Q6PCX9, Q70EL1, Q75IR6, Q76N89, Q7XUW3, Q84TV4, Q86UB2, Q8BJL1, Q8BL06, Q8CBX9, Q8H383, Q8H8C6, Q8K3A6, Q8K4P8, Q8LA16, Q8TB52, Q96S38

Diamond homologs: P15975, Q6IE24, Q70EK8, Q70EL1, Q8BL06

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 116 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Activation of BAD and translocation to mitochondria	7	78.4×	1e-10
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	7	69.2×	2e-10
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	69.2×	2e-10
Activation of BH3-only proteins	7	51.1×	2e-09
Budding and maturation of HIV virion	8	48.0×	2e-10
Pyroptosis	7	43.5×	6e-09
Endosomal Sorting Complex Required For Transport (ESCRT)	8	43.3×	4e-10
Late endosomal microautophagy	8	38.4×	1e-09

GO biological processes:

GO term	Partners	Fold	FDR
nuclear membrane reassembly	10	99.1×	9e-17
late endosome to lysosome transport	10	99.1×	9e-17
viral budding via host ESCRT complex	10	80.2×	1e-15
multivesicular body sorting pathway	10	80.2×	1e-15
midbody abscission	10	73.3×	3e-15
regulation of mitotic spindle assembly	10	73.3×	3e-15
regulation of centrosome duplication	8	58.6×	2e-11
plasma membrane repair	10	58.1×	4e-14

Disease & clinical

Clinical variants and AI predictions

ClinVar

177 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	148
Likely benign	11
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

4834 predictions. Top by Δscore:

Variant	Effect	Δscore
10:73500838:CCT:C	acceptor_gain	1.0000
10:73505321:A:AC	donor_gain	1.0000
10:73505322:C:CC	donor_gain	1.0000
10:73505322:CTGTT:C	donor_gain	1.0000
10:73519989:TTAG:T	acceptor_gain	1.0000
10:73523581:A:AT	donor_loss	1.0000
10:73523581:AC:A	donor_gain	1.0000
10:73523582:C:CT	donor_loss	1.0000
10:73523582:CC:C	donor_gain	1.0000
10:73536263:GCTCA:G	donor_loss	1.0000
10:73536264:CTCAC:C	donor_loss	1.0000
10:73536265:TCACC:T	donor_loss	1.0000
10:73536266:CAC:C	donor_loss	1.0000
10:73536267:A:C	donor_loss	1.0000
10:73536433:CCAAT:C	acceptor_gain	1.0000
10:73536434:CAAT:C	acceptor_gain	1.0000
10:73536434:CAATC:C	acceptor_gain	1.0000
10:73536435:AAT:A	acceptor_gain	1.0000
10:73536436:AT:A	acceptor_gain	1.0000
10:73536437:TC:T	acceptor_loss	1.0000
10:73536438:C:CC	acceptor_gain	1.0000
10:73536438:CT:C	acceptor_loss	1.0000
10:73536444:C:CT	acceptor_gain	1.0000
10:73536444:C:T	acceptor_gain	1.0000
10:73536445:A:T	acceptor_gain	1.0000
10:73536454:C:CT	acceptor_gain	1.0000
10:73536454:C:T	acceptor_gain	1.0000
10:73539442:ACCT:A	donor_gain	1.0000
10:73539443:CCTC:C	donor_gain	1.0000
10:73539445:T:TA	donor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000031081 (10:73604270 C>T), RS1000034890 (10:73574555 T>C), RS1000097938 (10:73602990 G>A), RS1000106526 (10:73574334 A>G), RS1000131563 (10:73554983 G>A,C), RS1000137397 (10:73603671 C>A,T), RS1000143306 (10:73527580 T>C), RS1000174951 (10:73623752 T>C), RS1000175059 (10:73508071 G>A), RS1000190182 (10:73603308 A>C), RS1000225951 (10:73507839 A>G), RS1000328332 (10:73534101 G>A), RS1000361663 (10:73547492 A>G), RS1000362945 (10:73580921 C>T), RS1000376146 (10:73547714 C>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010396_122	Gut microbiota (bacterial taxa, hurdle binary method)	8.000000e-07
GCST010396_93	Gut microbiota (bacterial taxa, hurdle binary method)	1.000000e-06
GCST010463_19	Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0007874	gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, decreases expression, increases expression, increases methylation	4
sodium arsenite	affects expression, decreases expression	2
GSK-J4	decreases expression	1
FR900359	affects phosphorylation	1
dicrotophos	increases expression	1
bufotalin	increases expression	1
triphenyl phosphate	affects expression	1
CGP 52608	affects binding, increases reaction	1
abrine	increases expression	1
bisphenol S	increases methylation	1
Caffeine	affects phosphorylation	1
Coumestrol	decreases expression	1
Doxorubicin	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Nickel	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tretinoin	decreases expression	1
Valproic Acid	decreases methylation, increases expression	1
Aflatoxin B1	increases methylation	1
Antirheumatic Agents	increases expression	1
Acrylamide	decreases expression	1

Cellosaurus cell lines

2 cell lines: 2 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B2KQ	Abcam HeLa USP54 KO	Cancer cell line	Female
CVCL_TX10	HAP1 USP54 (-)	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.