UTP15

Summary

UTP15 (UTP15 small subunit processome component, HGNC:25758) is a protein-coding gene on chromosome 5q13.2, encoding U3 small nucleolar RNA-associated protein 15 homolog (Q8TED0). Ribosome biogenesis factor. It is a common-essential gene (DepMap: required in 99.9% of cancer cell lines).

Enables RNA binding activity. Involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Located in endoplasmic reticulum and fibrillar center. Part of small-subunit processome.

Source: NCBI Gene 84135 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 63 total
• Cancer dependency (DepMap): dependent in 99.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_032175

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25758
Approved symbol	UTP15
Name	UTP15 small subunit processome component
Location	5q13.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12787, NET21, FLJ23637
Ensembl gene	ENSG00000164338
Ensembl biotype	protein_coding
OMIM	616194
Entrez	84135

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 12 protein_coding, 2 retained_intron

ENST00000296792, ENST00000508491, ENST00000508686, ENST00000509005, ENST00000510478, ENST00000512550, ENST00000513824, ENST00000543251, ENST00000862251, ENST00000862252, ENST00000862253, ENST00000918458, ENST00000918459, ENST00000918460

RefSeq mRNA: 3 — MANE Select: NM_032175 NM_001284430, NM_001284431, NM_032175

CCDS: CCDS34186, CCDS68893, CCDS68894

Canonical transcript exons

ENST00000296792 — 13 exons

Exon	Start	End
ENSE00001083635	73567262	73567434
ENSE00001083654	73577856	73578005
ENSE00001083655	73578751	73578852
ENSE00001083657	73579317	73579375
ENSE00001083661	73579017	73579150
ENSE00001403511	73579877	73583380
ENSE00003475611	73565743	73565912
ENSE00003501028	73569497	73569675
ENSE00003526394	73570586	73570711
ENSE00003529543	73576952	73577036
ENSE00003546940	73568420	73568604
ENSE00003583494	73568235	73568327
ENSE00003670164	73572489	73572624

Expression profiles

Bgee: expression breadth ubiquitous, 206 present calls, max score 91.88.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 20.0920 / max 169.1686, expressed in 1792 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
57044	16.5613	1783
57045	2.8644	1281
57046	0.6663	386

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	91.88	gold quality
epithelial cell of pancreas	CL:0000083	91.27	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	88.00	gold quality
adrenal tissue	UBERON:0018303	86.05	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.72	gold quality
skin of abdomen	UBERON:0001416	84.42	gold quality
skin of leg	UBERON:0001511	83.84	gold quality
islet of Langerhans	UBERON:0000006	83.76	gold quality
rectum	UBERON:0001052	83.19	gold quality
monocyte	CL:0000576	82.81	gold quality
leukocyte	CL:0000738	82.53	gold quality
zone of skin	UBERON:0000014	82.25	gold quality
smooth muscle tissue	UBERON:0001135	82.11	gold quality
vermiform appendix	UBERON:0001154	81.86	gold quality
tendon	UBERON:0000043	81.54	gold quality
bone marrow cell	CL:0002092	81.05	gold quality
muscle of leg	UBERON:0001383	80.18	gold quality
gastrocnemius	UBERON:0001388	80.06	gold quality
mucosa of stomach	UBERON:0001199	79.95	gold quality
body of stomach	UBERON:0001161	79.77	gold quality
pancreas	UBERON:0001264	79.59	gold quality
esophagus mucosa	UBERON:0002469	79.38	gold quality
stromal cell of endometrium	CL:0002255	79.25	gold quality
left adrenal gland	UBERON:0001234	79.20	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.03	gold quality
left uterine tube	UBERON:0001303	79.01	gold quality
left adrenal gland cortex	UBERON:0035825	79.00	gold quality
right adrenal gland cortex	UBERON:0035827	78.98	gold quality
lymph node	UBERON:0000029	78.96	gold quality
adrenal gland	UBERON:0002369	78.83	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.93

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

94 targeting UTP15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-432-3P	100.00	67.86	705
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-3681-3P	99.88	70.46	2254
HSA-MIR-4503	99.85	71.45	1869
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-374C-5P	99.80	72.06	2910
HSA-MIR-655-3P	99.80	72.19	2909
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-4766-5P	99.75	69.23	2662
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-5580-3P	99.70	69.41	2052
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-580-3P	99.67	69.23	1841
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-6134	99.63	65.68	1537

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 99.9% of screened cell lines, common-essential.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	utp15	ENSDARG00000002720
mus_musculus	Utp15	ENSMUSG00000041747
rattus_norvegicus	Utp15	ENSRNOG00000016591
drosophila_melanogaster	CG3071	FBGN0023527
caenorhabditis_elegans	Y23H5B.5	WBGENE00021276

Protein

Protein identifiers

U3 small nucleolar RNA-associated protein 15 homolog — Q8TED0 (reviewed: Q8TED0)

All UniProt accessions (4): A0A1Y8EI88, D6RF65, H0Y8P4, Q8TED0

UniProt curated annotations — full annotation on UniProt →

Function. Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.

Subunit / interactions. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. May be a component of the proposed t-UTP subcomplex of the ribosomal small subunit (SSU) processome containing at least UTP4, WDR43, HEATR1, UTP15, WDR75. Interacts directly with UTP4 and WDR43.

Subcellular location. Nucleus. Nucleolus.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8TED0-1	1	yes
Q8TED0-2	2
Q8TED0-3	3

RefSeq proteins (3): NP_001271359, NP_001271360, NP_115551* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR018983	U3_snoRNA-assocProt_15_C	Domain
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily

Pfam: PF00400, PF09384

UniProt features (55 total): strand 30, repeat 7, sequence conflict 4, sequence variant 3, turn 3, splice variant 2, helix 2, initiator methionine 1, chain 1, cross-link 1, modified residue 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
7RUO	X-RAY DIFFRACTION	1.8
7MQA	ELECTRON MICROSCOPY	2.7
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TED0-F1	82.24	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (2): 249, 2

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol

MSigDB gene sets: 126 (showing top): GOBP_RIBOSOME_BIOGENESIS, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_MATURATION_OF_SSU_RRNA, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, GARY_CD5_TARGETS_DN, FISCHER_DREAM_TARGETS, ZHANG_BREAST_CANCER_PROGENITORS_UP, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS, CUI_TCF21_TARGETS_2_UP, REACTOME_METABOLISM_OF_RNA, GOCC_PRERIBOSOME, GOCC_SMALL_SUBUNIT_PROCESSOME, GOCC_NUCLEOLUS, GOCC_RIBONUCLEOPROTEIN_COMPLEX

GO Biological Process (5): rRNA processing (GO:0006364), ribosomal small subunit biogenesis (GO:0042274), positive regulation of transcription by RNA polymerase I (GO:0045943), positive regulation of rRNA processing (GO:2000234), ribosome biogenesis (GO:0042254)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (7): fibrillar center (GO:0001650), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytoplasm (GO:0005737), endoplasmic reticulum (GO:0005783), small-subunit processome (GO:0032040), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
ribosome biogenesis	2
ribonucleoprotein complex biogenesis	2
nucleolus	2
nuclear lumen	2
intracellular membrane-bounded organelle	2
RNA processing	1
rRNA metabolic process	1
regulation of transcription by RNA polymerase I	1
transcription by RNA polymerase I	1
positive regulation of DNA-templated transcription	1
rRNA processing	1
positive regulation of RNA metabolic process	1
regulation of rRNA processing	1
nucleic acid binding	1
binding	1
intracellular membraneless organelle	1
intracellular anatomical structure	1
cytoplasm	1
endomembrane system	1
preribosome	1
t-UTP complex	1
nuclear protein-containing complex	1

Protein interactions and networks

STRING

2645 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UTP15	WDR43	Q15061	982
UTP15	UTP4	Q969X6	981
UTP15	HEATR1	Q9H583	972
UTP15	WDR75	Q8IWA0	941
UTP15	BMS1	Q14692	778
UTP15	NOP58	Q9Y2X3	753
UTP15	UTP6	Q9NYH9	744
UTP15	UTP18	Q9Y5J1	728
UTP15	NOP56	O00567	710
UTP15	WDR36	Q8NI36	710
UTP15	UTP14A	Q9BVJ6	704
UTP15	NOL10	Q9BSC4	699
UTP15	NOP14	P78316	645
UTP15	MPHOSPH10	O00566	629
UTP15	BYSL	Q13895	627

IntAct

91 interactions, top by confidence:

A	B	Type	Score
UTP4	UTP15	psi-mi:“MI:0407”(direct interaction)	0.810
C1D	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
EXOSC5	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
NOL7	WDR43	psi-mi:“MI:0914”(association)	0.640
NOP53	RRP8	psi-mi:“MI:0914”(association)	0.640
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
WDR43	UTP15	psi-mi:“MI:0407”(direct interaction)	0.590
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
LAMP3	METTL15	psi-mi:“MI:0914”(association)	0.530
NOL11	WDR43	psi-mi:“MI:0914”(association)	0.530
WDR75	WDR43	psi-mi:“MI:0914”(association)	0.530
FBL	ZNF316	psi-mi:“MI:0914”(association)	0.530
TBC1D15	MYO9A	psi-mi:“MI:0914”(association)	0.530
CSGALNACT2	GOLIM4	psi-mi:“MI:0914”(association)	0.530
UTP4	ANKRD28	psi-mi:“MI:0914”(association)	0.530
RBM4	NVL	psi-mi:“MI:0914”(association)	0.530
WDR43	WDR75	psi-mi:“MI:0914”(association)	0.530
TBC1D15	UBXN8	psi-mi:“MI:0914”(association)	0.530
NOL7	IPO5	psi-mi:“MI:0914”(association)	0.530
CSGALNACT2	TPST1	psi-mi:“MI:0914”(association)	0.530
PARP2	UTP15	psi-mi:“MI:0557”(adp ribosylation reaction)	0.440
UTP15	H4C16	psi-mi:“MI:0915”(physical association)	0.400
UTP15	PGK2	psi-mi:“MI:0915”(physical association)	0.400
ATM	RBM47	psi-mi:“MI:0914”(association)	0.350
Ncaph	ATP5MF-PTCD1	psi-mi:“MI:0914”(association)	0.350
HDAC6	GLOD5	psi-mi:“MI:0914”(association)	0.350
SORT1	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350

BioGRID (159): UTP15 (Affinity Capture-MS), UTP15 (Affinity Capture-MS), UTP15 (Affinity Capture-MS), UTP15 (Affinity Capture-MS), UTP15 (Affinity Capture-MS), NPM1 (Co-fractionation), TBL3 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation), UTP15 (Co-fractionation)

ESM2 similar proteins: A2RRU3, A7MB12, A8XSW2, A8XYW9, G5ECZ4, G5EFW7, O13282, O14053, O43071, O75529, O94365, P25635, P38328, P40968, P42000, P49846, P87177, P91341, Q04199, Q04305, Q05946, Q05BV3, Q12220, Q15269, Q20059, Q3MKM6, Q5F3D7, Q5REE0, Q5RFQ3, Q5XGE2, Q6ED65, Q7ZW33, Q7ZXZ2, Q8BHB4, Q8BQM8, Q8BU03, Q8C7V3, Q8SQS4, Q8TED0, Q8VYZ5

Diamond homologs: A2RRU3, A7MB12, O02482, O82266, O94365, Q10282, Q5F3D7, Q5REE0, Q5XGE2, Q7ZW33, Q7ZXZ2, Q8C7V3, Q8TED0, B6QC56, B8AP31, C0NRC6, C6HTE8, O35828, P49177, Q40687, Q5RBW3, A0A1W2PR48, O13166, O13168, O14435, O42469, O42470, O42478, P16371, P16520, P40066, P63002, P63003, P79083, Q04724, Q04725, Q04726, Q04727, Q07141, Q08117

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
UTP15	“form complex”	“UTP-A complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 116 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
rRNA modification in the nucleus and cytosol	9	23.4×	3e-08
Nuclear RNA decay	5	21.4×	5e-04
Major pathway of rRNA processing in the nucleolus and cytosol	13	11.2×	3e-08

GO biological processes:

GO term	Partners	Fold	FDR
ribosomal small subunit biogenesis	10	23.0×	1e-08
ribosomal large subunit biogenesis	5	22.4×	7e-04
rRNA processing	11	15.7×	4e-08
RNA processing	5	11.1×	9e-03
RNA splicing	8	7.1×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

63 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	58
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1838 predictions. Top by Δscore:

Variant	Effect	Δscore
5:73568232:A:AG	acceptor_gain	1.0000
5:73568233:A:G	acceptor_gain	1.0000
5:73568326:GA:G	donor_gain	1.0000
5:73568328:G:GG	donor_gain	1.0000
5:73568418:A:AG	acceptor_gain	1.0000
5:73568419:G:GG	acceptor_gain	1.0000
5:73568605:G:GG	donor_gain	1.0000
5:73572620:GA:G	donor_gain	1.0000
5:73576948:TTAGG:T	acceptor_loss	1.0000
5:73576949:TAGG:T	acceptor_loss	1.0000
5:73576951:G:GT	acceptor_loss	1.0000
5:73577034:GCA:G	donor_gain	1.0000
5:73577035:CA:C	donor_gain	1.0000
5:73577037:G:GG	donor_gain	1.0000
5:73577852:TTAGC:T	acceptor_loss	1.0000
5:73577854:A:AG	acceptor_gain	1.0000
5:73577855:G:GT	acceptor_gain	1.0000
5:73577855:GC:G	acceptor_gain	1.0000
5:73577983:G:GT	donor_gain	1.0000
5:73577984:A:T	donor_gain	1.0000
5:73577996:G:GT	donor_gain	1.0000
5:73578003:CGGGT:C	donor_loss	1.0000
5:73578006:G:A	donor_loss	1.0000
5:73578007:T:A	donor_loss	1.0000
5:73578744:A:AG	acceptor_gain	1.0000
5:73578746:TGCA:T	acceptor_loss	1.0000
5:73578747:GCA:G	acceptor_loss	1.0000
5:73578748:CAGGA:C	acceptor_loss	1.0000
5:73578749:A:AG	acceptor_gain	1.0000
5:73578749:A:AT	acceptor_loss	1.0000

AlphaMissense

3387 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:73568311:T:A	V56D	0.999
5:73572561:A:T	K249I	0.999
5:73567420:T:A	W26R	0.998
5:73567420:T:C	W26R	0.998
5:73568266:T:A	V41D	0.998
5:73568308:C:A	A55D	0.998
5:73568429:T:G	Y65D	0.998
5:73568502:G:C	R89P	0.998
5:73568520:T:C	L95P	0.998
5:73569573:T:A	W149R	0.998
5:73569573:T:C	W149R	0.998
5:73570586:G:A	G183E	0.998
5:73572614:T:C	S267P	0.998
5:73578809:T:C	L368P	0.998
5:73579108:G:C	R413P	0.998
5:73569543:T:C	S139P	0.997
5:73572509:T:A	W232R	0.997
5:73572509:T:C	W232R	0.997
5:73572562:A:C	K249N	0.997
5:73572562:A:T	K249N	0.997
5:73572612:G:A	G266D	0.997
5:73577881:G:A	G307E	0.997
5:73578836:T:C	L377P	0.997
5:73579099:T:C	L410P	0.997
5:73568507:G:C	D91H	0.996
5:73568508:A:T	D91V	0.996
5:73568526:C:A	A97D	0.996
5:73568529:G:A	G98D	0.996
5:73568553:T:C	L106P	0.996
5:73569516:T:C	F130L	0.996

dbSNP variants (sampled 300 via entrez): RS1000107909 (5:73580753 A>G), RS1000120750 (5:73564025 T>G), RS1000218021 (5:73573409 G>A), RS1000316267 (5:73565931 C>G,T), RS1000327010 (5:73573654 G>A), RS1000329196 (5:73566316 C>T), RS1000462808 (5:73571927 G>A), RS1000657839 (5:73564881 G>A,T), RS1000721020 (5:73565395 G>A), RS1000808385 (5:73569292 T>C), RS1001072354 (5:73577836 A>C), RS1001392620 (5:73575512 A>C), RS1001413388 (5:73565696 C>G), RS1001466679 (5:73565798 T>C,G), RS1001522088 (5:73578055 A>G)

Disease associations

OMIM: gene MIM:616194 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

49 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cadmium Chloride	decreases expression, increases abundance, increases expression	3
bisphenol A	decreases expression, affects cotreatment, increases expression	2
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	2
Formaldehyde	decreases expression	2
Tetrachlorodibenzodioxin	decreases expression	2
Valproic Acid	affects expression, decreases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	decreases expression	1
bisphenol F	affects cotreatment, increases expression	1
TAK-243	decreases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
sodium arsenate	decreases expression	1
arsenite	affects binding, increases reaction	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
nivalenol	increases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
abrine	increases expression	1
jinfukang	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Leflunomide	increases expression	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Cadmium	increases abundance, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Diethylstilbestrol	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.