UTP18

Summary

UTP18 (UTP18 small subunit processome component, HGNC:24274) is a protein-coding gene on chromosome 17q21.33, encoding U3 small nucleolar RNA-associated protein 18 homolog (Q9Y5J1). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. It is a common-essential gene (DepMap: required in 96.9% of cancer cell lines).

Enables RNA binding activity. Involved in ribosomal small subunit biogenesis. Located in nuclear membrane; nucleolus; and nucleoplasm. Part of small-subunit processome.

Source: NCBI Gene 51096 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 82 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 96.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_016001

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24274
Approved symbol	UTP18
Name	UTP18 small subunit processome component
Location	17q21.33
Locus type	gene with protein product
Status	Approved
Aliases	CGI-48
Ensembl gene	ENSG00000011260
Ensembl biotype	protein_coding
OMIM	612816
Entrez	51096

Gene structure

Transcript identifiers

Ensembl transcripts: 16 — 13 protein_coding, 2 nonsense_mediated_decay, 1 retained_intron

ENST00000225298, ENST00000508506, ENST00000579261, ENST00000582150, ENST00000582832, ENST00000583205, ENST00000583725, ENST00000854754, ENST00000854755, ENST00000854756, ENST00000932455, ENST00000932456, ENST00000932457, ENST00000942771, ENST00000942772, ENST00000942773

RefSeq mRNA: 1 — MANE Select: NM_016001 NM_016001

CCDS: CCDS42362

Canonical transcript exons

ENST00000225298 — 14 exons

Exon	Start	End
ENSE00000737795	51263274	51263386
ENSE00000737807	51266182	51266280
ENSE00000737810	51275866	51275991
ENSE00000737813	51277130	51277304
ENSE00000737822	51288029	51288203
ENSE00000820106	51260546	51260926
ENSE00002240469	51268837	51268904
ENSE00002259575	51273362	51273450
ENSE00002686233	51297782	51297933
ENSE00003460980	51280389	51280479
ENSE00003489487	51296965	51297003
ENSE00003554598	51293903	51294045
ENSE00003597710	51280005	51280105
ENSE00003616660	51285245	51285368

Expression profiles

Bgee: expression breadth ubiquitous, 297 present calls, max score 96.10.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.1893 / max 237.8671, expressed in 1810 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
161745	27.1255	1807
161744	1.0638	693

Top tissues by expression

299 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	96.10	gold quality
left testis	UBERON:0004533	95.88	gold quality
sperm	CL:0000019	95.78	gold quality
esophagus squamous epithelium	UBERON:0006920	95.66	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	95.61	gold quality
male germ cell	CL:0000015	95.25	gold quality
testis	UBERON:0000473	95.22	gold quality
adult organism	UBERON:0007023	95.20	gold quality
calcaneal tendon	UBERON:0003701	95.09	gold quality
cartilage tissue	UBERON:0002418	94.98	gold quality
gingival epithelium	UBERON:0001949	94.54	gold quality
tibia	UBERON:0000979	94.45	gold quality
squamous epithelium	UBERON:0006914	94.23	gold quality
visceral pleura	UBERON:0002401	94.20	gold quality
germinal epithelium of ovary	UBERON:0001304	94.12	gold quality
gingiva	UBERON:0001828	94.00	gold quality
epithelium of esophagus	UBERON:0001976	94.00	gold quality
pleura	UBERON:0000977	93.85	gold quality
parietal pleura	UBERON:0002400	93.80	gold quality
palpebral conjunctiva	UBERON:0001812	93.51	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.45	gold quality
placenta	UBERON:0001987	93.42	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.25	gold quality
oral cavity	UBERON:0000167	93.23	gold quality
skin of hip	UBERON:0001554	93.21	gold quality
eye	UBERON:0000970	93.19	gold quality
monocyte	CL:0000576	93.11	gold quality
middle temporal gyrus	UBERON:0002771	93.04	gold quality
mononuclear cell	CL:0000842	93.03	gold quality
leukocyte	CL:0000738	92.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.37

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

32 targeting UTP18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-499A-5P	99.98	70.79	1323
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-22-3P	99.93	68.13	917
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-143-3P	99.49	69.05	1457
HSA-MIR-4770	99.49	69.09	1451
HSA-MIR-4762-3P	99.43	69.72	2363
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-6088	99.29	68.45	1284
HSA-MIR-149-5P	99.25	67.16	1315
HSA-MIR-422A	99.18	65.83	550
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-1207-3P	98.99	66.22	1532
HSA-MIR-4477A	98.83	69.75	2952
HSA-MIR-378A-3P	98.43	66.10	548
HSA-MIR-378B	98.43	65.36	573
HSA-MIR-378C	98.43	66.10	548
HSA-MIR-378D	98.43	66.10	548
HSA-MIR-378E	98.43	65.99	551
HSA-MIR-378F	98.43	65.66	554
HSA-MIR-378H	98.43	66.16	545
HSA-MIR-378I	98.43	66.10	548
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-4303	98.01	68.13	2304
HSA-MIR-892B	98.00	67.11	821
HSA-MIR-3654	96.43	66.55	646
HSA-MIR-208A-3P	95.87	66.51	397
HSA-MIR-208B-3P	95.87	66.56	396

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 96.9% of screened cell lines, common-essential.

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Utp18	ENSMUSG00000054079
rattus_norvegicus	Utp18	ENSRNOG00000002644

Protein

Protein identifiers

U3 small nucleolar RNA-associated protein 18 homolog — Q9Y5J1 (reviewed: Q9Y5J1)

Alternative names: WD repeat-containing protein 50

All UniProt accessions (6): Q9Y5J1, F6VJE8, J3KSR7, J3QLD6, J3QR85, J3QRG0

UniProt curated annotations — full annotation on UniProt →

Function. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in nucleolar processing of pre-18S ribosomal RNA.

Subunit / interactions. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.

Subcellular location. Nucleus. Nucleolus.

Similarity. Belongs to the WD repeat UTP18 family.

RefSeq proteins (1): NP_057085* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001680	WD40_rpt	Repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf	Homologous_superfamily
IPR019775	WD40_repeat_CS	Conserved_site
IPR036322	WD40_repeat_dom_sf	Homologous_superfamily
IPR045161	Utp18	Family

Pfam: PF00400

UniProt features (25 total): modified residue 7, repeat 6, cross-link 4, compositionally biased region 3, region of interest 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
7MQA	ELECTRON MICROSCOPY	2.7
7MQ8	ELECTRON MICROSCOPY	3.6
7MQ9	ELECTRON MICROSCOPY	3.87

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y5J1-F1	77.92	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (11): 121, 124, 204, 205, 206, 210, 221, 84, 183, 201, 517

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-6790901	rRNA modification in the nucleus and cytosol
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol

MSigDB gene sets: 225 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, RNGTGGGC_UNKNOWN, GOBP_RIBOSOME_BIOGENESIS, MORF_MBD4, GOBP_MATURATION_OF_SSU_RRNA, MORF_RAD21, GGGTGGRR_PAX4_03, USF_C, SP1_Q2_01, PUJANA_CHEK2_PCC_NETWORK, WEI_MYCN_TARGETS_WITH_E_BOX, MORF_SKP1A, GOBP_RIBOSOMAL_SMALL_SUBUNIT_BIOGENESIS, ZIC1_01, DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN

GO Biological Process (2): rRNA processing (GO:0006364), ribosomal small subunit biogenesis (GO:0042274)

GO Molecular Function (2): RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (7): nucleus (GO:0005634), nucleoplasm (GO:0005654), nucleolus (GO:0005730), nuclear membrane (GO:0031965), small-subunit processome (GO:0032040), Pwp2p-containing subcomplex of 90S preribosome (GO:0034388), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
rRNA processing in the nucleus and cytosol	2

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
ribosome biogenesis	2
nuclear lumen	2
cellular anatomical structure	2
nucleolus	2
nuclear protein-containing complex	2
RNA processing	1
rRNA metabolic process	1
ribonucleoprotein complex biogenesis	1
nucleic acid binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular membraneless organelle	1
nucleus	1
nuclear envelope	1
organelle membrane	1
preribosome	1
t-UTP complex	1
90S preribosome	1

Protein interactions and networks

STRING

2309 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UTP18	TBL3	Q12788	986
UTP18	WDR36	Q8NI36	972
UTP18	UTP6	Q9NYH9	968
UTP18	PWP2	Q15269	963
UTP18	MTREX	P42285	954
UTP18	WDR3	Q9UNX4	929
UTP18	UTP4	Q969X6	846
UTP18	HEATR1	Q9H583	836
UTP18	UTP3	Q9NQZ2	833
UTP18	WDR43	Q15061	759
UTP18	UTP11	Q9Y3A2	742
UTP18	NOP53	Q9NZM5	729
UTP18	UTP15	Q8TED0	728
UTP18	UTP20	O75691	709
UTP18	NOL6	Q9H6R4	708

IntAct

109 interactions, top by confidence:

A	B	Type	Score
CCT2	TXNDC9	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
PTK2	TGFB1I1	psi-mi:“MI:0914”(association)	0.680
CCT5	TXNDC9	psi-mi:“MI:0914”(association)	0.640
KMT2A	MEN1	psi-mi:“MI:0914”(association)	0.640
C1D	ZFC3H1	psi-mi:“MI:0914”(association)	0.640
RPS14	CCZ1B	psi-mi:“MI:0914”(association)	0.640
PWP2	FBL	psi-mi:“MI:0914”(association)	0.610
NPM1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.610
UTP18	PWP2	psi-mi:“MI:0915”(physical association)	0.560
HAVCR2	TCAF2	psi-mi:“MI:0914”(association)	0.530
N	RBM47	psi-mi:“MI:0914”(association)	0.530
WDR43	WDR75	psi-mi:“MI:0914”(association)	0.530
MAGEB2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
CCT7	PEX7	psi-mi:“MI:0914”(association)	0.530
EXOSC4	ZFC3H1	psi-mi:“MI:0914”(association)	0.530
ADARB1	SPTY2D1	psi-mi:“MI:0914”(association)	0.530
TOMM20	TPP1	psi-mi:“MI:0914”(association)	0.480
UTP18	CSNK2A1	psi-mi:“MI:0217”(phosphorylation reaction)	0.440
UTP18	H1-5	psi-mi:“MI:0915”(physical association)	0.400
HCFC2	MEN1	psi-mi:“MI:0915”(physical association)	0.400
UTP18	ERBB2	psi-mi:“MI:0915”(physical association)	0.370
HNRNPU		psi-mi:“MI:0914”(association)	0.350
Eif3e	RPSA	psi-mi:“MI:0914”(association)	0.350
Eif3i	CBX4	psi-mi:“MI:0914”(association)	0.350
Xpo1	IFT56	psi-mi:“MI:0914”(association)	0.350
RRP1B	ZNF785	psi-mi:“MI:0914”(association)	0.350

BioGRID (166): UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), MPHOSPH10 (Co-fractionation), RBM19 (Co-fractionation), UTP18 (Co-fractionation), UTP18 (Affinity Capture-MS), UTP18 (Two-hybrid), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS), UTP18 (Affinity Capture-MS)

ESM2 similar proteins: A0JMQ0, A4IHS2, A9UZS7, B0WC36, B3MHX6, B3NLK7, B4GIU9, B4HN85, B4J9K1, B4KQU8, B4LKS9, B4MYI5, B4P528, F4IH25, O00423, O13046, O75717, P59328, P97452, Q05BC3, Q0D6V7, Q0VA16, Q14137, Q17LZ2, Q28XF0, Q2TAF3, Q32LB0, Q3TWF6, Q4V8C3, Q562C2, Q5EB92, Q5RAS1, Q5RJT2, Q5SSI6, Q5U2Z5, Q6DIP5, Q6GPP0, Q6GQ76, Q7K0Y1, Q7PTC5

Diamond homologs: Q5SSI6, Q9FMU5, Q9V7P1, Q9Y5J1, P40362, P78750, Q54MH6, Q9P4X3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
UTP18	“form complex”	“UTP-B complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 144 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
rRNA modification in the nucleus and cytosol	9	17.6×	4e-07
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	5	15.7×	1e-03
rRNA processing in the nucleus and cytosol	7	11.7×	3e-04
rRNA processing	7	10.7×	3e-04
Major pathway of rRNA processing in the nucleolus and cytosol	16	10.3×	1e-09
mRNA Polyadenylation	7	6.4×	5e-03
Processing of Capped Intron-Containing Pre-mRNA	7	6.0×	6e-03
Metabolism of RNA	12	5.2×	3e-04

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of transcription by RNA polymerase I	6	30.9×	1e-05
positive regulation of telomere maintenance via telomerase	5	29.1×	1e-04
ribosomal small subunit biogenesis	12	21.7×	2e-10
ribosomal large subunit biogenesis	5	17.6×	7e-04
regulation of alternative mRNA splicing, via spliceosome	7	13.6×	1e-04
RNA processing	7	12.2×	2e-04
negative regulation of translation	6	9.3×	3e-03
antiviral innate immune response	5	9.0×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

82 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	65
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2463 predictions. Top by Δscore:

Variant	Effect	Δscore
17:51260894:G:GT	donor_gain	1.0000
17:51260925:GG:G	donor_gain	1.0000
17:51260926:GG:G	donor_gain	1.0000
17:51260927:G:GG	donor_gain	1.0000
17:51260932:G:GT	donor_gain	1.0000
17:51260933:G:T	donor_gain	1.0000
17:51263268:CTGTA:C	acceptor_loss	1.0000
17:51263270:GTAGG:G	acceptor_loss	1.0000
17:51263271:TAG:T	acceptor_loss	1.0000
17:51263272:A:C	acceptor_loss	1.0000
17:51263382:GAAAT:G	donor_gain	1.0000
17:51263384:AAT:A	donor_gain	1.0000
17:51263385:AT:A	donor_gain	1.0000
17:51263386:TGTAA:T	donor_loss	1.0000
17:51263387:G:GA	donor_loss	1.0000
17:51263387:G:GG	donor_gain	1.0000
17:51263388:TAA:T	donor_loss	1.0000
17:51266179:TA:T	acceptor_loss	1.0000
17:51266180:A:AG	acceptor_gain	1.0000
17:51266180:AG:A	acceptor_gain	1.0000
17:51266180:AGG:A	acceptor_gain	1.0000
17:51266180:AGGGT:A	acceptor_loss	1.0000
17:51266181:G:A	acceptor_gain	1.0000
17:51266181:G:GG	acceptor_gain	1.0000
17:51266181:GGG:G	acceptor_gain	1.0000
17:51266181:GGGT:G	acceptor_gain	1.0000
17:51266181:GGGTT:G	acceptor_gain	1.0000
17:51266276:GAAGA:G	donor_gain	1.0000
17:51266277:AAGA:A	donor_gain	1.0000
17:51266278:AGA:A	donor_gain	1.0000

AlphaMissense

3662 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:51268868:T:A	W196R	0.996
17:51268868:T:C	W196R	0.996
17:51268870:G:C	W196C	0.996
17:51268870:G:T	W196C	0.996
17:51285265:T:A	W409R	0.996
17:51285265:T:C	W409R	0.996
17:51285362:C:A	A441D	0.996
17:51275929:T:C	F259L	0.995
17:51275931:C:A	F259L	0.995
17:51275931:C:G	F259L	0.995
17:51268838:T:C	F186L	0.994
17:51268840:C:A	F186L	0.994
17:51268840:C:G	F186L	0.994
17:51293904:T:A	V502D	0.994
17:51263355:T:A	W142R	0.992
17:51263355:T:C	W142R	0.992
17:51277227:C:A	A312D	0.992
17:51285361:G:C	A441P	0.990
17:51288166:C:A	A489E	0.990
17:51263357:G:C	W142C	0.989
17:51263357:G:T	W142C	0.989
17:51277232:A:C	S314R	0.989
17:51277234:T:A	S314R	0.989
17:51277234:T:G	S314R	0.989
17:51275930:T:C	F259S	0.988
17:51275986:T:C	F278L	0.988
17:51275988:T:A	F278L	0.988
17:51275988:T:G	F278L	0.988
17:51288046:T:A	V449E	0.988
17:51285368:G:A	G443D	0.987

dbSNP variants (sampled 300 via entrez): RS1000022706 (17:51279601 G>A,C), RS1000075663 (17:51274385 C>G), RS1000152256 (17:51291013 A>G), RS1000240467 (17:51259316 A>G), RS1000375758 (17:51297414 A>G), RS1000505999 (17:51278322 A>G), RS1000556238 (17:51291999 G>T), RS1000607304 (17:51291751 AAAG>A), RS1000611090 (17:51297913 G>A), RS1000619069 (17:51278113 A>G), RS1000629771 (17:51280579 C>T), RS1000745672 (17:51285017 C>T), RS1000938097 (17:51267454 T>A), RS1000967136 (17:51270150 C>T), RS1001004120 (17:51272635 A>G)

Disease associations

OMIM: gene MIM:612816 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST003993_14	Menarche (age at onset)	1.000000e-10
GCST008103_55	Bipolar disorder	4.000000e-07
GCST009391_505	Metabolite levels	2.000000e-07
GCST90020028_1424	Hip circumference adjusted for BMI	1.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004703	age at menarche
EFO:0010527	pyridoxate measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067108 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.52	Kd	30.24	nM	CHEMBL5653589
7.52	ED50	30.24	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2149748: Binding affinity to human UTP18 incubated for 45 mins by Kinobead based pull down assay	kd	0.0302	uM

CTD chemical–gene interactions

44 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases abundance, increases expression, affects cotreatment	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Aflatoxin B1	affects cotreatment, decreases expression, increases methylation	2
Particulate Matter	increases abundance, increases expression, decreases expression	2
FR900359	increases phosphorylation	1
TAK-243	increases sumoylation	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
deoxynivalenol	increases expression	1
trichostatin A	affects expression	1
beta-lapachone	increases expression	1
coumarin	increases phosphorylation	1
nivalenol	increases expression	1
beta-methylcholine	affects expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	affects expression	1
dorsomorphin	affects cotreatment, decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Vorinostat	affects cotreatment, decreases expression	1
Acetaminophen	decreases expression	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Benzo(a)pyrene	increases expression	1
Benztropine	increases expression	1
Cannabidiol	increases expression	1
Clozapine	increases expression	1
Diazinon	increases methylation	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Estradiol	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652790	Binding	Binding affinity to human UTP18 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.