UTS2B

Summary

UTS2B (urotensin 2B, HGNC:30894) is a protein-coding gene on chromosome 3q28, encoding Urotensin-2B (Q765I0). Potent vasoconstrictor.

Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region.

Source: NCBI Gene 257313 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 21 total
• MANE Select transcript: NM_198152

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30894
Approved symbol	UTS2B
Name	urotensin 2B
Location	3q28
Locus type	gene with protein product
Status	Approved
Aliases	URP, U2B
Ensembl gene	ENSG00000188958
Ensembl biotype	protein_coding
OMIM	618134
Entrez	257313

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 5 protein_coding, 3 nonsense_mediated_decay, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000340524, ENST00000425357, ENST00000427544, ENST00000432514, ENST00000440476, ENST00000446788, ENST00000463450, ENST00000464814, ENST00000490825, ENST00000899455, ENST00000915518

RefSeq mRNA: 1 — MANE Select: NM_198152 NM_198152

CCDS: CCDS3300

Canonical transcript exons

ENST00000340524 — 9 exons

Exon	Start	End
ENSE00001369529	191267168	191268441
ENSE00001383373	191276807	191276844
ENSE00001512014	191304492	191304548
ENSE00001512015	191316036	191316439
ENSE00001512016	191328631	191328709
ENSE00001512017	191330414	191330526
ENSE00003531376	191278072	191278170
ENSE00003664443	191282087	191282313
ENSE00003687596	191275252	191275345

Expression profiles

Bgee: expression breadth ubiquitous, 146 present calls, max score 82.43.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3131 / max 230.7094, expressed in 24 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
46106	0.1723	17
46107	0.0969	18
46105	0.0216	4
46108	0.0097	2
46101	0.0041	1
46104	0.0039	2
46102	0.0028	1
46103	0.0018	1

Top tissues by expression

238 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	82.43	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.83	gold quality
secondary oocyte	CL:0000655	69.78	gold quality
left testis	UBERON:0004533	68.59	gold quality
right testis	UBERON:0004534	67.64	gold quality
testis	UBERON:0000473	67.44	gold quality
stromal cell of endometrium	CL:0002255	65.96	gold quality
buccal mucosa cell	CL:0002336	60.78	gold quality
smooth muscle tissue	UBERON:0001135	60.77	gold quality
right uterine tube	UBERON:0001302	59.73	gold quality
right lobe of liver	UBERON:0001114	59.70	gold quality
vermiform appendix	UBERON:0001154	58.07	gold quality
colonic epithelium	UBERON:0000397	57.66	silver quality
liver	UBERON:0002107	57.40	gold quality
gall bladder	UBERON:0002110	57.28	gold quality
calcaneal tendon	UBERON:0003701	56.80	gold quality
bone marrow cell	CL:0002092	56.31	gold quality
right coronary artery	UBERON:0001625	56.03	gold quality
rectum	UBERON:0001052	55.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	55.25	gold quality
left ovary	UBERON:0002119	54.97	gold quality
cortical plate	UBERON:0005343	54.77	gold quality
lymph node	UBERON:0000029	54.61	gold quality
caecum	UBERON:0001153	54.13	gold quality
small intestine	UBERON:0002108	53.91	gold quality
amygdala	UBERON:0001876	53.79	gold quality
subcutaneous adipose tissue	UBERON:0002190	53.49	gold quality
omental fat pad	UBERON:0010414	53.46	gold quality
upper leg skin	UBERON:0004262	53.45	silver quality
peritoneum	UBERON:0002358	53.43	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	8000.07
E-ANND-3	no	4.34

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

83 targeting UTS2B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4803	99.98	71.99	3117
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-3688-3P	99.97	72.02	2834
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-7152-3P	99.97	67.47	849
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-338-5P	99.92	72.34	2951
HSA-MIR-652-5P	99.91	67.49	505
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-8062	99.88	68.43	995
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-3680-3P	99.75	72.51	3095
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-1283	99.69	72.42	3009
HSA-MIR-519A-3P	99.67	71.67	1868
HSA-MIR-519B-3P	99.67	71.67	1868
HSA-MIR-519C-3P	99.67	71.67	1870
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-567	99.63	68.57	1219

Literature-anchored findings (GeneRIF, showing 7)

• URP could possibly be the endogenous and functional ligand for the human UII receptor (PMID:14550283)
• These findings suggest that U-II plays key roles in accelerating the development of atherosclerosis, thereby leading to coronary artery disease. (PMID:16940699)
• Urotensin II gene may contribute to the genetic susceptibility to gestational diabetes mellitus in Chinese population (PMID:17327028)
• Elevated serum urotensin II is associated with chronic liver disease and portal hypertension (PMID:17919235)
• vascular remodelling processes in conjunction with enhanced vasoconstriction are involved in the pathogenesis of pulmonary hypertension; UII may play a novel role in the pathogenesis of this disorder (PMID:18000598)
• U2B’’ has a relaxed specificity for its RNA targets. (PMID:21684671)
• family-based analysis of association between blood pressure, glomerular filtration and genes of the urotensin-II pathway (urotensin-II, urotensin-II related peptide, urotensin-II receptor) saturated with 28 tagging single nucleotide polymorphisms (PMID:24391740)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Uts2b	ENSMUSG00000056423
rattus_norvegicus	Uts2b	ENSRNOG00000038512

Protein

Protein identifiers

Urotensin-2B — Q765I0 (reviewed: Q765I0)

Alternative names: Urotensin II-related peptide, Urotensin IIB, Urotensin-2 domain-containing protein

All UniProt accessions (4): C9JU87, F2Z3I1, F8WCV4, Q765I0

UniProt curated annotations — full annotation on UniProt →

Function. Potent vasoconstrictor.

Subcellular location. Secreted.

Similarity. Belongs to the urotensin-2 family.

RefSeq proteins (1): NP_937795* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001483	Urotensin_II	Conserved_site
IPR043255	U-IIB	Family

UniProt features (5 total): signal peptide 1, propeptide 1, peptide 1, disulfide bond 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q765I0-F1	66.82	0.06

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Disulfide bonds (1): 113–118

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-375276	Peptide ligand-binding receptors
R-HSA-416476	G alpha (q) signalling events

MSigDB gene sets: 60 (showing top): GOBP_REGULATION_OF_BLOOD_PRESSURE, GOBP_CIRCULATORY_SYSTEM_PROCESS, GOBP_REGULATION_OF_ANATOMICAL_STRUCTURE_SIZE, REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS, GOMF_G_PROTEIN_COUPLED_RECEPTOR_BINDING, GOMF_SIGNALING_RECEPTOR_BINDING, GOBP_VASCULAR_PROCESS_IN_CIRCULATORY_SYSTEM, GOMF_HORMONE_ACTIVITY, REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS, REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS, GOMF_SIGNALING_RECEPTOR_REGULATOR_ACTIVITY, GOBP_REGULATION_OF_TUBE_SIZE, GSE14415_INDUCED_TREG_VS_FOXP3_KO_INDUCED_TREG_IL2_CULTURE_DN, E2F2_TARGET_GENES, LHX9_TARGET_GENES

GO Biological Process (3): regulation of blood pressure (GO:0008217), blood vessel diameter maintenance (GO:0097746), signal transduction (GO:0007165)

GO Molecular Function (2): G protein-coupled receptor binding (GO:0001664), hormone activity (GO:0005179)

GO Cellular Component (1): extracellular region (GO:0005576)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Class A/1 (Rhodopsin-like receptors)	1
GPCR downstream signalling	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
blood circulation	2
regulation of biological quality	1
vascular process in circulatory system	1
regulation of tube diameter	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
signaling receptor binding	1
receptor ligand activity	1
cellular anatomical structure	1

Protein interactions and networks

STRING

512 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UTS2B	UTS2R	Q9UKP6	868
UTS2B	UTS2	O95399	833
UTS2B	SSTR2	P30874	512
UTS2B	GNG4	P50150	472
UTS2B	OSTN	P61366	461
UTS2B	ARHGAP36	Q6ZRI8	459
UTS2B	FREM3	P0C091	456
UTS2B	HTR1B	P28222	455
UTS2B	VWC2	Q2TAL6	447
UTS2B	ACTN2	P35609	446
UTS2B	RAB11FIP4	Q86YS3	442
UTS2B	TMC3	Q7Z5M5	436
UTS2B	CCL19	Q99731	434
UTS2B	CORT	O00230	433
UTS2B	ZNF784	Q8NCA9	417

IntAct

2 interactions, top by confidence:

A	B	Type	Score
UTS2B	RPN1	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (2): UTS2R (Reconstituted Complex), UTS2B (Proximity Label-MS)

ESM2 similar proteins: A8WU84, C0HKT1, C0HKT3, C0HKU2, D2IT41, D2Z1D6, E2A3M7, E2A6Z3, E2AJ76, E2AX75, E2AZE8, E2E4L2, O96690, P05110, P09929, P0DQY8, P18145, P28672, P28673, P28674, P33715, P61849, P61855, P80111, P85527, P85798, P86442, Q11099, Q18184, Q18234, Q18502, Q27441, Q29B55, Q75UG5, Q765I0, Q76CL2, Q7Q7R8, Q868F8, Q8T112, Q8WRC7

Diamond homologs: Q765I0, Q765I1, Q765I2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	11
Likely benign	4
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1593 predictions. Top by Δscore:

Variant	Effect	Δscore
3:191329719:GGAAG:G	donor_gain	1.0000
3:191329720:G:GT	donor_gain	1.0000
3:191329721:A:T	donor_gain	1.0000
3:191329722:AGGT:A	donor_loss	1.0000
3:191329723:GGTAA:G	donor_loss	1.0000
3:191329724:G:C	donor_loss	1.0000
3:191329725:T:G	donor_loss	1.0000
3:191275355:T:TC	acceptor_gain	0.9900
3:191277428:T:TA	donor_gain	0.9900
3:191329720:GAAG:G	donor_gain	0.9900
3:191329724:G:GG	donor_gain	0.9900
3:191276865:A:C	acceptor_gain	0.9800
3:191277425:A:AC	donor_gain	0.9800
3:191277426:C:CC	donor_gain	0.9800
3:191275346:C:CC	acceptor_gain	0.9700
3:191329376:A:AC	donor_gain	0.9700
3:191329377:C:CC	donor_gain	0.9700
3:191330410:TGACC:T	donor_loss	0.9700
3:191330411:GACCT:G	donor_loss	0.9700
3:191330412:ACCTG:A	donor_loss	0.9700
3:191330413:CCT:C	donor_loss	0.9700
3:191330413:CCTGG:C	donor_gain	0.9700
3:191275349:A:C	acceptor_gain	0.9600
3:191275342:CCAG:C	acceptor_gain	0.9500
3:191275343:CAG:C	acceptor_gain	0.9500
3:191275343:CAGC:C	acceptor_gain	0.9500
3:191275355:T:C	acceptor_gain	0.9500
3:191329722:AG:A	donor_gain	0.9500
3:191329723:GG:G	donor_gain	0.9500
3:191330449:C:A	donor_gain	0.9500

AlphaMissense

768 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:191268431:C:A	W115C	0.990
3:191268431:C:G	W115C	0.990
3:191268434:A:C	F114L	0.983
3:191268434:A:T	F114L	0.983
3:191268436:A:G	F114L	0.983
3:191268429:T:A	K116I	0.978
3:191268428:T:A	K116N	0.968
3:191268428:T:G	K116N	0.968
3:191268433:A:G	W115R	0.966
3:191268433:A:T	W115R	0.966
3:191268435:A:C	F114C	0.964
3:191268427:A:G	Y117H	0.963
3:191268429:T:G	K116T	0.963
3:191268426:T:C	Y117C	0.961
3:191268430:T:C	K116E	0.950
3:191268420:A:T	V119D	0.949
3:191268437:G:C	C113W	0.948
3:191268439:A:G	C113R	0.946
3:191268438:C:T	C113Y	0.943
3:191268435:A:G	F114S	0.938
3:191268423:C:T	C118Y	0.937
3:191268424:A:G	C118R	0.937
3:191268432:C:G	W115S	0.933
3:191268422:A:C	C118W	0.932
3:191268438:C:G	C113S	0.930
3:191268439:A:T	C113S	0.930
3:191268430:T:G	K116Q	0.915
3:191268423:C:G	C118S	0.912
3:191268424:A:T	C118S	0.912
3:191268426:T:G	Y117S	0.911

dbSNP variants (sampled 300 via entrez): RS1000041398 (3:191295220 C>T), RS1000068247 (3:191271913 A>C), RS1000071753 (3:191312853 A>C), RS1000091811 (3:191295503 T>C), RS1000131421 (3:191300254 T>C), RS1000143281 (3:191339032 C>G,T), RS1000255227 (3:191328910 A>C,G), RS1000262574 (3:191289364 G>A,T), RS1000265189 (3:191276334 C>A,G,T), RS1000282294 (3:191315834 T>C), RS1000300668 (3:191294191 G>T), RS1000305029 (3:191289147 C>T), RS1000356137 (3:191327617 A>C), RS1000362937 (3:191294633 A>T), RS1000363923 (3:191283634 G>T)

Disease associations

OMIM: gene MIM:618134 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST000892_2	Total ventricular volume (Alzheimer’s disease interaction)	9.000000e-06
GCST001951_1	Alzheimer’s disease biomarkers	5.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004760	t-tau measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

11 total (human), top 11 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Aflatoxin B1	decreases methylation, increases expression	2
bisphenol A	affects cotreatment, decreases methylation	1
2,2’,4,4’,5-brominated diphenyl ether	increases expression	1
belinostat	decreases expression	1
abrine	increases expression	1
NSC 689534	affects binding, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Copper	affects binding, decreases expression	1
Phenobarbital	decreases expression	1
Smoke	decreases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.