UTY

Summary

UTY (ubiquitously transcribed tetratricopeptide repeat containing, Y-linked, HGNC:12638) is a protein-coding gene on chromosome Yq11.221, encoding Histone demethylase UTY (O14607). Male-specific histone demethylase that catalyzes trimethylated ‘Lys-27’ (H3K27me3) demethylation in histone H3.

This gene encodes a protein containing tetratricopeptide repeats which are thought to be involved in protein-protein interactions. The encoded protein is also a minor histocompatibility antigen which may induce graft rejection of male stem cell grafts. A large number of alternatively spliced transcripts have been observed for this gene, but the full length nature of some of these variants has not been determined.

Source: NCBI Gene 7404 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 115 total
• MANE Select transcript: NM_001258249

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12638
Approved symbol	UTY
Name	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Location	Yq11.221
Locus type	gene with protein product
Status	Approved
Aliases	KDM6AL, KDM6C
Ensembl gene	ENSG00000183878
Ensembl biotype	protein_coding
OMIM	400009
Entrez	7404

Gene structure

Transcript identifiers

Ensembl transcripts: 27 — 19 protein_coding, 3 protein_coding_CDS_not_defined, 3 non_stop_decay, 2 nonsense_mediated_decay

ENST00000329134, ENST00000331397, ENST00000362096, ENST00000382893, ENST00000382896, ENST00000474365, ENST00000478900, ENST00000479713, ENST00000537580, ENST00000538878, ENST00000540140, ENST00000545955, ENST00000612274, ENST00000617789, ENST00000618474, ENST00000624098, ENST00000682112, ENST00000682216, ENST00000682761, ENST00000682913, ENST00000684226, ENST00000684326, ENST00000920132, ENST00000920133, ENST00000920134, ENST00000943643, ENST00000943644

RefSeq mRNA: 40 — MANE Select: NM_001258249 NM_001258249, NM_001258250, NM_001258251, NM_001258252, NM_001258253, NM_001258254, NM_001258255, NM_001258256, NM_001258257, NM_001258258, NM_001258259, NM_001258260, NM_001258261, NM_001258262, NM_001258263, NM_001258264, NM_001258265, NM_001258266, NM_001258267, NM_001258268, NM_001258269, NM_001258270, NM_001400170, NM_001400171, NM_001400173, NM_001400175, NM_001400177, NM_001400178, NM_001400181, NM_001400183, NM_001400185, NM_001400187, NM_001400189, NM_001400192, NM_001400195, NM_001400199, NM_001419806, NM_007125, NM_182659, NM_182660

CCDS: CCDS14783, CCDS14784, CCDS14785, CCDS59184, CCDS59185, CCDS76073, CCDS76074, CCDS76075, CCDS76076, CCDS76077, CCDS76078, CCDS76079, CCDS94713

Canonical transcript exons

ENST00000545955 — 30 exons

Exon	Start	End
ENSE00001696208	13355003	13355398
ENSE00001713248	13251017	13251187
ENSE00003740138	13358464	13358619
ENSE00003760914	13479254	13479317
ENSE00003761778	13260278	13260404
ENSE00003763345	13359088	13359222
ENSE00003764116	13357877	13357969
ENSE00003764349	13470121	13470229
ENSE00003765183	13306186	13306250
ENSE00003766641	13335563	13336335
ENSE00003766868	13369256	13369349
ENSE00003767034	13302877	13302991
ENSE00003767118	13410993	13411113
ENSE00003767180	13324601	13324706
ENSE00003767626	13297707	13297848
ENSE00003769216	13366267	13366393
ENSE00003769525	13449017	13449066
ENSE00003769684	13323555	13323760
ENSE00003771302	13359767	13359986
ENSE00003771339	13298957	13299144
ENSE00003771662	13326221	13326350
ENSE00003772193	13360430	13360528
ENSE00003772234	13393859	13393893
ENSE00003772506	13355923	13356018
ENSE00003772825	13396918	13396972
ENSE00003773199	13305399	13305547
ENSE00003773354	13414735	13414793
ENSE00003774613	13306038	13306112
ENSE00003919485	13248385	13249882
ENSE00003921406	13479514	13480033

Expression profiles

Bgee: expression breadth ubiquitous, 212 present calls, max score 84.12.

FANTOM5 (CAGE): breadth broad, TPM avg 9.9649 / max 239.9423, expressed in 882 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201257	9.3135	876
201256	0.3619	177
201255	0.1848	100
201253	0.1047	31

Top tissues by expression

270 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
buccal mucosa cell	CL:0002336	84.12	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	83.90	gold quality
corpus callosum	UBERON:0002336	82.34	gold quality
adrenal tissue	UBERON:0018303	82.08	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	81.37	gold quality
type B pancreatic cell	CL:0000169	81.12	gold quality
olfactory bulb	UBERON:0002264	81.06	gold quality
blood vessel layer	UBERON:0004797	79.23	gold quality
tendon of biceps brachii	UBERON:0008188	78.29	gold quality
rectum	UBERON:0001052	78.02	gold quality
right lung	UBERON:0002167	77.23	gold quality
metanephros cortex	UBERON:0010533	76.92	gold quality
epithelial cell of pancreas	CL:0000083	76.78	gold quality
prostate gland	UBERON:0002367	76.73	gold quality
cartilage tissue	UBERON:0002418	76.65	gold quality
corpus epididymis	UBERON:0004359	76.52	gold quality
tendon	UBERON:0000043	76.40	gold quality
middle frontal gyrus	UBERON:0002702	76.27	gold quality
secondary oocyte	CL:0000655	75.43	silver quality
pancreatic ductal cell	CL:0002079	75.39	silver quality
caput epididymis	UBERON:0004358	74.60	gold quality
oocyte	CL:0000023	74.36	silver quality
calcaneal tendon	UBERON:0003701	74.16	gold quality
mucosa of urinary bladder	UBERON:0001259	74.14	silver quality
cauda epididymis	UBERON:0004360	74.12	gold quality
diaphragm	UBERON:0001103	73.96	gold quality
medial globus pallidus	UBERON:0002477	73.88	gold quality
colonic epithelium	UBERON:0000397	73.36	gold quality
parietal pleura	UBERON:0002400	73.20	gold quality
oral cavity	UBERON:0000167	72.56	silver quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-109979	yes	6.89
E-ANND-3	yes	4.12
E-MTAB-6058	no	375.69

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): HAND2

Literature-anchored findings (GeneRIF, showing 7)

• UTY(KDM6C) is an active lysine demethylases and catalyzes demethylation of H3K27 peptides. (PMID:24798337)
• both UTX and UTY function as dose-dependent suppressors of urothelial bladder cancer development (PMID:27533081)
• UTY is co-regulated with KDM6A. UTY compensates for KDM6A in eutherian males and is responsible for the association between the loss of the Y chromosome and poor prognosis in a range of cancers. [review] (PMID:31097364)
• Identification of Potential Biomarkers for Intervertebral Disc Degeneration Using the Genome-Wide Expression Analysis. (PMID:31904996)
• X- and Y-Linked Chromatin-Modifying Genes as Regulators of Sex-Specific Cancer Incidence and Prognosis. (PMID:32732223)
• Increased Expression of Y-Encoded Demethylases During Differentiation of Human Male Neural Stem Cells. (PMID:33040644)
• Y-Chromosome Gene, Uty, Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines. (PMID:35504005)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	kdm6a	ENSDARG00000061759
mus_musculus	Uty	ENSMUSG00000068457
rattus_norvegicus	Uty	ENSRNOG00000060617
drosophila_melanogaster	Utx	FBGN0260749
caenorhabditis_elegans		WBGENE00007813
caenorhabditis_elegans		WBGENE00009089
caenorhabditis_elegans		WBGENE00017046
caenorhabditis_elegans		WBGENE00017571

Paralogs (2): KDM6B (ENSG00000132510), KDM6A (ENSG00000147050)

Protein

Protein identifiers

Histone demethylase UTY — O14607 (reviewed: O14607)

Alternative names: Ubiquitously-transcribed TPR protein on the Y chromosome, Ubiquitously-transcribed Y chromosome tetratricopeptide repeat protein, [histone H3]-trimethyl-L-lysine(27) demethylase UTY

All UniProt accessions (16): A0A087X0Y2, A0A087X248, O14607, A0A087X2I9, A0A096LPD8, A0A804HHT1, A0A804HI49, A0A804HJV1, A0A804HKG5, A0A804HL26, A0A8C8KHL4, A6NCS7, F4MH27, F5GWV3, F5H3N7, F5H8B4

UniProt curated annotations — full annotation on UniProt →

Function. Male-specific histone demethylase that catalyzes trimethylated ‘Lys-27’ (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity.

Subunit / interactions. Interacts with TLE1 and TLE2.

Subcellular location. Nucleus.

Similarity. Belongs to the UTX family.

Isoforms (5)

UniProt ID	Names	Canonical?
O14607-1	1, Long	yes
O14607-2	2, Short
O14607-3	3
O14607-4	4
O14607-5	5

RefSeq proteins (40): NP_001245178, NP_001245179, NP_001245180, NP_001245181, NP_001245182, NP_001245183, NP_001245184, NP_001245185, NP_001245186, NP_001245187, NP_001245188, NP_001245189, NP_001245190, NP_001245191, NP_001245192, NP_001245193, NP_001245194, NP_001245195, NP_001245196, NP_001245197, NP_001245198, NP_001245199, NP_001387099, NP_001387100, NP_001387102, NP_001387104, NP_001387106, NP_001387107, NP_001387110, NP_001387112, NP_001387114, NP_001387116, NP_001387118, NP_001387121, NP_001387124, NP_001387128, NP_001406735, NP_009056, NP_872600, NP_872601 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003347	JmjC_dom	Domain
IPR011990	TPR-like_helical_dom_sf	Homologous_superfamily
IPR019734	TPR_rpt	Repeat
IPR046941	KDM6_GATAL_sf	Homologous_superfamily
IPR048560	KDM6A_B-like_GATAL	Domain
IPR048562	KDM6A_B-like_C-hel	Domain
IPR051630	Corepressor-Demethylase	Family

Pfam: PF02373, PF13181, PF21322, PF21326

Catalyzed reactions (Rhea), 1 shown:

• N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2 (RHEA:60224)

UniProt features (93 total): helix 21, strand 19, sequence conflict 13, repeat 8, binding site 7, splice variant 6, compositionally biased region 5, region of interest 4, turn 4, mutagenesis site 3, chain 1, modified residue 1, domain 1

Structure

Experimental structures (PDB)

12 structures.

PDB	Method	Resolution (Å)
4UF0	X-RAY DIFFRACTION	1.78
5FY1	X-RAY DIFFRACTION	1.78
3ZLI	X-RAY DIFFRACTION	1.8
5FY7	X-RAY DIFFRACTION	1.86
5FXV	X-RAY DIFFRACTION	1.91
5FXZ	X-RAY DIFFRACTION	1.98
5FXX	X-RAY DIFFRACTION	1.99
3ZPO	X-RAY DIFFRACTION	2
5A1L	X-RAY DIFFRACTION	2
5FYM	X-RAY DIFFRACTION	2
5FXW	X-RAY DIFFRACTION	2.09
5FY0	X-RAY DIFFRACTION	2.14

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14607-F1	70.68	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (7): 1093; 1095; 1173; 1278; 1281; 1305; 1308

Post-translational modifications (1): 887

Mutagenesis-validated functional residues (3):

Position	Phenotype
1093	abolishes lysine demethylase activity.
1138	no effect on lysine demethylase activity.
1214	significantly higher lysine demethylase activity.

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3214842	HDMs demethylate histones

MSigDB gene sets: 144 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_UP, RRAGTTGT_UNKNOWN, GOMF_OXIDOREDUCTASE_ACTIVITY_ACTING_ON_PAIRED_DONORS_WITH_INCORPORATION_OR_REDUCTION_OF_MOLECULAR_OXYGEN, MARTINEZ_RB1_TARGETS_DN, MODULE_171, USF_01, MODULE_301, ATTACAT_MIR3803P, AACTTT_UNKNOWN, AFFAR_YY1_TARGETS_DN, MODULE_188, GOBP_CHROMATIN_REMODELING, MARTINEZ_RB1_AND_TP53_TARGETS_UP, GOBP_CIRCULATORY_SYSTEM_DEVELOPMENT, RUNNE_GENDER_EFFECT_UP

GO Biological Process (4): heart development (GO:0007507), regulation of gene expression (GO:0010468), chromatin organization (GO:0006325), chromatin remodeling (GO:0006338)

GO Molecular Function (8): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), chromatin DNA binding (GO:0031490), histone demethylase activity (GO:0032452), metal ion binding (GO:0046872), histone H3K27me2/H3K27me3 demethylase activity (GO:0071558), protein binding (GO:0005515), oxidoreductase activity (GO:0016491), dioxygenase activity (GO:0051213)

GO Cellular Component (3): nucleoplasm (GO:0005654), MLL3/4 complex (GO:0044666), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Chromatin modifying enzymes	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
animal organ development	1
circulatory system development	1
gene expression	1
regulation of macromolecule biosynthetic process	1
cellular component organization	1
chromatin organization	1
RNA polymerase II transcription regulatory region sequence-specific DNA binding	1
cis-regulatory region sequence-specific DNA binding	1
DNA binding	1
chromatin binding	1
protein demethylase activity	1
histone modifying activity	1
cation binding	1
2-oxoglutarate-dependent dioxygenase activity	1
histone H3 demethylase activity	1
binding	1
catalytic activity	1
oxidoreductase activity	1
nuclear lumen	1
cellular anatomical structure	1
histone methyltransferase complex	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

6213 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
UTY	KDM5D	Q9BY66	983
UTY	USP9Y	O00507	983
UTY	DDX3Y	O15523	982
UTY	TMSB4Y	O14604	879
UTY	RBMY1A1	P0DJD3	796
UTY	DAZ1	Q9NQZ3	795
UTY	ZFY	P08048	794
UTY	EIF1AY	O14602	791
UTY	CDY1	Q9Y6F8	764
UTY	KDM5C	P41229	753
UTY	SRY	Q05066	750
UTY	DDX3X	O00571	746
UTY	BPY2	O14599	731
UTY	RPS4Y1	P22090	727
UTY	DAZ2	Q13117	706

IntAct

8 interactions, top by confidence:

A	B	Type	Score
NCOA6	UTY	psi-mi:“MI:0914”(association)	0.530
MEP1B	UTY	psi-mi:“MI:0915”(physical association)	0.370
PRDX2	UTY	psi-mi:“MI:0915”(physical association)	0.370
UTY	KMT2D	psi-mi:“MI:0914”(association)	0.350
DYRK1A	TEX13D	psi-mi:“MI:0914”(association)	0.350
PAGR1	UTY	psi-mi:“MI:0914”(association)	0.350

BioGRID (32): UTY (Affinity Capture-MS), UTY (Affinity Capture-MS), UTY (Affinity Capture-MS), TLE1 (Two-hybrid), UTY (Reconstituted Complex), TLE2 (Two-hybrid), UTY (Proximity Label-MS), UTY (Affinity Capture-MS), UTY (Affinity Capture-MS), UTY (Affinity Capture-MS), UTY (Affinity Capture-MS), UTY (Affinity Capture-MS), WDR5 (Affinity Capture-MS), UTY (Affinity Capture-MS), HRG (Affinity Capture-MS)

ESM2 similar proteins: A2RRS8, A2VE78, A5WW08, A6NFN9, C0HAC0, D3YYM4, O14607, O17482, P79457, Q08AW4, Q0V9Y8, Q2HJ90, Q2KI79, Q2YDQ5, Q3MJ13, Q3V0L5, Q4KLV2, Q4KM95, Q562E2, Q5F479, Q5R6E1, Q5RFQ4, Q5SUS0, Q5XGI3, Q5XX13, Q6B4Z3, Q6GPJ8, Q6GQ34, Q6GQV7, Q6INS1, Q6IRU7, Q6P1H6, Q6ZPF3, Q7TP65, Q7ZVU1, Q8C0W1, Q8C2S5, Q8IVF5, Q8IW35, Q8IZM8

Diamond homologs: O14607, O15054, O15550, O70546, P79457, Q5NCY0, Q6B4Z3, Q95QK3, A0A096LPI5, O14628, Q6UX73, Q86U02, Q8N769, Q8N7M2, Q8NDZ0

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
2-oxoglutarate(2-)	“up-regulates activity”	UTY	“chemical activation”

Disease & clinical

Clinical variants and AI predictions

ClinVar

115 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	1
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

6930 predictions. Top by Δscore:

Variant	Effect	Δscore
Y:13260272:ACTC:A	donor_loss	1.0000
Y:13260273:CTCA:C	donor_loss	1.0000
Y:13260274:TCACC:T	donor_loss	1.0000
Y:13260275:CA:C	donor_loss	1.0000
Y:13260276:A:AC	donor_gain	1.0000
Y:13260276:A:C	donor_loss	1.0000
Y:13260277:C:CC	donor_gain	1.0000
Y:13260277:CCT:C	donor_gain	1.0000
Y:13260277:CCTCA:C	donor_gain	1.0000
Y:13260402:TAC:T	acceptor_gain	1.0000
Y:13260405:C:CA	acceptor_loss	1.0000
Y:13260406:T:C	acceptor_loss	1.0000
Y:13297700:CACTT:C	donor_loss	1.0000
Y:13297701:ACTTA:A	donor_loss	1.0000
Y:13297703:TTACT:T	donor_loss	1.0000
Y:13297704:TACTT:T	donor_loss	1.0000
Y:13297705:A:AC	donor_gain	1.0000
Y:13297705:AC:A	donor_loss	1.0000
Y:13297706:C:A	donor_loss	1.0000
Y:13297706:C:CT	donor_gain	1.0000
Y:13297706:CT:C	donor_gain	1.0000
Y:13297706:CTT:C	donor_gain	1.0000
Y:13297706:CTTA:C	donor_gain	1.0000
Y:13297706:CTTAA:C	donor_gain	1.0000
Y:13297709:A:AC	donor_gain	1.0000
Y:13297709:AAT:A	donor_gain	1.0000
Y:13297710:A:C	donor_gain	1.0000
Y:13297844:GCAGG:G	acceptor_gain	1.0000
Y:13297845:CAGG:C	acceptor_gain	1.0000
Y:13297845:CAGGC:C	acceptor_gain	1.0000

AlphaMissense

9514 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
Y:13298978:A:G	W1186R	1.000
Y:13298978:A:T	W1186R	1.000
Y:13298991:G:C	C1181W	1.000
Y:13298994:C:A	W1180C	1.000
Y:13298994:C:G	W1180C	1.000
Y:13298996:A:G	W1180R	1.000
Y:13298996:A:T	W1180R	1.000
Y:13299038:A:G	W1166R	1.000
Y:13299038:A:T	W1166R	1.000
Y:13299046:T:A	D1163V	1.000
Y:13302929:A:G	W1113R	1.000
Y:13302929:A:T	W1113R	1.000
Y:13302946:C:T	G1107D	1.000
Y:13302947:C:G	G1107R	1.000
Y:13302951:A:C	N1105K	1.000
Y:13302951:A:T	N1105K	1.000
Y:13305524:A:G	L1050P	1.000
Y:13305546:A:G	W1043R	1.000
Y:13305546:A:T	W1043R	1.000
Y:13323570:G:C	F990L	1.000
Y:13323570:G:T	F990L	1.000
Y:13323571:A:C	F990C	1.000
Y:13323571:A:G	F990S	1.000
Y:13323572:A:G	F990L	1.000
Y:13324609:A:G	L924P	1.000
Y:13324627:C:G	R918P	1.000
Y:13324630:A:C	I917R	1.000
Y:13324630:A:T	I917K	1.000
Y:13359839:G:C	C371W	1.000
Y:13359841:A:G	C371R	1.000

dbSNP variants (sampled 300 via entrez): RS1000048211 (Y:13320281 A>G), RS1000156757 (Y:13457049 T>A), RS1000276365 (Y:13248370 T>C,G), RS1000303520 (Y:13413410 G>C), RS1000313948 (Y:13474571 A>G), RS1000391406 (Y:13440565 G>A), RS1000424075 (Y:13441678 T>A), RS1000454898 (Y:13418372 A>G), RS1000552096 (Y:13419887 T>C), RS1000569059 (Y:13411577 C>G), RS1000760405 (Y:13448477 A>C), RS1000898520 (Y:13351067 C>T), RS1000922535 (Y:13319387 T>A), RS1001011994 (Y:13384840 A>C), RS1001080631 (Y:13386819 A>G)

Disease associations

OMIM: gene MIM:400009 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010733_4	Autism	3.000000e-09

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PubChem BioAssay actives

1 with measured affinity, of 3 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
[(5S)-5-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-6-aminohexanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-hydroxybutanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S,3R)-1-[[2-(carboxymethylamino)-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-6-oxohexyl]-trimethylazanium	1802884: AlphaScreen Assay from Article 10.1074/jbc.M114.555052: “Human UTY(KDM6C) is a male-specific N¿-methyl lysyl demethylase.”	kd	3.5000	uM

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression	2
Aflatoxin B1	increases methylation	2
FR900359	increases phosphorylation	1
trichostatin A	increases expression	1
arsenite	increases expression	1
2-bromopalmitate	decreases reaction, increases abundance, increases palmitoylation	1
potassium chromate(VI)	decreases expression	1
pentanal	decreases expression	1
abrine	increases expression	1
incobotulinumtoxinA	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Cadmium	decreases reaction, increases abundance, increases palmitoylation	1
Succimer	affects cotreatment, increases expression	1
Methyl Methanesulfonate	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Vanadates	increases expression	1
8-Bromo Cyclic Adenosine Monophosphate	decreases expression	1
Cadmium Chloride	decreases reaction, increases abundance, increases palmitoylation	1
Magnetite Nanoparticles	affects cotreatment, increases expression	1

Cellosaurus cell lines

1 cell lines: 1 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D6SS	WAe001-A-2F	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.