UVRAG-DT

Summary

UVRAG-DT (UVRAG divergent transcript, HGNC:53952) is a long non-coding RNA gene on chromosome 11q13.5.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53952
Approved symbol	UVRAG-DT
Name	UVRAG divergent transcript
Location	11q13.5
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC100506113
Ensembl gene	ENSG00000255507
Entrez	100506113
RNAcentral	URS0000A7649D — lncRNA, 689 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 89.62.

Top tissues by expression

246 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	89.62	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.03	gold quality
right testis	UBERON:0004534	88.61	gold quality
testis	UBERON:0000473	86.51	gold quality
skin of leg	UBERON:0001511	77.55	gold quality
sperm	CL:0000019	77.28	silver quality
skin of abdomen	UBERON:0001416	74.69	gold quality
buccal mucosa cell	CL:0002336	72.72	silver quality
zone of skin	UBERON:0000014	72.09	gold quality
tibialis anterior	UBERON:0001385	69.69	silver quality
hindlimb stylopod muscle	UBERON:0004252	69.49	gold quality
right uterine tube	UBERON:0001302	68.22	gold quality
ganglionic eminence	UBERON:0004023	66.86	gold quality
pancreatic ductal cell	CL:0002079	66.50	silver quality
omental fat pad	UBERON:0010414	65.95	gold quality
cortical plate	UBERON:0005343	65.94	gold quality
peritoneum	UBERON:0002358	65.88	gold quality
ventricular zone	UBERON:0003053	65.63	gold quality
monocyte	CL:0000576	65.53	gold quality
ileal mucosa	UBERON:0000331	65.26	silver quality
stromal cell of endometrium	CL:0002255	65.12	gold quality
leukocyte	CL:0000738	64.70	gold quality
adipose tissue of abdominal region	UBERON:0007808	64.56	gold quality
bone marrow cell	CL:0002092	64.43	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	64.29	gold quality
right lobe of liver	UBERON:0001114	64.23	gold quality
lower esophagus mucosa	UBERON:0035834	63.82	gold quality
subcutaneous adipose tissue	UBERON:0002190	60.48	gold quality
blood	UBERON:0000178	59.52	gold quality
gall bladder	UBERON:0002110	59.15	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	14.97
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 1 (showing top): chr11q13

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

472 predictions. Top by Δscore:

Variant	Effect	Δscore
11:75796513:G:GT	donor_gain	1.0000
11:75796529:GGAG:G	donor_gain	1.0000
11:75796530:GAG:G	donor_gain	1.0000
11:75796530:GAGG:G	donor_gain	1.0000
11:75796531:AGGTA:A	donor_loss	1.0000
11:75796532:GGTA:G	donor_loss	1.0000
11:75796533:GT:G	donor_loss	1.0000
11:75796534:T:A	donor_loss	1.0000
11:75797153:CTCA:C	acceptor_loss	1.0000
11:75797156:A:AG	acceptor_gain	1.0000
11:75797156:A:AT	acceptor_loss	1.0000
11:75797156:AG:A	acceptor_gain	1.0000
11:75797157:G:A	acceptor_loss	1.0000
11:75797157:G:GC	acceptor_gain	1.0000
11:75797157:GG:G	acceptor_gain	1.0000
11:75797157:GGT:G	acceptor_gain	1.0000
11:75797157:GGTA:G	acceptor_gain	1.0000
11:75797157:GGTAT:G	acceptor_gain	1.0000
11:75797329:ATGG:A	donor_gain	1.0000
11:75797330:TGG:T	donor_gain	1.0000
11:75797330:TGGG:T	donor_loss	1.0000
11:75797331:GG:G	donor_gain	1.0000
11:75797331:GGG:G	donor_gain	1.0000
11:75797331:GGGT:G	donor_loss	1.0000
11:75797332:GG:G	donor_gain	1.0000
11:75797333:G:C	donor_loss	1.0000
11:75797333:G:GG	donor_gain	1.0000
11:75797334:T:A	donor_loss	1.0000
11:75798224:CAG:C	acceptor_gain	1.0000
11:75798225:A:AG	acceptor_gain	1.0000

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000794020 (11:75813300 C>A,T), RS1001583691 (11:75814308 A>G), RS1001874756 (11:75816191 GTA>G,GTATA), RS1002326552 (11:75815412 G>A,C), RS1003158238 (11:75815071 GC>G), RS1003590539 (11:75816435 T>G), RS1004424924 (11:75815393 G>A,C,T), RS1004566653 (11:75813350 G>A), RS1004845275 (11:75815226 C>G,T), RS1005881723 (11:75816760 C>T), RS1006006127 (11:75816702 TCCA>T), RS1007005365 (11:75815341 T>C,G), RS1007230789 (11:75813401 C>A), RS1007262072 (11:75813908 G>T), RS1008228540 (11:75814852 C>T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

3 total (human), top 3 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
S-(1,2-dichlorovinyl)cysteine	decreases expression, decreases reaction	1
Lipopolysaccharides	decreases expression, decreases reaction	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.