VAC14-AS1

Summary

VAC14-AS1 (VAC14 antisense RNA 1, HGNC:48605) is a long non-coding RNA gene on chromosome 16q22.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48605
Approved symbol	VAC14-AS1
Name	VAC14 antisense RNA 1
Location	16q22.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000214353
Ensembl biotype	lncRNA
Entrez	100130894
RNAcentral	URS0000D77FC1 — lncRNA, 2192 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000398177, ENST00000562507, ENST00000662383, ENST00000666405

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000398177 — 6 exons

Exon	Start	End
ENSE00001531958	70771608	70773242
ENSE00001531961	70766443	70766556
ENSE00001531962	70761153	70761258
ENSE00001531964	70756013	70756087
ENSE00001531966	70755035	70755249
ENSE00002608776	70768846	70768943

Expression profiles

Bgee: expression breadth ubiquitous, 164 present calls, max score 78.44.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4467 / max 54.2742, expressed in 115 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
154901	0.2615	72
154902	0.1145	61
154904	0.0506	19
154903	0.0202	7

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	72.56	gold quality
nucleus accumbens	UBERON:0001882	72.40	gold quality
amygdala	UBERON:0001876	72.35	gold quality
hypothalamus	UBERON:0001898	71.67	gold quality
cerebellar hemisphere	UBERON:0002245	71.66	gold quality
cerebellar cortex	UBERON:0002129	71.57	gold quality
caudate nucleus	UBERON:0001873	71.09	gold quality
anterior cingulate cortex	UBERON:0009835	70.90	gold quality
sural nerve	UBERON:0015488	70.54	gold quality
cerebellum	UBERON:0002037	70.25	gold quality
right frontal lobe	UBERON:0002810	69.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.62	gold quality
bone marrow cell	CL:0002092	68.43	silver quality
putamen	UBERON:0001874	67.15	gold quality
substantia nigra	UBERON:0002038	65.38	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.23	gold quality
neocortex	UBERON:0001950	63.97	gold quality
medial globus pallidus	UBERON:0002477	63.77	silver quality
brain	UBERON:0000955	63.72	gold quality
colonic epithelium	UBERON:0000397	63.69	silver quality
temporal lobe	UBERON:0001871	63.29	gold quality
forebrain	UBERON:0001890	63.17	gold quality
midbrain	UBERON:0001891	62.97	gold quality
prefrontal cortex	UBERON:0000451	62.70	gold quality
frontal cortex	UBERON:0001870	62.61	gold quality
cerebral cortex	UBERON:0000956	62.50	gold quality
lateral globus pallidus	UBERON:0002476	61.99	silver quality
globus pallidus	UBERON:0001875	61.94	silver quality
Ammon’s horn	UBERON:0001954	61.78	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.84

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.