VASH1-AS1

Summary

VASH1-AS1 (VASH1 antisense RNA 1, HGNC:53215) is a long non-coding RNA gene on chromosome 14q24.3.

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:53215
Approved symbol	VASH1-AS1
Name	VASH1 antisense RNA 1
Location	14q24.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000258301
Entrez	100506603
RNAcentral	URS000075E224 — lncRNA, 1701 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth ubiquitous, 210 present calls, max score 93.15.

Top tissues by expression

281 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ganglionic eminence	UBERON:0004023	93.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	91.80	gold quality
apex of heart	UBERON:0002098	91.62	gold quality
cortical plate	UBERON:0005343	90.86	gold quality
right hemisphere of cerebellum	UBERON:0014890	90.16	gold quality
adenohypophysis	UBERON:0002196	89.76	gold quality
cerebellar hemisphere	UBERON:0002245	89.69	gold quality
spleen	UBERON:0002106	89.68	gold quality
cerebellar cortex	UBERON:0002129	89.52	gold quality
right frontal lobe	UBERON:0002810	89.50	gold quality
spinal cord	UBERON:0002240	88.96	gold quality
body of pancreas	UBERON:0001150	88.89	gold quality
amygdala	UBERON:0001876	88.89	gold quality
right adrenal gland	UBERON:0001233	88.57	gold quality
nucleus accumbens	UBERON:0001882	88.35	gold quality
left adrenal gland cortex	UBERON:0035825	88.23	gold quality
left adrenal gland	UBERON:0001234	87.97	gold quality
right adrenal gland cortex	UBERON:0035827	87.91	gold quality
putamen	UBERON:0001874	87.85	gold quality
pituitary gland	UBERON:0000007	87.70	gold quality
cingulate cortex	UBERON:0003027	87.41	gold quality
right atrium auricular region	UBERON:0006631	87.39	gold quality
caudate nucleus	UBERON:0001873	87.38	gold quality
anterior cingulate cortex	UBERON:0009835	87.25	gold quality
cerebellum	UBERON:0002037	87.09	gold quality
adrenal cortex	UBERON:0001235	86.72	gold quality
right lobe of liver	UBERON:0001114	86.62	gold quality
right coronary artery	UBERON:0001625	86.38	gold quality
left testis	UBERON:0004533	86.38	gold quality
ventricular zone	UBERON:0003053	86.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.90

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000214828 (14:76781825 G>A,C), RS1000749290 (14:76783573 T>C), RS1001359381 (14:76786446 G>C), RS1002700320 (14:76784173 T>C), RS1002855106 (14:76781326 C>G,T), RS1003036279 (14:76788016 G>A,T), RS1003088624 (14:76788405 G>A), RS1003633846 (14:76786212 G>A), RS1004368430 (14:76782721 T>G), RS1004815109 (14:76782657 C>T), RS1004952886 (14:76782967 G>A), RS1005171886 (14:76786036 A>G), RS1005451825 (14:76785615 A>G), RS1005621578 (14:76786320 G>A), RS1006459418 (14:76784018 T>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Particulate Matter	decreases expression, decreases reaction, increases abundance, increases expression	2
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	decreases expression, decreases reaction	1
Air Pollutants	increases abundance, increases expression	1
Vehicle Emissions	decreases expression, decreases reaction	1
Estradiol	increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Okadaic Acid	decreases expression	1
Acrylamide	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.