VAV3-AS1

Summary

VAV3-AS1 (VAV3 antisense RNA 1, HGNC:40608) is a long non-coding RNA gene on chromosome 1p13.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40608
Approved symbol	VAV3-AS1
Name	VAV3 antisense RNA 1
Location	1p13.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230489
Ensembl biotype	lncRNA
Entrez	100873946
RNAcentral	URS0000759E9F — lncRNA, 633 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 14 lncRNA

ENST00000438318, ENST00000715653, ENST00000715654, ENST00000715655, ENST00000715656, ENST00000715657, ENST00000715658, ENST00000715659, ENST00000715660, ENST00000820014, ENST00000820015, ENST00000820016, ENST00000820017, ENST00000820018

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000438318 — 3 exons

Exon	Start	End
ENSE00001672526	107994182	107994607
ENSE00001722828	107993505	107993635
ENSE00004027512	107964443	107964504

Expression profiles

Bgee: expression breadth broad, 93 present calls, max score 69.85.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.3926 / max 28.5233, expressed in 123 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
4337	0.5759	167
4340	0.1994	83
4341	0.1122	44
4339	0.0811	51

Top tissues by expression

93 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tonsil	UBERON:0002372	69.85	gold quality
lymph node	UBERON:0000029	69.09	gold quality
bone marrow cell	CL:0002092	66.36	silver quality
vermiform appendix	UBERON:0001154	61.35	gold quality
spleen	UBERON:0002106	60.88	gold quality
blood	UBERON:0000178	59.35	gold quality
granulocyte	CL:0000094	59.11	gold quality
bone marrow	UBERON:0002371	57.76	gold quality
leukocyte	CL:0000738	56.56	gold quality
calcaneal tendon	UBERON:0003701	56.26	gold quality
monocyte	CL:0000576	56.01	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	54.01	gold quality
islet of Langerhans	UBERON:0000006	53.82	gold quality
prefrontal cortex	UBERON:0000451	52.84	gold quality
liver	UBERON:0002107	52.36	gold quality
myometrium	UBERON:0001296	52.00	gold quality
gall bladder	UBERON:0002110	49.31	gold quality
descending thoracic aorta	UBERON:0002345	49.22	gold quality
muscle of leg	UBERON:0001383	47.70	silver quality
small intestine	UBERON:0002108	47.37	gold quality
multicellular organism	UBERON:0000468	47.22	gold quality
small intestine Peyer’s patch	UBERON:0003454	47.14	gold quality
gastrocnemius	UBERON:0001388	46.79	silver quality
body of pancreas	UBERON:0001150	46.54	silver quality
anterior cingulate cortex	UBERON:0009835	46.33	gold quality
left lobe of thyroid gland	UBERON:0001120	46.30	gold quality
thyroid gland	UBERON:0002046	45.86	gold quality
primary visual cortex	UBERON:0002436	45.69	silver quality
frontal cortex	UBERON:0001870	45.64	gold quality
right lobe of thyroid gland	UBERON:0001119	45.34	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	2.95

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• VAV3 rs7528153 and VAV3-AS1 rs1185222 polymorphisms are associated with an increased risk of developing hypertension. (PMID:32540412)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.