VCAN-AS1

Summary

VCAN-AS1 (VCAN antisense RNA 1, HGNC:40163) is a long non-coding RNA gene on chromosome 5q14.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:40163
Approved symbol	VCAN-AS1
Name	VCAN antisense RNA 1
Location	5q14.3
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000249835
Ensembl biotype	lncRNA
Entrez	105379054
RNAcentral	URS0000309AA2 — lncRNA, 424 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000512090, ENST00000513899

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000512090 — 3 exons

Exon	Start	End
ENSE00002038255	83534099	83534173
ENSE00002061565	83531352	83531416
ENSE00002064024	83562031	83562314

Expression profiles

Bgee: expression breadth ubiquitous, 126 present calls, max score 95.46.

Top tissues by expression

126 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
ventricular zone	UBERON:0003053	95.46	gold quality
granulocyte	CL:0000094	90.14	gold quality
calcaneal tendon	UBERON:0003701	88.78	gold quality
cortical plate	UBERON:0005343	88.34	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	85.99	gold quality
leukocyte	CL:0000738	84.78	gold quality
monocyte	CL:0000576	84.69	gold quality
corpus callosum	UBERON:0002336	84.07	gold quality
ganglionic eminence	UBERON:0004023	82.80	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.45	gold quality
bone marrow cell	CL:0002092	78.16	gold quality
blood	UBERON:0000178	78.07	gold quality
colonic epithelium	UBERON:0000397	77.95	gold quality
stromal cell of endometrium	CL:0002255	77.11	gold quality
adrenal tissue	UBERON:0018303	76.76	gold quality
endometrium	UBERON:0001295	76.28	gold quality
descending thoracic aorta	UBERON:0002345	75.52	gold quality
bone marrow	UBERON:0002371	74.80	gold quality
superior frontal gyrus	UBERON:0002661	74.42	gold quality
apex of heart	UBERON:0002098	74.06	gold quality
skeletal muscle tissue	UBERON:0001134	72.24	gold quality
muscle tissue	UBERON:0002385	71.41	gold quality
right coronary artery	UBERON:0001625	71.07	gold quality
placenta	UBERON:0001987	70.89	gold quality
ascending aorta	UBERON:0001496	70.68	gold quality
thoracic aorta	UBERON:0001515	70.63	gold quality
lymph node	UBERON:0000029	70.59	gold quality
urinary bladder	UBERON:0001255	70.07	gold quality
lung	UBERON:0002048	70.00	gold quality
right lung	UBERON:0002167	69.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.20

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA VCAN-AS1 contributes to the progression of gastric cancer via regulating p53 expression. (PMID:31637706)
• Long non-coding RNA VCAN-AS1 promotes the malignant behaviors of breast cancer by regulating the miR-106a-5p-mediated STAT3/HIF-1alpha pathway. (PMID:34365889)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.