VCF1

Summary

VCF1 (VCP nuclear cofactor family member 1, HGNC:25918) is a protein-coding gene on chromosome 17q25.1, encoding Protein VCF1 (Q969W3).

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 68 total
• GTEx eGene: eQTL in 9 tissues, sQTL in 15 (q < 0.05)
• Constraint (gnomAD): pLI 0.00 (LoF-tolerant), LOEUF 1.72 (unconstrained)
• MANE Select transcript: NM_001098832
• Notable: 68 clinical variants but no curated precision-oncology (CIViC) evidence yet

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25918
Approved symbol	VCF1
Name	VCP nuclear cofactor family member 1
Location	17q25.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ14775
Ensembl gene	ENSG00000133193
Ensembl biotype	protein_coding
OMIM	621109
Entrez	84923

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 8 protein_coding, 2 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

MANE Select: ENST00000405159

Transcript support level (Ensembl TSL; 1 = fully mRNA-supported): TSL 1: 2, TSL 2: 2, TSL 3: 2, TSL 4: 1

ENST00000405159, ENST00000403627, ENST00000579872, ENST00000580032, ENST00000581110, ENST00000583024, ENST00000583178, ENST00000923017, ENST00000947727, ENST00001079860, ENST00001119039, ENST00001142330

RefSeq mRNA: 5 — MANE Select: NM_001098832 NM_001098832, NM_001289410, NM_001289411, NM_001289412, NM_032837

CCDS: CCDS11693, CCDS45766, CCDS74143, CCDS74144

Canonical transcript exons

ENST00000405159 — 4 exons

Exon	Start	End
ENSE00003623436	73212678	73212740
ENSE00003680637	73227165	73227264
ENSE00003928165	73207365	73209768
ENSE00004800692	73232086	73232394

Expression profiles

Bgee: expression breadth ubiquitous, 255 present calls, max score 99.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.5455 / max 894.9366, expressed in 1824 samples.

Highest expression (Bgee): sperm, testis, epithelial cell of pancreas, pancreatic ductal cell, trabecular bone tissue.

Genetic regulation across tissues (GTEx eQTL / sQTL)

VCF1 is an eGene in GTEx v10 — its expression is genetically regulated (eQTL) in 9 tissues and its splicing (sQTL) in 15 (q < 0.05). Strongest associations first; slope = normalized effect of the lead variant’s alternative allele.

showing 20 of 24 significant tissue × QTL associations:

Tissue	QTL	q-value	Slope	Lead variant
Testis	eqtl	4.0e-34	+0.19	17:73191491:C:T
Cells Cultured fibroblasts	sqtl	6.8e-23	+0.57	17:73214631:C:A
Cells EBV-transformed lymphocytes	sqtl	2.7e-11	+0.55	17:73209715:A:G
Whole Blood	eqtl	3.5e-06	+0.11	17:73218611:G:A
Adipose Visceral Omentum	sqtl	1.0e-05	-0.30	17:73224313:C:T
Esophagus Muscularis	sqtl	6.0e-05	+0.36	17:73213990:T:C
Nerve Tibial	sqtl	1.1e-04	+0.30	17:73205960:C:CA
Artery Tibial	sqtl	5.9e-04	+0.29	17:73214786:C:A
Skin Sun Exposed Lower leg	sqtl	2.0e-03	+0.27	17:73214786:C:A
Prostate	eqtl	2.4e-03	-0.56	17:72596676:G:C
Whole Blood	sqtl	3.2e-03	+0.27	17:73209715:A:G
Adipose Subcutaneous	sqtl	4.4e-03	+0.25	17:73205960:C:CA
Thyroid	eqtl	5.7e-03	-0.16	17:73220935:G:T
Skin Not Sun Exposed Suprapubic	sqtl	9.7e-03	+0.26	17:73216980:T:G
Esophagus Gastroesophageal Junction	sqtl	9.8e-03	-0.34	17:73205960:C:CA
Thyroid	sqtl	1.2e-02	+0.23	17:73234964:T:C
Esophagus Mucosa	sqtl	1.4e-02	+0.28	17:73192144:C:T
Muscle Skeletal	sqtl	1.5e-02	+0.24	17:73216980:T:G
Esophagus Mucosa	eqtl	2.2e-02	+0.35	17:73949258:T:C
Lung	eqtl	2.6e-02	-0.16	17:73209891:T:C

FANTOM5 promoters

7 alternative TSS:

Promoter ID	TPM avg	Samples expressed
167899	40.0593	1822
167898	1.2761	645
167897	0.9603	534
167893	0.1904	74
167895	0.0214	4
167894	0.0212	11
167896	0.0169	4

Top tissues by expression

showing 100 of 256 tissues by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sperm	CL:0000019	99.60	gold quality
left testis	UBERON:0004533	97.90	gold quality
right testis	UBERON:0004534	97.66	gold quality
epithelial cell of pancreas	CL:0000083	97.16	gold quality
pancreatic ductal cell	CL:0002079	96.77	gold quality
testis	UBERON:0000473	96.24	gold quality
trabecular bone tissue	UBERON:0002483	94.14	gold quality
ileal mucosa	UBERON:0000331	93.37	gold quality
blood	UBERON:0000178	92.99	gold quality
bone marrow	UBERON:0002371	92.07	gold quality
upper arm skin	UBERON:0004263	91.80	gold quality
monocyte	CL:0000576	91.36	gold quality
leukocyte	CL:0000738	91.23	gold quality
gingival epithelium	UBERON:0001949	91.09	gold quality
tibialis anterior	UBERON:0001385	90.69	gold quality
oviduct epithelium	UBERON:0004804	90.49	gold quality
parotid gland	UBERON:0001831	90.41	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	89.98	gold quality
upper leg skin	UBERON:0004262	89.79	gold quality
gingiva	UBERON:0001828	89.70	gold quality
bone marrow cell	CL:0002092	88.80	gold quality
adult organism	UBERON:0007023	88.56	gold quality
nipple	UBERON:0002030	88.45	gold quality
endothelial cell	CL:0000115	88.13	gold quality
granulocyte	CL:0000094	88.08	gold quality
nasal cavity epithelium	UBERON:0005384	87.99	silver quality
skin of hip	UBERON:0001554	87.92	gold quality
calcaneal tendon	UBERON:0003701	87.57	gold quality
placenta	UBERON:0001987	87.49	gold quality
penis	UBERON:0000989	87.45	gold quality
deltoid	UBERON:0001476	87.45	silver quality
superior surface of tongue	UBERON:0007371	87.29	gold quality
stromal cell of endometrium	CL:0002255	87.26	gold quality
epithelium of nasopharynx	UBERON:0001951	87.23	gold quality
islet of Langerhans	UBERON:0000006	87.12	gold quality
synovial joint	UBERON:0002217	87.09	gold quality
left ventricle myocardium	UBERON:0006566	87.09	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	87.05	gold quality
ganglionic eminence	UBERON:0004023	86.99	gold quality
mucosa of paranasal sinus	UBERON:0005030	86.72	gold quality
germinal epithelium of ovary	UBERON:0001304	86.71	gold quality
nasal cavity mucosa	UBERON:0001826	86.59	gold quality
layer of synovial tissue	UBERON:0007616	86.43	gold quality
pharyngeal mucosa	UBERON:0000355	86.36	gold quality
vena cava	UBERON:0004087	86.32	gold quality
saphenous vein	UBERON:0007318	86.32	gold quality
tongue	UBERON:0001723	86.23	gold quality
body of tongue	UBERON:0011876	86.12	gold quality
skin of abdomen	UBERON:0001416	86.09	gold quality
zone of skin	UBERON:0000014	86.08	gold quality
epithelium of mammary gland	UBERON:0003244	86.08	gold quality
trachea	UBERON:0003126	86.05	gold quality
mammary duct	UBERON:0001765	85.98	gold quality
lymph node	UBERON:0000029	85.80	gold quality
cardia of stomach	UBERON:0001162	85.65	gold quality
skin of leg	UBERON:0001511	85.65	gold quality
endometrium	UBERON:0001295	85.46	gold quality
superficial temporal artery	UBERON:0001614	85.45	gold quality
tonsil	UBERON:0002372	85.16	gold quality
pancreas	UBERON:0001264	85.03	gold quality
cardiac muscle of right atrium	UBERON:0003379	84.85	silver quality
urethra	UBERON:0000057	84.84	gold quality
esophagus mucosa	UBERON:0002469	84.83	gold quality
gastrocnemius	UBERON:0001388	84.79	gold quality
quadriceps femoris	UBERON:0001377	84.76	silver quality
descending thoracic aorta	UBERON:0002345	84.76	gold quality
thymus	UBERON:0002370	84.75	gold quality
cortical plate	UBERON:0005343	84.75	gold quality
right coronary artery	UBERON:0001625	84.72	gold quality
tendon	UBERON:0000043	84.70	gold quality
muscle of leg	UBERON:0001383	84.68	gold quality
oocyte	CL:0000023	84.63	gold quality
ventricular zone	UBERON:0003053	84.60	gold quality
mucosa of transverse colon	UBERON:0004991	84.60	gold quality
pericardium	UBERON:0002407	84.59	gold quality
palpebral conjunctiva	UBERON:0001812	84.57	gold quality
amniotic fluid	UBERON:0000173	84.56	gold quality
mammary gland	UBERON:0001911	84.56	gold quality
vastus lateralis	UBERON:0001379	84.52	silver quality
thoracic mammary gland	UBERON:0005200	84.49	gold quality
hindlimb stylopod muscle	UBERON:0004252	84.41	gold quality
mammalian vulva	UBERON:0000997	84.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	84.34	gold quality
adipose tissue	UBERON:0001013	84.31	gold quality
Brodmann (1909) area 23	UBERON:0013554	84.27	gold quality
material anatomical entity	UBERON:0000465	84.25	gold quality
anatomical system	UBERON:0000467	84.24	gold quality
multicellular organism	UBERON:0000468	84.24	gold quality
adenohypophysis	UBERON:0002196	84.22	gold quality
pigmented layer of retina	UBERON:0001782	84.15	gold quality
vermiform appendix	UBERON:0001154	84.10	gold quality
fallopian tube	UBERON:0003889	84.06	gold quality
body of pancreas	UBERON:0001150	84.02	gold quality
popliteal artery	UBERON:0002250	84.01	gold quality
tibial artery	UBERON:0007610	84.01	gold quality
lower lobe of lung	UBERON:0008949	83.93	gold quality
mucosa of stomach	UBERON:0001199	83.92	gold quality
aorta	UBERON:0000947	83.87	gold quality
primary visual cortex	UBERON:0002436	83.87	gold quality
vagina	UBERON:0000996	83.84	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-GEOD-134144	yes	28.58
E-MTAB-10042	yes	25.83
E-HCAD-10	no	1.94
E-ANND-3	no	0.00

HPA expression

RNA tissue specificity: Tissue enhanced

showing 60 of 74 HPA tissues / cells by nTPM:

Tissue / cell	Axis	nTPM	Protein (IHC)
Testis	tissue	72.4	medium
Bone marrow	tissue	42.4	not detected
Thymus	tissue	19.5
Stomach 1	tissue	19.4	not detected
Nucleus accumbens	tissue	19.1
Putamen	tissue	17.9
Ventral pallidum	tissue	17.8
Septum	tissue	17.6
Choroid plexus	tissue	17.4
Midbrain	tissue	17.4
Cerebral cortex	tissue	17.3	medium
Superior colliculi	tissue	17.3
Somatosensory cortex	tissue	17.3
Occipital cortex	tissue	17.3
Basal ganglia	tissue	17.2	high
Hypothalamus	tissue	17.1
Skin 1	tissue	17.0	low
Prefrontal cortex	tissue	17.0
Motor cortex	tissue	16.9
Postcentral gyrus	tissue	16.9
Thalamus	tissue	16.8
Hippocampus	tissue	16.8	low
Lymph node	tissue	16.7	medium
Pons	tissue	16.5
Spinal cord	tissue	16.4
Hippocampal formation	tissue	16.1
Entorhinal cortex	tissue	16.1
Spleen	tissue	16.0	low
Placenta	tissue	15.9	medium
Tonsil	tissue	15.9	low
Medulla oblongata	tissue	15.7
Substantia nigra	tissue	15.7
Cerebellum	tissue	15.6	high
Locus coeruleus	tissue	15.5
Cingulate cortex	tissue	15.5
Retrosplenial cortex	tissue	15.3
Corpus callosum	tissue	15.2
Temporal cortex	tissue	15.1
Pituitary gland	tissue	14.9
Periaqueductal gray	tissue	14.8
Olfactory bulb	tissue	13.9
Amygdala	tissue	13.8
Cervix	tissue	13.6	not detected
Insular cortex	tissue	13.6
Appendix	tissue	13.5	low
Vagina	tissue	13.4	not detected
Retina	tissue	13.0
Breast	tissue	12.8	not detected
Adipose tissue	tissue	12.5	not detected
Colon	tissue	12.5	low
Urinary bladder	tissue	12.3	not detected
Prostate	tissue	11.9	low
Epididymis	tissue	11.8	not detected
Duodenum	tissue	11.8	medium
Esophagus	tissue	11.7	low
Rectum	tissue	11.7	not detected
Parathyroid gland	tissue	11.5
Tongue	tissue	11.3
Ovary	tissue	11.1	not detected
Skeletal muscle	tissue	11.0	not detected

Brain sub-regions (HPA Brain Atlas): detected in 191; highest nTPM — Cerebellar cortex (28.7), Flocculonodular lobe (26.0), Vermis (25.3), Somatomor cortex, precentral gyrus (white matter) (21.2), Postcentral gyrus, middle (20.5).

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

Targeting VCF1 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific).

showing 30 of 127 miRNAs:

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3162-3P	100.00	65.37	363
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-186-5P	99.99	70.83	3707
HSA-LET-7A-5P	99.98	72.29	1790
HSA-LET-7B-5P	99.98	72.31	1790
HSA-LET-7C-5P	99.98	72.29	1790
HSA-LET-7E-5P	99.98	72.29	1790
HSA-LET-7F-5P	99.98	72.56	1784
HSA-LET-7G-5P	99.98	72.37	1784
HSA-LET-7I-5P	99.98	72.37	1788
HSA-MIR-98-5P	99.98	72.33	1787
HSA-MIR-607	99.97	73.62	5593
HSA-LET-7D-5P	99.96	71.76	1632
HSA-MIR-4458	99.96	71.64	1650
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-145-5P	99.92	71.13	1836
HSA-MIR-5195-3P	99.92	70.92	1877
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-3671	99.90	73.04	3897
HSA-MIR-6499-3P	99.90	66.38	1212
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-4697-3P	99.89	67.09	1123
HSA-MIR-30A-3P	99.87	69.74	2928

Functional genomics

gnomAD constraint: pLI 2.89e-05, LOEUF 1.72, missense Z -1.19 — population loss-of-function intolerance (pLI ≥ 0.9 = LoF-intolerant; lower LOEUF = more constrained). gnomAD

Regional missense constraint (gnomAD RMC): no regional variation along ENST00000405159 — one region, missense o/e 1.06.

Literature-anchored findings (GeneRIF, showing 1)

• The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. (PMID:37713320)

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
rattus_norvegicus	Vcf1	ENSRNOG00000002851
drosophila_melanogaster	CG31898	FBGN0051898

Mouse-model phenotypes

Observed phenotypes of the mouse ortholog (MGI:106351) from MGI (Alliance of Genome Resources) — knockout/mutant phenotypes, ranked by annotation count. 2 distinct phenotype terms.

Mouse phenotype (MP)	Records
abnormal behavior	1
increased circulating aspartate transaminase level	1

Genomic neighbors (locus context)

Genes flanking this one on the chromosome (NCBI/Entrez gene neighborhood). Positional context only — some neighbors share regulatory elements (bidirectional promoters, antisense/overlapping transcripts), but chromosomal adjacency is not itself a functional relationship (see Interactions for that).

Symbol	Type	Entrez
SDK2-AS1	ncRNA	101928251
CDC42EP4	protein-coding	23580
SDK2	protein-coding	54549
MTNAP1	protein-coding	55028
CPSF4L	protein-coding	642843
COG1	protein-coding	9382
SSTR2	protein-coding	6752
SLC39A11	protein-coding	201266

Protein

Protein identifiers

Protein VCF1 — Q969W3 (reviewed: Q969W3)

Alternative names: VCP nuclear cofactor family member 1

All UniProt accessions (4): J3KSI9, J3KT52, J3KT76, Q969W3

UniProt curated annotations — full annotation on UniProt →

Similarity. Belongs to the VCF family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q969W3-1	1	yes
Q969W3-2	2

RefSeq proteins (5): NP_001092302, NP_001276339, NP_001276340, NP_001276341, NP_116226 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR029222	VCF1/2-like	Family

Pfam: PF15434

UniProt features (8 total): compositionally biased region 4, chain 1, region of interest 1, modified residue 1, splice variant 1

Structure

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q969W3-F1	62.96	0.10

Human Protein Atlas

Protein class: Predicted intracellular proteins

Protein evidence: Evidence at protein level

Subcellular location (HPA, imaging): nucleoplasm; cytosol

Antibody reliability (HPA): IH approved · IF approved

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1)

Type	Positions
Omega-n-methylarginine	4

Function

Pathways and Gene Ontology

Reactome pathways

0 curated (TAS) of 0; 0 disease pathways. Curated-first; evidence = TAS (manually curated) vs IEA (electronic inference).

MSigDB gene sets: 130 (showing top): RNGTGGGC_UNKNOWN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GTGCCTT_MIR506, ATTCTTT_MIR186, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, TGCCTTA_MIR124A, ALCALA_APOPTOSIS, SCGGAAGY_ELK1_02, YOSHIMURA_MAPK8_TARGETS_DN, ATGAAGG_MIR205, GAGCCAG_MIR149, FEV_TARGET_GENES, IRF5_TARGET_GENES, NCOA2_TARGET_GENES, NFKBIA_TARGET_GENES

GO Molecular Function (1): protein binding (GO:0005515)

GO top-level categories

1 GO namespaces:

Category	Terms
binding	1

Protein interactions and networks

STRING

showing 15 of 276 interactions by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
VCF1	CCDC127	Q96BQ5	853
VCF1	SUPT7L	O94864	814
VCF1	CNOT10	Q9H9A5	804
VCF1	TADA2B	Q86TJ2	792
VCF1	MTO1	Q9Y2Z2	769
VCF1	XPNPEP1	Q9NQW7	751
VCF1	AARS1	P49588	731
VCF1	ASB7	Q9H672	674
VCF1	CSNK2A2	P19784	661
VCF1	ASB10	Q8WXI3	494
VCF1	TBP	P20226	403
VCF1	AARS2	Q5JTZ9	369
VCF1	SHISAL2A	Q6UWV7	364
VCF1	FAM209A	Q5JX71	303
VCF1	XPNPEP2	O43895	302

IntAct

Human interaction partners of VCF1 in IntAct, one row per partner (best MIscore; records = supporting IntAct interaction records).

5 partners by confidence:

Partner	Interaction type	MIscore	Records
VCP	physical association	0.850	9
UBXN2B	physical association	0.670	3
PRKACA	physical association	0.560	3
SERPINH1	physical association	0.560	3
TGFBR2	physical association	0.560	3

Disease & clinical

Genetic variants

Variant evidence for VCF1: 68 ClinVar records (0 pathogenic / likely pathogenic); 7 GWAS associations.

ClinVar

68 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	57
Likely benign	3
Benign	0

SpliceAI

Top 10 splice-impact sites by Δscore (adjacent positions with the same effect merged into one range; 29 predictions of 372):

Position(s)	Effect	Δscore	Sites
17:73209769–73209770	acceptor_loss	1.0000	6
17:73227163–73227164	donor_loss	1.0000	6
17:73227265–73227266	acceptor_loss	0.9900	5
17:73232077	donor_gain	0.9900
17:73232084–73232085	donor_loss	0.9900	5
17:73227165	donor_loss	0.9800	2
17:73227265	acceptor_loss	0.9800
17:73227271	acceptor_gain	0.9700
17:73227160	donor_gain	0.9600
17:73227280	acceptor_gain	0.9400

AlphaMissense

211 missense substitutions predicted likely pathogenic (of 1,357 scored), across 56 residues. Top 20 hotspot residues, ranked by the number of likely-pathogenic substitutions (of those reachable by a single-nucleotide change), then by mean score:

Residue	Likely-pathogenic substitutions	Mean am_pathogenicity	Max am_pathogenicity
H174	8	0.966	0.989
N167	8	0.917	0.984
S177	8	0.900	0.990
F175	7	0.976	0.994
I166	7	0.912	0.993
K92	6	0.944	0.980
K75	6	0.925	0.966
R76	6	0.912	0.977
R171	6	0.879	0.963
A173	6	0.877	0.990
E172	6	0.723	0.889
Y163	5	0.944	0.972
L170	5	0.939	0.991
R93	5	0.899	0.965
R74	5	0.849	0.892
L178	5	0.834	0.982
W104	5	0.831	0.904
R78	5	0.819	0.906
R77	5	0.767	0.889
D105	5	0.734	0.844

HPA cancer prognostics

RNA cancer specificity: Low cancer specificity

Human Protein Atlas survival analysis — favorable = higher expression predicts better survival.

2 prognostic cancer types:

Cancer	Prognostic	p-value
Liver Hepatocellular Carcinoma (TCGA)	unfavorable	1.29e-07
Prostate Adenocarcinoma (TCGA)	unfavorable	0.00099

Disease associations

OMIM: gene MIM:621109 | disease phenotypes:

GWAS associations

7 associations:

Study	Trait	p-value
GCST90002396_192	Mean reticulocyte volume	3e-22
GCST90002397_48	Mean spheric corpuscular volume	1e-19
GCST90002404_449	Red cell distribution width	1e-17
GCST90002392_280	Mean corpuscular volume	2e-16
GCST90002390_303	Mean corpuscular hemoglobin	6e-15
GCST90002405_121	Reticulocyte count	9e-11
GCST90002403_81	Red blood cell count	2e-10

EFO canonical traits (from GWAS)

5 canonical traits:

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0010701	mean reticulocyte volume
EFO:0004305	erythrocyte count
EFO:0009188	Red cell distribution width
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (CPIC guideline: no)

CTD chemical–gene interactions

14 total (human), top 14 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, increases abundance, increases expression, decreases expression	3
Valproic Acid	affects expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
methacrylaldehyde	affects cotreatment, increases expression, increases abundance	1
jinfukang	affects cotreatment, increases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Ozone	affects cotreatment, increases expression, increases abundance	1
Smoke	decreases expression	1
Cyclosporine	increases expression	1
Volatile Organic Compounds	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

Via MONDO — disease-level, not drug-specific.