VESTAR

Summary

VESTAR (VEGFC mRNA stability associated lncRNA, HGNC:28325) is a long non-coding RNA gene on chromosome 14q32.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28325
Approved symbol	VESTAR
Name	VEGFC mRNA stability associated lncRNA
Location	14q32.33
Locus type	RNA, long non-coding
Status	Approved
Aliases	MGC23270
Ensembl gene	ENSG00000258701
Ensembl biotype	lncRNA
Entrez	196872
RNAcentral	URS00001B915D — lncRNA, 2518 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 lncRNA

ENST00000555578

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000555578 — 1 exons

Exon	Start	End
ENSE00002477759	104821201	104823718

Expression profiles

Bgee: expression breadth ubiquitous, 143 present calls, max score 71.51.

Top tissues by expression

229 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	71.51	gold quality
gingival epithelium	UBERON:0001949	70.66	gold quality
colonic epithelium	UBERON:0000397	70.55	gold quality
stromal cell of endometrium	CL:0002255	66.11	gold quality
buccal mucosa cell	CL:0002336	66.00	gold quality
gingiva	UBERON:0001828	65.26	gold quality
vena cava	UBERON:0004087	65.04	gold quality
tibia	UBERON:0000979	64.07	silver quality
germinal epithelium of ovary	UBERON:0001304	63.37	gold quality
quadriceps femoris	UBERON:0001377	62.86	gold quality
vastus lateralis	UBERON:0001379	62.82	gold quality
ventricular zone	UBERON:0003053	62.23	gold quality
skeletal muscle tissue	UBERON:0001134	61.16	gold quality
amniotic fluid	UBERON:0000173	61.08	gold quality
skin of hip	UBERON:0001554	60.88	silver quality
bone marrow	UBERON:0002371	60.85	gold quality
trabecular bone tissue	UBERON:0002483	60.71	gold quality
tonsil	UBERON:0002372	60.68	gold quality
epithelium of nasopharynx	UBERON:0001951	60.67	gold quality
mucosa of sigmoid colon	UBERON:0004993	60.63	gold quality
pericardium	UBERON:0002407	60.30	gold quality
granulocyte	CL:0000094	60.00	gold quality
palpebral conjunctiva	UBERON:0001812	59.78	gold quality
colonic mucosa	UBERON:0000317	59.56	silver quality
corpus callosum	UBERON:0002336	59.43	gold quality
nipple	UBERON:0002030	59.38	gold quality
placenta	UBERON:0001987	59.36	gold quality
inferior vagus X ganglion	UBERON:0005363	59.27	gold quality
decidua	UBERON:0002450	59.24	silver quality
saphenous vein	UBERON:0007318	59.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.11

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• [The low expression of long non-coding RNA Linc00638 contributes to rheumatoid arthritis progression by regulating inflammation and oxidative stress]. (PMID:34308844)
• Expression of LINC00638 in rheumatoid arthritis patients with damp-heat obstruction syndrome and the regulatory mechanisms for inflammation and oxidative stress.", trans “LINC00638. (PMID:35545408)
• Overexpression of long noncoding RNA LINC00638 inhibits inflammation and oxidative stress in rheumatoid arthritis fibroblast-like synoviocytes by regulating the Nrf2/HO-1 pathway. (PMID:35759235)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.