VHRT

Summary

VHRT (ventricular heart development associated lncRNA, HGNC:50688) is a long non-coding RNA gene on chromosome 12q24.11.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50688
Approved symbol	VHRT
Name	ventricular heart development associated lncRNA
Location	12q24.11
Locus type	RNA, long non-coding
Status	Approved
Aliases	MASCC1, RP1-46F2.2
Ensembl gene	ENSG00000185847
Ensembl biotype	lncRNA
Entrez	100131138
RNAcentral	URS000075E0AF — lncRNA, 374 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000331096, ENST00000547607, ENST00000548368, ENST00000553177, ENST00000652865, ENST00000654512, ENST00000657482, ENST00000658431, ENST00000658709, ENST00000666099, ENST00000686735, ENST00000691265, ENST00000691467, ENST00000781012, ENST00000781013, ENST00000781014, ENST00000781015, ENST00000781016, ENST00000781017, ENST00000781018, ENST00000781019, ENST00000781020, ENST00000781021

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000331096 — 2 exons

Exon	Start	End
ENSE00001372364	110936602	110936698
ENSE00004152748	110937185	110937451

Expression profiles

Bgee: expression breadth ubiquitous, 170 present calls, max score 99.24.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5228 / max 39.3256, expressed in 110 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
128015	0.4025	100
128014	0.1203	61

Top tissues by expression

247 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	99.24	gold quality
biceps brachii	UBERON:0001507	99.11	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	99.07	gold quality
vastus lateralis	UBERON:0001379	98.13	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.03	gold quality
quadriceps femoris	UBERON:0001377	97.36	gold quality
skeletal muscle tissue	UBERON:0001134	96.46	gold quality
muscle of leg	UBERON:0001383	96.24	gold quality
gastrocnemius	UBERON:0001388	96.19	gold quality
body of tongue	UBERON:0011876	93.81	gold quality
deltoid	UBERON:0001476	93.48	gold quality
apex of heart	UBERON:0002098	93.12	gold quality
muscle tissue	UBERON:0002385	89.39	gold quality
tibialis anterior	UBERON:0001385	89.25	silver quality
heart left ventricle	UBERON:0002084	88.29	gold quality
cardiac ventricle	UBERON:0002082	87.85	gold quality
tongue	UBERON:0001723	85.70	gold quality
left ventricle myocardium	UBERON:0006566	81.39	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.48	silver quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.14	gold quality
heart right ventricle	UBERON:0002080	77.65	gold quality
superior surface of tongue	UBERON:0007371	76.76	gold quality
heart	UBERON:0000948	73.96	gold quality
trabecular bone tissue	UBERON:0002483	73.91	gold quality
ganglionic eminence	UBERON:0004023	72.38	gold quality
myocardium	UBERON:0002349	70.37	silver quality
cortical plate	UBERON:0005343	70.04	gold quality
sural nerve	UBERON:0015488	68.66	silver quality
ventricular zone	UBERON:0003053	62.49	gold quality
pharyngeal mucosa	UBERON:0000355	61.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.61

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• In-silico and in-vitro evidence suggest LINC01405 as a sponge for miR-29b and miR-497-5p, and a potential regulator of Wnt, PI3K, and TGFB signaling pathways in breast carcinoma. (PMID:38225865)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.