VIM-AS1

Summary

VIM-AS1 (VIM antisense RNA 1, HGNC:44879) is a long non-coding RNA gene on chromosome 10p13.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44879
Approved symbol	VIM-AS1
Name	VIM antisense RNA 1
Location	10p13
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000229124
Ensembl biotype	lncRNA
OMIM	619982
Entrez	100507347
RNAcentral	URS000075B948 — lncRNA, 1883 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 10 lncRNA

ENST00000437232, ENST00000605833, ENST00000661048, ENST00000664157, ENST00000741279, ENST00000741280, ENST00000741281, ENST00000741282, ENST00000741283, ENST00000741284

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000437232 — 4 exons

Exon	Start	End
ENSE00001666614	17217602	17217675
ENSE00001724053	17214239	17215364
ENSE00001747070	17226856	17226898
ENSE00001801662	17216167	17216274

Expression profiles

Bgee: expression breadth ubiquitous, 135 present calls, max score 95.90.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 11.2659 / max 277.2304, expressed in 1508 samples.

FANTOM5 promoters (6 alternative TSS)

Promoter ID	TPM avg	Samples expressed
108514	8.9999	1494
108497	1.2460	156
108498	0.7115	147
108495	0.1447	51
108499	0.0958	21
108496	0.0680	29

Top tissues by expression

137 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	95.90	gold quality
leukocyte	CL:0000738	95.40	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	90.27	gold quality
granulocyte	CL:0000094	89.12	gold quality
blood	UBERON:0000178	88.28	gold quality
spleen	UBERON:0002106	81.86	gold quality
bone marrow cell	CL:0002092	80.25	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	80.10	gold quality
bone marrow	UBERON:0002371	78.87	gold quality
lymph node	UBERON:0000029	78.21	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.51	gold quality
right uterine tube	UBERON:0001302	77.38	gold quality
endometrium	UBERON:0001295	76.36	gold quality
vermiform appendix	UBERON:0001154	75.85	gold quality
right lobe of thyroid gland	UBERON:0001119	75.67	gold quality
fallopian tube	UBERON:0003889	75.23	gold quality
thyroid gland	UBERON:0002046	75.12	gold quality
left lobe of thyroid gland	UBERON:0001120	74.95	gold quality
body of pancreas	UBERON:0001150	74.86	gold quality
left uterine tube	UBERON:0001303	74.28	gold quality
popliteal artery	UBERON:0002250	74.07	gold quality
tibial artery	UBERON:0007610	74.07	gold quality
thymus	UBERON:0002370	73.63	gold quality
descending thoracic aorta	UBERON:0002345	73.52	gold quality
right lung	UBERON:0002167	73.18	gold quality
upper lobe of left lung	UBERON:0008952	72.67	gold quality
endocervix	UBERON:0000458	72.21	gold quality
thoracic aorta	UBERON:0001515	72.10	gold quality
ascending aorta	UBERON:0001496	72.05	gold quality
lung	UBERON:0002048	72.00	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9543	yes	49439.53
E-ANND-3	yes	6.40

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 8)

• VIM-AS1 was significantly upregulated in high-grade colorectal cancer. (PMID:29656793)
• lncRNA VIM-AS1 and lncRNA CTBP1-AS2 expression levels are associated with type 2 diabetes susceptibility. (PMID:30506719)
• lncRNA VIM-AS1 was overexpressed in prostate cancer (PCa) tissues and cell lines and promoted PCa proliferation and metastasis via epithelial-mesenchymal transition through regulating vimentin, which might provide a novel target for the diagnosis and therapy for PCa. (PMID:31786880)
• Long non-coding RNA VIM Antisense RNA 1 (VIM-AS1) sponges microRNA-29 to participate in diabetic retinopathy. (PMID:32447557)
• Knockdown of long non-coding RNA VIM-AS1 inhibits glioma cell proliferation and migration, and increases the cell apoptosis via modulation of WEE1 targeted by miR-105-5p. (PMID:32633376)
• lncRNA VIMAS1 promotes cell proliferation, metastasis and epithelialmesenchymal transition by activating the Wnt/betacatenin pathway in gastric cancer. (PMID:33173977)
• Clinical significance of Vimentin Antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers. (PMID:35202907)
• VIMAS1 promotes proliferation and drives enzalutamide resistance in prostate cancer via IGF2BP2mediated HMGCS1 mRNA stabilization. (PMID:36734275)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.