VLDLR-AS1

Summary

VLDLR-AS1 (VLDLR antisense RNA 1, HGNC:49621) is a long non-coding RNA gene on chromosome 9p24.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:49621
Approved symbol	VLDLR-AS1
Name	VLDLR antisense RNA 1
Location	9p24.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	lincRNA-VLDLR
Ensembl gene	ENSG00000236404
Ensembl biotype	lncRNA
Entrez	401491
RNAcentral	URS00008121F7 — lncRNA, 928 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 45 — 45 lncRNA

ENST00000416826, ENST00000424605, ENST00000447278, ENST00000453601, ENST00000648733, ENST00000653026, ENST00000653709, ENST00000655564, ENST00000657269, ENST00000657742, ENST00000667661, ENST00000668403, ENST00000671040, ENST00000691704, ENST00000742983, ENST00000742984, ENST00000742985, ENST00000742986, ENST00000742987, ENST00000742988, ENST00000742989, ENST00000742990, ENST00000742991, ENST00000742992, ENST00000742993, ENST00000742994, ENST00000742995, ENST00000742996, ENST00000742997, ENST00000742998, ENST00000742999, ENST00000743000, ENST00000743001, ENST00000743002, ENST00000743003, ENST00000743004, ENST00000743005, ENST00000743006, ENST00000743007, ENST00000743008, ENST00000743009, ENST00000743010, ENST00000743011, ENST00000743012, ENST00000743013

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000416826 — 11 exons

Exon	Start	End
ENSE00001635383	2425397	2425540
ENSE00001663423	2493075	2493180
ENSE00001691185	2621229	2621413
ENSE00001700269	2494180	2494302
ENSE00001706556	2521903	2522046
ENSE00001718137	2422702	2424510
ENSE00001725706	2536359	2536453
ENSE00001745481	2523053	2523157
ENSE00001754823	2525538	2525717
ENSE00001761445	2506419	2506540
ENSE00002071092	2539399	2539552

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 86.90.

FANTOM5 (CAGE): breadth broad, TPM avg 2.0462 / max 86.6803, expressed in 749 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
99742	1.5766	617
99743	0.3536	195
99744	0.0827	32
99741	0.0333	19

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	86.90	gold quality
apex of heart	UBERON:0002098	86.67	gold quality
left ovary	UBERON:0002119	85.10	gold quality
cortical plate	UBERON:0005343	84.74	gold quality
colonic epithelium	UBERON:0000397	83.50	gold quality
secondary oocyte	CL:0000655	83.43	gold quality
right atrium auricular region	UBERON:0006631	83.12	gold quality
cardiac atrium	UBERON:0002081	82.26	gold quality
right ovary	UBERON:0002118	80.20	gold quality
heart left ventricle	UBERON:0002084	79.56	gold quality
cardiac ventricle	UBERON:0002082	78.97	gold quality
ovary	UBERON:0000992	78.44	gold quality
heart	UBERON:0000948	77.13	gold quality
hindlimb stylopod muscle	UBERON:0004252	77.03	gold quality
mucosa of transverse colon	UBERON:0004991	76.37	gold quality
islet of Langerhans	UBERON:0000006	72.80	gold quality
cerebellar hemisphere	UBERON:0002245	71.15	gold quality
cerebellar cortex	UBERON:0002129	71.04	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.97	gold quality
right hemisphere of cerebellum	UBERON:0014890	70.74	gold quality
myocardium	UBERON:0002349	69.56	gold quality
adipose tissue	UBERON:0001013	69.20	gold quality
cerebellum	UBERON:0002037	68.92	gold quality
ganglionic eminence	UBERON:0004023	68.90	gold quality
pancreas	UBERON:0001264	68.87	gold quality
muscle of leg	UBERON:0001383	68.82	gold quality
adipose tissue of abdominal region	UBERON:0007808	68.44	gold quality
omental fat pad	UBERON:0010414	68.23	gold quality
spinal cord	UBERON:0002240	68.19	gold quality
gastrocnemius	UBERON:0001388	68.15	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-11268	yes	792.32
E-ANND-3	yes	6.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• linc-VLDLR is identified as an EV-enriched lncRNA that contributes to cellular stress responses. (PMID:24874432)
• High expression of Linc-VLDLR and ABCG2 gene in esophageal cancer cells affected the formation of esophageal cancer drug resistance (PMID:30606658)
• Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans. (PMID:38338752)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.