VN1R5

Summary

VN1R5 (vomeronasal 1 receptor 5 (gene/pseudogene), HGNC:19870) is a protein-coding gene on chromosome 1q44, encoding Vomeronasal type-1 receptor 5 (Q7Z5H4). Putative pheromone receptor.

Predicted to enable pheromone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in plasma membrane.

Source: NCBI Gene 317705 — RefSeq curated summary.

At a glance

• GWAS associations: 1

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:19870
Approved symbol	VN1R5
Name	vomeronasal 1 receptor 5 (gene/pseudogene)
Location	1q44
Locus type	gene with protein product
Status	Approved
Aliases	V1RL5
Ensembl gene	ENSG00000197617
Ensembl biotype	protein_coding
Entrez	317705

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding_LoF

ENST00000472952

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000472952 — 1 exons

Exon	Start	End
ENSE00001810682	247255972	247257210

Expression profiles

Bgee: expression breadth tissue_specific, 3 present calls, max score 43.37.

Top tissues by expression

189 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	43.37	gold quality
middle temporal gyrus	UBERON:0002771	42.71	gold quality
secondary oocyte	CL:0000655	42.57	gold quality
oviduct epithelium	UBERON:0004804	42.52	gold quality
colonic epithelium	UBERON:0000397	41.81	gold quality
vastus lateralis	UBERON:0001379	41.41	gold quality
quadriceps femoris	UBERON:0001377	41.37	gold quality
superficial temporal artery	UBERON:0001614	41.33	gold quality
palpebral conjunctiva	UBERON:0001812	41.10	gold quality
mucosa of paranasal sinus	UBERON:0005030	40.98	gold quality
bone marrow cell	CL:0002092	40.82	gold quality
amniotic fluid	UBERON:0000173	40.69	gold quality
upper leg skin	UBERON:0004262	40.65	silver quality
jejunal mucosa	UBERON:0000399	40.59	gold quality
biceps brachii	UBERON:0001507	40.57	gold quality
cortical plate	UBERON:0005343	40.57	silver quality
epithelium of nasopharynx	UBERON:0001951	40.45	gold quality
myocardium	UBERON:0002349	40.45	gold quality
gingival epithelium	UBERON:0001949	40.43	gold quality
germinal epithelium of ovary	UBERON:0001304	40.33	gold quality
esophagus squamous epithelium	UBERON:0006920	40.29	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	40.27	gold quality
jejunum	UBERON:0002115	40.18	gold quality
cartilage tissue	UBERON:0002418	40.06	gold quality
mammary duct	UBERON:0001765	39.98	gold quality
mucosa of sigmoid colon	UBERON:0004993	39.95	gold quality
deltoid	UBERON:0001476	39.83	gold quality
saphenous vein	UBERON:0007318	39.83	gold quality
parotid gland	UBERON:0001831	39.81	gold quality
oocyte	CL:0000023	39.80	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ENAD-17	no	27.84
E-ANND-3	no	0.81

Regulation

Is transcription factor: no

Cross-species orthologs

91 orthologs

Organism	Symbol	Gene ID
danio_rerio	ora1	ENSDARG00000098601
mus_musculus	Vmn1r45	ENSMUSG00000044248
mus_musculus	Vmn1r54	ENSMUSG00000047203
mus_musculus	Vmn1r26	ENSMUSG00000048697
mus_musculus	Vmn1r48	ENSMUSG00000057592
mus_musculus	Vmn1r53	ENSMUSG00000057697
mus_musculus	Vmn1r12	ENSMUSG00000057981
mus_musculus	Vmn1r33	ENSMUSG00000059375
mus_musculus	Vmn1r35	ENSMUSG00000060699
mus_musculus	Vmn1r47	ENSMUSG00000060724
mus_musculus	Vmn1r52	ENSMUSG00000060816
mus_musculus	Vmn1r8	ENSMUSG00000061208
mus_musculus	Vmn1r46	ENSMUSG00000061653
mus_musculus	V1ra8	ENSMUSG00000062546
mus_musculus	Vmn1r51	ENSMUSG00000062818
mus_musculus	Vmn1r32	ENSMUSG00000062905
mus_musculus	Vmn1r13	ENSMUSG00000064259
mus_musculus	Vmn1r239-ps	ENSMUSG00000067262
mus_musculus	Vmn1r43	ENSMUSG00000068231
mus_musculus	Vmn1r42	ENSMUSG00000068232
mus_musculus	Vmn1r44	ENSMUSG00000068234
mus_musculus	Vmn1r27	ENSMUSG00000071428
mus_musculus	Vmn1r4	ENSMUSG00000071893
mus_musculus	Vmn1r5	ENSMUSG00000090346
mus_musculus	Vmn1r34	ENSMUSG00000091012
mus_musculus	Vmn1r1	ENSMUSG00000091013
mus_musculus	Vmn1r18	ENSMUSG00000091382
mus_musculus	Vmn1r9	ENSMUSG00000091541
mus_musculus	Vmn1r29	ENSMUSG00000091734
mus_musculus	Vmn1r23	ENSMUSG00000093376
mus_musculus	Vmn1r7	ENSMUSG00000093696
mus_musculus	Vmn1r39	ENSMUSG00000093755
mus_musculus	Vmn1r50	ENSMUSG00000094553
mus_musculus	Vmn1r41	ENSMUSG00000094586
mus_musculus	Vmn1r30	ENSMUSG00000095670
mus_musculus	Vmn1r49	ENSMUSG00000095932
mus_musculus	Vmn1r40	ENSMUSG00000096051
mus_musculus	Vmn1r14	ENSMUSG00000114982
mus_musculus	Vmn1r22	ENSMUSG00000115091
mus_musculus	Vmn1r38	ENSMUSG00000115170
mus_musculus	Vmn1r10	ENSMUSG00000115181
mus_musculus	Vmn1r15	ENSMUSG00000115199
mus_musculus	Vmn1r11	ENSMUSG00000115236
mus_musculus	Vmn1r20	ENSMUSG00000115253
mus_musculus	Vmn1r21	ENSMUSG00000115343
mus_musculus	Vmn1r31	ENSMUSG00000115404
mus_musculus	Vmn1r37	ENSMUSG00000115467
mus_musculus	Vmn1r36	ENSMUSG00000115482
mus_musculus	Vmn1r24	ENSMUSG00000115507
mus_musculus	Vmn1r17	ENSMUSG00000115644
mus_musculus	Vmn1r25	ENSMUSG00000115668
mus_musculus	Vmn1r6	ENSMUSG00000115701
mus_musculus	Vmn1r28	ENSMUSG00000115705
mus_musculus	Vmn1r16	ENSMUSG00000115792
mus_musculus	Vmn1r19	ENSMUSG00000115799
rattus_norvegicus	Vom1r94	ENSRNOG00000031140
rattus_norvegicus	Vom1r71	ENSRNOG00000047851
rattus_norvegicus	Vom1r104	ENSRNOG00000049645
rattus_norvegicus	Vom1r102	ENSRNOG00000055950
rattus_norvegicus	Vom1r90	ENSRNOG00000058136
rattus_norvegicus	Vom1r96	ENSRNOG00000058628
rattus_norvegicus	Vom1r93	ENSRNOG00000063902
rattus_norvegicus	Vom1r103	ENSRNOG00000066287
rattus_norvegicus	Vom1r92	ENSRNOG00000067584
rattus_norvegicus	Vom1r97	ENSRNOG00000068663
rattus_norvegicus		ENSRNOG00000071664
rattus_norvegicus		ENSRNOG00000074119
rattus_norvegicus	Vom1r84	ENSRNOG00000074749
rattus_norvegicus	Vom1r67	ENSRNOG00000076239
rattus_norvegicus	Vom1r82	ENSRNOG00000077107
rattus_norvegicus	Vom1r73	ENSRNOG00000078759
rattus_norvegicus	Vom1r81	ENSRNOG00000079351
rattus_norvegicus	Vom1r88	ENSRNOG00000080641
rattus_norvegicus	Vom1r68	ENSRNOG00000080833
rattus_norvegicus	Vom1r100	ENSRNOG00000081972
rattus_norvegicus	Vom1r76	ENSRNOG00000082378
rattus_norvegicus		ENSRNOG00000083344
rattus_norvegicus		ENSRNOG00000083546
rattus_norvegicus	Vom1r87	ENSRNOG00000084180
rattus_norvegicus		ENSRNOG00000084671
rattus_norvegicus	Vom1r75	ENSRNOG00000085944
rattus_norvegicus	Vom1r72	ENSRNOG00000086376
rattus_norvegicus		ENSRNOG00000086495
rattus_norvegicus	Vom1r85	ENSRNOG00000086806
rattus_norvegicus		ENSRNOG00000088568
rattus_norvegicus		ENSRNOG00000088569
rattus_norvegicus		ENSRNOG00000089194
rattus_norvegicus	Vom1r98	ENSRNOG00000089562
rattus_norvegicus	Vom1r99	ENSRNOG00000089889
rattus_norvegicus	Vom1r70	ENSRNOG00000090431
rattus_norvegicus	Vom1r69	ENSRNOG00000091387

Paralogs (3): VN1R1 (ENSG00000178201), VN1R2 (ENSG00000196131), VN1R4 (ENSG00000228567)

Protein

Protein identifiers

Vomeronasal type-1 receptor 5 — Q7Z5H4 (reviewed: Q7Z5H4)

Alternative names: G-protein coupled receptor GPCR26, V1r-like receptor 5

All UniProt accessions (0):

UniProt curated annotations — full annotation on UniProt →

Function. Putative pheromone receptor.

Subcellular location. Cell membrane.

Polymorphism. There is an allele VN1R5*2 with a truncating mutation in position 46. It was found with a frequency of about 32%.

Miscellaneous. The chimpanzee and orangutan orthologous proteins do not exist, their genes are pseudogenes.

Similarity. Belongs to the G-protein coupled receptor 1 family.

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004072	Vmron_rcpt_1	Family

Pfam: PF03402

UniProt features (19 total): topological domain 8, transmembrane region 7, chain 1, glycosylation site 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z5H4-F1	64.56	0.06

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (1): 297

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 34 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_UP, chr1q44, MARSON_BOUND_BY_FOXP3_STIMULATED, GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_ODORANT_BINDING, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP, WONG_ADULT_TISSUE_STEM_MODULE, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B, BRUINS_UVC_RESPONSE_LATE, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, GOBP_RESPONSE_TO_PHEROMONE, RAO_BOUND_BY_SALL4_ISOFORM_A, RAO_BOUND_BY_SALL4_ISOFORM_B, HMGA1_TARGET_GENES

GO Biological Process (1): response to pheromone (GO:0019236)

GO Molecular Function (2): pheromone binding (GO:0005550), pheromone receptor activity (GO:0016503)

GO Cellular Component (1): plasma membrane (GO:0005886)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
response to chemical	1
odorant binding	1
G protein-coupled receptor activity	1
pheromone binding	1
membrane	1
cell periphery	1

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

3 interactions, top by confidence:

A	B	Type	Score
JUN	TPM3	psi-mi:“MI:0914”(association)	0.350
CEP164	NKRF	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (7): VN1R5 (Proximity Label-MS), VN1R5 (Affinity Capture-MS), VN1R5 (Affinity Capture-MS), VN1R5 (Affinity Capture-MS), VN1R5 (Affinity Capture-MS), VN1R5 (Affinity Capture-MS), VN1R5 (Affinity Capture-MS)

ESM2 similar proteins: P04201, P12526, P23749, P30554, P35410, P59529, P59533, P59534, Q3KNA1, Q3UG50, Q3UG61, Q4VHE7, Q5Y4Z0, Q645S2, Q645S5, Q645Y7, Q646A5, Q646A9, Q646C8, Q646E9, Q646F0, Q67ES2, Q67ES7, Q697L2, Q697L3, Q697L4, Q697L5, Q697L6, Q6L786, Q7TN38, Q7TN40, Q7TN41, Q7TN44, Q7TN51, Q7TQA6, Q7TQA9, Q7YRP1, Q7Z5H4, Q8TDS7, Q8VCJ6

Diamond homologs: A0A0R4IM31, Q7YRP1, Q7Z5H4, Q7Z5H5, Q8WN92, Q9GZP7, Q5J3E5, Q5J3F6, Q5J3G9, Q5J3K5, Q5J3K9, Q5J3L4, Q5J3L6, Q5J3L7, Q5J3M3, Q5J3M4, Q5J3M9, Q5J3N1, Q62850, Q8R2E6, Q8TDU5, Q8VBS7, Q8VIC6, Q8VIC7, Q8VIC9, Q9EP51, Q9EP79, Q9EP93, Q9EPB8, Q9EQ44, Q9EQ45, Q9EQ46, Q9EQ47, Q9EQ48, Q9EQ51, Q9EQ52, Q9WUF1, Q7YRP2, Q8NFZ6, Q9BXE9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

0 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000756949 (1:247255071 G>T), RS1002787370 (1:247254993 A>G), RS1002817116 (1:247254731 T>A), RS1007188024 (1:247257621 A>G), RS1007295639 (1:247255790 G>A), RS1007841965 (1:247256057 T>G), RS1010445202 (1:247257331 C>A,T), RS1012562239 (1:247254891 T>A), RS1012955362 (1:247255056 G>A,C), RS1013422615 (1:247255274 G>A), RS1014371311 (1:247256473 C>T), RS1014971476 (1:247255207 T>C,G), RS1015311056 (1:247254129 A>G), RS1015901062 (1:247255505 T>G), RS1016448451 (1:247255791 G>A,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST002929_1	Chromium levels	1.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

2 total (human), top 2 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression	1
Atrazine	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.