VPS13B-DT

Summary

VPS13B-DT (VPS13B divergent transcript, HGNC:54375) is a long non-coding RNA gene on chromosome 8q22.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:54375
Approved symbol	VPS13B-DT
Name	VPS13B divergent transcript
Location	8q22.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	OLC8
Ensembl gene	ENSG00000253948
Ensembl biotype	lncRNA
Entrez	105375666
RNAcentral	URS00026A1D86 — lncRNA, 1197 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 23 lncRNA

ENST00000521696, ENST00000653552, ENST00000661471, ENST00000663007, ENST00000664437, ENST00000664472, ENST00000686056, ENST00000689048, ENST00000721818, ENST00000721819, ENST00000721820, ENST00000721821, ENST00000721822, ENST00000721823, ENST00000721824, ENST00000721825, ENST00000721826, ENST00000721827, ENST00000721828, ENST00000721829, ENST00000721830, ENST00000721831, ENST00000721832

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000521696 — 2 exons

Exon	Start	End
ENSE00002097170	99012869	99013044
ENSE00002112566	98996763	98996966

Expression profiles

Bgee: expression breadth ubiquitous, 244 present calls, max score 92.07.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 3.6606 / max 54.2742, expressed in 1476 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
94104	3.1574	1371
94105	0.5032	260

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
putamen	UBERON:0001874	92.07	gold quality
nucleus accumbens	UBERON:0001882	91.44	gold quality
quadriceps femoris	UBERON:0001377	91.41	gold quality
vastus lateralis	UBERON:0001379	91.18	gold quality
caudate nucleus	UBERON:0001873	91.00	gold quality
amygdala	UBERON:0001876	90.51	gold quality
tibialis anterior	UBERON:0001385	90.43	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	90.03	gold quality
substantia nigra	UBERON:0002038	89.98	gold quality
pons	UBERON:0000988	89.82	gold quality
spinal cord	UBERON:0002240	89.82	gold quality
hypothalamus	UBERON:0001898	89.75	gold quality
anterior cingulate cortex	UBERON:0009835	89.60	gold quality
midbrain	UBERON:0001891	89.57	gold quality
vena cava	UBERON:0004087	89.55	gold quality
biceps brachii	UBERON:0001507	89.48	gold quality
cerebellar vermis	UBERON:0004720	89.25	gold quality
cardiac muscle of right atrium	UBERON:0003379	89.19	silver quality
Brodmann (1909) area 9	UBERON:0013540	89.10	gold quality
lateral globus pallidus	UBERON:0002476	89.08	gold quality
left ventricle myocardium	UBERON:0006566	88.71	gold quality
sural nerve	UBERON:0015488	88.31	gold quality
globus pallidus	UBERON:0001875	88.29	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	88.19	gold quality
medial globus pallidus	UBERON:0002477	87.98	gold quality
skeletal muscle tissue	UBERON:0001134	87.94	gold quality
right frontal lobe	UBERON:0002810	87.93	gold quality
myocardium	UBERON:0002349	87.87	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	87.76	gold quality
corpus epididymis	UBERON:0004359	87.68	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• showed that OLC8 facilitated migration and viability of MKN1 and AGS cells (PMID:31273847)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.