VPS26B

Summary

VPS26B (VPS26 retromer complex component B, HGNC:28119) is a protein-coding gene on chromosome 11q25, encoding Vacuolar protein sorting-associated protein 26B (Q4G0F5). Acts as a component of the retromer cargo-selective complex (CSC).

Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in early endosome and late endosome. Predicted to be part of retromer complex. Predicted to be active in glutamatergic synapse; postsynaptic early endosome; and postsynaptic recycling endosome.

Source: NCBI Gene 112936 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 31 total — 1 pathogenic
• Druggable target: yes
• MANE Select transcript: NM_052875

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28119
Approved symbol	VPS26B
Name	VPS26 retromer complex component B
Location	11q25
Locus type	gene with protein product
Status	Approved
Aliases	MGC10485, Pep8b
Ensembl gene	ENSG00000151502
Ensembl biotype	protein_coding
OMIM	610027
Entrez	112936

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 7 protein_coding, 3 retained_intron, 2 nonsense_mediated_decay

ENST00000281187, ENST00000525095, ENST00000525918, ENST00000527586, ENST00000530402, ENST00000531741, ENST00000532160, ENST00000860204, ENST00000860205, ENST00000911842, ENST00000911843, ENST00000957932

RefSeq mRNA: 1 — MANE Select: NM_052875 NM_052875

CCDS: CCDS8495

Canonical transcript exons

ENST00000281187 — 6 exons

Exon	Start	End
ENSE00001000001	134244938	134245080
ENSE00001099786	134234897	134235053
ENSE00001194641	134224671	134225345
ENSE00001279598	134245444	134247788
ENSE00003570973	134239991	134240155
ENSE00003584878	134243119	134243294

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 96.44.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.3895 / max 126.8866, expressed in 1816 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117699	29.0096	1816
117700	0.3799	168

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	96.44	gold quality
right hemisphere of cerebellum	UBERON:0014890	95.91	gold quality
cerebellar hemisphere	UBERON:0002245	95.69	gold quality
upper arm skin	UBERON:0004263	95.63	gold quality
cerebellar cortex	UBERON:0002129	95.62	gold quality
embryo	UBERON:0000922	95.02	gold quality
ganglionic eminence	UBERON:0004023	95.02	gold quality
cerebellum	UBERON:0002037	94.87	gold quality
granulocyte	CL:0000094	94.78	gold quality
right frontal lobe	UBERON:0002810	94.64	gold quality
prefrontal cortex	UBERON:0000451	94.60	gold quality
skin of leg	UBERON:0001511	93.94	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.84	gold quality
skin of abdomen	UBERON:0001416	93.74	gold quality
anterior cingulate cortex	UBERON:0009835	93.69	gold quality
right uterine tube	UBERON:0001302	93.64	gold quality
body of pancreas	UBERON:0001150	93.31	gold quality
nucleus accumbens	UBERON:0001882	93.06	gold quality
stromal cell of endometrium	CL:0002255	92.94	gold quality
frontal cortex	UBERON:0001870	92.89	gold quality
body of uterus	UBERON:0009853	92.87	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	92.82	gold quality
neocortex	UBERON:0001950	92.73	gold quality
caudate nucleus	UBERON:0001873	92.66	gold quality
islet of Langerhans	UBERON:0000006	92.47	gold quality
zone of skin	UBERON:0000014	92.23	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.22	gold quality
left ovary	UBERON:0002119	92.18	gold quality
putamen	UBERON:0001874	92.12	gold quality
pancreas	UBERON:0001264	92.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.82

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

125 targeting VPS26B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-188-3P	100.00	68.76	1240
HSA-MIR-6758-5P	100.00	66.21	1470
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-6759-5P	99.99	66.54	785
HSA-MIR-3667-3P	99.99	67.17	1636
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-6768-5P	99.92	67.36	1942
HSA-MIR-12133	99.92	71.82	2006
HSA-MIR-1271-5P	99.91	71.99	1972
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-1343-3P	99.89	66.78	1815
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-6780A-5P	99.88	66.69	2776

Literature-anchored findings (GeneRIF, showing 2)

• Colocalization of Vps26 paralogues with different endosomally located Rab proteins shows prolonged association of Vps26B-retromer with maturing endosomes relative to Vps26A-retromer. (PMID:21920005)
• Authors propose that PAR-2 plasma membrane repopulation is regulated by Vps26B-retromer, describing a potential novel role for this complex. (PMID:26113136)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	vps26b	ENSDARG00000015823
danio_rerio	vps26bl	ENSDARG00000055433
mus_musculus	Vps26b	ENSMUSG00000031988
rattus_norvegicus	Vps26b	ENSRNOG00000047235
drosophila_melanogaster	Vps26	FBGN0014411
caenorhabditis_elegans		WBGENE00006931

Paralogs (2): VPS26A (ENSG00000122958), VPS26C (ENSG00000157538)

Protein

Protein identifiers

Vacuolar protein sorting-associated protein 26B — Q4G0F5 (reviewed: Q4G0F5)

Alternative names: Vesicle protein sorting 26B

All UniProt accessions (3): Q4G0F5, A0A0D9SFQ6, H0YCI7

UniProt curated annotations — full annotation on UniProt →

Function. Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1.

Subunit / interactions. Component of the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting VPS subcomplex (VPS,) formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35. The CSC has a highly elongated structure with VPS26 and VPS29 binding independently at opposite distal ends of VPS35 as central platform. The CSC is believed to associate with variable sorting nexins to form functionally distinct retromer complex variants. The originally described retromer complex (also called SNX-BAR retromer) is a pentamer containing the CSC and a heterodimeric membrane-deforming subcomplex formed between SNX1 or SNX2 and SNX5 or SNX6 (also called SNX-BAR subcomplex); the respective CSC and SNX-BAR subcomplexes associate with low affinity. The CSC associates with SNX3 to form a SNX3-retromer complex. The CSC associates with SNX27, the WASH complex and the SNX-BAR subcomplex to form the SNX27-retromer complex. Interacts with VPS29, VPS35, TBC1D5, GOLPH3, SNX27.

Subcellular location. Cytoplasm. Membrane. Early endosome. Late endosome.

Similarity. Belongs to the VPS26 family.

RefSeq proteins (1): NP_443107* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR014752	Arrestin-like_C_sf	Homologous_superfamily
IPR028934	Vps26-related	Family

Pfam: PF03643

UniProt features (5 total): modified residue 3, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q4G0F5-F1	87.11	0.76

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 302, 304, 319

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 219 (showing top): GSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN, GSE45365_NK_CELL_VS_CD8_TCELL_DN, GOBP_REGULATION_OF_AUTOPHAGY, GCM_GSPT1, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_RESPONSE_TO_PEPTIDE, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_VESICLE_MEDIATED_TRANSPORT, AP2_Q3, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_MACROAUTOPHAGY, YORDY_RECIPROCAL_REGULATION_BY_ETS1_AND_SP100_UP, GOBP_DEFENSE_RESPONSE_TO_OTHER_ORGANISM, GOBP_REGULATION_OF_CATABOLIC_PROCESS, GOBP_REGULATION_OF_CELLULAR_LOCALIZATION

GO Biological Process (6): intracellular protein transport (GO:0006886), regulation of macroautophagy (GO:0016241), retrograde transport, endosome to Golgi (GO:0042147), cellular response to type II interferon (GO:0071346), regulation of neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0098696), protein transport (GO:0015031)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (12): endosome (GO:0005768), early endosome (GO:0005769), late endosome (GO:0005770), cytosol (GO:0005829), retromer complex (GO:0030904), retromer, cargo-selective complex (GO:0030906), phagocytic vesicle (GO:0045335), postsynaptic recycling endosome (GO:0098837), postsynaptic early endosome (GO:0098842), glutamatergic synapse (GO:0098978), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
intracellular protein localization	2
endomembrane system	2
endosome	2
membrane protein complex	2
postsynapse	2
postsynaptic endosome	2
protein transport	1
intracellular transport	1
regulation of autophagy	1
macroautophagy	1
intercellular transport	1
endosomal transport	1
cytosolic transport	1
response to type II interferon	1
cellular response to cytokine stimulus	1
regulation of biological quality	1
neurotransmitter receptor localization to postsynaptic specialization membrane	1
regulation of protein localization to synapse	1
regulation of receptor localization to synapse	1
regulation of protein localization to cell periphery	1
regulation of protein localization to membrane	1
transport	1
establishment of protein localization	1
binding	1
cytoplasmic vesicle	1
cytoplasm	1
retromer complex	1
endocytic vesicle	1
recycling endosome	1
early endosome	1
synapse	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1184 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
VPS26B	VPS35	Q96QK1	999
VPS26B	VPS29	Q9UBQ0	997
VPS26B	SNX27	Q96L92	913
VPS26B	SNX1	Q13596	892
VPS26B	SNX2	P82862	854
VPS26B	SNX3	O60493	788
VPS26B	SNX5	Q9Y5X3	731
VPS26B	TBC1D5	Q92609	702
VPS26B	SNX6	Q9UNH7	678
VPS26B	SNX32	Q86XE0	598
VPS26B	SNX4	O95219	569
VPS26B	SNX17	Q15036	548
VPS26B	ENTR1	Q96C92	543
VPS26B	DNAJC13	O75165	523
VPS26B	WASHC1	A8K0Z3	518

IntAct

64 interactions, top by confidence:

A	B	Type	Score
VPS26B	VPS35	psi-mi:“MI:0915”(physical association)	0.910
TBC1D5	VPS26A	psi-mi:“MI:0914”(association)	0.810
VPS29	VPS26C	psi-mi:“MI:0914”(association)	0.760
VPS29	VPS26B	psi-mi:“MI:0914”(association)	0.730
NPLOC4	VPS26B	psi-mi:“MI:0915”(physical association)	0.560
VPS26B	NPLOC4	psi-mi:“MI:0915”(physical association)	0.560
VPS26A	VPS26B	psi-mi:“MI:0914”(association)	0.530
TRMO	STAT5B	psi-mi:“MI:0914”(association)	0.530
KXD1	HIP1	psi-mi:“MI:0914”(association)	0.530
ZFC3H1	HNRNPCL1	psi-mi:“MI:0914”(association)	0.530
SNX3	VPS26A	psi-mi:“MI:0914”(association)	0.530
PNMA2	CCDC85C	psi-mi:“MI:0914”(association)	0.530
VPS35	SPAG9	psi-mi:“MI:0914”(association)	0.530
VPS26B	ABCD1	psi-mi:“MI:0914”(association)	0.350
VPS26B	KIF1B	psi-mi:“MI:0914”(association)	0.350
E6	PLOD2	psi-mi:“MI:0914”(association)	0.350
VPS26B	CFAP410	psi-mi:“MI:0914”(association)	0.350
ZFC3H1	ANKHD1	psi-mi:“MI:0914”(association)	0.350
MRM1	KIAA0391	psi-mi:“MI:0914”(association)	0.350
LOXL3	MSI1	psi-mi:“MI:0914”(association)	0.350
ENG	IGKV2-28	psi-mi:“MI:0914”(association)	0.350
M		psi-mi:“MI:0914”(association)	0.350

BioGRID (127): VPS26B (Affinity Capture-RNA), VPS26B (Affinity Capture-RNA), VPS26B (Affinity Capture-RNA), VPS26B (Affinity Capture-MS), VPS29 (Affinity Capture-MS), VPS35 (Affinity Capture-MS), NEK1 (Affinity Capture-MS), SUPT5H (Affinity Capture-MS), ATE1 (Affinity Capture-MS), TBC1D5 (Affinity Capture-MS), C21orf2 (Affinity Capture-MS), BTBD9 (Affinity Capture-MS), SNX27 (Affinity Capture-MS), VPS26B (Affinity Capture-MS), VPS26B (Co-fractionation)

ESM2 similar proteins: A0A7J6K9S4, A5PF44, C4R360, C5DL84, C5DRZ0, O01258, O17972, O45782, O75436, P30647, P40335, P40336, P53179, Q02331, Q09219, Q0VD53, Q10243, Q17388, Q18268, Q19829, Q28HT6, Q4G0F5, Q55CA0, Q5BKM4, Q5R436, Q5RAV3, Q68F29, Q6AY86, Q6CTM7, Q6DFB9, Q6DFU4, Q6DH23, Q6DTM3, Q6FWV1, Q6IRD0, Q6PAW0, Q6PB19, Q6PBN2, Q6TNP8, Q754G2

Diamond homologs: O01258, O75436, P40335, P40336, Q0VD53, Q10243, Q28HT6, Q4G0F5, Q55CA0, Q5BKM4, Q5R436, Q68F29, Q6AY86, Q6DFB9, Q6DFU4, Q6DH23, Q6IRD0, Q6TNP8, Q7ZV03, Q8C0E2, Q8I4T1, Q9FJD0, Q9T091, Q9W552

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 60 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
endocytic recycling	6	36.5×	5e-06
retrograde transport, endosome to Golgi	6	28.0×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

31 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	17
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
393778	GRCh37/hg19 11q24.1-25(chr11:121501072-134868348)x1	Pathogenic

SpliceAI

1162 predictions. Top by Δscore:

Variant	Effect	Δscore
11:134225341:GATCG:G	donor_gain	1.0000
11:134225343:TCGGT:T	donor_loss	1.0000
11:134225345:GGT:G	donor_loss	1.0000
11:134225346:G:C	donor_loss	1.0000
11:134225347:T:G	donor_loss	1.0000
11:134240137:T:G	donor_gain	1.0000
11:134240156:G:GG	donor_gain	1.0000
11:134243116:CA:C	acceptor_loss	1.0000
11:134243117:A:AG	acceptor_gain	1.0000
11:134243118:G:GA	acceptor_gain	1.0000
11:134243118:GA:G	acceptor_gain	1.0000
11:134243118:GAT:G	acceptor_gain	1.0000
11:134243118:GATA:G	acceptor_gain	1.0000
11:134243118:GATAC:G	acceptor_gain	1.0000
11:134243291:CGAG:C	donor_loss	1.0000
11:134243293:AG:A	donor_loss	1.0000
11:134243294:GG:G	donor_loss	1.0000
11:134243295:G:T	donor_loss	1.0000
11:134243296:T:A	donor_loss	1.0000
11:134244932:CTACA:C	acceptor_loss	1.0000
11:134244933:TACA:T	acceptor_loss	1.0000
11:134244936:A:AG	acceptor_gain	1.0000
11:134244936:A:T	acceptor_loss	1.0000
11:134244937:G:GA	acceptor_loss	1.0000
11:134244937:G:GG	acceptor_gain	1.0000
11:134244937:GGA:G	acceptor_gain	1.0000
11:134244937:GGAGA:G	acceptor_gain	1.0000
11:134245077:GCAG:G	donor_gain	1.0000
11:134245079:AGG:A	donor_loss	1.0000
11:134245080:GGTG:G	donor_loss	1.0000

AlphaMissense

2233 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:134225259:T:A	V46D	1.000
11:134225264:G:A	G48R	1.000
11:134225264:G:C	G48R	1.000
11:134225264:G:T	G48W	1.000
11:134225265:G:A	G48E	1.000
11:134225336:G:A	G72R	1.000
11:134225336:G:C	G72R	1.000
11:134225336:G:T	G72W	1.000
11:134225337:G:A	G72E	1.000
11:134225337:G:T	G72V	1.000
11:134234929:T:C	F86L	1.000
11:134234930:T:C	F86S	1.000
11:134234931:T:A	F86L	1.000
11:134234931:T:G	F86L	1.000
11:134234999:T:C	F109S	1.000
11:134235034:G:A	G121R	1.000
11:134235034:G:C	G121R	1.000
11:134235034:G:T	G121W	1.000
11:134235035:G:A	G121E	1.000
11:134235035:G:T	G121V	1.000
11:134235050:T:C	L126P	1.000
11:134235053:G:C	R127P	1.000
11:134239992:T:G	Y128D	1.000
11:134240002:G:C	R131P	1.000
11:134240056:T:A	V149D	1.000
11:134240101:T:A	M164K	1.000
11:134240101:T:C	M164T	1.000
11:134240101:T:G	M164R	1.000
11:134240102:G:A	M164I	1.000
11:134240102:G:C	M164I	1.000

dbSNP variants (sampled 300 via entrez): RS1000236606 (11:134241395 G>A), RS1000388468 (11:134248228 G>A), RS1000444119 (11:134242710 G>C), RS1000731010 (11:134244493 C>T), RS1000814728 (11:134240957 T>G), RS1000894427 (11:134232137 C>T), RS1000953966 (11:134238724 T>C), RS1000983281 (11:134225633 G>A), RS1000988579 (11:134226876 A>G), RS1000996789 (11:134237189 T>C), RS1001144387 (11:134233225 G>A), RS1001186069 (11:134244250 T>A), RS1001490960 (11:134233465 T>C,G), RS1001551014 (11:134240623 A>G), RS1001554793 (11:134231798 C>A,T)

Disease associations

OMIM: gene MIM:610027 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002701_37	Verbal declarative memory	2.000000e-06
GCST90000047_174	Age at first sexual intercourse	4.000000e-08

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004874	memory performance
EFO:0006805	word list delayed recall measurement
EFO:0009749	age at first sexual intercourse measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067157 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases abundance	4
Arsenic	affects methylation, affects cotreatment, decreases expression, increases abundance	2
Benzo(a)pyrene	decreases expression, increases expression	2
bisphenol F	increases expression	1
uranyl acetate	affects expression	1
bisphenol A	increases expression	1
beta-lapachone	increases expression	1
manganese chloride	decreases expression, increases abundance, affects cotreatment	1
coumarin	decreases phosphorylation	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	decreases expression	1
abrine	decreases expression	1
Fulvestrant	decreases methylation	1
Air Pollutants	affects expression, increases abundance	1
Atrazine	increases expression	1
Caffeine	decreases phosphorylation	1
Diazinon	increases methylation	1
Manganese	decreases expression, increases abundance, affects cotreatment	1
Ozone	affects expression, increases abundance	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases methylation	1
Tretinoin	affects cotreatment, decreases expression	1
Uranium	affects expression	1
Valproic Acid	decreases methylation	1
Aflatoxin B1	decreases methylation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5652812	Binding	Binding affinity to human VPS26B incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.