VPS26C

Summary

VPS26C (VPS26 endosomal protein sorting factor C, HGNC:3044) is a protein-coding gene on chromosome 21q22.13, encoding Vacuolar protein sorting-associated protein 26C (O14972). Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex.

The region of chromosome 21 between genes CBR and ERG (CBR-ERG region), which spans 2.5 Mb on 21q22.2, has been defined by analysis of patients with partial trisomy 21. It contributes significantly to the pathogenesis of many characteristics of Down syndrome, including morphological features, hypotonia, and cognitive disability. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region and is predictated to contain eight exons. DSCR3 is expressed in most tissues examined.

Source: NCBI Gene 10311 — RefSeq curated summary.

At a glance

• Gene–disease (curated): neurodevelopmental disorder (Limited, GenCC)
• Clinical variants (ClinVar): 49 total — 1 likely-pathogenic
• Dosage sensitivity (ClinGen): haploinsufficiency no evidence, triplosensitivity no evidence
• MANE Select transcript: NM_006052

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:3044
Approved symbol	VPS26C
Name	VPS26 endosomal protein sorting factor C
Location	21q22.13
Locus type	gene with protein product
Status	Approved
Aliases	DCRA
Ensembl gene	ENSG00000157538
Ensembl biotype	protein_coding
OMIM	605298
Entrez	10311

Gene structure

Transcript identifiers

Ensembl transcripts: 29 — 20 protein_coding, 7 protein_coding_CDS_not_defined, 2 retained_intron

ENST00000309117, ENST00000398998, ENST00000399000, ENST00000399001, ENST00000462467, ENST00000475009, ENST00000476950, ENST00000480452, ENST00000488368, ENST00000492514, ENST00000495858, ENST00000497493, ENST00000498789, ENST00000875971, ENST00000875974, ENST00000875976, ENST00000875982, ENST00000875984, ENST00000875986, ENST00000875989, ENST00000875991, ENST00000929122, ENST00000929123, ENST00000929124, ENST00000942454, ENST00000942455, ENST00000942456, ENST00000942457, ENST00000942458

RefSeq mRNA: 4 — MANE Select: NM_006052 NM_001331018, NM_001331021, NM_001331022, NM_006052

CCDS: CCDS33553, CCDS82671, CCDS82672, CCDS82673

Canonical transcript exons

ENST00000309117 — 8 exons

Exon	Start	End
ENSE00003458727	37238460	37238609
ENSE00003490386	37223422	37225626
ENSE00003505095	37232377	37232451
ENSE00003520824	37233362	37233442
ENSE00003523339	37240496	37240639
ENSE00003615492	37228223	37228373
ENSE00003635629	37227654	37227806
ENSE00003849406	37267238	37267334

Expression profiles

Bgee: expression breadth ubiquitous, 280 present calls, max score 94.84.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 23.9712 / max 296.0451, expressed in 1816 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
190392	21.4583	1812
190394	1.7009	920
190393	0.4453	220
190395	0.3666	173

Top tissues by expression

296 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	94.84	gold quality
mononuclear cell	CL:0000842	94.41	gold quality
leukocyte	CL:0000738	94.34	gold quality
rectum	UBERON:0001052	93.27	gold quality
granulocyte	CL:0000094	92.52	gold quality
gall bladder	UBERON:0002110	92.41	gold quality
gastrocnemius	UBERON:0001388	92.30	gold quality
secondary oocyte	CL:0000655	92.17	gold quality
muscle of leg	UBERON:0001383	92.16	gold quality
right adrenal gland cortex	UBERON:0035827	92.14	gold quality
right adrenal gland	UBERON:0001233	92.06	gold quality
stromal cell of endometrium	CL:0002255	92.05	gold quality
left adrenal gland	UBERON:0001234	91.87	gold quality
adrenal tissue	UBERON:0018303	91.65	gold quality
cortical plate	UBERON:0005343	91.60	gold quality
left adrenal gland cortex	UBERON:0035825	91.50	gold quality
right coronary artery	UBERON:0001625	91.45	gold quality
islet of Langerhans	UBERON:0000006	91.33	gold quality
hindlimb stylopod muscle	UBERON:0004252	91.14	gold quality
colonic epithelium	UBERON:0000397	90.93	gold quality
transverse colon	UBERON:0001157	90.85	gold quality
descending thoracic aorta	UBERON:0002345	90.83	gold quality
adrenal gland	UBERON:0002369	90.83	gold quality
popliteal artery	UBERON:0002250	90.59	gold quality
tibial artery	UBERON:0007610	90.59	gold quality
body of pancreas	UBERON:0001150	90.56	gold quality
mucosa of stomach	UBERON:0001199	90.55	gold quality
metanephros cortex	UBERON:0010533	90.53	gold quality
small intestine Peyer’s patch	UBERON:0003454	90.52	gold quality
heart left ventricle	UBERON:0002084	90.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.57

Regulation

Is transcription factor: no

Functional genomics

ClinGen dosage: haploinsufficiency 0 (no evidence), triplosensitivity 0 (no evidence). ClinGen Gene Dosage Map

Literature-anchored findings (GeneRIF, showing 3)

• Heterotrimer composed of DSCR3, C16orf62 and VPS29 orchestrates endosomal cargo retrieval and recycling. (PMID:28892079)
• These studies illustrate that GFP-HsDSCR3 is able to complement the vps26c root hair phenotype in Arabidopsis, indicating a deep conservation of cellular function for this large retromer subunit across plant and animal kingdoms. (PMID:29495075)
• VPS26C homozygous nonsense variant in two cousins with neurodevelopmental deficits, growth failure, skeletal abnormalities, and distinctive facial features. (PMID:31845315)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	vps26c	ENSDARG00000075650
mus_musculus	Vps26c	ENSMUSG00000022898
rattus_norvegicus	Vps26c	ENSRNOG00000001681
drosophila_melanogaster	CG4074	FBGN0037017

Paralogs (2): VPS26A (ENSG00000122958), VPS26B (ENSG00000151502)

Protein

Protein identifiers

Vacuolar protein sorting-associated protein 26C — O14972 (reviewed: O14972)

Alternative names: Down syndrome critical region protein 3, Down syndrome critical region protein A

All UniProt accessions (4): O14972, A8MTY9, A8MY26, B7Z606

UniProt curated annotations — full annotation on UniProt →

Function. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. (Microbial infection) The heterotrimeric retriever complex, in collaboration with the CCC complex, mediates the exit of human papillomavirus to the cell surface.

Subunit / interactions. Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.

Subcellular location. Endosome.

Tissue specificity. Ubiquitously expressed.

Similarity. Belongs to the VPS26 family.

Isoforms (2)

UniProt ID	Names	Canonical?
O14972-1	1	yes
O14972-2	2

RefSeq proteins (4): NP_001317947, NP_001317950, NP_001317951, NP_006043* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR014752	Arrestin-like_C_sf	Homologous_superfamily
IPR014756	Ig_E-set	Homologous_superfamily
IPR028934	Vps26-related	Family

Pfam: PF03643

UniProt features (25 total): strand 17, turn 4, helix 2, chain 1, splice variant 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
8SYN	ELECTRON MICROSCOPY	2.94
8SYO	ELECTRON MICROSCOPY	2.94
9AU7	ELECTRON MICROSCOPY	3.4
8P0X	ELECTRON MICROSCOPY	7.5

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-O14972-F1	93.00	0.81

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 165 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, TGACCTY_ERR1_Q2, GOBP_VESICLE_MEDIATED_TRANSPORT, SCHLOSSER_SERUM_RESPONSE_DN, NADLER_HYPERGLYCEMIA_AT_OBESITY, GOBP_ENDOCYTIC_RECYCLING, FISCHER_DREAM_TARGETS, GOBP_LOCALIZATION_WITHIN_MEMBRANE, chr21q22, SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN, CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN, MORF_PPP2CA, MARSON_BOUND_BY_FOXP3_STIMULATED, GOCC_MEMBRANE_PROTEIN_COMPLEX

GO Biological Process (2): intracellular protein transport (GO:0006886), endocytic recycling (GO:0032456)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), endosome (GO:0005768)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular protein localization	1
protein transport	1
intracellular transport	1
endosomal transport	1
vesicle-mediated transport to the plasma membrane	1
binding	1
intracellular membrane-bounded organelle	1
endomembrane system	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

464 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
VPS26C	VPS35L	Q7Z3J2	996
VPS26C	VPS29	Q9UBQ0	995
VPS26C	CCDC93	Q567U6	913
VPS26C	CCDC22	O60826	901
VPS26C	PSMG1	O95456	763
VPS26C	SNX17	Q15036	756
VPS26C	COMMD1	Q8N668	721
VPS26C	SNX27	Q96L92	701
VPS26C	COMMD2	Q86X83	680
VPS26C	VPS35	Q96QK1	679
VPS26C	DENND10	Q8TCE6	673
VPS26C	CRELD1	Q96HD1	648
VPS26C	COMMD4	Q9H0A8	634
VPS26C	SNX31	Q8N9S9	628
VPS26C	PIGP	P57054	616

IntAct

133 interactions, top by confidence:

A	B	Type	Score
CCDC22	VPS26C	psi-mi:“MI:0914”(association)	0.790
VPS26C	CCDC22	psi-mi:“MI:0914”(association)	0.790
VPS29	VPS26C	psi-mi:“MI:0914”(association)	0.760
COMMD1	VPS26C	psi-mi:“MI:0914”(association)	0.730
COMMD4	VPS26C	psi-mi:“MI:0914”(association)	0.730
VPS35L	VPS26C	psi-mi:“MI:0914”(association)	0.730
VPS26C	VPS35L	psi-mi:“MI:0914”(association)	0.730
COMMD8	VPS26C	psi-mi:“MI:0914”(association)	0.640
COMMD3	VPS26C	psi-mi:“MI:0914”(association)	0.640
COMMD6	VPS26C	psi-mi:“MI:0914”(association)	0.640
DENND10	VPS26C	psi-mi:“MI:0914”(association)	0.640
CCDC93	VPS26C	psi-mi:“MI:0914”(association)	0.640

BioGRID (115): DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Co-fractionation), DSCR3 (Co-fractionation), DSCR3 (Co-fractionation), DSCR3 (Co-fractionation), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS), DSCR3 (Affinity Capture-MS)

ESM2 similar proteins: A0A0B4J1F4, A6NEK1, G3X9X1, O14972, O15344, O15519, O35075, O70263, O70583, O94955, P82457, P82458, Q2HY40, Q2TBA3, Q32KX1, Q32NJ2, Q497K5, Q4VX76, Q54DI8, Q568M3, Q5M7W1, Q5R5L7, Q5R811, Q5R8Q5, Q5RD56, Q5RDY3, Q5RF33, Q60584, Q62807, Q6TXF1, Q6ZWE6, Q7TP90, Q7TPQ9, Q7ZX59, Q80WG7, Q8BG60, Q8BM47, Q8IY47, Q8NCT1, Q8W4D4

Diamond homologs: O14972, O35075, Q54DI8, Q5RF33

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 67 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Neddylation	10	10.3×	7e-06

GO biological processes:

GO term	Partners	Fold	FDR
endocytic recycling	5	21.9×	7e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

49 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	1
Uncertain significance	36
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
974902	NM_006052.2(VPS26C):c.178G>T (p.Glu60Ter)	Likely pathogenic

SpliceAI

2103 predictions. Top by Δscore:

Variant	Effect	Δscore
21:37227649:CTTA:C	donor_loss	1.0000
21:37227650:TTAC:T	donor_loss	1.0000
21:37227651:TA:T	donor_loss	1.0000
21:37227652:A:AC	donor_gain	1.0000
21:37227652:AC:A	donor_gain	1.0000
21:37227652:ACC:A	donor_gain	1.0000
21:37227653:C:CC	donor_gain	1.0000
21:37227653:CC:C	donor_gain	1.0000
21:37227653:CCC:C	donor_gain	1.0000
21:37227653:CCCA:C	donor_gain	1.0000
21:37227803:CACC:C	acceptor_gain	1.0000
21:37227804:ACC:A	acceptor_gain	1.0000
21:37227804:ACCCT:A	acceptor_loss	1.0000
21:37227805:CC:C	acceptor_gain	1.0000
21:37227805:CCC:C	acceptor_gain	1.0000
21:37227805:CCCTG:C	acceptor_loss	1.0000
21:37227806:CC:C	acceptor_gain	1.0000
21:37227807:C:CC	acceptor_gain	1.0000
21:37227807:CTGCG:C	acceptor_loss	1.0000
21:37228370:CTCT:C	acceptor_gain	1.0000
21:37228372:CT:C	acceptor_gain	1.0000
21:37232452:C:CC	acceptor_gain	1.0000
21:37233360:A:AC	donor_gain	1.0000
21:37233361:C:CC	donor_gain	1.0000
21:37233361:CAG:C	donor_gain	1.0000
21:37238606:TAGG:T	acceptor_gain	1.0000
21:37238608:GG:G	acceptor_gain	1.0000
21:37238608:GGC:G	acceptor_loss	1.0000
21:37238609:GCT:G	acceptor_loss	1.0000
21:37238610:C:CC	acceptor_gain	1.0000

AlphaMissense

1950 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
21:37225622:A:C	F272L	1.000
21:37225622:A:T	F272L	1.000
21:37225624:A:G	F272L	1.000
21:37228243:A:G	L213P	1.000
21:37238470:A:T	V114D	1.000
21:37238479:C:A	G111V	1.000
21:37238479:C:T	G111D	1.000
21:37238480:C:G	G111R	1.000
21:37238486:A:C	Y109D	1.000
21:37240564:C:G	G45R	1.000
21:37240564:C:T	G45R	1.000
21:37227685:G:C	C260W	0.999
21:37227687:A:G	C260R	0.999
21:37227691:G:C	F258L	0.999
21:37227691:G:T	F258L	0.999
21:37227693:A:G	F258L	0.999
21:37227767:T:G	Q233P	0.999
21:37228230:C:A	E217D	0.999
21:37228230:C:G	E217D	0.999
21:37228231:T:A	E217V	0.999
21:37228232:C:T	E217K	0.999
21:37228237:C:G	R215P	0.999
21:37228238:G:T	R215S	0.999
21:37228243:A:T	L213Q	0.999
21:37228249:A:G	L211P	0.999
21:37228297:C:T	G195E	0.999
21:37228298:C:G	G195R	0.999
21:37228298:C:T	G195R	0.999
21:37228342:C:T	G180E	0.999
21:37233378:A:G	F139S	0.999

dbSNP variants (sampled 300 via entrez): RS1000016088 (21:37238154 G>A), RS1000023894 (21:37255874 G>A,C,T), RS1000056599 (21:37256143 C>T), RS1000086277 (21:37226353 C>A), RS1000153224 (21:37227553 C>G,T), RS1000220587 (21:37228466 G>A), RS1000251567 (21:37261624 T>C), RS1000269756 (21:37227347 A>G), RS1000296848 (21:37243285 G>A,T), RS1000299617 (21:37244902 C>G), RS1000346208 (21:37239239 C>T), RS1000391034 (21:37243019 C>T), RS1000617447 (21:37243723 T>C), RS1000747991 (21:37230901 A>G), RS1000821021 (21:37237648 C>A)

Disease associations

OMIM: gene MIM:605298 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
neurodevelopmental disorder	Limited	Autosomal dominant

Mondo (1): neurodevelopmental disorder (MONDO:0700092)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D065886	Neurodevelopmental Disorders	F03.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression	2
bisphenol A	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
di-n-butylphosphoric acid	affects expression	1
bisphenol B	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Fluoxetine	increases expression	1
Ivermectin	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Potassium Dichromate	increases expression	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D9VN	Ubigene HEK293 VPS26C KO	Transformed cell line	Female

Clinical trials (associated diseases)

202 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04586348	PHASE4	UNKNOWN	Prenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115	PHASE4	UNKNOWN	Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT02559102	PHASE3	COMPLETED	Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079	PHASE3	COMPLETED	Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480	PHASE3	RECRUITING	Reducing Missed Appointments
NCT07377032	PHASE3	RECRUITING	TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT02909959	PHASE2	COMPLETED	Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348	PHASE2	RECRUITING	Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372	PHASE2	COMPLETED	Safety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT00503191	PHASE1	COMPLETED	NeuroModulation Technique Treatment of Autism
NCT04475848	PHASE1	COMPLETED	A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
NCT06300398	PHASE1	COMPLETED	IAMA-6 Oral Dose Study in Healthy Adults
NCT01783041	PHASE2/PHASE3	COMPLETED	Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
NCT05767385	PHASE2/PHASE3	RECRUITING	Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
NCT05675098	EARLY_PHASE1	NOT_YET_RECRUITING	Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
NCT00783783	Not specified	COMPLETED	CYP2D6 Pharmacogenetics in Risperidone-Treated Children
NCT01778504	Not specified	RECRUITING	Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01850784	Not specified	UNKNOWN	High Energy Formula Feeding in Infants With Congenital Heart Disease
NCT01922791	Not specified	COMPLETED	Nutrition and Pregnancy Intervention Study
NCT01942525	Not specified	UNKNOWN	Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
NCT02003170	Not specified	COMPLETED	Etiology and Early Diagnosis of Neurodevelopmental Disorders
NCT02118649	Not specified	ACTIVE_NOT_RECRUITING	Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game
NCT02557191	Not specified	TERMINATED	Biomarkers, Neurodevelopment and Preterm Infants
NCT02690675	Not specified	COMPLETED	Iron Supplement Effect on Child Development
NCT02694003	Not specified	COMPLETED	Better Nights, Better Days for Children With Neurodevelopment Disorders
NCT02792894	Not specified	COMPLETED	Family Networks (FaNs) for Children With Developmental Disorders and Delays
NCT02871674	Not specified	UNKNOWN	Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial
NCT02887157	Not specified	COMPLETED	Analyzing Retinal Microanatomy in ROP
NCT02898298	Not specified	COMPLETED	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
NCT02912780	Not specified	UNKNOWN	Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit
NCT03023293	Not specified	COMPLETED	n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
NCT03023644	Not specified	COMPLETED	Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
NCT03032991	Not specified	UNKNOWN	Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
NCT03088189	Not specified	TERMINATED	Effect of Parental Peri-conceptional Vitamin B12 Supplementation on Infant Neurocognitive Development in Offspring
NCT03096028	Not specified	COMPLETED	Developmental Origins of Mental Health Disorders
NCT03148782	Not specified	COMPLETED	Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase
NCT03172104	Not specified	COMPLETED	Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age
NCT03222375	Not specified	RECRUITING	SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
NCT03229928	Not specified	COMPLETED	Clinical Testing of a Real-Time Behavior Measurement Tool: Measuring Outcomes for CHAnge
NCT03232489	Not specified	UNKNOWN	Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice