VPS37B

Summary

VPS37B (VPS37B subunit of ESCRT-I, HGNC:25754) is a protein-coding gene on chromosome 12q24.31, encoding Vacuolar protein sorting-associated protein 37B (Q9H9H4). Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

Enables calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex.

Source: NCBI Gene 79720 — RefSeq curated summary.

At a glance

• GWAS associations: 13
• Clinical variants (ClinVar): 54 total
• MANE Select transcript: NM_024667

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25754
Approved symbol	VPS37B
Name	VPS37B subunit of ESCRT-I
Location	12q24.31
Locus type	gene with protein product
Status	Approved
Aliases	FLJ12750
Ensembl gene	ENSG00000139722
Ensembl biotype	protein_coding
OMIM	610037
Entrez	79720

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 4 protein_coding, 1 retained_intron

ENST00000267202, ENST00000371248, ENST00000535765, ENST00000543590, ENST00000852158

RefSeq mRNA: 1 — MANE Select: NM_024667 NM_024667

CCDS: CCDS9239

Canonical transcript exons

ENST00000267202 — 4 exons

Exon	Start	End
ENSE00000939889	122870890	122871061
ENSE00000939890	122868480	122868562
ENSE00001314131	122865330	122867607
ENSE00002244083	122895952	122896124

Expression profiles

Bgee: expression breadth ubiquitous, 273 present calls, max score 96.76.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 39.5065 / max 1026.3619, expressed in 1811 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
133862	39.5065	1811

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	96.76	gold quality
sural nerve	UBERON:0015488	96.37	gold quality
ventricular zone	UBERON:0003053	94.86	gold quality
oocyte	CL:0000023	94.82	gold quality
esophagus mucosa	UBERON:0002469	94.73	gold quality
cartilage tissue	UBERON:0002418	94.52	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.51	gold quality
secondary oocyte	CL:0000655	94.11	gold quality
mucosa of transverse colon	UBERON:0004991	93.92	gold quality
pancreatic ductal cell	CL:0002079	93.33	gold quality
body of stomach	UBERON:0001161	92.82	gold quality
palpebral conjunctiva	UBERON:0001812	92.81	gold quality
granulocyte	CL:0000094	92.72	gold quality
minor salivary gland	UBERON:0001830	92.58	gold quality
amniotic fluid	UBERON:0000173	92.41	gold quality
esophagus squamous epithelium	UBERON:0006920	92.33	gold quality
oral cavity	UBERON:0000167	92.10	gold quality
epithelium of esophagus	UBERON:0001976	92.06	gold quality
mouth mucosa	UBERON:0003729	91.91	gold quality
ganglionic eminence	UBERON:0004023	91.70	gold quality
saliva-secreting gland	UBERON:0001044	91.69	gold quality
esophagus	UBERON:0001043	91.46	gold quality
transverse colon	UBERON:0001157	91.40	gold quality
blood	UBERON:0000178	91.24	gold quality
left lobe of thyroid gland	UBERON:0001120	91.11	gold quality
right lobe of thyroid gland	UBERON:0001119	90.86	gold quality
stomach	UBERON:0000945	90.83	gold quality
upper lobe of left lung	UBERON:0008952	90.71	gold quality
squamous epithelium	UBERON:0006914	90.23	gold quality
upper lobe of lung	UBERON:0008948	90.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

86 targeting VPS37B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-513A-5P	100.00	69.77	2465
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-4525	99.94	64.38	675
HSA-MIR-5010-5P	99.94	64.11	705
HSA-MIR-454-3P	99.91	74.01	1925
HSA-MIR-130A-3P	99.90	73.31	1861
HSA-MIR-130B-3P	99.90	73.27	1850
HSA-MIR-301A-3P	99.90	73.15	1839
HSA-MIR-301B-3P	99.90	73.19	1836
HSA-MIR-3666	99.90	73.24	1833
HSA-MIR-4295	99.90	73.11	1838
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057

Literature-anchored findings (GeneRIF, showing 1)

• VPS37B and appeared to interact with ALG-2 in a stronger manner than TSG101 does. (PMID:23924735)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	vps37ba	ENSDARG00000039319
danio_rerio	vps37bb	ENSDARG00000101143
mus_musculus	Vps37b	ENSMUSG00000066278
rattus_norvegicus	Vps37b	ENSRNOG00000001086
drosophila_melanogaster	Vps37B	FBGN0037299

Paralogs (3): VPS37A (ENSG00000155975), VPS37C (ENSG00000167987), VPS37D (ENSG00000176428)

Protein

Protein identifiers

Vacuolar protein sorting-associated protein 37B — Q9H9H4 (reviewed: Q9H9H4)

Alternative names: ESCRT-I complex subunit VPS37B

All UniProt accessions (3): Q9H9H4, F5H1F6, F5H4M0

UniProt curated annotations — full annotation on UniProt →

Function. Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

Subunit / interactions. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with CEP55. Interacts with IST1.

Subcellular location. Late endosome membrane.

Tissue specificity. Widely expressed. Expressed in macrophages and lymphocytes.

Similarity. Belongs to the VPS37 family.

RefSeq proteins (1): NP_078943* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR009851	Mod_r	Domain
IPR029012	Helix_hairpin_bin_sf	Homologous_superfamily
IPR037202	ESCRT_assembly_dom	Homologous_superfamily

Pfam: PF07200

UniProt features (10 total): region of interest 3, compositionally biased region 2, helix 2, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
6VME	X-RAY DIFFRACTION	2.19

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H9H4-F1	76.42	0.45

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 218

Function

Pathways and Gene Ontology

Reactome pathways

5 pathways

ID	Pathway
R-HSA-162588	Budding and maturation of HIV virion
R-HSA-174490	Membrane binding and targetting of GAG proteins
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-9610379	HCMV Late Events
R-HSA-9615710	Late endosomal microautophagy

MSigDB gene sets: 317 (showing top): ATF_B, REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT, GOBP_ENDOSOME_ORGANIZATION, GOBP_INTRACELLULAR_PROTEIN_TRANSPORT, GOBP_VESICLE_ORGANIZATION, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GOBP_PROTEIN_TARGETING, GOBP_MACROMOLECULE_CATABOLIC_PROCESS, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_VACUOLAR_TRANSPORT, CREBP1_Q2, GOBP_VESICLE_MEDIATED_TRANSPORT, REACTOME_MEMBRANE_TRAFFICKING, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_MACROAUTOPHAGY

GO Biological Process (11): protein targeting to membrane (GO:0006612), protein targeting to vacuole (GO:0006623), macroautophagy (GO:0016236), viral release from host cell (GO:0019076), multivesicular body assembly (GO:0036258), viral budding via host ESCRT complex (GO:0039702), ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162), protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043328), membrane fission (GO:0090148), positive regulation of viral budding via host ESCRT complex (GO:1903774), protein transport (GO:0015031)

GO Molecular Function (2): calcium-dependent protein binding (GO:0048306), protein binding (GO:0005515)

GO Cellular Component (9): ESCRT I complex (GO:0000813), cytoplasm (GO:0005737), endosome (GO:0005768), plasma membrane (GO:0005886), endosome membrane (GO:0010008), midbody (GO:0030496), late endosome membrane (GO:0031902), extracellular exosome (GO:0070062), membrane (GO:0016020)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Late Phase of HIV Life Cycle	1
Synthesis And Processing Of GAG, GAGPOL Polyproteins	1
Membrane Trafficking	1
HCMV Infection	1
Autophagy	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	3
protein targeting	2
intracellular protein transport	2
protein localization to vacuole	2
establishment of protein localization to vacuole	2
endosome membrane	2
establishment of protein localization to membrane	1
vacuolar transport	1
autophagosome assembly	1
autophagy	1
viral process	1
viral life cycle	1
exit from host cell	1
multivesicular body organization	1
organelle assembly	1
viral budding	1
ubiquitin-dependent protein catabolic process	1
protein catabolic process in the vacuole	1
multivesicular body sorting pathway	1
late endosome to vacuole transport via multivesicular body sorting pathway	1
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	1
membrane organization	1
viral budding via host ESCRT complex	1
regulation of viral budding via host ESCRT complex	1
positive regulation of viral life cycle	1
transport	1
intracellular protein localization	1
establishment of protein localization	1
calcium ion binding	1
protein binding	1
binding	1
ESCRT complex	1
membrane protein complex	1
intracellular anatomical structure	1
endomembrane system	1
cytoplasmic vesicle	1
membrane	1
cell periphery	1
endosome	1
cytoplasmic vesicle membrane	1

Protein interactions and networks

STRING

539 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
VPS37B	VPS28	Q9UK41	984
VPS37B	TSG101	Q99816	949
VPS37B	VPS4A	Q9UN37	912
VPS37B	MVB12A	Q96EY5	833
VPS37B	MVB12B	Q9H7P6	711
VPS37B	CHMP3	Q9Y3E7	663
VPS37B	A0A140T963	A0A140T963	663
VPS37B	VPS25	Q9BRG1	643
VPS37B	CHMP1A	Q9HD42	639
VPS37B	CHMP5	Q9NZZ3	617
VPS37B	VPS36	Q86VN1	593
VPS37B	CHMP6	Q96FZ7	588
VPS37B	CHMP1B	Q7LBR1	573
VPS37B	CHMP2A	O43633	560
VPS37B	UBAP1	Q9NZ09	537

IntAct

171 interactions, top by confidence:

A	B	Type	Score
CEP55	TSG101	psi-mi:“MI:0914”(association)	0.970
VPS28	VPS37B	psi-mi:“MI:0915”(physical association)	0.890
VPS37B	VPS28	psi-mi:“MI:0915”(physical association)	0.890
CEP55	VPS37C	psi-mi:“MI:0914”(association)	0.800
VPS37B	SMARCD1	psi-mi:“MI:0915”(physical association)	0.780
VPS37B	SH3YL1	psi-mi:“MI:0915”(physical association)	0.780
SMARCD1	VPS37B	psi-mi:“MI:0915”(physical association)	0.780
SH3YL1	VPS37B	psi-mi:“MI:0915”(physical association)	0.780
TSG101	VPS37C	psi-mi:“MI:0914”(association)	0.780
GRB2	WIPF3	psi-mi:“MI:0914”(association)	0.730
VPS37B	NCK2	psi-mi:“MI:0915”(physical association)	0.720
BYSL	VPS37B	psi-mi:“MI:0915”(physical association)	0.720
UBASH3B	VPS37B	psi-mi:“MI:0915”(physical association)	0.720
VPS37B	BYSL	psi-mi:“MI:0915”(physical association)	0.720
VPS37B	UBASH3B	psi-mi:“MI:0915”(physical association)	0.720

BioGRID (108): VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), VPS37B (Two-hybrid), UBASH3B (Two-hybrid), FBF1 (Two-hybrid), VPS37B (Affinity Capture-MS)

ESM2 similar proteins: A0JPN4, A2A9T0, A5D8V6, A6ND36, A6QQJ8, A7MCY6, E9Q2Z1, O14529, O54714, O70260, O88902, P70298, P98175, Q07912, Q0IIJ3, Q13227, Q13625, Q148V8, Q15025, Q15942, Q3SZL6, Q3U564, Q3UIL6, Q499E4, Q5BJU7, Q5D1E7, Q5D1E8, Q5NVG8, Q5R9T2, Q5RBV9, Q5U2X5, Q5XIA0, Q61140, Q62415, Q62523, Q63767, Q6DG50, Q6IQ23, Q810I0, Q8CG79

Diamond homologs: A5D8V6, Q5R9T2, Q810I0, Q86XT2, Q8R0J7, Q8R105, Q9H9H4, Q9SCP9, Q8CHS8, Q8NEZ2

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 74 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Endosomal Sorting Complex Required For Transport (ESCRT)	8	53.6×	6e-10
Budding and maturation of HIV virion	6	44.5×	4e-07
Late endosomal microautophagy	7	41.5×	4e-08
HCMV Late Events	7	12.5×	1e-04

GO biological processes:

GO term	Partners	Fold	FDR
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	8	133.8×	2e-13
multivesicular body assembly	8	66.9×	5e-11
viral budding via host ESCRT complex	5	63.7×	1e-06
membrane fission	9	58.7×	8e-12
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	6	51.8×	2e-07
macroautophagy	8	30.6×	3e-08

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1134 predictions. Top by Δscore:

Variant	Effect	Δscore
12:122867604:TGTT:T	acceptor_gain	1.0000
12:122867605:GTT:G	acceptor_gain	1.0000
12:122867606:TT:T	acceptor_gain	1.0000
12:122867607:TCT:T	acceptor_loss	1.0000
12:122867608:C:CC	acceptor_gain	1.0000
12:122868563:C:CC	acceptor_gain	1.0000
12:122870885:GTTAC:G	donor_loss	1.0000
12:122870886:TTACC:T	donor_loss	1.0000
12:122870887:TACCT:T	donor_loss	1.0000
12:122870889:C:CG	donor_loss	1.0000
12:122870908:T:C	donor_gain	1.0000
12:122870937:T:A	donor_gain	1.0000
12:122871061:TCT:T	acceptor_loss	1.0000
12:122871062:C:CC	acceptor_gain	1.0000
12:122871062:C:CG	acceptor_loss	1.0000
12:122871063:T:A	acceptor_loss	1.0000
12:122895946:GCTCA:G	donor_loss	1.0000
12:122895947:CTCA:C	donor_loss	1.0000
12:122895948:TCA:T	donor_loss	1.0000
12:122895949:CAC:C	donor_loss	1.0000
12:122895950:A:C	donor_loss	1.0000
12:122895950:ACCT:A	donor_gain	1.0000
12:122895951:CCTC:C	donor_gain	1.0000
12:122895953:T:TA	donor_gain	1.0000
12:122867603:ATGTT:A	acceptor_gain	0.9900
12:122867605:GTTCT:G	acceptor_gain	0.9900
12:122868490:T:TA	donor_gain	0.9900
12:122868559:CTGT:C	acceptor_gain	0.9900
12:122870892:A:AC	donor_gain	0.9900
12:122870893:A:C	donor_gain	0.9900

AlphaMissense

1818 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
12:122867537:C:G	R146P	0.999
12:122868517:A:G	L110P	0.999
12:122867498:A:G	L159P	0.998
12:122867519:C:G	R152P	0.998
12:122867560:G:C	F138L	0.998
12:122867560:G:T	F138L	0.998
12:122867561:A:G	F138S	0.998
12:122867562:A:G	F138L	0.998
12:122870994:A:G	L60P	0.998
12:122867516:C:G	R153P	0.997
12:122870934:A:G	L80P	0.997
12:122871007:C:G	A56P	0.997
12:122896010:A:G	L18P	0.997
12:122867550:A:C	Y142D	0.996
12:122867591:A:G	F128S	0.996
12:122868520:A:G	L109P	0.996
12:122867526:G:C	H150D	0.995
12:122867529:C:G	A149P	0.995
12:122868512:C:G	A112P	0.995
12:122871015:C:G	R53P	0.995
12:122896001:A:G	L21P	0.995
12:122871006:G:T	A56E	0.994
12:122871009:A:G	L55P	0.994
12:122871027:A:G	L49P	0.994
12:122868503:C:G	A115P	0.993
12:122870996:G:C	N59K	0.993
12:122870996:G:T	N59K	0.993
12:122871017:G:C	N52K	0.993
12:122871017:G:T	N52K	0.993
12:122867601:C:G	A125P	0.992

dbSNP variants (sampled 300 via entrez): RS1000037591 (12:122881894 C>T), RS1000090174 (12:122874683 T>C), RS1000119167 (12:122871930 G>A), RS1000163742 (12:122875029 T>G), RS1000344487 (12:122867910 G>A), RS1000399748 (12:122874127 T>C), RS1000491154 (12:122864834 C>A,G,T), RS1000609864 (12:122880478 A>C,G,T), RS1000690911 (12:122865520 C>T), RS1000726176 (12:122870497 C>T), RS1001006671 (12:122885765 G>C), RS1001144473 (12:122895488 C>T), RS1001165589 (12:122892575 C>A), RS1001261428 (12:122892237 A>C), RS1001682194 (12:122881807 TA>T,TAA)

Disease associations

OMIM: gene MIM:610037 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

13 associations (top):

Study	Trait	p-value
GCST007277_17	Tourette syndrome	2.000000e-06
GCST90020024_249	A body shape index	3.000000e-08
GCST90020024_428	A body shape index	3.000000e-08
GCST90020025_33	Waist-to-hip ratio adjusted for BMI	8.000000e-11
GCST90020025_401	Waist-to-hip ratio adjusted for BMI	5.000000e-09
GCST90020025_402	Waist-to-hip ratio adjusted for BMI	7.000000e-11
GCST90020025_41	Waist-to-hip ratio adjusted for BMI	8.000000e-11
GCST90020027_1210	Waist-hip index	4.000000e-11
GCST90020027_1243	Waist-hip index	6.000000e-11
GCST90020027_1253	Waist-hip index	2.000000e-08
GCST90020028_1249	Hip circumference adjusted for BMI	2.000000e-11
GCST90020028_1258	Hip circumference adjusted for BMI	2.000000e-11
GCST90020029_361	Waist circumference adjusted for body mass index	4.000000e-10

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007789	BMI-adjusted waist circumference
EFO:0007788	BMI-adjusted waist-hip ratio
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

52 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Tobacco Smoke Pollution	affects expression, increases expression	4
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
(+)-JQ1 compound	decreases expression	2
Cyclosporine	increases expression	2
aristolochic acid I	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	affects methylation	1
beta-lapachone	increases expression	1
cobaltous chloride	increases expression	1
perfluorooctanoic acid	decreases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
aflatoxin B2	decreases methylation	1
cupric chloride	increases expression	1
4-aminophenylarsenoxide	affects binding, decreases reaction	1
isobutyl alcohol	affects cotreatment, increases abundance, increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	decreases expression	1
CGP 52608	affects binding, increases reaction	1
perfluoro-n-nonanoic acid	decreases expression	1
perfluorohexanesulfonic acid	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
abrine	increases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Sunitinib	decreases expression	1
Arsenic Trioxide	decreases reaction, affects binding	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	increases abundance, increases expression, affects cotreatment	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.