VPS45-AS1

Summary

VPS45-AS1 (VPS45 antisense RNA 1, HGNC:58766) is a long non-coding RNA gene on chromosome 1q21.2.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:58766
Approved symbol	VPS45-AS1
Name	VPS45 antisense RNA 1
Location	1q21.2
Locus type	RNA, long non-coding
Status	Approved
Aliases	AC244033.2
Ensembl gene	ENSG00000285184
Ensembl biotype	lncRNA
Entrez	144093365

Gene structure

Transcript identifiers

Ensembl transcripts: 51 — 51 lncRNA

ENST00000642888, ENST00000643984, ENST00000648868, ENST00000692914, ENST00000764240, ENST00000764241, ENST00000764242, ENST00000764243, ENST00000764244, ENST00000764245, ENST00000764246, ENST00000764247, ENST00000764248, ENST00000764249, ENST00000764250, ENST00000764251, ENST00000764252, ENST00000764253, ENST00000764254, ENST00000764255, ENST00000764256, ENST00000764257, ENST00000764258, ENST00000764259, ENST00000764260, ENST00000764261, ENST00000764262, ENST00000764263, ENST00000764264, ENST00000764265, ENST00000764266, ENST00000764267, ENST00000764268, ENST00000764269, ENST00000764270, ENST00000764271, ENST00000764272, ENST00000764273, ENST00000764274, ENST00000764275, ENST00000764276, ENST00000764277, ENST00000764278, ENST00000764279, ENST00000764280, ENST00000764281, ENST00000764282, ENST00000764283, ENST00000764284, ENST00000764285, ENST00000764286

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000642888 — 5 exons

Exon	Start	End
ENSE00003814888	150050482	150050540
ENSE00003821737	150048455	150048551
ENSE00003821993	150066970	150067692
ENSE00003823357	150054509	150054640
ENSE00003828247	150046727	150047945

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 77.77.

Top tissues by expression

133 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	77.77	silver quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	77.60	silver quality
skeletal muscle tissue	UBERON:0001134	73.46	gold quality
cerebellar cortex	UBERON:0002129	72.22	gold quality
cerebellum	UBERON:0002037	72.19	gold quality
cerebellar hemisphere	UBERON:0002245	72.14	gold quality
hindlimb stylopod muscle	UBERON:0004252	72.08	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.29	gold quality
ganglionic eminence	UBERON:0004023	70.56	gold quality
muscle tissue	UBERON:0002385	70.32	gold quality
ventricular zone	UBERON:0003053	69.50	gold quality
nucleus accumbens	UBERON:0001882	68.82	gold quality
muscle of leg	UBERON:0001383	68.41	gold quality
superior frontal gyrus	UBERON:0002661	68.38	gold quality
apex of heart	UBERON:0002098	67.82	gold quality
putamen	UBERON:0001874	67.67	gold quality
gastrocnemius	UBERON:0001388	67.55	gold quality
caudate nucleus	UBERON:0001873	67.45	gold quality
prefrontal cortex	UBERON:0000451	67.24	gold quality
cortical plate	UBERON:0005343	67.00	gold quality
amygdala	UBERON:0001876	66.92	gold quality
bone marrow cell	CL:0002092	66.89	silver quality
temporal lobe	UBERON:0001871	66.89	gold quality
primary visual cortex	UBERON:0002436	66.85	gold quality
brain	UBERON:0000955	66.78	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.54	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.50	gold quality
frontal cortex	UBERON:0001870	66.34	gold quality
cerebral cortex	UBERON:0000956	66.20	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.84

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.