VPS72

Summary

VPS72 (vacuolar protein sorting 72 homolog, HGNC:11644) is a protein-coding gene on chromosome 1q21.3, encoding Vacuolar protein sorting-associated protein 72 homolog (Q15906). Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. It is a selective cancer dependency (DepMap: 62.1% of cell lines).

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Source: NCBI Gene 6944 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 17 total
• Cancer dependency (DepMap): dependent in 62.1% of screened cell lines
• MANE Select transcript: NM_005997

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:11644
Approved symbol	VPS72
Name	vacuolar protein sorting 72 homolog
Location	1q21.3
Locus type	gene with protein product
Status	Approved
Aliases	YL-1, YL1, Swc2
Ensembl gene	ENSG00000163159
Ensembl biotype	protein_coding
OMIM	600607
Entrez	6944

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 9 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000354473, ENST00000368892, ENST00000463470, ENST00000471423, ENST00000496809, ENST00000859398, ENST00000859399, ENST00000859400, ENST00000859401, ENST00000859402, ENST00000915996, ENST00000915997

RefSeq mRNA: 3 — MANE Select: NM_005997 NM_001271087, NM_001271088, NM_005997

CCDS: CCDS59201, CCDS989

Canonical transcript exons

ENST00000368892 — 6 exons

Exon	Start	End
ENSE00000000170	151190005	151190197
ENSE00001929723	151176304	151177031
ENSE00003592537	151185506	151185620
ENSE00003610727	151178001	151178145
ENSE00003616902	151185798	151185950
ENSE00003627570	151184317	151184493

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 97.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 42.9290 / max 328.5775, expressed in 1822 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
14416	42.9290	1822

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.92	gold quality
oocyte	CL:0000023	97.87	gold quality
ganglionic eminence	UBERON:0004023	97.37	gold quality
cortical plate	UBERON:0005343	96.86	gold quality
ventricular zone	UBERON:0003053	95.56	gold quality
calcaneal tendon	UBERON:0003701	95.36	gold quality
gastrocnemius	UBERON:0001388	94.70	gold quality
muscle of leg	UBERON:0001383	94.65	gold quality
islet of Langerhans	UBERON:0000006	94.21	gold quality
endometrium epithelium	UBERON:0004811	93.99	gold quality
embryo	UBERON:0000922	93.75	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.32	gold quality
smooth muscle tissue	UBERON:0001135	93.27	gold quality
stromal cell of endometrium	CL:0002255	93.23	gold quality
prefrontal cortex	UBERON:0000451	93.06	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.82	gold quality
muscle organ	UBERON:0001630	92.80	gold quality
lower esophagus	UBERON:0013473	92.79	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	92.79	gold quality
popliteal artery	UBERON:0002250	92.57	gold quality
tibial artery	UBERON:0007610	92.56	gold quality
monocyte	CL:0000576	92.51	gold quality
granulocyte	CL:0000094	92.48	gold quality
mucosa of stomach	UBERON:0001199	92.44	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.33	gold quality
mononuclear cell	CL:0000842	92.22	gold quality
leukocyte	CL:0000738	92.17	gold quality
cerebellar cortex	UBERON:0002129	91.77	gold quality
cerebellar hemisphere	UBERON:0002245	91.76	gold quality
rectum	UBERON:0001052	91.75	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): MYC, ZBTB17

miRNA regulators (miRDB)

28 targeting VPS72, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-4760-5P	99.80	69.88	1619
HSA-MIR-8061	99.63	69.44	1411
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-766-5P	99.47	67.91	2225
HSA-MIR-32-3P	99.36	68.20	2517
HSA-MIR-6510-5P	99.14	66.59	1081
HSA-MIR-4434	99.10	67.01	1984
HSA-MIR-5703	99.10	67.09	2053
HSA-MIR-4463	98.56	66.05	1071
HSA-MIR-6878-5P	98.49	67.91	2142
HSA-MIR-4511	98.32	67.97	1500
HSA-MIR-4436B-3P	98.25	65.26	1494
HSA-MIR-4423-3P	97.98	69.66	912
HSA-MIR-649	97.96	67.21	704
HSA-MIR-376A-5P	97.70	65.61	863
HSA-MIR-6783-5P	97.67	67.21	1528
HSA-MIR-3127-5P	97.52	65.24	786
HSA-MIR-6824-5P	97.41	68.43	583
HSA-MIR-1225-3P	97.29	64.60	876
HSA-MIR-3667-5P	97.16	64.87	591
HSA-MIR-383-5P	96.86	67.55	820

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 62.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 6)

• Results identify YL1 as a subunit of the TRRAP/TIP60 HAT complex, and also as a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP. (PMID:15647280)
• The 2.7-A-resolution crystal structure of the human YL1-H2A.Z-H2B complex shows that YL1 binding, similarly to ANP32E binding, triggers an extension of the H2A.Z alphaC helix. (PMID:26974126)
• VPS72/YL1-Mediated H2A.Z Deposition Is Required for Nuclear Reassembly after Mitosis. (PMID:32708675)
• Vacuolar protein sorting-associated protein 72 homolog (VPS72) binding to lysine acetyltransferase 5 (KAT5) promotes the proliferation, invasion and migration of hepatocellular carcinoma through regulating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. (PMID:35383533)
• Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression. (PMID:36631007)
• Prognostic marker VPS72 could promote the malignant progression of prostate cancer. (PMID:38858662)

Cross-species orthologs

6 orthologs

Organism	Symbol	Gene ID
danio_rerio	vps72a	ENSDARG00000063718
danio_rerio	vps72b	ENSDARG00000088567
mus_musculus	Vps72	ENSMUSG00000008958
rattus_norvegicus	Vps72	ENSRNOG00000021081
drosophila_melanogaster	YL-1	FBGN0032321
caenorhabditis_elegans	C17E4.6	WBGENE00007645

Protein

Protein identifiers

Vacuolar protein sorting-associated protein 72 homolog — Q15906 (reviewed: Q15906)

Alternative names: Protein YL-1, Transcription factor-like 1

All UniProt accessions (1): Q15906

UniProt curated annotations — full annotation on UniProt →

Function. Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

Subunit / interactions. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Also part of a multiprotein complex which contains SRCAP and which binds to H2AZ1/H2AZ. Interacts (via N-terminal domain) with heterodimer H2BC11 and H2AZ1. The interaction with H2AZ1 is enhanced by VPS72 phosphorylation which is promoted by ZNHIT1.

Subcellular location. Nucleus.

Post-translational modifications. Phosphorylation is enhanced by ZNHIT1 and promotes the interaction of VPS72 with histone H2AZ1.

Similarity. Belongs to the VPS72/YL1 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q15906-1	1	yes
Q15906-2	2

RefSeq proteins (3): NP_001258016, NP_001258017, NP_005988* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR013272	Vps72/YL1_C	Domain
IPR046757	YL1_N	Domain

Pfam: PF05764, PF08265

UniProt features (31 total): helix 7, strand 6, compositionally biased region 3, mutagenesis site 2, sequence conflict 2, turn 2, region of interest 2, modified residue 2, chain 1, DNA-binding region 1, splice variant 1, sequence variant 1, cross-link 1

Structure

Experimental structures (PDB)

17 structures.

PDB	Method	Resolution (Å)
9INC	X-RAY DIFFRACTION	2.01
8QR1	ELECTRON MICROSCOPY	2.4
5FUG	X-RAY DIFFRACTION	2.7
9C57	ELECTRON MICROSCOPY	2.75
9CAE	ELECTRON MICROSCOPY	3.07
8X15	ELECTRON MICROSCOPY	3.2
8X19	ELECTRON MICROSCOPY	3.2
8X1C	ELECTRON MICROSCOPY	3.2
8XVT	ELECTRON MICROSCOPY	3.2
9CA7	ELECTRON MICROSCOPY	3.35
9CAC	ELECTRON MICROSCOPY	3.43
9CA9	ELECTRON MICROSCOPY	3.56
9CA8	ELECTRON MICROSCOPY	3.92
9CAB	ELECTRON MICROSCOPY	3.94
9CAA	ELECTRON MICROSCOPY	4.04
9C62	ELECTRON MICROSCOPY	5.28
8XVG	ELECTRON MICROSCOPY	9.4

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q15906-F1	73.98	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (3): 127, 129, 115

Mutagenesis-validated functional residues (2):

Position	Phenotype
29–37	highly decreases interaction with h2az1 and h2bc11. abolishes interaction with h2az1 and h2bc11 and exchange of h2a for
43–46	almost abolishes interaction with h2az1 and h2bc11. abolishes interaction with h2az1 and h2bc11 and exchange of h2a for

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-3214847	HATs acetylate histones

MSigDB gene sets: 203 (showing top): GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR, GOBP_REGULATION_OF_DNA_RECOMBINATION, GOBP_SOMATIC_STEM_CELL_POPULATION_MAINTENANCE, YAGI_AML_WITH_INV_16_TRANSLOCATION, MORF_RAB5A, ENK_UV_RESPONSE_KERATINOCYTE_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, HSIAO_HOUSEKEEPING_GENES, GOBP_REGULATION_OF_DOUBLE_STRAND_BREAK_REPAIR_VIA_HOMOLOGOUS_RECOMBINATION, GOBP_REGULATION_OF_DNA_REPAIR, PATIL_LIVER_CANCER, GCM_PRKCG, GCM_RING1, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1

GO Biological Process (11): negative regulation of transcription by RNA polymerase II (GO:0000122), chromatin remodeling (GO:0006338), regulation of DNA-templated transcription (GO:0006355), somatic stem cell population maintenance (GO:0035019), regulation of apoptotic process (GO:0042981), transcription initiation-coupled chromatin remodeling (GO:0045815), positive regulation of DNA-templated transcription (GO:0045893), regulation of cell cycle (GO:0051726), positive regulation of double-strand break repair via homologous recombination (GO:1905168), regulation of double-strand break repair (GO:2000779), chromatin organization (GO:0006325)

GO Molecular Function (4): DNA binding (GO:0003677), histone binding (GO:0042393), histone chaperone activity (GO:0140713), protein binding (GO:0005515)

GO Cellular Component (6): nucleosome (GO:0000786), nucleus (GO:0005634), nucleoplasm (GO:0005654), nuclear speck (GO:0016607), protein-containing complex (GO:0032991), NuA4 histone acetyltransferase complex (GO:0035267)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Chromatin modifying enzymes	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
DNA-templated transcription	2
regulation of transcription by RNA polymerase II	1
transcription by RNA polymerase II	1
negative regulation of DNA-templated transcription	1
chromatin organization	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
stem cell population maintenance	1
apoptotic process	1
regulation of programmed cell death	1
transcription initiation at RNA polymerase II promoter	1
positive regulation of gene expression, epigenetic	1
regulation of DNA-templated transcription	1
positive regulation of RNA biosynthetic process	1
cell cycle	1
regulation of cellular process	1
double-strand break repair via homologous recombination	1
regulation of double-strand break repair via homologous recombination	1
positive regulation of DNA recombination	1
positive regulation of double-strand break repair	1
regulation of DNA repair	1
double-strand break repair	1
cellular component organization	1
nucleic acid binding	1
protein binding	1
histone binding	1
protein carrier activity	1
binding	1
chromatin	1
protein-DNA complex	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1
nuclear ribonucleoprotein granule	1
cellular_component	1
H4/H2A histone acetyltransferase complex	1

Protein interactions and networks

STRING

1688 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
VPS72	SRCAP	Q6ZRS2	960
VPS72	DMAP1	Q9NPF5	950
VPS72	CFDP1	Q9UEE9	949
VPS72	RUVBL1	P82276	945
VPS72	YEATS4	O95619	942
VPS72	TRRAP	Q9Y4A5	929
VPS72	RUVBL2	Q9Y230	913
VPS72	H2AZ1	P0C0S5	864
VPS72	KAT5	Q92993	857
VPS72	ZNHIT1	O43257	852
VPS72	BRD8	Q9H0E9	775
VPS72	SMARCA2	P51531	718
VPS72	MORF4L1	Q9UBU8	681
VPS72	H2BC21	Q16778	661
VPS72	ANP32E	Q9BTT0	637
VPS72	MRGBP	Q9NV56	637

IntAct

177 interactions, top by confidence:

A	B	Type	Score
RUVBL1	VPS72	psi-mi:“MI:0915”(physical association)	0.880
RUVBL1	ZNHIT1	psi-mi:“MI:0914”(association)	0.860
MRGBP	YEATS4	psi-mi:“MI:0914”(association)	0.840
RUVBL2	ZNHIT1	psi-mi:“MI:0914”(association)	0.810
YEATS4	ZNHIT1	psi-mi:“MI:0914”(association)	0.790
INO80E	TFPT	psi-mi:“MI:0914”(association)	0.790
ZNHIT1	YEATS4	psi-mi:“MI:0914”(association)	0.790
H2AZ1	ZNHIT1	psi-mi:“MI:0914”(association)	0.770
MRGBP	ACTL6A	psi-mi:“MI:0914”(association)	0.760
TRRAP	ATXN7	psi-mi:“MI:0914”(association)	0.740
MBTD1	YEATS4	psi-mi:“MI:0914”(association)	0.730
MORF4L1	SIN3B	psi-mi:“MI:0914”(association)	0.730
ZNHIT1	ACTL6A	psi-mi:“MI:0914”(association)	0.720
ACTL6A	ZNHIT1	psi-mi:“MI:0914”(association)	0.720
NFIC	NFIB	psi-mi:“MI:2364”(proximity)	0.690
VPS72	ZNHIT1	psi-mi:“MI:0914”(association)	0.690
MDFI	VPS72	psi-mi:“MI:0915”(physical association)	0.670

BioGRID (224): VPS72 (Two-hybrid), HMBOX1 (Two-hybrid), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), VPS72 (Affinity Capture-MS), CALCOCO2 (Two-hybrid), VPS72 (Two-hybrid), CCDC85B (Two-hybrid)

ESM2 similar proteins: A0A286Y9D1, C0HKD8, C0HKD9, F4HVZ5, F4IDY7, F4IP06, O00566, O14012, O15541, O48713, O94416, O94667, O94880, P34648, P38326, P55080, P55081, Q05021, Q10580, Q14320, Q15906, Q16U25, Q17QX9, Q28BK4, Q2VPH1, Q4KLV7, Q568K9, Q5E9F6, Q5EA98, Q5R5V9, Q5XIB2, Q62481, Q67ER4, Q6FML0, Q6GNJ8, Q6NXY9, Q754T8, Q7KN79, Q7PYQ5, Q810V0

Diamond homologs: F4IP06, Q15906, Q5E9F6, Q5R5V9, Q62481, Q6GNJ8, Q9VKM6

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
VPS72	“form complex”	“NuA4 complex”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 150 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Global Genome Nucleotide Excision Repair (GG-NER)	5	23.6×	1e-04
DNA Damage Recognition in GG-NER	7	20.6×	5e-06
HATs acetylate histones	22	18.0×	3e-19
Nucleotide Excision Repair	5	14.7×	8e-04
Replacement of protamines by nucleosomes in the male pronucleus	5	14.0×	9e-04
Chromatin organization	16	13.5×	1e-11
Formation of the beta-catenin:TCF transactivating complex	10	12.4×	1e-06
Chromatin modifying enzymes	16	11.9×	5e-11

GO biological processes:

GO term	Partners	Fold	FDR
regulation of double-strand break repair	17	71.6×	3e-26
positive regulation of double-strand break repair via homologous recombination	19	52.7×	3e-26
positive regulation of telomere maintenance in response to DNA damage	6	48.9×	1e-07
regulation of DNA strand elongation	6	45.8×	1e-07
regulation of chromosome organization	6	40.7×	3e-07
regulation of DNA replication	9	23.9×	1e-08
positive regulation of DNA repair	7	18.2×	6e-06
regulation of DNA repair	9	18.0×	1e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

17 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	2
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

2319 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:151176780:C:G	R320P	1.000
1:151176811:A:C	Y310D	1.000
1:151176831:T:C	D303G	1.000
1:151176863:A:C	C292W	1.000
1:151176864:C:T	C292Y	1.000
1:151176865:A:G	C292R	1.000
1:151178125:C:G	A195P	1.000
1:151178133:C:G	R192P	1.000
1:151184319:A:G	L187P	1.000
1:151184323:A:G	S186P	1.000
1:151184353:C:G	A176P	1.000
1:151184361:A:G	L173P	1.000
1:151184364:A:G	L172P	1.000
1:151185885:A:C	F61L	1.000
1:151185885:A:T	F61L	1.000
1:151185886:A:C	F61C	1.000
1:151185887:A:G	F61L	1.000
1:151185889:T:A	D60V	1.000
1:151185890:C:G	D60H	1.000
1:151190035:G:C	F29L	1.000
1:151190035:G:T	F29L	1.000
1:151190037:A:G	F29L	1.000
1:151176772:A:C	Y323D	0.999
1:151176775:C:G	A322P	0.999
1:151176781:G:T	R320S	0.999
1:151176783:A:C	I319S	0.999
1:151176783:A:T	I319N	0.999
1:151176792:A:G	F316S	0.999
1:151176811:A:T	Y310N	0.999
1:151176816:A:T	I308K	0.999

dbSNP variants (sampled 300 via entrez): RS1000210359 (1:151182667 C>T), RS1000224725 (1:151190160 A>G,T), RS1000338835 (1:151189837 C>T), RS1000496608 (1:151178325 T>A), RS1000550546 (1:151185103 C>A,G), RS1000730423 (1:151182302 T>C), RS1001021362 (1:151184866 T>G), RS1001034876 (1:151177837 T>C), RS1001092334 (1:151191342 T>C), RS1001544573 (1:151183466 C>T), RS1001622917 (1:151181639 C>G), RS1001659081 (1:151183142 T>A), RS1001819853 (1:151176821 T>C), RS1001980034 (1:151188136 A>G), RS1002218154 (1:151176962 A>G)

Disease associations

OMIM: gene MIM:600607 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, decreases expression	2
Cadmium Chloride	decreases expression, increases expression	2
FR900359	increases phosphorylation	1
pirinixic acid	affects binding, decreases expression, increases activity	1
trichostatin A	affects expression	1
sodium arsenite	affects cotreatment, decreases expression	1
isobutyl alcohol	increases abundance, increases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
4-hydroxy-equilenin	decreases expression	1
perfluorooctane sulfonic acid	increases expression	1
fenpyroximate	decreases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
picoxystrobin	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Air Pollutants, Occupational	decreases expression	1
Ethanol	affects cotreatment, increases abundance, increases expression	1
Antimycin A	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	affects methylation	1
Demecolcine	decreases expression	1
Doxorubicin	decreases expression	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Nickel	decreases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, increases abundance, increases expression	1
Rotenone	decreases expression	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression, affects cotreatment	1

Cellosaurus cell lines

3 cell lines: 3 embryonic stem cell

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_A7U5	SEES3-1V human VPS72, clone1	Embryonic stem cell	Male
CVCL_A7U6	SEES3-1V human VPS72, clone2	Embryonic stem cell	Male
CVCL_A7U7	SEES3-1V human VPS72, clone3	Embryonic stem cell	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.