VPS9D1-AS1

Summary

VPS9D1-AS1 (VPS9D1 antisense RNA 1, HGNC:48915) is a long non-coding RNA gene on chromosome 16q24.3.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:48915
Approved symbol	VPS9D1-AS1
Name	VPS9D1 antisense RNA 1
Location	16q24.3
Locus type	RNA, long non-coding
Status	Approved
Aliases	MYU, FAISL
Ensembl gene	ENSG00000261373
Ensembl biotype	lncRNA
Entrez	100128881
RNAcentral	URS000003F392 — lncRNA, 1753 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000562298, ENST00000562866

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000562298 — 2 exons

Exon	Start	End
ENSE00002580482	89716528	89716637
ENSE00002593595	89717344	89718164

Expression profiles

Bgee: expression breadth ubiquitous, 154 present calls, max score 89.57.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 12.8283 / max 192.1120, expressed in 1296 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
155639	9.8239	1217
155638	2.6185	963
155640	0.3859	204

Top tissues by expression

242 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	89.57	gold quality
lower esophagus mucosa	UBERON:0035834	85.74	gold quality
right uterine tube	UBERON:0001302	78.89	gold quality
esophagus mucosa	UBERON:0002469	77.36	gold quality
granulocyte	CL:0000094	77.25	gold quality
mucosa of transverse colon	UBERON:0004991	75.76	gold quality
right hemisphere of cerebellum	UBERON:0014890	74.37	gold quality
left adrenal gland cortex	UBERON:0035825	73.81	gold quality
left adrenal gland	UBERON:0001234	73.26	gold quality
stromal cell of endometrium	CL:0002255	73.21	gold quality
cerebellar hemisphere	UBERON:0002245	72.55	gold quality
vermiform appendix	UBERON:0001154	72.49	gold quality
cerebellar cortex	UBERON:0002129	72.43	gold quality
bone marrow cell	CL:0002092	72.37	silver quality
right adrenal gland	UBERON:0001233	72.19	gold quality
right adrenal gland cortex	UBERON:0035827	71.79	gold quality
right lobe of liver	UBERON:0001114	71.42	gold quality
metanephros cortex	UBERON:0010533	71.37	gold quality
adrenal cortex	UBERON:0001235	71.08	gold quality
monocyte	CL:0000576	70.82	gold quality
body of pancreas	UBERON:0001150	70.79	gold quality
cerebellum	UBERON:0002037	70.76	gold quality
spleen	UBERON:0002106	70.70	gold quality
adrenal gland	UBERON:0002369	70.59	gold quality
left ovary	UBERON:0002119	70.58	gold quality
leukocyte	CL:0000738	70.47	gold quality
tendon of biceps brachii	UBERON:0008188	70.46	gold quality
right ovary	UBERON:0002118	70.42	gold quality
adenohypophysis	UBERON:0002196	70.09	gold quality
pituitary gland	UBERON:0000007	69.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 11)

• the MYU/hnRNP-K/CDK6 pathway functions downstream of Wnt/c-Myc signaling and plays a critical role in the proliferation and tumorigenicity of colon cancer cells. (PMID:27568568)
• Data suggest that downregulated long non-coding RNA VPS9D1-AS1 may be used as a prognosis predictor of gastric cancer. (PMID:29036784)
• Overexpression of VPS9D1-AS1 serves as a promising biomarker to predict the prognosis of non-small cell lung cancer. (PMID:30119235)
• Study demonstrated that lncRNA MYU functions as an oncogene in prostate cancer at least in part through the miR-184/c-Myc axis. (PMID:30132573)
• ZEB1 activated-VPS9D1-AS1 promotes the tumorigenesis and progression of prostate cancer by sponging miR-4739 to upregulate MEF2D. (PMID:31918265)
• LncRNA VPS9D1-AS1 promotes cell proliferation in acute lymphoblastic leukemia through modulating GPX1 expression by miR-491-5p and miR-214-3p evasion. (PMID:32808668)
• The lncRNA VPS9D1-AS1 Promotes Hepatocellular Carcinoma Cell Cycle Progression by Regulating the HuR/CDK4 Axis. (PMID:34558987)
• VPS9D1-AS1 gene rs7206570 polymorphism associated with the clinical stage of colorectal cancer and binding with hsa-miR-361-3p. (PMID:35022999)
• Long non-coding RNA MYU promotes ovarian cancer cell proliferation by sponging miR-6827-5p and upregulating HMGA1. (PMID:36776216)
• LncRNA VPS9D1-AS1 regulates miR-187-3p/fibroblast growth factor receptor-like 1 axis to promote proliferation, migration, and invasion of prostate cancer cells. (PMID:37929340)
• Long noncoding RNA VPS9D1-AS1 promotes the progression of endometrial cancer via regulation of the miR-187-3p/S100A4 axis. (PMID:38953363)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.