VTRNA1-1

Summary

VTRNA1-1 (vault RNA 1-1, HGNC:12654) is a gene on chromosome 5q31.3.

Vaults are large cytoplasmic ribonucleoproteins of about 13 MD. They are composed of a major vault protein, MVP (MIM 605088), 2 minor vault proteins, TEP1 (MIM 601686) and PARP4 (MIM 607519), and a nontranslated RNA component, VTRNA1-1 (Kickhoefer et al., 1999 [PubMed 10551828]).

Source: NCBI Gene 56664 — RefSeq curated summary.

At a glance

• Gene type: non-coding (vault_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12654
Approved symbol	VTRNA1-1
Name	vault RNA 1-1
Location	5q31.3
Locus type	RNA, vault
Status	Approved
Aliases	hvg-1, HVG1, vRNA, VR1
Ensembl gene	ENSG00000199990
Ensembl biotype	vault_RNA
OMIM	612695
Entrez	56664
RNAcentral	URS00005CCF67 — ncRNA, 98 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 vault_RNA

ENST00000363120

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000363120 — 1 exons

Exon	Start	End
ENSE00001437883	140711275	140711373

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 98.31.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.5141 / max 65.2490, expressed in 108 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
58935	0.5141	108

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.31	gold quality
adrenal tissue	UBERON:0018303	93.50	gold quality
granulocyte	CL:0000094	91.88	gold quality
liver	UBERON:0002107	87.51	gold quality
adult mammalian kidney	UBERON:0000082	86.69	gold quality
kidney	UBERON:0002113	83.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	82.80	gold quality
bone marrow	UBERON:0002371	81.06	gold quality
blood	UBERON:0000178	78.85	gold quality
monocyte	CL:0000576	78.31	gold quality
stomach	UBERON:0000945	77.40	gold quality
islet of Langerhans	UBERON:0000006	76.97	gold quality
muscle of leg	UBERON:0001383	76.35	gold quality
urinary bladder	UBERON:0001255	75.75	gold quality
gastrocnemius	UBERON:0001388	75.03	gold quality
lymph node	UBERON:0000029	74.89	gold quality
adrenal gland	UBERON:0002369	74.68	gold quality
lung	UBERON:0002048	74.26	gold quality
heart	UBERON:0000948	74.22	gold quality
omental fat pad	UBERON:0010414	72.87	gold quality
descending thoracic aorta	UBERON:0002345	72.72	gold quality
right lobe of liver	UBERON:0001114	71.64	gold quality
heart left ventricle	UBERON:0002084	71.59	gold quality
adipose tissue	UBERON:0001013	71.41	gold quality
colon	UBERON:0001155	71.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.13	gold quality
intestine	UBERON:0000160	71.08	gold quality
body of stomach	UBERON:0001161	70.73	gold quality
body of pancreas	UBERON:0001150	70.69	gold quality
thoracic aorta	UBERON:0001515	70.54	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.08

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• VTRNA1-1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. (PMID:21555518)
• Human vtRNA1-1 Levels Modulate Signaling Pathways and Regulate Apoptosis in Human Cancer Cells. (PMID:32316166)

Cross-species orthologs

0 orthologs

Paralogs (7): VTRNA3-1P (ENSG00000199422), VTRNA1-2 (ENSG00000202111), VTRNA1-3 (ENSG00000202515), VTRNA2-2P (ENSG00000251900), Vault (ENSG00000252283), Vault (ENSG00000252328), Vault (ENSG00000252485)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.