VTRNA1-2

Summary

VTRNA1-2 (vault RNA 1-2, HGNC:12655) is a gene on chromosome 5q31.3.

At a glance

• Gene type: non-coding (vault_RNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:12655
Approved symbol	VTRNA1-2
Name	vault RNA 1-2
Location	5q31.3
Locus type	RNA, vault
Status	Approved
Aliases	hvg-2, HVG2, VR2
Ensembl gene	ENSG00000202111
Ensembl biotype	vault_RNA
OMIM	612696
Entrez	56663
RNAcentral	URS0000000A8C — ncRNA, 88 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 vault_RNA

ENST00000365241

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000365241 — 1 exons

Exon	Start	End
ENSE00001808742	140718925	140719013

Expression profiles

Bgee: expression breadth broad, 70 present calls, max score 93.58.

Top tissues by expression

70 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.58	gold quality
adrenal tissue	UBERON:0018303	92.61	gold quality
muscle of leg	UBERON:0001383	87.43	gold quality
liver	UBERON:0002107	87.34	gold quality
endometrium	UBERON:0001295	80.79	gold quality
vermiform appendix	UBERON:0001154	79.66	gold quality
islet of Langerhans	UBERON:0000006	76.05	gold quality
stomach	UBERON:0000945	75.96	gold quality
myometrium	UBERON:0001296	75.60	gold quality
tibial nerve	UBERON:0001323	75.16	gold quality
body of stomach	UBERON:0001161	74.23	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.22	gold quality
blood	UBERON:0000178	74.07	gold quality
left adrenal gland	UBERON:0001234	73.52	gold quality
body of pancreas	UBERON:0001150	73.11	gold quality
right adrenal gland cortex	UBERON:0035827	73.08	gold quality
gall bladder	UBERON:0002110	72.59	gold quality
heart	UBERON:0000948	72.14	gold quality
left coronary artery	UBERON:0001626	72.10	gold quality
right atrium auricular region	UBERON:0006631	72.02	gold quality
left adrenal gland cortex	UBERON:0035825	71.95	gold quality
intestine	UBERON:0000160	71.84	gold quality
colon	UBERON:0001155	71.48	gold quality
lung	UBERON:0002048	71.29	gold quality
omental fat pad	UBERON:0010414	71.19	gold quality
right adrenal gland	UBERON:0001233	71.14	gold quality
monocyte	CL:0000576	71.02	gold quality
tonsil	UBERON:0002372	70.73	gold quality
tibial artery	UBERON:0007610	70.56	gold quality
popliteal artery	UBERON:0002250	70.03	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.90

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• VTRNA1-2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. (PMID:21555518)

Cross-species orthologs

0 orthologs

Paralogs (7): VTRNA3-1P (ENSG00000199422), VTRNA1-1 (ENSG00000199990), VTRNA1-3 (ENSG00000202515), VTRNA2-2P (ENSG00000251900), Vault (ENSG00000252283), Vault (ENSG00000252328), Vault (ENSG00000252485)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.