VWC2

Summary

VWC2 (von Willebrand factor C domain containing 2, HGNC:30200) is a protein-coding gene on chromosome 7p12.2, encoding Brorin (Q2TAL6). BMP antagonist which may play a role in neural development.

This gene encodes a secreted bone morphogenic protein antagonist. The encoded protein is possibly involved in neural function and development and may have a role in cell adhesion.

Source: NCBI Gene 375567 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_198570

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30200
Approved symbol	VWC2
Name	von Willebrand factor C domain containing 2
Location	7p12.2
Locus type	gene with protein product
Status	Approved
Aliases	PSST739, UNQ739
Ensembl gene	ENSG00000188730
Ensembl biotype	protein_coding
OMIM	611108
Entrez	375567

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000340652, ENST00000855725, ENST00000855726, ENST00000855727, ENST00000855728, ENST00000855729, ENST00000855730, ENST00000855731

RefSeq mRNA: 1 — MANE Select: NM_198570 NM_198570

CCDS: CCDS5508

Canonical transcript exons

ENST00000340652 — 4 exons

Exon	Start	End
ENSE00001364704	49773638	49774113
ENSE00001367427	49802711	49802840
ENSE00001387358	49912034	49921950
ENSE00001390308	49775333	49776131

Expression profiles

Bgee: expression breadth broad, 96 present calls, max score 80.55.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.4097 / max 48.2534, expressed in 128 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
78609	0.2556	106
78610	0.0832	53
78611	0.0532	30
78612	0.0176	5

Top tissues by expression

230 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cerebellar cortex	UBERON:0002129	80.55	gold quality
cerebellar hemisphere	UBERON:0002245	80.54	gold quality
right hemisphere of cerebellum	UBERON:0014890	80.24	gold quality
cerebellum	UBERON:0002037	79.85	gold quality
heart left ventricle	UBERON:0002084	71.59	gold quality
apex of heart	UBERON:0002098	71.57	gold quality
cardiac ventricle	UBERON:0002082	70.85	gold quality
right atrium auricular region	UBERON:0006631	70.64	gold quality
left ovary	UBERON:0002119	70.23	gold quality
cerebellar vermis	UBERON:0004720	69.64	gold quality
prefrontal cortex	UBERON:0000451	69.49	gold quality
cardiac atrium	UBERON:0002081	69.26	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	67.96	silver quality
heart	UBERON:0000948	66.03	gold quality
anterior cingulate cortex	UBERON:0009835	65.61	gold quality
primary visual cortex	UBERON:0002436	65.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.26	gold quality
amygdala	UBERON:0001876	64.65	gold quality
ovary	UBERON:0000992	64.53	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	64.13	gold quality
right ovary	UBERON:0002118	63.56	gold quality
neocortex	UBERON:0001950	63.51	gold quality
right frontal lobe	UBERON:0002810	63.45	gold quality
frontal cortex	UBERON:0001870	63.12	gold quality
hypothalamus	UBERON:0001898	62.63	gold quality
cortical plate	UBERON:0005343	61.11	gold quality
cerebral cortex	UBERON:0000956	60.51	gold quality
occipital lobe	UBERON:0002021	59.53	gold quality
brain	UBERON:0000955	58.81	gold quality
Brodmann (1909) area 23	UBERON:0013554	58.05	silver quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-35	yes	72.90
E-HCAD-25	yes	43.01
E-ANND-3	yes	5.68

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

186 targeting VWC2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4482-3P	99.98	72.50	3147
HSA-MIR-302C-5P	99.97	72.56	3642
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-8082	99.95	67.27	1170
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-552-5P	99.93	68.56	1583
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-3119	99.92	71.34	2390
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-5680	99.91	69.83	3421
HSA-MIR-3671	99.90	73.04	3897

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	vwc2	ENSDARG00000076495
mus_musculus	Vwc2	ENSMUSG00000050830
rattus_norvegicus	Vwc2	ENSRNOG00000049076

Paralogs (19): CHRDL2 (ENSG00000054938), CHRD (ENSG00000090539), CHRDL1 (ENSG00000101938), TECTA (ENSG00000109927), VWF (ENSG00000110799), MUC5B (ENSG00000117983), KCP (ENSG00000135253), ZAN (ENSG00000146839), CRIM1 (ENSG00000150938), BMPER (ENSG00000164619), OTOGL (ENSG00000165899), VWCE (ENSG00000167992), VWC2L (ENSG00000174453), MUC6 (ENSG00000184956), OTOG (ENSG00000188162), MUC2 (ENSG00000198788), MUC19 (ENSG00000205592), MUC5AC (ENSG00000215182), FCGBP (ENSG00000275395)

Protein

Protein identifiers

Brorin — Q2TAL6 (reviewed: Q2TAL6)

Alternative names: Brain-specific chordin-like protein, von Willebrand factor C domain-containing protein 2

All UniProt accessions (1): Q2TAL6

UniProt curated annotations — full annotation on UniProt →

Function. BMP antagonist which may play a role in neural development. Promotes cell adhesion.

Subunit / interactions. Peripherally associated with AMPAR complex. AMPAR complex consists of an inner core made of 4 pore-forming GluA/GRIA proteins (GRIA1, GRIA2, GRIA3 and GRIA4) and 4 major auxiliary subunits arranged in a twofold symmetry. One of the two pairs of distinct binding sites is occupied either by CNIH2, CNIH3 or CACNG2, CACNG3. The other harbors CACNG2, CACNG3, CACNG4, CACNG8 or GSG1L. This inner core of AMPAR complex is complemented by outer core constituents binding directly to the GluA/GRIA proteins at sites distinct from the interaction sites of the inner core constituents. Outer core constituents include at least PRRT1, PRRT2, CKAMP44/SHISA9, FRRS1L and NRN1. The proteins of the inner and outer core serve as a platform for other, more peripherally associated AMPAR constituents, including VWC2. Alone or in combination, these auxiliary subunits control the gating and pharmacology of the AMPAR complex and profoundly impact their biogenesis and protein processing.

Subcellular location. Secreted. Extracellular space. Extracellular matrix. Basement membrane. Synapse.

RefSeq proteins (1): NP_940972* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001007	VWF_dom	Domain
IPR042979	VWC2/VWC2L	Family
IPR057856	VWC2L_C	Domain
IPR059152	VWC2L_N	Domain

Pfam: PF23331, PF23333, PF23334

UniProt features (10 total): domain 2, compositionally biased region 2, signal peptide 1, chain 1, region of interest 1, short sequence motif 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q2TAL6-F1	69.08	0.26

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 144 (showing top): GOBP_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, GOBP_POSITIVE_REGULATION_OF_NEURON_DIFFERENTIATION, TATTATA_MIR374, GOBP_NEUROGENESIS, GOBP_PROTEIN_LOCALIZATION_TO_CELL_PERIPHERY, GOBP_POSITIVE_REGULATION_OF_CELL_ADHESION, GOBP_NEGATIVE_REGULATION_OF_CELLULAR_RESPONSE_TO_GROWTH_FACTOR_STIMULUS, GOBP_REGULATION_OF_NEURON_DIFFERENTIATION, GOBP_REGULATION_OF_TRANSMEMBRANE_RECEPTOR_PROTEIN_SERINE_THREONINE_KINASE_SIGNALING_PATHWAY, GOBP_POSITIVE_REGULATION_OF_CELL_DIFFERENTIATION, GOBP_NEGATIVE_REGULATION_OF_BMP_SIGNALING_PATHWAY, GOBP_RESPONSE_TO_BMP, GOBP_REGULATION_OF_CELL_SUBSTRATE_ADHESION, GOBP_RESPONSE_TO_GROWTH_FACTOR, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE

GO Biological Process (4): positive regulation of cell-substrate adhesion (GO:0010811), negative regulation of BMP signaling pathway (GO:0030514), positive regulation of neuron differentiation (GO:0045666), neurotransmitter receptor localization to postsynaptic specialization membrane (GO:0099645)

GO Molecular Function (2): molecular_function (GO:0003674), protein binding (GO:0005515)

GO Cellular Component (9): basement membrane (GO:0005604), interstitial matrix (GO:0005614), obsolete extracellular space (GO:0005615), AMPA glutamate receptor complex (GO:0032281), extrinsic component of postsynaptic membrane (GO:0098890), glutamatergic synapse (GO:0098978), extracellular region (GO:0005576), extracellular matrix (GO:0031012), synapse (GO:0045202)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
extracellular matrix	2
regulation of cell-substrate adhesion	1
cell-substrate adhesion	1
positive regulation of cell adhesion	1
BMP signaling pathway	1
regulation of BMP signaling pathway	1
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	1
negative regulation of cellular response to growth factor stimulus	1
neuron differentiation	1
positive regulation of cell differentiation	1
regulation of neuron differentiation	1
protein-containing complex localization	1
receptor localization to synapse	1
regulation of postsynaptic membrane neurotransmitter receptor levels	1
protein localization to postsynaptic specialization membrane	1
binding	1
ionotropic glutamate receptor complex	1
postsynaptic membrane	1
extrinsic component of synaptic membrane	1
synapse	1
cellular anatomical structure	1
external encapsulating structure	1
cell junction	1

Protein interactions and networks

STRING

958 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
VWC2	CHRD	Q9H2X0	819
VWC2	NRN1	Q9NPD7	622
VWC2	BMP6	P22004	620
VWC2	VWCE	Q96DN2	601
VWC2	NOG	Q13253	591
VWC2	CCDC175	P0C221	591
VWC2	PRR35	P0CG20	575
VWC2	GSG1L	Q6UXU4	527
VWC2	KBTBD12	Q3ZCT8	521
VWC2	BMP2	P12643	511
VWC2	CLVS2	Q5SYC1	506
VWC2	RRP36	Q96EU6	492
VWC2	ZPBP	Q9BS86	487
VWC2	BMPER	Q8N8U9	478
VWC2	TOGARAM1	Q9Y4F4	463

IntAct

178 interactions, top by confidence:

A	B	Type	Score
VWC2	ZNF696	psi-mi:“MI:0915”(physical association)	0.670
KRTAP5-9	VWC2	psi-mi:“MI:0915”(physical association)	0.560
OTX1	VWC2	psi-mi:“MI:0915”(physical association)	0.560
POU4F2	VWC2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE2C	psi-mi:“MI:0915”(physical association)	0.560
VWC2	KRTAP2-4	psi-mi:“MI:0915”(physical association)	0.560
CYSRT1	VWC2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	UBQLN2	psi-mi:“MI:0915”(physical association)	0.560
HOXA1	VWC2	psi-mi:“MI:0915”(physical association)	0.560
KRTAP10-8	VWC2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	ADAMTSL4	psi-mi:“MI:0915”(physical association)	0.560
VWC2	UBQLN1	psi-mi:“MI:0915”(physical association)	0.560
VWC2	CRY2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	SCNM1	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE2D	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE3A	psi-mi:“MI:0915”(physical association)	0.560
HPCAL1	VWC2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE3D	psi-mi:“MI:0915”(physical association)	0.560
VWC2	SGTB	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE1F	psi-mi:“MI:0915”(physical association)	0.560
VWC2	SHFL	psi-mi:“MI:0915”(physical association)	0.560
VWC2	CNNM3	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE1C	psi-mi:“MI:0915”(physical association)	0.560
VWC2	FAM90A1	psi-mi:“MI:0915”(physical association)	0.560
VWC2	FUCA2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	KRTAP13-2	psi-mi:“MI:0915”(physical association)	0.560
VWC2	LCE3E	psi-mi:“MI:0915”(physical association)	0.560
VWC2	ZNF417	psi-mi:“MI:0915”(physical association)	0.560
VWC2	CATSPER1	psi-mi:“MI:0915”(physical association)	0.560
VWC2	KRTAP13-3	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (63): VWC2 (Affinity Capture-MS), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid), VWC2 (Two-hybrid)

ESM2 similar proteins: A0A1W2PP97, A6NLX4, A6QNY1, P0DJK0, P12838, P13207, P22389, P22749, P23943, P29473, P29474, P55056, P70313, P79209, P97270, P98162, Q1RMT9, Q28969, Q2TAL6, Q2VPJ9, Q4TUC0, Q566C8, Q5BIR3, Q5JTB6, Q5NRP8, Q5RCS3, Q5SPX3, Q5XIX0, Q62600, Q64322, Q7TMJ8, Q7TPD7, Q7TSF4, Q80TT8, Q867D0, Q8BZT7, Q8C8N3, Q8K1T4, Q8K4Z2, Q8MJW9

Diamond homologs: A0A1D5NSM8, A1A5Y0, A2AVA0, A2RUV0, A2VCU8, A5A8Y8, A6QR11, B3EWY9, B5DFC9, G3I6Z6, O75095, O88322, P07996, P0C6B8, P10493, P12105, P14585, P21783, P35441, P35448, P35555, P35556, P41990, P46531, P82279, P98133, Q01705, Q07008, Q14112, Q20911, Q28178, Q2PC93, Q2TAL6, Q2VWQ2, Q3U515, Q4LDE5, Q5R3Z7, Q5RBP1, Q61220, Q61554

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 57 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Formation of the cornified envelope	9	20.3×	1e-08
Keratinization	14	20.0×	1e-13

GO biological processes:

GO term	Partners	Fold	FDR
keratinization	9	40.5×	2e-10

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	55
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1488 predictions. Top by Δscore:

Variant	Effect	Δscore
7:49802704:GTTTC:G	acceptor_loss	0.9900
7:49802705:TTTCA:T	acceptor_loss	0.9900
7:49802706:TTCAG:T	acceptor_loss	0.9900
7:49802707:TCAGG:T	acceptor_loss	0.9900
7:49802708:CA:C	acceptor_loss	0.9900
7:49826200:T:G	acceptor_gain	0.9900
7:49826204:T:A	acceptor_gain	0.9900
7:49912123:G:GT	donor_gain	0.9900
7:49802710:GGT:G	acceptor_gain	0.9800
7:49826191:T:TA	acceptor_gain	0.9800
7:49826199:A:AG	acceptor_gain	0.9800
7:49912177:C:T	donor_gain	0.9800
7:49776129:GTG:G	donor_gain	0.9700
7:49826202:ACT:A	acceptor_gain	0.9700
7:49910474:T:G	donor_gain	0.9700
7:49776077:G:GT	donor_gain	0.9600
7:49776128:CGTGG:C	donor_loss	0.9600
7:49776130:TGGT:T	donor_loss	0.9600
7:49776131:GGTAA:G	donor_loss	0.9600
7:49776132:G:GC	donor_loss	0.9600
7:49776132:G:GG	donor_gain	0.9600
7:49776133:T:TT	donor_loss	0.9600
7:49776173:G:GT	donor_gain	0.9600
7:49802709:A:AG	acceptor_gain	0.9600
7:49802710:G:GG	acceptor_gain	0.9600
7:49776134:A:C	donor_loss	0.9500
7:49793079:T:G	acceptor_gain	0.9500
7:49773916:A:G	donor_gain	0.9400
7:49802709:AG:A	acceptor_gain	0.9400
7:49802710:GG:G	acceptor_gain	0.9400

AlphaMissense

2118 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
7:49775898:T:A	C155S	1.000
7:49775899:G:C	C155S	1.000
7:49775941:T:G	F169C	1.000
7:49775973:T:A	C180S	1.000
7:49775974:G:C	C180S	1.000
7:49776127:T:G	F231C	1.000
7:49802789:T:A	C259S	1.000
7:49802789:T:C	C259R	1.000
7:49802790:G:C	C259S	1.000
7:49912042:T:A	C279S	1.000
7:49912042:T:C	C279R	1.000
7:49912043:G:C	C279S	1.000
7:49912044:C:G	C279W	1.000
7:49912134:G:C	W309C	1.000
7:49912134:G:T	W309C	1.000
7:49775898:T:C	C155R	0.999
7:49775899:G:A	C155Y	0.999
7:49775900:C:G	C155W	0.999
7:49775940:T:C	F169L	0.999
7:49775941:T:C	F169S	0.999
7:49775942:C:A	F169L	0.999
7:49775942:C:G	F169L	0.999
7:49775967:T:C	C178R	0.999
7:49775973:T:C	C180R	0.999
7:49775974:G:A	C180Y	0.999
7:49775975:C:G	C180W	0.999
7:49775994:T:A	C187S	0.999
7:49775995:G:C	C187S	0.999
7:49776009:T:A	C192S	0.999
7:49776009:T:C	C192R	0.999

dbSNP variants (sampled 300 via entrez): RS1000018041 (7:49791271 C>G,T), RS1000018716 (7:49882754 T>C), RS1000043554 (7:49776149 G>A,C,T), RS1000057468 (7:49903993 A>G), RS1000062416 (7:49841043 A>C), RS1000077271 (7:49834583 C>G), RS1000142679 (7:49897190 C>T), RS1000146899 (7:49917721 T>C,G), RS1000186590 (7:49869752 C>A), RS1000194769 (7:49897492 A>G), RS1000196201 (7:49833400 A>T), RS1000200385 (7:49853005 C>G), RS1000243555 (7:49866409 G>T), RS1000257157 (7:49847010 C>G,T), RS1000301108 (7:49869948 T>C)

Disease associations

OMIM: gene MIM:611108 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST002707_7	Serum thyroid-stimulating hormone levels	5.000000e-06
GCST002783_395	Body mass index	2.000000e-06
GCST002783_482	Body mass index	4.000000e-06
GCST003264_198	Post bronchodilator FEV1/FVC ratio	3.000000e-06
GCST004747_20	Lung cancer in never smokers	4.000000e-06
GCST004904_76	Body mass index	5.000000e-10
GCST005024_21	Pursuit maintenance gain	7.000000e-06
GCST006585_810	Blood protein levels	1.000000e-22
GCST008478_28	Neurological blood protein biomarker levels	5.000000e-17
GCST012420_13	tricyclic pyrone compound response (IC50)	9.000000e-06
GCST90000050_57	Age at first birth	1.000000e-08

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index
EFO:0004713	FEV/FVC ratio
EFO:0008433	pursuit maintenance gain measurement
EFO:0600033	response to mitochondrial complex I inhibitor
EFO:0009101	age at first birth measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

16 total (human), top 16 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	2
bisphenol A	decreases methylation	1
N-acetyl-4-benzoquinoneimine	affects response to substance	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression	1
CGP 52608	affects binding, increases reaction	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
bisphenol S	affects cotreatment, decreases methylation, increases methylation	1
MT19c compound	decreases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Catechin	affects cotreatment, decreases expression	1
Diazinon	increases methylation	1
Doxorubicin	decreases expression	1
Lipopolysaccharides	decreases expression, affects response to substance, increases expression	1
Plant Extracts	affects cotreatment, decreases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.